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公开(公告)号：US20190022130A1
公开(公告)日：2019-01-24
申请号：US16137447
申请日：2018-09-20
发明人： Pierre F. LEBRETON
摘要： An injectable monophase hydrogel is provided that is made of a reaction mixture of hyaluronic acids having different molecular weights.
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公开(公告)号：US20180206965A1
公开(公告)日：2018-07-26
申请号：US15414248
申请日：2017-01-24
发明人： Antoine DUC , Bastien MANDAROUX
CPC分类号： A61B17/06004 , A61B17/06109 , A61B17/06166 , A61B17/3468 , A61B2017/00792 , A61B2017/00898 , A61B2017/00942 , A61B2017/06009 , A61B2017/06042 , A61F2/0059 , A61F2210/0061
摘要： Devices and methods for inserting an implant into skin or other tissue of a patient can include a hyaluronic thread that is coupled at along distal portion with an insertion device. The insertion device can include a cover member and a piston that can collectively facilitate engagement with or disengagement of the distal portion of the thread with the device. For example, the piston can be positioned within an inner cavity of the cover member, and the distal portion of the thread can be engaged by and/or between the piston and the cover member. The thread can be released by movement of the piston relative to the cover member. Thus, some insertion devices can grasp or engage the distal portion of the thread and “push” the distal portion thread into and through into skin or other tissue of a patient.
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公开(公告)号：US20170273886A1
公开(公告)日：2017-09-28
申请号：US15514329
申请日：2014-09-30
摘要： The present specification generally relates to an injectable dermal filler composition that includes crosslinked hyaluronic acid-based polymer and an antioxidant.
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公开(公告)号：US20160317571A1
公开(公告)日：2016-11-03
申请号：US15209561
申请日：2016-07-13
发明人： Pierre F. Lebreton
IPC分类号： A61K31/738 , A61K9/00
CPC分类号： A61K31/738 , A61K9/0019 , A61L27/20 , A61L27/50 , A61L27/52 , C08B37/0072 , C08J3/24 , C08J2305/08 , C08L5/08
摘要： An injectable monophase hydrogel is provided and is made of a reaction mixture of a high molecular weight hyaluronic acid and a low molecular weight hyaluronic acid.
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公开(公告)号：US09238013B2
公开(公告)日：2016-01-19
申请号：US13746170
申请日：2013-01-21
发明人： Pierre Lebreton
IPC分类号： A61K31/167 , A61K8/42 , A61K8/73 , A61L27/20 , A61L27/52 , A61L27/54 , A61Q19/08 , A61K31/728
CPC分类号： A61L27/52 , A61K8/42 , A61K8/735 , A61K9/0021 , A61K9/06 , A61K31/167 , A61K31/728 , A61K47/36 , A61L27/20 , A61L27/54 , A61L2300/402 , A61L2300/602 , A61L2400/06 , A61Q19/08 , C08L5/08
摘要： Disclosed herein are cohesive soft tissue fillers, for example, dermal and subdermal fillers, based on hyaluronic acids and pharmaceutically acceptable salts thereof. In one aspect, hyaluronic acid-based compositions described herein include a therapeutically effective amount of at least one anesthetic agent, for example, lidocaine. The present hyaluronic acid-based compositions including lidocaine have an enhanced stability and cohesivity, relative to conventional compositions including lidocaine, for example when subjected to sterilization techniques or when stored for long periods of time. Methods and processes of preparing such hyaluronic acid-based compositions are also provided.
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公开(公告)号：US09125840B2
公开(公告)日：2015-09-08
申请号：US14078057
申请日：2013-11-12
发明人： Pierre F. Lebreton
IPC分类号： A61K31/728 , A61K31/715 , A61K8/73 , A61K8/34 , A61Q19/08 , A61Q19/00
CPC分类号： A61K8/345 , A61K8/73 , A61K8/735 , A61K2800/91 , A61Q19/00 , A61Q19/007 , A61Q19/08
摘要： The present specification discloses fluid compositions comprising a matrix polymer and stabilizing component, methods of making such fluid compositions, and methods of treating skin conditions in an individual using such fluid compositions.
摘要翻译： 本说明书公开了包含基质聚合物和稳定组分的流体组合物，制备这种流体组合物的方法，以及使用这种流体组合物处理个体皮肤状况的方法。
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公开(公告)号：US09089518B2
公开(公告)日：2015-07-28
申请号：US13653266
申请日：2012-10-16
发明人： Pierre Lebreton
IPC分类号： C07H1/00 , A61K31/167 , A61K8/42 , A61K8/73 , A61L27/20 , A61L27/52 , A61L27/54 , A61Q19/08 , A61K31/728
CPC分类号： A61L27/52 , A61K8/42 , A61K8/735 , A61K9/0021 , A61K9/06 , A61K31/167 , A61K31/728 , A61K47/36 , A61L27/20 , A61L27/54 , A61L2300/402 , A61L2300/602 , A61L2400/06 , A61Q19/08 , C08L5/08
摘要： Disclosed herein are cohesive soft tissue fillers, for example, dermal and subdermal fillers, based on hyaluronic acids and pharmaceutically acceptable salts thereof. In one aspect, hyaluronic acid-based compositions described herein include a therapeutically effective amount of at least one anesthetic agent, for example, lidocaine. The present hyaluronic acid-based compositions including lidocaine have an enhanced stability and cohesivity, relative to conventional compositions including lidocaine, for example when subjected to sterilization techniques or when stored for long periods of time. Methods and processes of preparing such hyaluronic acid-based compositions are also provided.
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公开(公告)号：US20140213546A1
公开(公告)日：2014-07-31
申请号：US14242747
申请日：2014-04-01
发明人： Pierre F. Lebreton
CPC分类号： A61L27/52 , A61K8/42 , A61K8/735 , A61K9/0021 , A61K9/06 , A61K31/167 , A61K31/728 , A61K47/36 , A61L27/20 , A61L27/54 , A61L2300/402 , A61L2300/602 , A61L2400/06 , A61Q19/08 , C08L5/08
摘要： Disclosed herein are cohesive soft tissue fillers, for example, dermal and subdermal fillers, based on hyaluronic acids and pharmaceutically acceptable salts thereof. In one aspect, hyaluronic acid-based compositions described herein include a therapeutically effective amount of at least one anesthetic agent, for example, lidocaine. The present hyaluronic acid-based compositions including lidocaine have an enhanced stability and cohesivity, relative to conventional compositions including lidocaine, for example when subjected to sterilization techniques or when stored for long periods of time. Methods and processes of preparing such hyaluronic acid-based compositions are also provided.
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公开(公告)号：US20130131011A1
公开(公告)日：2013-05-23
申请号：US13746170
申请日：2013-01-21
发明人： Pierre Lebreton
IPC分类号： A61K31/728 , A61K31/167
CPC分类号： A61L27/52 , A61K8/42 , A61K8/735 , A61K9/0021 , A61K9/06 , A61K31/167 , A61K31/728 , A61K47/36 , A61L27/20 , A61L27/54 , A61L2300/402 , A61L2300/602 , A61L2400/06 , A61Q19/08 , C08L5/08
摘要： Disclosed herein are cohesive soft tissue fillers, for example, dermal and subdermal fillers, based on hyaluronic acids and pharmaceutically acceptable salts thereof. In one aspect, hyaluronic acid-based compositions described herein include a therapeutically effective amount of at least one anesthetic agent, for example, lidocaine. The present hyaluronic acid-based compositions including lidocaine have an enhanced stability and cohesivity, relative to conventional compositions including lidocaine, for example when subjected to sterilization techniques or when stored for long periods of time. Methods and processes of preparing such hyaluronic acid-based compositions are also provided.
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公开(公告)号：US11224501B2
公开(公告)日：2022-01-18
申请号：US16805576
申请日：2020-02-28
发明人： Antoine Duc , Bastien Mandaroux
摘要： Devices and methods for inserting an implant into skin or other tissue of a patient can include an insertion device that can enclose and support a hyaluronic thread as it is injected into a patient's skin or other tissue. The device can include a cover member, a non-tubular support member, and the thread. The cover member can have a proximal portion, a closed distal portion, and an inner cavity extending from the proximal portion toward the closed distal portion. The thread can be positioned along a longitudinal length of support member, between the support member and the cover member. The non-tubular support member can extend within the inner cavity of the cover member. The cover member can be moveable relative to the support member to expose the thread.
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