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公开(公告)号：US09704696B2
公开(公告)日：2017-07-11
申请号：US15075082
申请日：2016-03-18
Applicant: Thermo Fisher Scientific (Bremen) GmbH
Inventor： Alexander Alekseevich Makarov
CPC classification number: H01J49/10 , G01N27/622 , H01J49/0027 , H01J49/0031 , H01J49/0481 , H01J49/06 , H01J49/063 , H01J49/401 , H01J49/4215 , H01J49/423 , H01J49/425 , H01J49/426 , H01J49/427 , H01J49/4295
Abstract: An ion spectrometer is provided, comprising: an ion source, arranged to generate ions continuously with a first range of mass to charge ratios; and an ion trap, arranged to receive ions from the ion source along an axis, and to eject ions with a second range of mass to charge ratios orthogonally to that axis, the second range of mass to charge ratios being narrower than the first range of mass to charge ratios. In some embodiments, ions generated by the ion source continuously flow into the ion trap. Additionally or alternatively, ion optics receive ions ejected from the ion trap and cool the ions without substantial fragmentation. An ion analyser receives ions ejected from the ion trap or ion optics and separates the ions in accordance with at least one characteristic of the ions.
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公开(公告)号：US20160329197A1
公开(公告)日：2016-11-10
申请号：US15108714
申请日：2014-01-16
Applicant: SHIMADZU CORPORATION
Inventor： Shinichi YAMAGUCHI
CPC classification number: H01J49/005 , H01J49/0031 , H01J49/0036 , H01J49/004 , H01J49/40 , H01J49/427
Abstract: The objective of the present invention is to obtain an MS2 spectrum for each of a plurality of different ion species even when their m/z values are extremely close to each other and prevent separate setting of each ion species as the precursor ion. In the vicinity of the target m/z, a precursor-ion selection window covering a predetermined m/z range (2×ΔM) is gradually shifted in predetermined steps (Δm) to define a plurality of windows as the condition of the precursor-ion selection. When an MS2 analysis is performed on the same sample for each window, the intensities of the product-ion peaks which appear on the MS2 spectrum change with the change in the central m/z value of the window. From this intensity change, which of the plurality of ion species selected as the precursor ion is the origin of each product ion is determined. Based on the result of this determination, the product ions are sorted out and an MS2 spectrum is reconstructed for each ion species.
Abstract translation: 本发明的目的是即使当它们的m / z值彼此非常接近并且防止作为前体离子的每个离子种类的单独设置时，也可以获得多种不同离子种类中的每一种的MS2谱。 在目标m / z附近，覆盖预定m / z范围（2×ΔM）的前体离子选择窗口以预定步长（Δm）逐渐移动，以将多个窗口定义为前体 - 离子选择。 当对每个窗口对同一样品进行MS2分析时，出现在MS2光谱上的产物离子峰的强度随窗口中心m / z值的变化而变化。 根据该强度变化，确定选择为前体离子的多个离子种中的哪一个是每个产物离子的来源。 基于该测定的结果，对产物离子进行分选，并为每个离子种类重建MS2光谱。
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公开(公告)号：US09472385B2
公开(公告)日：2016-10-18
申请号：US14677857
申请日：2015-04-02
Applicant: Thermo Finnigan LLC
Inventor： Alexander A. Makarov , Eduard V. Denisov , Alexander Kholomeev
CPC classification number: H01J49/0031 , H01J49/022 , H01J49/36 , H01J49/423 , H01J49/427
Abstract: The present invention provides a radio frequency (RF) power supply in a mass spectrometer. The power supply provides an RF signal to electrodes of a storage device to create a trapping field. The RF field is usually collapsed prior to ion ejection. In an illustrative embodiment the RF power supply includes a RF signal supply; a coil arranged to receive the signal provided by the RF signal supply and to provide an output RF signal for supply to electrodes of an ion storage device; and a shunt including a switch operative to switch between a first open position and a second closed position in which the shunt shorts the coil output.
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公开(公告)号：US09431230B2
公开(公告)日：2016-08-30
申请号：US14367261
申请日：2012-11-28
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Takashi Baba
IPC: H01J49/42
CPC classification number: H01J49/427 , H01J49/4225 , H01J49/4295
Abstract: In a mass spectrometer, a method for trapping ions includes providing at least first and second multipole rod sets positioned in tandem, introducing a plurality of ions into the first rod set, applying an RF potential to at least one of said rod sets to generate a radial trapping potential within said rod sets, applying a radial DC potential to said first rod set so as to modulate said radial trapping potential set as a function of m/z of said ions, and applying a DC potential between said two rod sets to provide an axial bias potential between said two rod sets. The method can further comprise selecting an axial barrier potential to selectively extract ions having an m/z ratio less than a threshold from said first rod set into said second rod set.
Abstract translation: 在质谱仪中，捕获离子的方法包括：提供至少串联定位的第一和第二多极棒组，将多个离子引入到第一棒组中，将RF电势施加到所述棒组中的至少一个，以产生 在所述杆组内的径向捕获电位，向所述第一棒组施加径向DC电位，以便调节作为所述离子的m / z的函数的所述径向捕获电位，以及在所述两个棒组之间施加DC电位以提供 所述两个杆组之间的轴向偏置电位。 所述方法还可以包括选择轴向阻挡势，以选择性地将具有小于阈值的m / z比的离子从所述第一棒组中提取到所述第二棒组中。
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公开(公告)号：US09406495B2
公开(公告)日：2016-08-02
申请号：US14389642
申请日：2013-02-26
Inventor： Gongyu Jiang , Wenjian Sun
CPC classification number: H01J49/423 , H01J49/0027 , H01J49/063 , H01J49/4255 , H01J49/427
Abstract: A linear ion beam bonding apparatus and an array structure thereof, comprising a pair of primary radiofrequency electrodes (501 and 502) extending along the axial direction and oppositely arranged on two sides of the central axis of the linear ion beam bonding apparatus. Section patterns on different section planes of each of the primary radiofrequency electrodes (501 and 502) and perpendicular to the central axis are all kept symmetric via a primary symmetric plane (506) of the central axis. Radiofrequency voltages attached to the primary radiofrequency electrodes (501 and 502) are of identical phases. An ion extraction groove (84) is arranged on at least one of the primary radiofrequency electrodes (501 and 502), while at least one pair of auxiliary electrodes (503 and 505) are arranged on two sides of the pair of primary radiofrequency electrodes (501 and 502). The auxiliary electrodes (503 and 505) are arranged in duality to the primary symmetric plane (506). At least one of the auxiliary electrodes (503 and 505) is provided with a finite number of symmetric planes (507), while a minimal angle greater than 0 degrees and less than 90 degrees is provided between each symmetric plane (507) and the symmetric plane (506) of the primary radiofrequency electrodes (501 and 502). By means of this, a quadrupole field component of an ion beam bonding radiofrequency electric field within the ion beam bonding apparatus is strengthened.
Abstract translation: 一种线性离子束接合装置及其阵列结构，包括沿着轴向延伸并且相对设置在线性离子束接合装置的中心轴线的两侧的一对初级射频电极（501和502）。 主要射频电极（501和502）的每一个并且垂直于中心轴的不同截面的截面图案都通过中心轴的主对称平面（506）保持对称。 附加到主射频电极（501和502）的射频电压具有相同的相位。 离子提取槽（84）布置在主射频电极（501和502）中的至少一个上，而至少一对辅助电极（503和505）布置在一对主射频电极 501和502）。 辅助电极（503和505）与主对称平面（506）的对置布置。 至少一个辅助电极（503和505）设置有有限数量的对称平面（507），而在每个对称平面（507）和对称平面（507）之间提供大于0度且小于90度的最小角度 平面（506）的主射频电极（501和502）。 由此，离子束接合装置内的离子束结合射频电场的四极场成分被加强。
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Patent Agency Ranking
公开(公告)号：US09312114B2
公开(公告)日：2016-04-12
申请号：US14717369
申请日：2015-05-20
Applicant: Thermo Fisher Scientific (Bremen) GmbH
Inventor： Christian Albrecht Hock , Dmitry Grinfeld , Richard Heming
CPC classification number: H01J49/427 , H01J49/0031 , H01J49/0481 , H01J49/063 , H01J49/282 , H01J49/40 , H01J49/4225 , H01J49/424 , H01J49/4245
Abstract: A method of ejecting ions to be analyzed from a quadrupole ion trap in which a trapping field is created by one or more RF voltages applied to one or more electrodes of the trap, the method comprising the steps of cooling the ions to be analyzed within the quadrupole ion trap until the ions are thermalized, reducing the amplitude of one or more RF voltages applied to the quadrupole ion trap and applying the reduced amplitude RF voltages for one half cycle after the one or more RF voltages have reached a zero crossing point, turning off the RF voltages applied to the quadrupole ion trap, and ejecting the ions to be analyzed from the quadrupole ion trap.
Abstract translation: 从四极离子阱中排出要分析的离子的方法，其中通过施加到阱的一个或多个电极的一个或多个RF电压产生捕获场，该方法包括以下步骤：将待分析的离子冷却在 四极离子阱，直到离子被热化，减少施加到四极离子阱的一个或多个RF电压的幅度，并且在一个或多个RF电压已经达到过零点之后将减小幅度的RF电压施加一个半周期，转动 关闭施加到四极离子阱的RF电压，并从四极离子阱中喷射待分析的离子。
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57.发明申请公开(公告)号：US20160099137A1
公开(公告)日：2016-04-07
申请号：US14872402
申请日：2015-10-01
Applicant: 908 Devices Inc.
Inventor： Christopher D. Brown , Evgeny Krylov , Michael Goodwin , Kerin Gregory , Andrew J. Bartfay-Szabo
IPC: H01J49/00
CPC classification number: H01J49/0095 , H01J49/0036 , H01J49/022 , H01J49/025 , H01J49/427
Abstract: The disclosure features mass spectrometry systems and methods that include an ion source, an ion trap, a detector subsystem featuring first and second detector elements, and a controller electrically connected to the ion source, the ion trap, and the detector subsystem and configured so that during operation of the system, the controller: applies an electrical signal to the ion source to generate positively and negatively charged particles from sample particles in the system; applies an electrical signal to the ion trap to eject a plurality of particles from the ion trap through a common aperture of the ion trap, and determines information about the sample particles based on first and second electrical signals generated by the ejected particles.
Abstract translation: 本公开的特征是质谱系统和方法，其包括离子源，离子阱，具有第一和第二检测器元件的检测器子系统，以及电连接到离子源，离子阱和检测器子系统的控制器， 在系统运行期间，控制器：向离子源施加电信号以产生来自系统中样品颗粒的带正电荷和带负电荷的颗粒; 将电信号施加到离子阱以从离子阱通过离子阱的公共孔排出多个颗粒，并且基于由喷出的颗粒产生的第一和第二电信号来确定关于样品颗粒的信息。
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公开(公告)号：US20160042935A1
公开(公告)日：2016-02-11
申请号：US14774473
申请日：2014-03-13
Applicant: MICROMASS UK LIMITED
Inventor： Kevin Giles , Martin Raymond Green , Jason Lee Wildgoose
CPC classification number: H01J49/065 , G01N27/622 , H01J49/0031 , H01J49/4265 , H01J49/427
Abstract: A method of mass and/or ion mobility spectrometry is disclosed comprising: trapping ions in an annular or co-axial ion trap; and then axially ejecting at least some of said ions from said annular or co-axial ion trap into an annular ion guide. Ions trapped in the ion trap are distributed around the entire circumference of the annular or co-axial ion trap. As the ions travel along at least a portion of the length of the ion guide their motion around the circumference of the annular ion guide is unrestricted and the ions separate axially as they travel along the ion guide.
Abstract translation: 公开了一种质量和/或离子迁移光谱法的方法，包括：将离子捕获在环形或同轴离子阱中; 然后将至少一些所述离子从所述环形或同轴离子阱轴向排出到环形离子导向器中。 捕获在离子阱中的离子分布在环形或同轴离子阱的整个圆周周围。 当离子沿着离子导体的长度的至少一部分行进时，它们围绕环形离子引导件的圆周的运动是不受限制的，并且当它们沿着离子导向件行进时，离子轴向分离。
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公开(公告)号：US20150170898A1
公开(公告)日：2015-06-18
申请号：US14389642
申请日：2013-02-26
Inventor： Gongyu Jiang , Wenjian Sun
CPC classification number: H01J49/423 , H01J49/0027 , H01J49/063 , H01J49/4255 , H01J49/427
Abstract: A linear ion beam bonding apparatus and an array structure thereof, comprising a pair of primary radiofrequency electrodes (501 and 502) extending along the axial direction and oppositely arranged on two sides of the central axis of the linear ion beam bonding apparatus. Section patterns on different section planes of each of the primary radiofrequency electrodes (501 and 502) and perpendicular to the central axis are all kept symmetric via a primary symmetric plane (506) of the central axis. Radiofrequency voltages attached to the primary radiofrequency electrodes (501 and 502) are of identical phases. An ion extraction groove (84) is arranged on at least one of the primary radiofrequency electrodes (501 and 502), while at least one pair of auxiliary electrodes (503 and 505) are arranged on two sides of the pair of primary radiofrequency electrodes (501 and 502). The auxiliary electrodes (503 and 505) are arranged in duality to the primary symmetric plane (506). At least one of the auxiliary electrodes (503 and 505) is provided with a finite number of symmetric planes (507), while a minimal angle greater than 0 degrees and less than 90 degrees is provided between each symmetric plane (507) and the symmetric plane (506) of the primary radiofrequency electrodes (501 and 502). By means of this, a quadrupole field component of an ion beam bonding radiofrequency electric field within the ion beam bonding apparatus is strengthened.
Abstract translation: 一种线性离子束接合装置及其阵列结构，包括沿着轴向延伸并且相对设置在线性离子束接合装置的中心轴线的两侧的一对初级射频电极（501和502）。 主要射频电极（501和502）的每一个并且垂直于中心轴的不同截面的截面图案都通过中心轴的主对称平面（506）保持对称。 附加到主射频电极（501和502）的射频电压具有相同的相位。 离子提取槽（84）布置在主射频电极（501和502）中的至少一个上，而至少一对辅助电极（503和505）布置在一对主射频电极 501和502）。 辅助电极（503和505）与主对称平面（506）的对置布置。 至少一个辅助电极（503和505）设置有有限数量的对称平面（507），而在每个对称平面（507）和对称平面（507）之间提供大于0度且小于90度的最小角度 平面（506）的主射频电极（501和502）。 由此，离子束接合装置内的离子束结合射频电场的四极场成分被加强。
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公开(公告)号：US20140264002A1
公开(公告)日：2014-09-18
申请号：US14194279
申请日：2014-02-28
Applicant: Morpho Detection, LLC
Inventor： Lyndon Karl Goedecke
IPC: G01N27/62
CPC classification number: G01N27/622 , H01J49/427
Abstract: An apparatus for detecting constituents in a sample includes a casing and an ionization chamber defined by the casing. The apparatus also includes an ion collector positioned downstream of the ionization chamber. The apparatus further includes a spectral analysis device coupled to the ion collector. The spectral analysis device is configured to generate a detection spectrum representative of ions collected at the ion collector. The detection spectrum includes an analyte peak portion and a peak tailing portion. The apparatus also includes a control system that is configured to generate a first pulse having a first polarity to initiate a discharge of stored ions from the ionization chamber. The control system is also configured to generate a second pulse substantially immediately after the first pulse. The second pulse has a second polarity opposite the first polarity and is configured to reduce the peak tailing portion.
Abstract translation: 用于检测样品中成分的装置包括壳体和由壳体限定的电离室。 该装置还包括位于电离室下游的离子收集器。 该装置还包括耦合到离子收集器的光谱分析装置。 光谱分析装置被配置为产生代表在离子收集器处收集的离子的检测光谱。 检测光谱包括分析物峰部分和峰尾部分。 该装置还包括控制系统，其被配置为产生具有第一极性的第一脉冲以开始从电离室释放存储的离子。 控制系统还被配置为基本上紧接在第一脉冲之后产生第二脉冲。 第二脉冲具有与第一极性相反的第二极性，并且被配置为减小峰值尾部。
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