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公开(公告)号：US10222320B2
公开(公告)日：2019-03-05
申请号：US15489488
申请日：2017-04-17
Applicant: Beckman Coulter, Inc.
Inventor： Carlos Ramirez , Jiuliu Lu
Abstract: Methods and systems for automatically identifying and enumerating early granulated cells (EGC) in blood samples are disclosed. In one embodiment a method for identifying EGC in a blood sample includes analyzing white blood cells of the blood sample using a low angle light scatter (LALS) parameter, separating the EGCs from the other white blood cells using the LALS parameter, and enumerating the separated EGCs.
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公开(公告)号：US20170219475A1
公开(公告)日：2017-08-03
申请号：US15489488
申请日：2017-04-17
Applicant: Beckman Coulter, Inc.
Inventor： Carlos Ramirez , Jiuliu Lu
CPC classification number: G01N15/147 , G01N15/1429 , G01N21/53 , G01N33/5094 , G01N2021/4707 , G01N2021/4769
Abstract: Methods and systems for automatically identifying and enumerating early granulated cells (EGC) in blood samples are disclosed. In one embodiment a method for identifying EGC in a blood sample includes analyzing white blood cells of the blood sample using a low angle light scatter (LALS) parameter, separating the EGCs from the other white blood cells using the LALS parameter, and enumerating the separated EGCs.
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公开(公告)号：US09588102B2
公开(公告)日：2017-03-07
申请号：US14812088
申请日：2015-07-29
Applicant: Beckman Coulter, Inc.
Inventor： Patricio Vidal , Christophe Godefroy , Phaisit Chewputtanagul , Jiuliu Lu
IPC: G01N33/00 , G01N31/00 , G01N33/49 , C12Q1/06 , G06F19/00 , G01N27/02 , G01N15/00 , G01N21/49 , G01N21/59 , G01N35/08 , G01N15/12 , G01N15/10 , G01N15/14
CPC classification number: G01N33/49 , C12Q1/06 , G01N15/00 , G01N15/12 , G01N15/14 , G01N15/1456 , G01N15/1459 , G01N21/49 , G01N21/59 , G01N27/02 , G01N33/4915 , G01N35/08 , G01N2015/0065 , G01N2015/0073 , G01N2015/008 , G01N2015/1006 , G01N2015/1037 , G01N2015/1402 , G01N2015/1413 , G01N2015/1486 , G06F19/00 , G16H50/20
Abstract: Embodiments of the present invention encompass automated systems and methods for analyzing white blood cell parameters in an individual based on a biological sample obtained from blood of the individual. Exemplary techniques involve correlating aspects of direct current (DC) impedance, radiofrequency (RF) conductivity, and/or light measurement data obtained from the biological sample with an evaluation of white blood cell conditions in the individual.
Abstract translation: 本发明的实施方案包括基于从个体的血液获得的生物样品来分析个体中的白细胞参数的自动化系统和方法。 示例性技术涉及将来自生物样品的直流（DC）阻抗，射频（RF）电导率和/或光测量数据的方面与个体中的白细胞状况的评估相关联。
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公开(公告)号：US10429401B2
公开(公告)日：2019-10-01
申请号：US14804214
申请日：2015-07-20
Applicant: Beckman Coulter, Inc.
Inventor： Sebastian Streibl , Jiuliu Lu , Bian Qian , Melvin Ayala
Abstract: Container identification data from a container inspection unit that analyzes a container containing a liquid is combined with liquid level detection raw data from a liquid level detection unit that analyzes the container containing the liquid and a liquid level detection result is generated. The liquid level detection result is cross-checked with additional data from the container inspection unit. The result can be used to plan a route for the container in the laboratory automation system.
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公开(公告)号：US20160018427A1
公开(公告)日：2016-01-21
申请号：US14804214
申请日：2015-07-20
Applicant: Beckman Coulter, Inc.
Inventor： Sebastian Streibl , Jiuliu Lu , Bian Qian , Melvin Ayala
CPC classification number: G01N35/00584 , G01F23/00 , G01N33/49 , G01N35/00732 , G01N35/1016 , G01N2035/1025
Abstract: Container identification data from a container inspection unit that analyzes a container containing a liquid is combined with liquid level detection raw data from a liquid level detection unit that analyzes the container containing the liquid and a liquid level detection result is generated. The liquid level detection result is cross-checked with additional data from the container inspection unit. The result can be used to plan a route for the container in the laboratory automation system.
Abstract translation: 来自分析容纳液体的容器的容器检查单元的容器识别数据与来自分析容纳液体的容器的液面检测单元的液面检测原始数据组合，并且产生液位检测结果。 液位检测结果与来自容器检查单元的附加数据交叉检查。 结果可用于计划实验室自动化系统中容器的路线。
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Patent Agency Ranking
6.发明授权Systems and methods for detecting the presence of a biological status using clustering 有权使用聚类检测生物状态存在的系统和方法公开(公告)号：US09519751B2
公开(公告)日：2016-12-13
申请号：US13853897
申请日：2013-03-29
Applicant: Beckman Coulter, Inc.
Inventor： Jiuliu Lu , Zihua Wang , Antonio Arevalo Reyes , Erik Alan Gustafson , John Steven Riley
CPC classification number: G06F19/24 , C12Q1/689 , C12Q2600/112 , G06F19/12 , G06F19/18
Abstract: A method for determining the presence of a biological entity. The method may include entering into a digital computer, at least a plurality of first input values associated with a first genetic element, a plurality of second input values associated with a second genetic element, and a plurality of third input values associated with a third genetic element associated with a plurality of samples. The method also includes determining a threshold value associated with the third genetic element, separating the samples using the threshold value into a first set of samples and a second set of samples, clustering the first set of samples in a feature space defined by the first genetic element and the second genetic element, defining a first boundary space using the first set of samples, and defining a second boundary space using the second set of samples.
Abstract translation: 用于确定生物实体的存在的方法。 该方法可以包括进入数字计算机，与第一遗传元件相关联的至少多个第一输入值，与第二遗传元件相关联的多个第二输入值以及与第三遗传元件相关联的多个第三输入值 元素与多个样本相关联。 该方法还包括确定与第三遗传元件相关联的阈值，使用阈值将样本分离成第一组样本和第二组样本，将第一组样本聚集在由第一遗传学定义的特征空间中 元素和第二遗传元素，使用第一组样本定义第一边界空间，以及使用第二组样本定义第二边界空间。
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公开(公告)号：US20140011232A1
公开(公告)日：2014-01-09
申请号：US13935154
申请日：2013-07-03
Applicant: BECKMAN COULTER, INC.
Inventor： Patricio Vidal , Christophe Godefroy , Phaisit Chewputtanagul , Jiuliu Lu
CPC classification number: G01N33/49 , C12Q1/06 , G01N15/00 , G01N15/12 , G01N15/14 , G01N15/1456 , G01N15/1459 , G01N21/49 , G01N21/59 , G01N27/02 , G01N33/4915 , G01N35/08 , G01N2015/0065 , G01N2015/0073 , G01N2015/008 , G01N2015/1006 , G01N2015/1037 , G01N2015/1402 , G01N2015/1413 , G01N2015/1486 , G06F19/00 , G16H50/20
Abstract: Embodiments of the present invention encompass automated systems and methods for analyzing white blood cell parameters in an individual based on a biological sample obtained from blood of the individual. Exemplary techniques involve correlating aspects of direct current (DC) impedance, radiofrequency (RF) conductivity, and/or light measurement data obtained from the biological sample with an evaluation of white blood cell conditions in the individual.
Abstract translation: 本发明的实施方案包括基于从个体的血液获得的生物样品来分析个体中的白细胞参数的自动化系统和方法。 示例性技术涉及将来自生物样品的直流（DC）阻抗，射频（RF）电导率和/或光测量数据的方面与个体中的白细胞状况的评估相关联。
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公开(公告)号：US20180196070A1
公开(公告)日：2018-07-12
申请号：US15911647
申请日：2018-03-05
Applicant: Beckman Coulter, Inc.
Inventor： Jiuliu Lu , Phaisit Chewputtanagul , Christophe Godefroy , Patricio Vidal , John Riley
CPC classification number: G01N33/80 , G01N15/0211 , G01N15/10 , G01N15/12 , G01N15/1459 , G01N2015/0084
Abstract: Embodiments of the present invention encompass automated systems and methods for analyzing immature platelet parameters in an individual based on a biological sample obtained from blood of the individual. Exemplary techniques involve correlating aspects of direct current (DC) impedance, radiofrequency (RF) conductivity, and/or light measurement data obtained from the biological sample with an evaluation of immature platelet conditions in the individual.
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9.发明申请公开(公告)号：US20170140096A1
公开(公告)日：2017-05-18
申请号：US15349868
申请日：2016-11-11
Applicant: Beckman Coulter, Inc.
Inventor： Jiuliu Lu , Zihua Wang , Antonio Arevalo Reyes , Erik Alan Gustafson , John Steven Riley
CPC classification number: G16B40/00 , C12Q1/689 , C12Q2600/112 , G16B5/00 , G16B20/00
Abstract: A method for determining the presence of a biological entity. The method may include entering into a digital computer, at least a plurality of first input values associated with a first genetic element, a plurality of second input values associated with a second genetic element, and a plurality of third input values associated with a third genetic element associated with a plurality of samples. The method also includes determining a threshold value associated with the third genetic element, separating the samples using the threshold value into a first set of samples and a second set of samples, clustering the first set of samples in a feature space defined by the first genetic element and the second genetic element, defining a first boundary space using the first set of samples, and defining a second boundary space using the second set of samples.
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公开(公告)号：US20150330963A1
公开(公告)日：2015-11-19
申请号：US14812088
申请日：2015-07-29
Applicant: Beckman Coulter, Inc.
Inventor： Patricio Vidal , Christophe Godefroy , Phaisit Chewputtanagul , Jiuliu Lu
CPC classification number: G01N33/49 , C12Q1/06 , G01N15/00 , G01N15/12 , G01N15/14 , G01N15/1456 , G01N15/1459 , G01N21/49 , G01N21/59 , G01N27/02 , G01N33/4915 , G01N35/08 , G01N2015/0065 , G01N2015/0073 , G01N2015/008 , G01N2015/1006 , G01N2015/1037 , G01N2015/1402 , G01N2015/1413 , G01N2015/1486 , G06F19/00 , G16H50/20
Abstract: Embodiments of the present invention encompass automated systems and methods for analyzing white blood cell parameters in an individual based on a biological sample obtained from blood of the individual. Exemplary techniques involve correlating aspects of direct current (DC) impedance, radiofrequency (RF) conductivity, and/or light measurement data obtained from the biological sample with an evaluation of white blood cell conditions in the individual.
Abstract translation: 本发明的实施方案包括基于从个体的血液获得的生物样品来分析个体中的白细胞参数的自动化系统和方法。 示例性技术涉及将来自生物样品的直流（DC）阻抗，射频（RF）电导率和/或光测量数据的方面与个体中的白细胞状况的评估相关联。
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