摘要:
Novel compounds of structural formula (I) are activators of AMP-protein kinase and are useful in the treatment, prevention and suppression of diseases mediated by the AMPK-activated protein kinase. The compounds of the present invention are useful in the treatment of Type 2 diabetes, hyperglycemia, metabolic syndrome, obesity, hypercholesterolemia, and hypertension.
摘要:
A stream of defect data is received from a reticle inspection system. The defect data identifies defects that were detected for a plurality of different portions of a reticle. Before reviewing the defect data to determine whether the reticle passes inspection and as the stream of defect data continues to be received, some of the defects are automatically grouped with other most recently one or more received defects so as to form groups of substantially matching defects. Before reviewing the defect data to determine whether the reticle passes inspection and after all of the defect data for the reticle is received, one or more of the groups of defects that have a number above a predetermined threshold are automatically filtered from the defect data so as to form filtered defect data. The filtered defect data may then be provided to a review station for determining whether the reticle passes.
摘要:
Techniques are described for forming a waveguide photodetector. In one example, a method of forming a waveguide photodetector includes forming a waveguide on a substrate, e.g., silicon on insulator, depositing a first oxide coating over the waveguide and on the SOI substrate, creating a seed window through the first oxide coating to a bulk silicon layer of the SOI substrate, depositing a photodetector material into the seed window and on top of the first oxide coating over the waveguide, depositing a second oxide coating over the photodetector material and over the first oxide coating deposited over the waveguide and on the SOI substrate, and applying thermal energy to liquefy the photodetector material.
摘要:
Techniques are described to form an optical waveguide switch that could reach a very high extinction ratio. In particular, this disclosure describes an asymmetric MZI, in which different waveguide capacitor structures are used in two arms of the MZI: a first arm with a waveguide capacitor to achieve the mainly phase modulation and a second arm with a waveguide capacitor to achieve mainly the magnitude modulation, respectively. Using the asymmetric MZI in accordance with this disclosure, one can design an algorithm to achieve almost unlimited extinction ration during the switching operation.
摘要:
An electro-optic polymer semiconductor integrated circuit includes one or more doped regions configured to drive one or more electrodes, and the electrodes are configured to drive a juxtaposed electro-optic core. The assembly may include a planarization layer disposed at least partially coplanar with the electrodes. The circuit may include an integrated multiplexer, driver configured to receive a signal from the multiplexer, at least one high speed electrode configured to be driven by the driver and modulate light energy passed through a hyperpolarizable poled chromophore regions disposed near the high speed electrode. The circuit may include a calibration storage circuit. The circuit may include, during fabrication, structures to provide voltage to a buried electrode and a shield to prevent damage from the poling field.
摘要:
A modified porous membrane comprising a polymeric hydrophilic coating bonded to a porous membrane is described. The polymeric hydrophilic coatings grafted to the porous membranes comprise, for example, a PEG moiety such as a PEGMA, a PEGDA, or a TMPET, wherein the polymeric hydrophilic coating on the porous membrane decreases non-specific binding of unwanted material to the porous membrane and increases the signal to noise ratio in immunoassays, in vitro diagnostic tests, and point of care tests. Methods of making these modified porous membranes are also disclosed.
摘要:
A modified porous membrane comprising a polymer coating grafted to a porous membrane is described. The polymer coatings grafted to the porous membranes generally comprise a polymer of variable length of an electron beam (e-beam) reactive moiety, designated “poly-(A)x,” a linkage group that forms a bond between the between the poly-(A)x, and a functional B group available to react with a chemical group on a biomolecule, wherein the polymer coating on the porous membrane facilitates the immobilization of a biomolecule, such as DNA, RNA, a protein, and an antibody, on the porous membrane. The compositions find use in immunoassays, in vitro diagnostic tests, point of care tests, techniques for the isolation of a biomolecule from a biological sample, and other methods that require the immobilization of a biomolecule on a porous membrane. Methods of making these modified porous membranes are also disclosed.
摘要:
A cam indexer includes a driving assembly, a driving plate, a multi-task dial, a latching assembly and a positioning assembly. The driving plate defines an arc-groove at the periphery thereof and a cam surface at the bottom of the arc-groove, the driving plate further includes a receiving end and a resisting end positioned at opposite ends of the cam surface. The multi-task dial defines four positioning grooves along the periphery thereof; the latching assembly is fixed to the driving plate and elastically engages in first one positioning groove, the positioning assembly elastically engages in a second one positioning groove. The latching assembly and the positioning assembly are adapted to detach from the positioning grooves when the driving plate is driven by the driving assembly, such that the cam indexer functions as a partitioning mechanism.
摘要:
An automatic conveying device includes a conveyer bracket, a wheel assembly, a transmission mechanism, and a loading assembly. The wheel assembly is rotatably assembled to a bottom portion of the conveyer bracket for supporting the conveyer bracket. The transmission mechanism is assembled within the conveyer bracket and connected with the wheel assembly, thereby driving the wheel assembly to rotate. The loading assembly is mounted upon the conveyer bracket and movably assembled with the transmission mechanism, for accepting objects as a load and driving the transmission mechanism to work. The loading assembly moves downward relative to the conveyer bracket under the weight of the objects placed on the loading assembly, and is capable of moving upward back to its original position, when the objects are removed.