公开(公告)号：US10429401B2

公开(公告)日：2019-10-01

申请号：US14804214

申请日：2015-07-20

Applicant: Beckman Coulter, Inc.

Inventor： Sebastian Streibl ,  Jiuliu Lu ,  Bian Qian ,  Melvin Ayala

IPC: G01F23/00 ,  G01N35/00 ,  G01N33/49 ,  G01N35/10

Abstract: Container identification data from a container inspection unit that analyzes a container containing a liquid is combined with liquid level detection raw data from a liquid level detection unit that analyzes the container containing the liquid and a liquid level detection result is generated. The liquid level detection result is cross-checked with additional data from the container inspection unit. The result can be used to plan a route for the container in the laboratory automation system.

公开(公告)号：US20190227086A1

公开(公告)日：2019-07-25

申请号：US16277218

申请日：2019-02-15

Applicant: Beckman Coulter, Inc.

Inventor： Andras Guttman ,  Clarence Lew ,  Marton Szigeti ,  Csaba Varadi

IPC: G01N35/00 ,  C08B37/00

Abstract: The present teachings relate to methods, systems, and kits for the preparation, purification and/or analysis of a glycan or glycoconjugate, and specifically to a magnetic bead based sample preparation protocol that can enable full automation and reduced sample preparation time relative to current methods of glycoanalysis. In some aspects, the sample preparation protocol can provide for glycoconjugate capture, glycan release, fluorescent derivatization, and glycan purification for subsequent capillary electrophoresis, liquid chromatography, or other glycoanalytical method without requiring time-consuming sample preparation steps such as centrifugation or vacuum-centrifugation.

公开(公告)号：US20190154718A1

公开(公告)日：2019-05-23

申请号：US16198366

申请日：2018-11-21

Applicant: Beckman Coulter, Inc.

Inventor： Craig R. Veiner

IPC: G01N35/10 ,  G01N33/50

Abstract: Certain types of automated medical analysis equipment are used to analyze blood or other fluids. The equipment may thus use various diluents or reagents that allow the blood or other fluids to be run through the analysis equipment for analysis and data collection. Disclosed is a diluent preparation module that combines purified water and reagent concentrate for use by this equipment. Also disclosed is a diluent preparation unit that combines more than one diluent preparation modules for redundancy and back-up purposes. Also disclosed are systems for supplying the Diluent prepared by the diluent preparation module or diluent preparation unit to one or more analytic instruments.

公开(公告)号：US20190101438A1

公开(公告)日：2019-04-04

申请号：US16152643

申请日：2018-10-05

Applicant: Beckman Coulter, Inc.

Inventor： Michael M. Morrell ,  Timothy Reed

IPC: G01J1/04 ,  G01N21/85 ,  G01N21/59 ,  G01N21/53 ,  G01N15/14

Abstract: A filter mask for use in a flow cytometer includes light blocking features and light passing apertures. The flow cytometer operates to evaluate one or more characteristics of a sample by illuminating the sample and a carrier fluid and collecting light rays that are radiated from the sample and the carrier fluid. The light rays are passed through the filter mask. The light blocking features of the filter mask are arranged to selectively block radiated light at certain radiation angles, while permit light rays having other radiation angles to pass therethrough. A sensor analyzer receives the light rays that pass through to evaluate at least one characteristic of the sample. The light rays can also be separated into two beams, which can be independently filtered using different filter masks. The results can then be compared to provide even more information regarding characteristics of the sample.

公开(公告)号：USD837398S1

公开(公告)日：2019-01-01

申请号：US29600884

申请日：2017-04-17

Applicant: Beckman Coulter, Inc.

Designer： Hannah Rae Buvala ,  Christopher Dallas Griner ,  Richard Milson

公开(公告)号：US20180231573A1

公开(公告)日：2018-08-16

申请号：US15510612

申请日：2015-09-11

Applicant: Beckman Coulter, Inc.

Inventor： Andreas VAN AGTHOVEN ,  Fabrice MALERGUE ,  Christophe GODEFROY ,  Enrique RABELLINO

IPC: G01N33/72 ,  G01N33/58 ,  G01N33/49 ,  G01N33/80 ,  G01N15/14

CPC classification number: G01N33/723 ,  G01N15/1459 ,  G01N33/492 ,  G01N33/582 ,  G01N33/721 ,  G01N33/726 ,  G01N33/80 ,  G01N2015/0076 ,  G01N2015/1402 ,  G01N2015/1477 ,  G01N2015/1488 ,  G01N2333/805

Abstract: Systems and methods are provided for determining the age of cellular hemoglobin in individual red blood cells in a blood sample by determining the percentage of HbA1c. In embodiments, a method includes measuring side scatter and fluorescence of the individual red blood cells and identifying immature red blood cells and mature red blood cells from the side scatter and fluorescence measurement. In embodiments, data collected includes the exact number of red blood cells, the fraction limits in fluorescence and side scatter units, the mean value of each fraction in fluorescence and side scatter units, the mean FL1 values per fraction in arbitrary units and the mean side scatter values per fraction in arbitrary units. In embodiments, a method also includes deriving a HbA1c content from the measured mean fluorescence of the individual red blood cells and determining the percentage of HbA1c from the HbA1c content and the hemoglobin content of the red blood cells.

公开(公告)号：US10048284B2

公开(公告)日：2018-08-14

申请号：US14699734

申请日：2015-04-29

Applicant: Beckman Coulter, Inc.

Inventor： Martin Müller ,  Andreas Weihs ,  Gerhard Gunzer ,  Michael Eberhardt

IPC: G01N35/00 ,  B65G47/28 ,  B01D21/26 ,  B04B7/08 ,  B04B15/00 ,  B25J11/00 ,  B04B9/14 ,  G01N35/04 ,  G01B11/02 ,  G01B11/08 ,  G01B11/10 ,  G01M1/14 ,  G01N21/27 ,  G01N35/10 ,  B04B7/02 ,  B04B13/00 ,  B65D51/24 ,  G01L19/08 ,  B04B11/04 ,  G01B11/24 ,  G01F23/00 ,  B01L3/00

Abstract: A sample container cap is disclosed. The sample cap container includes a sample cap body capable of covering an opening of a sample container and a centrifugation status indicator device in the top of the sample cap body. The centrifugation status indicator device includes: a first substance having a first density and a first color, and a second substance having a second density and a second color. The centrifugation status indicator device displays the first substance when the sample container has been centrifuged. The first substance can be a gel, and the second substance can include a plurality of particles. The second density is higher than the first density and the second color is different from the first color.

公开(公告)号：US20180188154A1

公开(公告)日：2018-07-05

申请号：US15714473

申请日：2017-09-25

Applicant: Beckman Coulter, Inc.

Inventor： Marshall Donnie Graham ,  William Gerry Graham ,  James P. Clarkin ,  Mark A. Wells ,  Jose M. Cano ,  Carlos Alberto Arboleda ,  Armando J. Sanchez

IPC: G01N21/05 ,  C03B23/047

CPC classification number: G01N21/05 ,  C03B23/047 ,  C03C27/00 ,  G01N15/1434 ,  G01N2015/1006 ,  G01N2015/1452 ,  G01N2015/1486 ,  G01N2015/149 ,  G01N2201/02 ,  Y02P40/57

Abstract: An improved optical flow cell adapted for use in a flow cytometer for differentiating formed bodies (e.g., blood cells) in liquid suspensions. Preferably manufactured by assembling, aligning, and optically joining at least two elements made from transparent material, the improved flow cell has a seamless internal flow channel of preferably non-circular cross-section in a cylindrical first element through which prepared samples can be metered and an independent second element having an external envelope suited to acquisition of optical parameters from formed bodies in such suspensions, the second element being conforming and alignable to the first element so that non-axisymmetric refractive effects on optical characterizing parameters of formed bodies passing through the flow channel in the first element may be minimized before the two elements are optically joined and fixed in working spatial relationship. Preferably, such first element is formed by a glass-drawing process in which a relatively large glass preform having a rectilinear internal channel of a desired cross-sectional shape is heated and drawn to achieve a desired cross-sectional area of reduced size. Preferably, such second element is provided by through-boring a suitable commercial optical component to conform to such first element. Also disclosed are preferred methods for differentiating formed bodies using the flow cell of the invention.

公开(公告)号：US20180180526A1

公开(公告)日：2018-06-28

申请号：US15829566

申请日：2017-12-01

Applicant: Beckman Coulter, Inc.

Inventor： George C. Malachowski ,  Paul Barclay Purcell ,  Edward Allan Stanton ,  Kenneth Michael Evans

IPC: G01N15/14 ,  G01N33/50 ,  G01N15/10 ,  G01N15/00

CPC classification number: G01N15/1429 ,  G01N15/1436 ,  G01N15/1468 ,  G01N15/1475 ,  G01N33/5005 ,  G01N2015/0065 ,  G01N2015/1006 ,  G01N2015/149

Abstract: In flow cytometry, particles (2) can be distinguished between populations (8) by combining n-dimensional parameter data, which may be derived from signal data from a particle, to mathematically achieve numerical results representative of an alteration (48). An alteration may include a rotational alteration, a scaled alteration, or perhaps even a translational alteration. Alterations may enhance separation of data points which may provide real-time classification (49) of signal data corresponding to individual particles into one of at least two populations.

公开(公告)号：US20180172564A1

公开(公告)日：2018-06-21

申请号：US15899072

申请日：2018-02-19

Applicant: Beckman Coulter, Inc.

Inventor： Andreas Van Agthoven

IPC: G01N1/30

CPC classification number: G01N1/30

Abstract: The present invention relates to a cell treatment composition for the permeabilization of fixed blood cells, to the use of said composition, to a method for the treatment of a biological sample comprising fixation of said sample and subsequently contacting said biological sample with said cell treatment composition. The invention further relates and to a kit comprising said cell treatment composition.