公开(公告)号：US20220313870A1

公开(公告)日：2022-10-06

申请号：US17527025

申请日：2021-11-15

申请人： Allergan Industrie, SAS

发明人： Pierre F. LEBRETON

IPC分类号： A61L27/52 ,  A61K8/42 ,  A61K8/73 ,  A61L27/54 ,  A61Q19/08 ,  A61K9/00 ,  A61K9/06 ,  A61K47/36 ,  A61Q19/00 ,  A61K8/02 ,  A61K8/37 ,  A61L27/20 ,  A61K31/167 ,  A61K31/728

摘要： Disclosed herein are soft tissue fillers, for example, dermal and subdermal fillers, based on hyaluronic acids and pharmaceutically acceptable salts thereof. Some of the hyaluronic acid-based compositions can include a therapeutically effective amount of at least one anesthetic agent, for example, lidocaine. Compared to conventional compositions that include lidocaine, some of the hyaluronic acid-based compositions disclosed herein can have an enhanced stability, for example, when subjected to sterilization techniques or when stored for long periods of time. Methods and processes of preparing such compositions are also provided.

公开(公告)号：US11020512B2

公开(公告)日：2021-06-01

申请号：US16695001

申请日：2019-11-25

申请人： ALLERGAN INDUSTRIE, SAS

发明人： Pierre F. Lebreton

IPC分类号： A61L27/52 ,  A61K8/42 ,  A61K8/73 ,  A61L27/54 ,  A61Q19/08 ,  A61K9/00 ,  A61K9/06 ,  A61K47/36 ,  A61Q19/00 ,  A61K8/02 ,  A61K8/37 ,  A61L27/20 ,  A61K31/167 ,  A61K31/728 ,  A61L2/00

摘要： Disclosed herein are cohesive soft tissue fillers, for example, dermal and subdermal fillers, based on hyaluronic acids and pharmaceutically acceptable salts thereof. In one aspect, hyaluronic acid-based compositions described herein include a therapeutically effective amount of at least one anesthetic agent, for example, lidocaine. The present hyaluronic acid-based compositions including lidocaine have an enhanced stability and cohesivity, relative to conventional compositions including lidocaine, for example when subjected to sterilization techniques or when stored for long periods of time. Methods and processes of preparing such hyaluronic acid-based compositions are also provided.

公开(公告)号：US20200345612A1

公开(公告)日：2020-11-05

申请号：US16877315

申请日：2020-05-18

申请人： Allergan Industrie, SAS

发明人： Pierre LEBRETON ,  Olivier GUETTA

IPC分类号： A61K8/73 ,  A61Q19/08 ,  A61K8/67 ,  A61K8/34 ,  A61Q19/00 ,  A61K8/42 ,  A61K8/04

摘要： Injectable compositions and methods of treating skin can help improve hydration, elasticity and/or texture of the skin. The compositions can be based on crosslinked hyaluronic acid matrices made with low molecular weight hyaluronic acids.

公开(公告)号：US20190224366A1

公开(公告)日：2019-07-25

申请号：US16370679

申请日：2019-03-29

申请人： Allergan Industrie, SAS

发明人： Jean-Xavier ROCA MARTINEZ ,  Aurore AYGLON

IPC分类号： A61L27/20

摘要： Methods of treating chin retrusion in a subject by increasing a glabella-subnasale-pogonion (G-Sn-Pog) facial angle of the subject are provided, which may include injecting a first volume of a dermal filler into a pogonion, injecting a second volume of a dermal filler into a mentum, and/or injecting a third volume of the dermal filler into a left pre-j owl sulcus and/or a right pre-jowl sulcus, wherein the G-Sn-Pog facial angle of the subject is increased by at least about 1 or more. Methods of treating chin retrusion are provided that may include injecting a first volume of a dermal filler into a pogonion, injecting a second volume of a dermal filler into a mentum, and/or injecting a third volume of the dermal filler into a left pre-j owl sulcus and/or a right pre-jowl sulcus, wherein the chin retrusion of the subject is decreased by at least about 2 mm.

公开(公告)号：US20190192732A1

公开(公告)日：2019-06-27

申请号：US16290274

申请日：2019-03-01

申请人： Allergan Industrie, SAS

发明人： Cecile Gousse ,  Pierre F. Lebreton ,  Nicholas Prost

IPC分类号： A61L27/20 ,  A61K8/41 ,  A61K8/42 ,  A61K8/73 ,  A61Q19/08 ,  A61Q19/00 ,  A61L27/54 ,  A61L27/00

摘要： The disclosure provides hyaluronic acid (HA) gel formulations and methods for treating the appearance of the skin. The formulations contain hyaluronic acid and at least one additional ingredient. Methods for treating lines, wrinkles, fibroblast depletions, and scars with the disclosed composition are provided as well.

公开(公告)号：US10080767B2

公开(公告)日：2018-09-25

申请号：US15209561

申请日：2016-07-13

申请人： Allergan Industrie SAS

发明人： Pierre F. Lebreton

IPC分类号： A61K31/738 ,  A61L27/20 ,  A61L27/50 ,  A61L27/52 ,  C08B37/08 ,  C08J3/24 ,  C08L5/08 ,  A61K9/00

CPC分类号： A61K31/738 ,  A61K9/0019 ,  A61L27/20 ,  A61L27/50 ,  A61L27/52 ,  C08B37/0072 ,  C08J3/24 ,  C08J2305/08 ,  C08L5/08

摘要： An injectable monophase hydrogel is provided and is made of a reaction mixture of a high molecular weight hyaluronic acid and a low molecular weight hyaluronic acid.

公开(公告)号：US20180206963A1

公开(公告)日：2018-07-26

申请号：US15414195

申请日：2017-01-24

申请人： Allergan Industrie SAS

发明人： Antoine DUC ,  Bastien MANDAROUX

IPC分类号： A61F2/00 ,  A61F2/02 ,  A61F2/10

CPC分类号： A61F2/0059 ,  A61F2/02 ,  A61F2/105

摘要： Devices and methods for inserting an implant into skin or other tissue of a patient can include an insertion device that can enclose and support a hyaluronic thread as it is injected into a patient's skin or other tissue. The device can include a cover member, a non-tubular support member, and the thread. The cover member can have a proximal portion, a closed distal portion, and an inner cavity extending from the proximal portion toward the closed distal portion. The thread can be positioned along a longitudinal length of support member, between the support member and the cover member. The non-tubular support member can extend within the inner cavity of the cover member. The cover member can be moveable relative to the support member to expose the thread.

公开(公告)号：US09585821B2

公开(公告)日：2017-03-07

申请号：US14830119

申请日：2015-08-19

申请人： Allergan Industrie SAS

发明人： Pierre F. Lebreton

IPC分类号： A61K31/728 ,  A61K31/715 ,  A61K8/34 ,  A61K8/73 ,  A61Q19/08 ,  A61Q19/00

CPC分类号： A61K8/345 ,  A61K8/73 ,  A61K8/735 ,  A61K2800/91 ,  A61Q19/00 ,  A61Q19/007 ,  A61Q19/08

摘要： The present specification discloses fluid compositions comprising a matrix polymer and stabilizing component, methods of making such fluid compositions, and methods of treating skin conditions in an individual using such fluid compositions.

摘要翻译： 本说明书公开了包含基质聚合物和稳定组分的流体组合物，制备这种流体组合物的方法，以及使用这种流体组合物处理个体皮肤状况的方法。

公开(公告)号：US20160045413A1

公开(公告)日：2016-02-18

申请号：US14830119

申请日：2015-08-19

申请人： Allergan Industrie SAS

发明人： Pierre F. Lebreton

IPC分类号： A61K8/34 ,  A61Q19/08 ,  A61Q19/00 ,  A61K8/73

CPC分类号： A61K8/345 ,  A61K8/73 ,  A61K8/735 ,  A61K2800/91 ,  A61Q19/00 ,  A61Q19/007 ,  A61Q19/08

摘要： The present specification discloses fluid compositions comprising a matrix polymer and stabilizing component, methods of making such fluid compositions, and methods of treating skin conditions in an individual using such fluid compositions.

摘要翻译： 本说明书公开了包含基质聚合物和稳定组分的流体组合物，制备这种流体组合物的方法，以及使用这种流体组合物处理个体皮肤状况的方法。

公开(公告)号：US20150327972A1

公开(公告)日：2015-11-19

申请号：US14791147

申请日：2015-07-02

申请人： Allergan Industrie SAS

发明人： Kenneth N. Horne ,  Jayakumar Rajadas ,  Geoffrey C. Gurtner ,  Naveen Jayakumar

IPC分类号： A61F2/00 ,  A61L17/04

CPC分类号： A61F2/0059 ,  A61L15/28 ,  A61L15/60 ,  A61L17/04 ,  A61L17/06 ,  A61L27/20 ,  A61L27/52 ,  A61L31/042 ,  A61L31/145 ,  A61L2430/34 ,  C08L5/00

摘要： This disclosure relates generally to soft tissue augmentation threads, methods of making such threads and uses thereof, for example, in aesthetic applications (e.g., facial contouring, soft tissue augmentation products), surgery (e.g., sutures), drug delivery, negative pressure wound therapy, moist wound dressing, and the like.

摘要翻译： 本公开一般涉及软组织增强螺纹，制造这种螺纹的方法及其用途，例如在美学应用（例如，面部轮廓，软组织增强产品），手术（例如缝线），药物递送，负压伤口 治疗，潮湿伤口敷料等。