GUIDING IMPLANTATION OF AN ENERGY DELIVERY COMPONENT IN A BODY

    公开(公告)号:US20240226544A1

    公开(公告)日:2024-07-11

    申请号:US18559049

    申请日:2022-05-05

    摘要: A system for guiding implantation of an energy delivery component of a cardiac pacing device at a fixation location within a heart of a patient is provided. During a procedure to implant an energy pulse delivery component, the system receives a patient cardiogram collected during pacing of the energy pulse delivery component while the energy pulse delivery component is positioned at a current location within the heart. The system then determines based on the patient cardiogram the current location of the energy pulse delivery component. The system then outputs an indication of the current location to guide affixing of the energy pulse delivery component at the intended fixation location. This process is repeated until the energy pulse delivery component is at the fixation location. The system also evaluates the effectiveness of pacing at intermediate location to optimize the final location based upon simulated electro-mechanics of the system in near-real time.

    SYSTEMS, DEVICES, AND METHODS RELATING TO MEDICATION DOSE GUIDANCE

    公开(公告)号:US20240225535A1

    公开(公告)日:2024-07-11

    申请号:US18511003

    申请日:2023-11-16

    摘要: Systems, devices and methods are provided for titration of a medication dose for a patient or user. The titration may be based on determining a hypoglycemic risk of a user for a plurality of time-of-day periods. The determination of the hypoglycemic risk may be accomplished by known methods, including the glucose pattern analysis, glucose dysregulation analysis, low alarm frequency analysis, and combinations thereof. The system may then select a recommended action based on the analyte pattern type. The system may then store an indicator of the recommended action in a computer memory for output. The system may then output the recommended action. The recommended action may be outputted to the user, an HCP, or a caregiver. The recommended action may also vary depending on who is receiving the recommended action.

    METHOD AND SYSTEM FOR PREDICTING INDIVIDUALIZED BINARY RESPONSE TO A TREATMENT

    公开(公告)号:US20240221959A1

    公开(公告)日:2024-07-04

    申请号:US18288612

    申请日:2022-04-28

    申请人: UCB BIOPHARMA SRL

    摘要: A method is provided for constructing a machine learning algorithm for predicting a response variable for a neurological condition. The method includes extracting variables for characterizing a patient cohort from electronic historical medical data; selecting variables from the extracted variables using a random forest defined by an initial response variable; fitting a Bayesian generalized linear mixed model (GLMM) using the initial response variable; extracting a predictive probability from the Bayesian GLMM for each of the selected variables; determining a target response variable from the predictive probability and the initial response variable; using the random forest and the Bayesian GLMM to obtain final estimated predictive probabilities based on target response variable for each of the selected variables to identify relevant selected variables; and constructing the machine learning algorithm to utilize the relevant selected variables for predicting the response variable for the neurological condition.

    Visualization of biomedical predictions

    公开(公告)号:US12027271B2

    公开(公告)日:2024-07-02

    申请号:US17051002

    申请日:2019-04-30

    IPC分类号: G16H50/30 G16H50/70

    CPC分类号: G16H50/30 G16H50/70

    摘要: The mobile device receives a prediction result via a digital cellular mobile telecommunication network. The prediction result has been generated by a program logic using a biomedical model. The prediction result includes a prediction score, a first confidence interval of prediction scores known to have a percentage of false negative predictions below a predefined FN-percentage threshold and a second confidence interval of score values known to have a percentage of false positive predictions below a predefined FP-percentage threshold. The mobile device displays an analog scale icon including a background area having the prediction score, an analog scale representing the score range; a pointer; a first sub-range indicator indicating the size and position of the first confidence interval; and a second sub-range indicator indicating the size and position of the second confidence interval within the score range.

    INTELLIGENT THROMBUS ASPIRATION SYSTEM
    60.
    发明公开

    公开(公告)号:US20240206891A1

    公开(公告)日:2024-06-27

    申请号:US18542037

    申请日:2023-12-15

    IPC分类号: A61B17/22 G16H40/63 G16H50/70

    摘要: The present disclosure relates to the field of medical equipment, and provides an intelligent thrombus aspiration system, including a negative pressure suction pump, a blood collection tank, a thrombus aspiration connection unit, a suction catheter and a man-machine interaction module. The man-machine interaction module is configured to transmit a target catheter diameter of the suction catheter to the thrombus aspiration connection unit in response to a command for selecting the target catheter diameter. The thrombus aspiration connection unit is configured to obtain historical treatment data corresponding to the target catheter diameter, cluster the historical treatment data through a neural network model so as to obtain a target suction frequency, a target suction duration and a target suction negative pressure corresponding to the target catheter diameter, and control the negative pressure suction pump and the suction catheter in accordance with the target suction frequency, the target suction duration and the target suction negative pressure. According to the present disclosure, it is able to automatically generate an optimum suction strategy corresponding to the target catheter diameter, determine a suction state of the suction catheter, thereby to reduce the amount of bleeding of a patient without reducing the suction efficiency, and remarkably improve a clinical effect of thrombus aspiration.