公开(公告)号：US20120178775A1

公开(公告)日：2012-07-12

申请号：US13343686

申请日：2012-01-04

Applicant: Che-Kun James SHEN ,  Kuen-Jer Tsai

Inventor： Che-Kun James SHEN ,  Kuen-Jer Tsai

IPC: A61K31/439 ,  A61P25/00

CPC classification number: A61K31/4433 ,  A61K31/132 ,  A61K31/138 ,  A61K31/513 ,  A61K31/55 ,  A61K31/7016

Abstract: Methods for rescuing learning, memory and/or motor function deficits associated with frontotemporal lobar degeneration with ubiquitinated inclusions (FTLD-U) are disclosed. The method comprises: a) administering to an animal having FTLD-U a therapeutically effective amount of an autophagy inducer; b) causing a decrease in the amount of ubiquitinated TDP-43 aggregation forms in the brain of the animal; and c) causing an improvement of the learning, memory capacities and/or motor function of the animal.

Abstract translation: 公开了拯救与泛素化包涵体（FTLD-U）的额颞叶退变相关的学习，记忆和/或运动功能缺陷的方法。 该方法包括：a）向具有FTLD-U的动物施用治疗有效量的自噬诱导物; b）导致动物脑中泛素化的TDP-43聚集形式的量减少; 和c）改善动物的学习，记忆能力和/或运动功能。

公开(公告)号：US20120156424A1

公开(公告)日：2012-06-21

申请号：US12968913

申请日：2010-12-15

Applicant: Kuei-hsien Chen ,  Ming-Shien Hu ,  Chun-Chiang Kuo ,  Li-chyong Chen

Inventor： Kuei-hsien Chen ,  Ming-Shien Hu ,  Chun-Chiang Kuo ,  Li-chyong Chen

IPC: B32B5/00 ,  C23C16/32 ,  H05H1/46 ,  B32B9/04 ,  C23C16/26 ,  B82Y30/00

CPC classification number: B82Y30/00 ,  B82Y40/00 ,  Y10T428/24174 ,  Y10T428/266

Abstract: A nanosheet includes a 2H—SiC layer having a first surface and a second surface, the first and second surfaces being opposed to each other; a first graphene layer formed of 1-10 graphenes being disposed on the first surface; and a second graphene layer formed of 1-10 graphenes being disposed on the second surface.

Abstract translation: 纳米片包括具有第一表面和第二表面的2H-SiC层，第一和第二表面彼此相对; 由1-10个石墨烯形成的第一石墨烯层设置在第一表面上; 并且由1-10个石墨烯形成的第二石墨烯层设置在第二表面上。

公开(公告)号：US20120126112A1

公开(公告)日：2012-05-24

申请号：US13365105

申请日：2012-02-02

Applicant: Chung Hsuan Chen ,  Jung-Lee Lin ,  Nien-Yeen Hsu ,  Yi-Sheng Wang

Inventor： Chung Hsuan Chen ,  Jung-Lee Lin ,  Nien-Yeen Hsu ,  Yi-Sheng Wang

IPC: H01J49/40 ,  H05H9/00 ,  H01J49/10

CPC classification number: H05H5/047 ,  H01J49/06 ,  H01J49/40 ,  H01J49/403

Abstract: A novel system and methods for accelerating analytes including, without limitation, molecular ions, biomolecules, polymers, nano- and microparticles, is provided. The invention can be useful for increasing detection sensitivity in applications such as mass spectrometry, performing collision-induced dissociation molecular structure analysis, and probing surfaces and samples using accelerated analyte.

Abstract translation: 提供了一种用于加速分析物的新系统和方法，包括但不限于分子离子，生物分子，聚合物，纳米和微粒。 本发明可用于在诸如质谱法，进行碰撞诱导的解离分子结构分析和使用加速分析物的探测表面和样品等应用中提高检测灵敏度。

公开(公告)号：US08168413B2

公开(公告)日：2012-05-01

申请号：US11939311

申请日：2007-11-13

Applicant: Huan-Cheng Chang ,  Wunshain Fann ,  Chau-Chung Han

Inventor： Huan-Cheng Chang ,  Wunshain Fann ,  Chau-Chung Han

IPC: C12N13/00 ,  C09K11/08 ,  B01J19/08

CPC classification number: C09K11/65 ,  C01B32/28 ,  Y10T428/2982

Abstract: A method for preparing luminescent diamond particles (e.g., fluorescent nanodiamonds). The method includes irradiating diamond particles with an ion beam and heating the irradiated diamond particles in a non-oxidizing atmosphere at a temperature between 600 and 1000° C. The diamond particles have a diameter of 1 nm to 1 mm and the ion beam has a kinetic energy of 1 KeV to 900 MeV. Also disclosed are luminescent diamond particles prepared by this method and methods of using them.

Abstract translation: 制备发光金刚石颗粒（例如荧光纳米金刚石）的方法。 该方法包括用离子束照射金刚石颗粒并在600-1000℃的温度下在非氧化性气氛中加热照射的金刚石颗粒。金刚石颗粒的直径为1nm至1mm，离子束具有 1 KeV至900 MeV的动能。 还公开了通过该方法制备的发光金刚石颗粒和使用它们的方法。

公开(公告)号：US20120093721A1

公开(公告)日：2012-04-19

申请号：US13201753

申请日：2010-02-19

Applicant: Han-Chung Wu ,  Chien-Yu Chiu

Inventor： Han-Chung Wu ,  Chien-Yu Chiu

IPC: A61K49/00 ,  A61K51/08 ,  C07K7/08 ,  C12Q1/04 ,  B82Y15/00

CPC classification number: C07K7/08

Abstract: Cancer-targeting peptides and uses thereof in cancer diagnosis.

Abstract translation: 癌症靶向肽及其在癌症诊断中的应用。

公开(公告)号：US08142999B2

公开(公告)日：2012-03-27

申请号：US13100665

申请日：2011-05-04

Applicant: Yuan-Tsong Chen ,  Shuen-Iu Hung ,  Chih-Lung Shen ,  Chi-Feng Chang ,  Hsin-Yu Lin ,  Wei-Hsuan Chen

Inventor： Yuan-Tsong Chen ,  Shuen-Iu Hung ,  Chih-Lung Shen ,  Chi-Feng Chang ,  Hsin-Yu Lin ,  Wei-Hsuan Chen

IPC: C12Q1/68 ,  C12P19/34 ,  C12M1/34

CPC classification number: C12Q1/6881 ,  C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/142 ,  C12Q2600/156 ,  C12Q2600/16 ,  C12Q2600/172 ,  Y10T436/143333

Abstract: This invention relates to a method of determining the presence of certain HLA alleles, such as HLA-B*1502 or HLA-B*5801, and a kit for carrying out this method. Also disclosed is a method for assessing whether a patient is at risk for developing adverse drug reactions (e.g., Stevens-Johnson syndrome, toxic epidermal necrolysis, or hypersensitivity syndrome) based on the presence or absence of a genetic marker (e.g., HLA-B*1502, HLA-B*5801, or HLA-B*4601).

Abstract translation: 本发明涉及确定某些HLA等位基因如HLA-B * 1502或HLA-B * 5801的存在的方法以及用于实施该方法的试剂盒。 还公开了一种基于遗传标记（例如HLA-B）的存在或不存在来评估患者是否处于发展不良药物反应（例如，史蒂文斯 - 约翰逊综合征，中毒性表皮坏死松解症或超敏反应综合征）的风险中的方法 * 1502，HLA-B * 5801或HLA-B * 4601）。

公开(公告)号：US08105827B2

公开(公告)日：2012-01-31

申请号：US11851042

申请日：2007-09-06

Applicant: Yu-Chan Chao ,  Catherine Y. Y. Liu ,  Carol P. Y. Wu

Inventor： Yu-Chan Chao ,  Catherine Y. Y. Liu ,  Carol P. Y. Wu

IPC: C12N15/85 ,  C12N15/86 ,  C12N1/21 ,  C12N1/15 ,  C12N5/14 ,  C12N1/19

CPC classification number: C12N15/85 ,  C12N2800/107 ,  C12N2830/00

Abstract: Disclosed are recombinant non-insect host cells and use of activation of CMV or SV40 promoters by IE1, IE2 and the enhancer hr of the baculovirus in non-insect host cells for expression heterologous RNAs or polypeptides. Also disclosed are methods of using the cells.

Abstract translation: 公开了重组非昆虫宿主细胞，并且使用IE6，IE2中的CMV或SV40启动子和非昆虫宿主细胞中杆状病毒的增强子hr用于表达异源RNA或多肽的活化。 还公开了使用细胞的方法。

公开(公告)号：US20110307200A1

公开(公告)日：2011-12-15

申请号：US13157387

申请日：2011-06-10

Applicant: Chun-Nan Hsu ,  Jane Yung-Jen Hsu ,  Gu-Yuan Lin ,  Shih-Chiang Lee

Inventor： Chun-Nan Hsu ,  Jane Yung-Jen Hsu ,  Gu-Yuan Lin ,  Shih-Chiang Lee

IPC: G06F19/00 ,  G01R21/00

CPC classification number: G06Q50/06 ,  G01R22/10

Abstract: An approach to measuring power consumption of multiple appliances adopts a transition probability to model the correlation and causality of appliance events caused by human behavior. The sequential order and relevance of using appliances can be taken into account. For instance, correlation between the use of (e.g., states of) different electrical appliances may be used.

Abstract translation: 测量多个设备功耗的方法采用转移概率来模拟人类行为引起的家电事件的相关性和因果关系。 可以考虑使用电器的顺序和相关性。 例如，可以使用不同电器的使用（例如，状态）之间的相关性。

公开(公告)号：US08053769B2

公开(公告)日：2011-11-08

申请号：US12565109

申请日：2009-09-23

Applicant: Chih-Wei Chu ,  Shiau-Shin Cheng

Inventor： Chih-Wei Chu ,  Shiau-Shin Cheng

IPC: H01L35/24 ,  H01L51/00 ,  H01L29/24 ,  H01L51/30

CPC classification number: H01L51/0504 ,  H01L27/28

Abstract: A transistor includes a first semiconductor layer associated with a first electrode; a second semiconductor layer associated with a second electrode; and a discontinuous layer between the first and second semiconductor layer. The discontinuous layer has a plurality of openings being formed on a non-uniform organic surface. Applications of the transistor include an inverter that operates at low supply voltage and high frequency.

Abstract translation: 晶体管包括与第一电极相关联的第一半导体层; 与第二电极相关联的第二半导体层; 以及第一和第二半导体层之间的不连续层。 不连续层具有形成在非均匀有机表面上的多个开口。 晶体管的应用包括在低电源电压和高频率下工作的逆变器。

公开(公告)号：US08048860B2

公开(公告)日：2011-11-01

申请号：US12263896

申请日：2008-11-03

Applicant: Wen-Chin Yang ,  Shu-Lin Chang ,  Lee-Tian Chang ,  Yi-Ming Chiang ,  Lie-Fen Shyur

Inventor： Wen-Chin Yang ,  Shu-Lin Chang ,  Lee-Tian Chang ,  Yi-Ming Chiang ,  Lie-Fen Shyur

IPC: A61K31/7032 ,  C07G3/00 ,  C07H15/10

CPC classification number: A61K36/28 ,  C07H15/10

Abstract: A method of treating a Th1-mediated disorder includes administering to a subject in need of the treatment an effective amount of a compound of the formula I: wherein R1 is H, alkyl, aryl, or cyclyl; R2 is pyranose; R3 is H or alkyl; m is 2, 3, 4, 5, or 6; n is 0, 1, 2, or 3; o is 0, 1, 2, 3, 4; p is 1, 2, 3, or 4; and the Th1-mediated disorder is non-obese diabetes, Crohn's colitis, autoimmune hemolytic anemia, rheumatoid arthritis, autoimmune encephalitis, multiple sclerosis, or autoimmune myocarditis. Also disclosed is a pharmaceutical composition including a compound of formula I above and a pharmaceutically acceptable carrier.

Abstract translation: 治疗Th1介导的病症的方法包括向需要治疗的受试者施用有效量的式I化合物：其中R 1是H，烷基，芳基或环基; R2是吡喃糖; R3是H或烷基; m为2,3,4,5或6; n为0,1,2或3; o是0，1，2，3，4; p是1,2,3或4; 并且Th1介导的病症是非肥胖性糖尿病，克罗恩病的结肠炎，自身免疫性溶血性贫血，类风湿性关节炎，自身免疫性脑炎，多发性硬化或自身免疫性心肌炎。 还公开了包含上述式I化合物和药学上可接受的载体的药物组合物。