公开(公告)号：US20110065743A1

公开(公告)日：2011-03-17

申请号：US12911244

申请日：2010-10-25

申请人： Frank Ivy CARROLL ,  Hernan A. Navarro ,  Lawrence E. Brieaddy ,  Scott P. Runyon ,  James B. Thomas

发明人： Frank Ivy CARROLL ,  Hernan A. Navarro ,  Lawrence E. Brieaddy ,  Scott P. Runyon ,  James B. Thomas

IPC分类号： A61K31/485 ,  C07D489/02 ,  C07D221/28 ,  A61K31/4748 ,  C07D471/18 ,  C07D211/18 ,  A61K31/451 ,  C07D401/12 ,  A61K31/453 ,  A61P25/00 ,  A61P9/10 ,  A61P3/04

CPC分类号： A61K31/445 ,  A61K31/4545 ,  A61K31/506 ,  A61K31/53 ,  C07D211/22 ,  C07D405/12 ,  C07D409/12

摘要： Kappa opioid receptor antagonists are provided that yield significant improvements in functional binding assays to kappa opioid receptors, and the use of these antagonists in treatment of disease states that are ameliorated by binding of the kappa opioid receptor such as heroin or cocaine addictions.

摘要翻译： 提供了卡帕阿片受体拮抗剂，其对卡帕阿片受体的功能结合测定产生显着的改善，以及这些拮抗剂在治疗通过κ阿片样受体如海洛因或可卡因成瘾的结合而改善的疾病状态中的用途。

公开(公告)号：US20110031388A1

公开(公告)日：2011-02-10

申请号：US12921508

申请日：2009-02-27

申请人： Christopher A. Bower ,  Kristin Hedgepath Gilchrist ,  Brian R. Stoner ,  Dorota Temple

发明人： Christopher A. Bower ,  Kristin Hedgepath Gilchrist ,  Brian R. Stoner ,  Dorota Temple

IPC分类号： H01J49/26 ,  G01N23/00 ,  G01T1/00 ,  B01D59/44 ,  H01J27/02 ,  H05K13/00 ,  B82Y99/00

CPC分类号： H01J49/025 ,  H01J37/244 ,  H01J49/0018 ,  H01J2237/24405 ,  Y10T29/49002

摘要： A detector array and method for making the detector array. The array includes a substrate including a plurality of trenches formed therein, and includes a plurality of collectors electrically isolated from each other, formed on the walls of the trenches, and configured to collect charge particles incident on respective ones of the collectors and to output from said collectors signals indicative of charged particle collection. The array includes a plurality of readout circuits disposed on a side of the substrate opposite openings to the collectors. The readout circuits are configured to read charge collection signals from respective ones of the plurality of collectors.

摘要翻译： 用于制造检测器阵列的检测器阵列和方法。 该阵列包括一个衬底，该衬底包括形成在其中的多个沟槽，并且包括彼此电隔离的多个集电极，形成在沟槽的壁上，并且被配置成收集入射在相应集电极上的电荷粒子，并从 所述收集器信号指示带电粒子收集。 该阵列包括多个读出电路，该读出电路设置在基板的与集电体相对的开口的一侧。 读出电路被配置为从多个收集器中的相应的一个收集器读取电荷收集信号。

公开(公告)号：US20110006204A1

公开(公告)日：2011-01-13

申请号：US12921525

申请日：2009-02-24

申请人： Christopher A. Bower ,  Kristin Hedgepath Gilchrist ,  Brian R. Stoner

发明人： Christopher A. Bower ,  Kristin Hedgepath Gilchrist ,  Brian R. Stoner

IPC分类号： H01J99/00 ,  G01T1/00 ,  H01J49/26 ,  H01J27/20 ,  H01J27/02 ,  H01J37/28 ,  H01J37/26 ,  B01D59/44 ,  H01L31/18

CPC分类号： H01J49/025

摘要： A detector array and method for making the detector array. The detector array includes a substrate including a plurality of trenches formed therein, and a plurality of collectors electrically isolated from each other, formed on the walls of the trenches, and configured to collect charged particles incident on respective ones of the collectors and to output from the collectors signals indicative of charged particle collection. In the detector array, adjacent ones of the plurality of trenches are disposed in a staggered configuration relative to one another. The method forms in a substrate a plurality of trenches across a surface of the substrate such that adjacent ones of the trenches are in a staggered sequence relative to one another, forms in the plurality of trenches a plurality of collectors, and connects a plurality of electrodes respectively to the collectors.

摘要翻译： 用于制造检测器阵列的检测器阵列和方法。 探测器阵列包括一个衬底，该衬底包括形成在其中的多个沟槽，以及形成在沟槽壁上的彼此电隔离的多个集电极，并且被配置成收集入射在相应集电极上的带电粒子，并从 收集器信号指示带电粒子收集。 在检测器阵列中，多个沟槽中的相邻的沟槽相对于彼此以交错的配置布置。 该方法在衬底中形成穿过衬底的表面的多个沟槽，使得相邻的沟槽相对于彼此处于交错的序列，在多个沟槽中形成多个集电极，并且连接多个电极 分别给收藏家。

公开(公告)号：US20100270685A1

公开(公告)日：2010-10-28

申请号：US12754396

申请日：2010-04-05

申请人： Erik P. VICK ,  Dean M. Malta ,  Matthew R. Lueck ,  Dorota Temple

发明人： Erik P. VICK ,  Dean M. Malta ,  Matthew R. Lueck ,  Dorota Temple

IPC分类号： H01L23/48 ,  H01L21/768 ,  H05K3/46 ,  H01L21/60

CPC分类号： H01L23/481 ,  H01L24/29 ,  H01L24/83 ,  H01L25/0657 ,  H01L25/50 ,  H01L2224/2919 ,  H01L2224/838 ,  H01L2225/06541 ,  H01L2924/01006 ,  H01L2924/01013 ,  H01L2924/01029 ,  H01L2924/01033 ,  H01L2924/01074 ,  H01L2924/01075 ,  H01L2924/01078 ,  H01L2924/01082 ,  H01L2924/0132 ,  H01L2924/01322 ,  H01L2924/014 ,  H01L2924/0665 ,  H01L2924/10329 ,  H01L2924/14 ,  H01L2924/1461 ,  H01L2924/15788 ,  Y10T29/5317 ,  H01L2924/00 ,  H01L2924/01014 ,  H01L2924/01032 ,  H01L2924/01031

摘要： An electronic package and method and system for forming the electronic package. The electronic package has a first substrate including a first electronic device and including through-holes extending through an entire thickness of the first substrate. The electronic package has a second substrate bonded to the first substrate, metallizations formed in the through-holes of the first substrate to connect to components of the first electronic device, and a patternable substance disposed between the first substrate and the second substrate and adhering the first substrate and the second substrate together in regions apart from the metallizations. The method and system form through-holes extending through an entire thickness of the first substrate, deposit and pattern an adherable substance on the second substrate in a pattern having openings which expose connections for a second electronic device of the second substrate, align and attach the first substrate and the second substrate together, and form metallizations in the through-holes to connect to the connections for the second electronic device.

摘要翻译： 一种用于形成电子封装的电子封装和方法和系统。 电子封装具有包括第一电子器件的第一衬底，并且包括延伸穿过第一衬底的整个厚度的通孔。 电子封装具有接合到第一基板的第二基板，形成在第一基板的通孔中以连接到第一电子设备的部件的金属化，以及设置在第一基板和第二基板之间的可图案物质， 第一基板和第二基板一起在与金属化部分分开的区域中。 所述方法和系统形成延伸穿过第一基底的整个厚度的通孔，以具有露出第二基底的第二电子器件的连接的开口的图案沉积和图案化第二基底上的可粘附物质，对准并附着 第一基板和第二基板在一起，并且在通孔中形成金属化以连接到用于第二电子设备的连接。

公开(公告)号：US20100209602A1

公开(公告)日：2010-08-19

申请号：US12770421

申请日：2010-04-29

申请人： James Lynn Davis ,  Anthony L. Adrady ,  David S. Ensor ,  Li Han ,  Howard J. Walls

发明人： James Lynn Davis ,  Anthony L. Adrady ,  David S. Ensor ,  Li Han ,  Howard J. Walls

IPC分类号： C09K11/02

CPC分类号： G02B6/0008 ,  C09K11/565 ,  C09K11/883 ,  D01D5/0007 ,  D01F11/00 ,  D04H1/413 ,  D04H1/42 ,  D04H1/4382 ,  D06M11/52 ,  H01L33/501 ,  H01L2924/0002 ,  H01L2924/00

摘要： A device for stimulable light emission that includes a fiber mat of nanofibers having an average fiber diameter in a range between 100 and 2000 nm, and includes plural stimulable particles disposed in association with the nanofibers. The stimulable particles produce secondary light emission upon receiving primary light at a wavelength λ. The average fiber diameter is comparable in size to the wavelength λ in order to provide scattering sites within the fiber mat for the primary light. Various methods for making suitable luminescent nanofiber mats include: electrospinning a polymer solution including or not including the stimulable particles and forming from the electrospun solution nanofibers having an average fiber diameter between 100 and 2000 nm. Methods, which electrospin without the stimulable particles, introduce the stimulable particles during electrospinning or after electrospinning to the fibers and therefore to the resultant fiber mat.

摘要翻译： 一种可刺激发光的装置，其包括平均纤维直径在100和2000nm之间的纳米纤维的纤维垫，并且包括与纳米纤维相关联地设置的多个可刺激的颗粒。 可接受的颗粒在接收波长为λ的原始光时产生二次发光。 平均纤维直径在尺寸上与波长λ相当，以便为初级光提供纤维垫内的散射部位。 用于制备合适的发光纳米纤维毡的各种方法包括：将包含或不包含可刺激颗粒的聚合物溶液静电纺丝并由平均纤维直径在100和2000nm之间的电纺丝溶液纳米纤维形成。 没有刺激性颗粒的静电纺丝的方法是在静电纺丝过程中或静电纺丝后引入可刺激的颗粒到纤维上，从而导致所得的纤维垫。

公开(公告)号：US20100183302A1

公开(公告)日：2010-07-22

申请号：US12663610

申请日：2008-04-16

申请人： Michael Lamvik ,  Scott Goodwin ,  Gary E. McGuire

发明人： Michael Lamvik ,  Scott Goodwin ,  Gary E. McGuire

IPC分类号： H04J14/00 ,  G02B6/26 ,  G02B6/36

CPC分类号： G02B6/3502 ,  G02B6/1221 ,  G02B6/136 ,  G02B6/355 ,  G02B6/3558 ,  G02B6/357 ,  G02B6/3596 ,  G02B2006/12069 ,  G02B2006/12145

摘要： An optical device for switching an optical signal between a first optical path and a second optical path, including a substrate, a first guide forming at least a portion of the first optical path, formed on the substrate, and having a movable portion separated from the substrate, a second guide forming at least a portion of the second optical path and disposed adjacent to the first guide, and means for electro statically bending the movable portion so as to optically couple the first guide to the second guide.

摘要翻译： 一种用于在包括基板的第一光路和第二光路之间切换光信号的光学装置，形成在所述基板上的第一光路的至少一部分的第一引导件，并且具有与所述第一光路分离的可动部分 基板，形成第二光路的至少一部分并且邻近第一引导件设置的第二引导件，以及用于静电地弯曲可移动部分以便将第一引导件光耦合到第二引导件的装置。

公开(公告)号：US20100168583A1

公开(公告)日：2010-07-01

申请号：US12447915

申请日：2006-11-03

申请人： David Dausch ,  Olaf Von Ramm ,  John Castellucci

发明人： David Dausch ,  Olaf Von Ramm ,  John Castellucci

IPC分类号： A61B8/14

CPC分类号： A61B8/4488 ,  A61B8/12 ,  A61B8/4438 ,  A61B8/445 ,  B06B1/0622

摘要： A method of generating an enhanced receive signal from a piezoelectric ultrasound transducer is described. The method comprises providing a piezoelectric ultrasound transducer comprising a piezoelectric element operable in flexural mode, receiving a acoustic signal by the piezoelectric element, applying a DC bias to the piezoelectric element prior to receiving the acoustic signal and/or concurrently with receiving the acoustic signal, and generating an enhanced receive signal from the piezoelectric element as a result of receiving the acoustic signal by the piezoelectric element. pMUT-based imaging probes using the above method are also described.

摘要翻译： 描述了从压电超声换能器产生增强的接收信号的方法。 该方法包括提供压电超声波换能器，其包括可弯曲模式操作的压电元件，通过压电元件接收声信号，在接收声信号之前和/或与接收声信号同时向压电元件施加DC偏压， 以及作为由压电元件接收声信号的结果，从压电元件产生增强的接收信号。 还描述了使用上述方法的基于pMUT的成像探针。

公开(公告)号：US20090238760A1

公开(公告)日：2009-09-24

申请号：US12297717

申请日：2007-04-19

申请人： Clarence Edgar Cook ,  Kevin M Cook ,  Clyde Ray Tallent ,  Brian Frazier Thomas ,  Hernan Andres Navarro

发明人： Clarence Edgar Cook ,  Kevin M Cook ,  Clyde Ray Tallent ,  Brian Frazier Thomas ,  Hernan Andres Navarro

IPC分类号： A61K51/04 ,  C07D221/16 ,  A61K31/435 ,  A01N43/42 ,  G01N33/567

CPC分类号： C07D221/16

摘要： Hexahydroindenopyridine compounds are disclosed which act as contraceptive agents by disrupting spermatogenesis, acting as spermicides or sperm motility inhibitors and/or act as antifungals; antispermatogenic, sperm motility inhibitors, spermicidal or antifungal compositions containing the compounds; and methods for disrupting spermatogenesis, inhibiting sperm motility, killing motile sperm or treating fungi using the compounds and compositions. Also disclosed are radioactive compounds which may be used to study the binding of antifertility compounds to specific sites in the body and the use of such compounds for that purpose.

摘要翻译： 公开了六氢茚基吡啶化合物，其通过破坏精子发生作用作为避孕药，用作杀精剂或精子活力抑制剂和/或作为抗真菌剂; 抗精子活力抑制剂，含有这些化合物的杀精或抗真菌组合物; 以及使用化合物和组合物破坏精子发生，抑制精子活力，杀死活动精子或治疗真菌的方法。 还公开了可用于研究抗生物化合物与体内特定部位结合的放射性化合物，以及用于该目的的这些化合物的用途。

公开(公告)号：US07592277B2

公开(公告)日：2009-09-22

申请号：US11130269

申请日：2005-05-17

申请人： Anthony L. Andrady ,  David S. Ensor ,  Teri A. Walker ,  Purva Prabhu

发明人： Anthony L. Andrady ,  David S. Ensor ,  Teri A. Walker ,  Purva Prabhu

IPC分类号： D04H1/00 ,  D04H13/00 ,  D04H3/00 ,  D04H5/00

CPC分类号： D01D5/0061 ,  D04H1/4291 ,  Y10T428/29 ,  Y10T428/2913 ,  Y10T428/2915 ,  Y10T428/298 ,  Y10T442/60 ,  Y10T442/614 ,  Y10T442/615 ,  Y10T442/625 ,  Y10T442/626 ,  Y10T442/659 ,  Y10T442/66 ,  Y10T442/681 ,  Y10T442/69 ,  Y10T442/692 ,  Y10T442/696 ,  Y10T442/697 ,  Y10T442/699

摘要： An apparatus and method in which the apparatus includes a first electrospinning device configured to electrospin first fibers of a first substance, a second electrospinning device configured to electrospin second fibers of a second substance such that first and second fibers combine in a mat formation region, and a biasing device configured to bias the first electrospinning device with a first electric polarity and to bias the second electrospinning device with a second electric polarity of opposite polarity to the first electric polarity to promote attraction and coalescence between the first and second fibers. The method electrospins under the first electric polarity first fibers from the first substance, electrospins under the second electric polarity fibers from the second substance, and coalesces the first and second fibers to form the fiber mat.

摘要翻译： 一种装置和方法，其中所述装置包括构造成电旋转第一物质的第一纤维的第一静电纺丝装置，构造成静电纺第二物质的第二纤维以使第一和第二纤维在垫形成区域中结合的第二静电纺丝装置，以及 偏置装置，被配置为以第一电极性偏置第一静电纺丝装置，并且以与第一电极性相反的极性的第二电极极偏置第二静电纺丝装置，以促进第一和第二纤维之间的吸引和聚结。 该方法在来自第一物质的第一电极性第一纤维下电纺丝，在来自第二物质的第二电极性纤维下电纺丝，并且聚结第一和第二纤维以形成纤维垫。

公开(公告)号：US20090079463A1

公开(公告)日：2009-03-26

申请号：US11981853

申请日：2007-10-31

申请人： Robert O. Conn

发明人： Robert O. Conn

IPC分类号： G01R31/26

CPC分类号： H05K7/20927 ,  H01L23/473 ,  H01L23/481 ,  H01L24/05 ,  H01L24/29 ,  H01L24/32 ,  H01L25/0652 ,  H01L2224/0557 ,  H01L2224/29101 ,  H01L2225/0652 ,  H01L2225/06527 ,  H01L2225/06541 ,  H01L2225/06555 ,  H01L2225/06572 ,  H01L2225/06589 ,  H01L2924/0002 ,  H01L2924/01005 ,  H01L2924/01006 ,  H01L2924/01013 ,  H01L2924/01019 ,  H01L2924/01029 ,  H01L2924/01033 ,  H01L2924/01074 ,  H01L2924/01077 ,  H01L2924/014 ,  H01L2924/14 ,  H01L2924/19041 ,  H01L2924/19042 ,  H01L2924/00 ,  H01L2224/05552

摘要： A reconfigurable high performance computer includes a stack of semiconductor substrate assemblies (SSAs). Some SSAs involve FPGA dice that are surface mounted, as bare dice, to a semiconductor substrate. Other SSAs involve memory dice that are surface mounted to a semiconductor substrate. Elastomeric connectors are sandwiched between, and interconnect, adjacent semiconductor substrates proceeding down the stack. Each SSA includes a local defect memory and a self-test mechanism. The self-test mechanism periodically tests the SSA and its interconnects, and stores resulting defect information into its local defect memory. The computer is configured to realize a user design and then is run. A defect is then detected. If the defect is determined to be inma part of the computer used in the realization of user design, then the computer is reconfigured not to use the defective part and running of the computer is resumed, otherwise the computer resumes running without reconfiguration.

摘要翻译： 可重构的高性能计算机包括一堆半导体衬底组件（SSAs）。 一些SSA涉及将半导体衬底表面安装（如裸裸片）的FPGA裸片。 其他SSA涉及表面安装到半导体衬底的存储芯片。 弹性连接器被夹在相邻的半导体衬底之间并且互连在堆叠之下。 每个SSA包括本地缺陷记忆和自检机制。 自检机制定期测试SSA及其互连，并将其产生的缺陷信息存储到其本地缺陷存储器中。 计算机被配置为实现用户设计，然后运行。 然后检测到缺陷。 如果确定缺陷是用于实现用户设计的计算机的一部分，则重新配置计算机不使用有缺陷的部分，并恢复计算机的运行，否则计算机在没有重新配置的情况下恢复运行。