公开(公告)号：US06905835B2

公开(公告)日：2005-06-14

申请号：US09866232

申请日：2001-05-25

申请人： Luis Tomás Sorell Gómez ,  Boris Ernesto Acevedo Castro

发明人： Luis Tomás Sorell Gómez ,  Boris Ernesto Acevedo Castro

IPC分类号： A61K39/395 ,  G01N33/53 ,  G01N33/564 ,  G01N33/573

CPC分类号： G01N33/564 ,  G01N33/573 ,  Y10S435/97 ,  Y10S435/971 ,  Y10S436/81

摘要： A non-instrumental assay for the diagnosis of celiac disease based on the general immunochromatographic assay principles. The assay is rapid and simple and allows the reliable detection of anti transglutaminase antibodies, of both IgA and IgG isotype, in samples of human serum, plasma or blood, using as tracer the antigen transglutaminase conjugated to a colored substance, like colloidal gold or colored latex particles. The conjugated antigen is deposited onto an inert fibrous support, from where it can be released by a liquid sample. The antibodies in the sample react with the conjugated antigen developing an immunocomplex that migrates through a carrier membrane, like nitrocellulose or nylon with a pore size that allows a laminar flow of the reagents, until it reacts with the same antigen transglutaminase immobilized onto a reactive zone of the membrane. As a consequence of this reaction the immunocomplex will be trapped in the reaction site and a colored signal will be seen. Therefore a visually detectable signal in the reactive zone of the membrane indicates a positive result for the detection of anti transglutaminase antibodies in the sample.

摘要翻译： 基于一般免疫色谱测定原理的用于诊断乳糜泻的非仪器性测定法。 该测定是快速和简单的，并且允许在人血清，血浆或血液样品中可靠地检测IgA和IgG同种型的抗转谷氨酰胺抗体，使用与着色物质缀合的抗原转谷氨酰胺酶，如胶体金或着色剂 胶乳颗粒。 缀合的抗原沉积在惰性纤维载体上，从其可以被液体样品释放。 样品中的抗体与共轭抗原反应，发生免疫复合物，其通过载体膜迁移，如硝化纤维素或尼龙，其孔径允许试剂层流，直到其与固定在反应区上的相同抗原转谷氨酰胺酶反应 的膜。 作为该反应的结果，免疫复合物将被捕获在反应位点，并且将看到有色信号。 因此，膜的反应性区域中的视觉上可检测的信号指示样品中抗转谷氨酰胺酶抗体检测的阳性结果。

公开(公告)号：US20020107201A1

公开(公告)日：2002-08-08

申请号：US10003858

申请日：2001-10-31

申请人： Centro de Ingenieria genetica y biotecnologia

发明人： Manuel de Jesus Arana Rosainz ,  Santiago Chinea Glay ,  Maribel Guerra Vallespi ,  Osvaldo Reyes Acosta

IPC分类号： A61K038/10 ,  C07K007/08

CPC分类号： C07K14/47 ,  A61K38/00

摘要： The present invention is for a pharmaceutical composition comprising an effective amount of an lipopolysaccharide (LPS) binding and -neutralizing peptide. The LPS binding and neutralizing peptides of the present invention are analogues of peptides from a lipopolysaccharide binding protein region whose primary sequence have been substituted at particular amino acid sites to obtain an effective binding to and neutralization of LPS.

摘要翻译： 本发明涉及包含有效量的脂多糖（LPS）结合和中和肽的药物组合物。 本发明的LPS结合和中和肽是来自脂多糖结合蛋白区域的肽的类似物，其一级序列已在特定氨基酸位点被取代，以获得LPS的有效结合和中和。

公开(公告)号：US09364524B2

公开(公告)日：2016-06-14

申请号：US14662482

申请日：2015-03-19

申请人： Centro de Ingenieria Genetica Y Biotecnologia

发明人： Jesus Arturo Junco Barranco ,  Osvaldo Reyes Acosta ,  Eddy Emilio Bover Fuentes ,  Franklin Fuentes Aguilar ,  Eulogio Pimentel Vazquez ,  Roberto Basulto Baker ,  Gerardo Enrique Guillen Nieto ,  Yovisleidys Lopez Saez ,  Hilda Elisa Garay Perez ,  Lesvia Calzada Aguilera ,  Maria Castro Santana ,  Niurka Oneysi Arteaga More ,  Luis Alberto Aguero Barrocal

IPC分类号： A61K39/00 ,  A61K38/09 ,  A61K47/48

CPC分类号： A61K39/0011 ,  A61K38/09 ,  A61K39/0006 ,  A61K47/48261 ,  A61K47/4833 ,  A61K47/6415 ,  A61K47/646 ,  A61K2039/585 ,  A61K2039/6037 ,  A61K2300/00

摘要： A pharmaceutical composition using natural gonadotropin—releasing hormone (GnRH), and/or some of its mimetic peptides, indistinctly bound by its amino or carboxyl extremes to a carrier molecule; in one case by its carboxyl extreme and in the other case by the amino terminal extreme, thus eliciting a faster and more potent immunological response against the endogenous GnRH hormone. This finally leads to the ablation of the GnRH and consequently of the rest of the involved hormones in the stream GnRH/LH-FSH/Testosterone-(estrogens). An advantage of this formulation consists on facilitating the exposition to the immune system of a greater number of epitopes of the GnRH or its mimetics, minimizing thus the steric hindrance produced by the carriers. This invention has a direct application in the castration of pets and animals of economic interest, in the control of human fertility as well as in the treatment of hormone-sensitive tumors, such as that of the prostate, the breast, ovary, the endometry, testicles, hypophysis, salivary glands and other kinds of human tumors.

摘要翻译： 使用天然促性腺激素释放激素（GnRH）和/或其一些模拟肽的药物组合物，其不明显地被其氨基或羧基末端与载体分子结合; 在一种情况下其羧基末端，另一种情况下由氨基末端极端，从而引发对内源GnRH激素的更快更有效的免疫应答。 这最终导致消化GnRH，从而导致流GnRH / LH-FSH /睾酮（雌激素）中涉及的其他激素的消融。 该制剂的优点在于促进免疫系统暴露于更多数量的GnRH或其模拟物的表位，从而最小化载体产生的空间位阻。 本发明直接应用于经济兴趣的宠物和动物的阉割，控制人的生育能力以及治疗激素敏感性肿瘤，如前列腺，乳腺，卵巢， 睾丸，垂体，唾液腺等多种人体肿瘤。

公开(公告)号：US09119830B2

公开(公告)日：2015-09-01

申请号：US13989921

申请日：2011-11-30

申请人： Mario Pablo Estrada Garcia ,  Juna Maria Lugo Gonzalez ,  Yamila Carpio Gonzalez ,  Carolina Tafalla Piñeiro

发明人： Mario Pablo Estrada Garcia ,  Juna Maria Lugo Gonzalez ,  Yamila Carpio Gonzalez ,  Carolina Tafalla Piñeiro

IPC分类号： A61K9/08 ,  A61K31/7056 ,  A61K38/22 ,  A61K9/00 ,  A61K9/51

CPC分类号： A61K38/2278 ,  A61K9/0019 ,  A61K9/0056 ,  A61K9/08 ,  A61K9/5153 ,  A61K31/7056 ,  A61K38/22 ,  A61K2300/00

摘要： The present invention relates to the use of pituitary adenylate cyclase activating polypeptide (PACAP) in the treatment of viral diseases and infectious diseases caused by viruses in aquatic organisms. PACAP, alone or combined with an antiviral molecule, demonstrated its effectiveness by increasing the survival of fish or crustaceans infected by viruses when it was administered orally, by injection or by immersion baths. Furthermore, it was observed that treated organisms keep or increase its weight as compared to infected and non-treated organisms. PACAP or PACAP-containing combinations decreased the viral load in tissues and organs susceptible to viral infections as it was determined by RT-PCR.

摘要翻译： 本发明涉及垂体腺苷酸环化酶活化多肽（PACAP）用于治疗由水生生物体中的病毒引起的病毒性疾病和感染性疾病的用途。 单独或与抗病毒分子组合的PACAP通过口服，注射或浸浴进行口服，通过增加感染病毒的鱼或甲壳类动物的存活来证明其有效性。 此外，观察到与感染和未处理的生物体相比，被处理的生物体保持或增加其重量。 含PACAP或含PACAP的组合降低了病毒感染的组织和器官中的病毒载量，如通过RT-PCR确定的。

公开(公告)号：US09055744B2

公开(公告)日：2015-06-16

申请号：US13865437

申请日：2013-04-18

申请人： Centro de Ingenieria Genetica y Biotecnologia

发明人： Orlando Borras Hidalgo ,  Roxana Caridad Portieles Alvarez ,  Merardo Pujol Ferrer ,  Gil Alberto Enriquez Obregon ,  Ernesto Manuel Gonzalez Ramos ,  Camilo Ayra Pardo ,  Carlos Guillermo Borroto Nordelo

IPC分类号： C12N15/82 ,  A01N37/18 ,  C07K14/415

CPC分类号： A01N37/18 ,  C07K14/415 ,  C12N15/8279 ,  C12N15/8282

摘要： The present invention reveals a nucleic acid sequence from Nicotiana megalosiphon encoding for an anti-pathogenic protein. The invention comprises the use of this nucleic acid molecule in transgenic plants of agricultural interest to confer resistance to pathogens. The invention also includes a bioproduct that comprises this anti-pathogenic protein to control plant pathogen agents.

摘要翻译： 本发明揭示了编码抗病原性蛋白质的烟草巨乳的核酸序列。 本发明包括在农业感兴趣的转基因植物中使用该核酸分子来赋予对病原体的抗性。 本发明还包括一种生物产物，其包含该抗病原性蛋白质以控制植物病原体。

公开(公告)号：US08852601B2

公开(公告)日：2014-10-07

申请号：US10501697

申请日：2003-01-22

申请人： Mario Pablo Estrada Garcia ,  Rebeca Martinez Rodriguez ,  Amilcar Arenal Cruz ,  Rafael Marcos Pimentel Pérez ,  Antonio Morales Rojas ,  Eulogio Pimentel Vázquez ,  Alexander Espinosa Vázquez ,  Carmen Aday Garcia Molina ,  Edenaida Cabrera González ,  Mirta Vinjoy Campa ,  Sergio Toledo Pérez ,  Olimpia Carrillo Famés ,  Claudina Zaldivar Muñoz

发明人： Mario Pablo Estrada Garcia ,  Rebeca Martinez Rodriguez ,  Amilcar Arenal Cruz ,  Rafael Marcos Pimentel Pérez ,  Antonio Morales Rojas ,  Eulogio Pimentel Vázquez ,  Alexander Espinosa Vázquez ,  Carmen Aday Garcia Molina ,  Edenaida Cabrera González ,  Mirta Vinjoy Campa ,  Sergio Toledo Pérez ,  Olimpia Carrillo Famés ,  Claudina Zaldivar Muñoz

IPC分类号： A61K39/00 ,  C12N15/09 ,  C07K7/06 ,  A23K1/18 ,  A61K38/25 ,  A61K38/08 ,  A23K1/165 ,  A23K1/16

CPC分类号： C07K7/06 ,  A23K20/147 ,  A23K20/168 ,  A23K20/184 ,  A23K50/80 ,  A61K38/08 ,  A61K38/25

摘要： The invention is related with the chemical synthesis for increase the growth rate in marketable fish and crustaceanThe aim of this invention is supply GHRP-6 to induce directly or indirectly the release of growthing hormone or like, to produce the increase of circulating growthing hormone level in the blood of the fishes. The peptide is stable, soluble and biologically active.The peptide is able to stimulate growth, improve the larvae quality, and increase the defense against pathogen agents, the dry weight, the protein concentration and the RNA in muscle of fish and crustaceans.

摘要翻译： 本发明涉及用于增加可销售鱼类和甲壳类动物生长速率的化学合成本发明的目的是提供GHRP-6直接或间接诱导生长激素等的释放，以产生循环生长激素水平的增加 在鱼的血中。 该肽是稳定的，可溶的和生物活性的。 该肽能够刺激生长，提高幼虫质量，增加对鱼和甲壳类动物肌肉的病原体，干重，蛋白质浓度和RNA的防御。

公开(公告)号：US20140294889A1

公开(公告)日：2014-10-02

申请号：US14238377

申请日：2012-08-24

申请人： Centro De Ingenieria Genetica y Biotecnologia

发明人： Juana Maria Lugo Gonzalez ,  Yamila Carpio Gonzalez ,  Mario Pablo Estrada Garcia

IPC分类号： A61K39/39

CPC分类号： A61K39/39 ,  A61K39/0003 ,  A61K39/002 ,  A61K39/0208 ,  A61K39/12 ,  A61K39/205 ,  A61K2039/53 ,  A61K2039/552 ,  A61K2039/55516 ,  A61K2039/55566 ,  A61K2039/6031 ,  C12N2720/10034 ,  C12N2760/20034 ,  C12N2770/24334

摘要： The present invention relates to the use of the pituitary adenylate cyclase activating peptide (PACAP) as a molecular adjuvant for vaccines. Among other applications, these vaccines may be used in the protection against infectious agents such as viruses, bacteria and ectoparasites affecting mammals, birds and aquatic organisms. The PACAP, combined with a particular antigen, demonstrates its effectiveness as adjuvant increasing the host immune response against that antigen. This type of response can be observed when the vaccine compositions or combinations that include PACAP are administered orally, by injection, or by immersion baths, in case of aquatic organisms.

摘要翻译： 本发明涉及垂体腺苷酸环化酶活化肽（PACAP）作为疫苗的分子佐剂的用途。 除其他应用之外，这些疫苗可用于防止感染性物质的侵害，例如影响哺乳动物，鸟类和水生生物的病毒，细菌和外寄生虫。 与特定抗原结合的PACAP证明其作为佐剂增加针对该抗原的宿主免疫应答的有效性。 当在水生生物的情况下，当疫苗组合物或包含PACAP的组合在口服，注射或浸浴中进行施用时，可以观察到这种类型的反应。

公开(公告)号：US08722742B2

公开(公告)日：2014-05-13

申请号：US12919416

申请日：2009-02-27

申请人： Yuliet Mazola Reyes ,  Glay Chinea Santiago ,  Osmany Guirola Cruz ,  Roberto Vera Alvarez ,  Vivian Huerta Galindo ,  Noralvis Fleitas Salazar ,  Alexis Musacchio Lasa

发明人： Yuliet Mazola Reyes ,  Glay Chinea Santiago ,  Osmany Guirola Cruz ,  Roberto Vera Alvarez ,  Vivian Huerta Galindo ,  Noralvis Fleitas Salazar ,  Alexis Musacchio Lasa

IPC分类号： A01N41/06 ,  A61K31/18 ,  A61K31/535 ,  A61K31/497 ,  A61K31/4965 ,  A01N43/40 ,  A61K31/445

CPC分类号： A61K31/16 ,  A61K31/18 ,  A61K31/381 ,  A61K31/41 ,  A61K31/426 ,  A61K31/428 ,  A61K31/44 ,  A61K31/495 ,  A61K31/4965 ,  A61K31/50 ,  A61K31/506 ,  A61K31/535 ,  A61K31/55 ,  A61K47/54 ,  Y02A50/385 ,  Y02A50/387 ,  Y02A50/389 ,  Y02A50/393 ,  Y02A50/395

摘要： Use of chemical compounds obtained in silico for the preparation of pharmaceutical compositions to attenuate or inhibit Dengue virus infection. Particularly, through the interference or the modulation of several stages of viral replication cycle related with the entry of virus into host cells and the assembly of mature progeny virions. The invention also comprises the use of such pharmaceutical compositions for prophylactic and/or therapeutic treatment of infection caused by all four serotypes of Dengue virus and other flaviviruses.

摘要翻译： 使用在硅胶中获得的化学化合物用于制备药物组合物以减轻或抑制登革热病毒感染。 特别是通过与病毒进入宿主细胞相关的几个阶段的病毒复制循环的干扰或调节以及成熟后代病毒粒子的组装。 本发明还包括使用这种药物组合物预防和/或治疗由登革热病毒和其他黄病毒的四种血清型引起的感染。

公开(公告)号：US08722626B2

公开(公告)日：2014-05-13

申请号：US13150526

申请日：2011-06-01

申请人： Jorge Berlanga Acosta ,  Danay Cibrian Vera ,  Diana Garcia Del Barco Herrera ,  Gerardo Enrique Guillén Nieto ,  José Suarez Alba ,  Ernesto Lopez Mola ,  Manuel Selman-Housein Sosa ,  Mariela Vazquez Castillo

发明人： Jorge Berlanga Acosta ,  Danay Cibrian Vera ,  Diana Garcia Del Barco Herrera ,  Gerardo Enrique Guillén Nieto ,  José Suarez Alba ,  Ernesto Lopez Mola ,  Manuel Selman-Housein Sosa ,  Mariela Vazquez Castillo

IPC分类号： A61P19/04 ,  A61K38/08 ,  C07K7/06

CPC分类号： A61K38/05 ,  A61K38/08 ,  A61K38/25

摘要： The present invention is related to the use of secretagogue peptides repeatedly administered as part of a pharmaceutical composition that prevent and eradicate the deposition of pathological fibrotic material in parenchymal tissues of internal organs like the liver, lungs, esophagus, small intestine, kidneys, blood vessels, joints, and other systemic forms of cutaneous fibrosis of any etiopathogenesis. Additionally, these peptides prevent and eradicate deposition of amiloid and hyaline materials in any of their correspondent chemical forms and tissue manifestations in the brain, cerebellum, blood vessels, liver, intestines, kidneys, spleen, pancreas, joints and the skin, among others. By this way, cellular, tissular and organ dysfunctions generated by these depositions are corrected. The peptides of the present invention are infiltrated or topically applied, contributing to prevent and eradicate keloids and hypertrophic scars in the skin, derived as sequelae of burns and other cutaneous trauma.

摘要翻译： 本发明涉及使用作为药物组合物的一部分反复施用的促分泌素肽，其用于预防和消除病理性纤维化物质在诸如肝，肺，食管，小肠，肾脏，血管等脏器的实质组织中的沉积 ，关节和其他全身形式的皮肤纤维化的任何发病机制。 此外，这些肽预防和消除了在脑，小脑，血管，肝，肠，肾，脾脏，胰腺，关节和皮肤等中的任何相应的化学形式和组织表现的淀粉样和透明物质的沉积。 通过这种方式，校正由这些沉积产生的细胞，组织和器官功能障碍。 本发明的肽被渗透或局部应用，有助于预防和消除作为烧伤和其它皮肤创伤后遗症的皮肤中的瘢痕疙瘩和肥厚性瘢痕。

公开(公告)号：US08673313B2

公开(公告)日：2014-03-18

申请号：US12671335

申请日：2008-07-31

申请人： Isis del Carmen Torrens Madrazo ,  Maribel Guerra Vallespi ,  Milaid Granadillo Rodriguez ,  Osvaldo Reyes Acosta ,  Boris Ernesto Acevedo Castro

发明人： Isis del Carmen Torrens Madrazo ,  Maribel Guerra Vallespi ,  Milaid Granadillo Rodriguez ,  Osvaldo Reyes Acosta ,  Boris Ernesto Acevedo Castro

IPC分类号： A61K39/12 ,  A61K39/02

CPC分类号： A61K39/12 ,  A61K2039/585 ,  A61K2039/6031 ,  C12N2710/20034

摘要： The present invention relates to use of a new cell penetrating peptides (CPP) and in particular to the region 32-51 of protein Limulus antilipopolisacárido (LALF) and its analogous. This invention refers to compositions containing these peptides associated to biomolecules with therapeutics properties. This invention consist of compositions comprise the covalent fusion of biomolecules, between this human papillomavirus antigens (HPV) to these CPP for induce a potent immune cellular responses against HPV and HPV protein antigen-exhibiting cells including HPV-associated tumors. The referred compositions are applicable in the pharmaceutical industry as vaccine for therapeutic use in human.

摘要翻译： 本发明涉及使用新的细胞穿透肽（CPP），特别涉及蛋白鲎抗脂蛋白（LALF）的区域32-51及其类似物。 本发明涉及包含与具有治疗学性质的生物分子相关联的这些肽的组合物。 本发明由组合物组成，包括生物分子的共价融合，在该人乳头状瘤病毒抗原（HPV）与这些CPP之间，用于诱导对HPV和HPV蛋白抗原呈递细胞（包括HPV相关肿瘤）的有效免疫细胞应答。 所提及的组合物可用作制药工业中用于人类治疗用途的疫苗。