公开(公告)号：US20140335023A1

公开(公告)日：2014-11-13

申请号：US14339053

申请日：2014-07-23

Applicant: Dyax Corp.

Inventor： Daniel J. Sexton ,  Malini Viswanathan

IPC: C07K16/40 ,  A61K49/00

CPC classification number: C07K16/40 ,  A61K49/0004 ,  A61K2039/505 ,  C07K2317/76 ,  C07K2317/92

Abstract: Plasma kallikrein binding proteins and methods of using such proteins are described.

公开(公告)号：US20140286864A1

公开(公告)日：2014-09-25

申请号：US14109508

申请日：2013-12-17

Applicant: Bracco Suisse SA ,  Dyax Corp.

Inventor： AARON K. SATO ,  DANIEL J. SEXTON ,  DANIEL T. DRANSFIELD ,  ROBERT CHARLES LADNER ,  CHRISTOPHE ARBOGAST ,  PHILIPPE BUSSAT ,  HONG FAN ,  SUDHA KHURANA ,  KAREN E. LINDER ,  EDMUND R. MARINELLI ,  PALANIAPPA NANJAPPAN ,  ADRIAN D. NUNN ,  RADHAKRISHNA K. PILLAI ,  SIBYLLE POCHON ,  KONDAREDDIAR RAMALINGAM ,  AJAY SHRIVASTAVA ,  BO SONG ,  ROLF E. SWENSON ,  MATHEW A. VON WRONSKI ,  FENG YAN

IPC: A61K49/22 ,  A61K51/08 ,  C07K14/00

CPC classification number: A61K49/221 ,  A61K38/00 ,  A61K47/62 ,  A61K49/223 ,  A61K51/088 ,  C07K7/08 ,  C07K14/001 ,  C07K14/52 ,  C07K14/71 ,  C07K2319/00 ,  Y02A50/411 ,  Y02A50/58

Abstract: The present invention provides polypeptides, peptide dimer, and multimeric complexes comprising at least one binding moiety for KDR or VEGF/KDR complex, which have a variety of uses wherever treating, detecting, isolating or localizing angiogenesis is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding KDR or VEGF/KDR complex with high affinity (e.g., having a KD

公开(公告)号：US20140221611A1

公开(公告)日：2014-08-07

申请号：US13966852

申请日：2013-08-14

Applicant: DYAX CORP.

Inventor： Jinan Yu ,  M. Daniel Potter ,  Brian D. Kelley ,  Jeffrey S. Deetz ,  James E. Booth

IPC: C07K7/06 ,  C07K14/755

CPC classification number: C07K7/06 ,  C07K7/08 ,  C07K14/00 ,  C07K14/755

Abstract: It is an object of the present invention to provide novel binding molecules for factor VIII and factor VIII-like proteins. Preferred binding molecules of the present invention exhibit not only distinct characteristics for binding of the target factor VIII polypeptides but also specific and desirable characteristics for release (elution) of the target polypeptides. Especially preferred binding molecules according to the invention are short polypeptide sequences, characterized by a stable loop structure.

Abstract translation: 本发明的目的是为因子VIII和因子VIII样蛋白提供新的结合分子。 本发明优选的结合分子不仅显示了靶因子VIII多肽的结合的明显特征，而且还显示了靶多肽的释放（洗脱）的特异性和期望特征。 根据本发明的特别优选的结合分子是短多肽序列，其特征在于稳定的环结构。

公开(公告)号：US20140205545A1

公开(公告)日：2014-07-24

申请号：US14031562

申请日：2013-09-19

Applicant: Dyax Corp. ,  Bracco Suisse S.A.

Inventor： Hong FAN ,  Karen E. Linder ,  Edmund R. Marinelli ,  Palaniappa Nanjappan ,  Adrian D. Nunn ,  Radhakrishna K. Pillai ,  Kondareddiar Ramalingam ,  Ajay Shrivastava ,  Bo Song ,  Rolf E. Swenson ,  Mathew A. Von Wronski ,  Aaron K. Sato ,  Sharon Michele Walker ,  Daniel T. Dransfield

IPC: A61K47/42 ,  A61K49/22

CPC classification number: A61K47/48246 ,  A61K38/16 ,  A61K47/42 ,  A61K47/60 ,  A61K47/64 ,  A61K49/221 ,  A61K49/223 ,  C07K7/08 ,  C07K7/64 ,  Y02A50/411

Abstract: The invention provides compositions and methods for therapeutic and diagnostic applications.

Abstract translation: 本发明提供用于治疗和诊断应用的组合物和方法。

公开(公告)号：US20140135226A1

公开(公告)日：2014-05-15

申请号：US14048526

申请日：2013-10-08

Applicant: Dyax Corp.

Inventor： Robert Charles Ladner ,  Shannon Hogan ,  Kristin L. Rookey

IPC: C12N15/10

CPC classification number: C12N15/1037 ,  B03C1/01 ,  B03C1/288 ,  C40B30/04 ,  G01N33/56983 ,  G01N2500/10

Abstract: Disclosed are methods for identifying desired members from a display libraries, including bacteriophage display libraries. Display library members can be amplified in the presence of a target compound so that cycles of selection can be rapidly completed.

Abstract translation: 公开了用于从显示库识别所需成员的方法，包括噬菌体展示文库。 显示库成员可以在目标化合物存在下扩增，以便可以快速完成选择周期。

公开(公告)号：US20140018261A9

公开(公告)日：2014-01-16

申请号：US13754261

申请日：2013-01-30

Applicant: DYAX CORP.

Inventor： Robert Charles Ladner

IPC: C12N15/10 ,  C07K16/00

CPC classification number: C12N15/1037 ,  C07K16/00 ,  C07K16/005 ,  C07K2317/565 ,  C40B40/02 ,  C40B40/08 ,  C40B40/10

Abstract: Focused libraries of vectors or genetic packages that display, display and express, or comprise a member of a diverse family of antibody peptides, polypeptides or proteins and collectively display, display and express, or comprise at least a portion of the focused diversity of the family. The libraries have length and sequence diversities that mimic that found in native human antibodies.

Abstract translation: 显示，显示和表达或组成抗体肽，多肽或蛋白质不同家族成员的集中的载体文库或遗传包，并且共同显示，显示和表达或包含至少一部分家庭聚焦多样性 。 这些文库具有模拟在天然人抗体中发现的长度和序列多样性。

公开(公告)号：US20040180422A1

公开(公告)日：2004-09-16

申请号：US10723981

申请日：2003-11-26

Applicant: DYAX CORP.

Inventor： Rene Hoet ,  Robert Charles Ladner ,  Nicolas Frans

IPC: C12N005/02 ,  C12N005/00 ,  C12N007/01 ,  C12N007/00 ,  C07H021/04 ,  C12Q001/70

CPC classification number: C40B40/02 ,  C12N7/00 ,  C12N15/1037 ,  C12N15/86 ,  C12N2795/00022 ,  C12N2795/00043 ,  C12N2830/002 ,  C12N2830/38 ,  C12N2830/55

Abstract: Disclosed are methods and compositions useful, e.g., for controlling the valency of display proteins during display library screenings and selections. In one embodiment, they are applicable to phage and phage libraries that are based on bacteriophage, e.g., filamentous bacteriophage.

Abstract translation: 公开了可用于例如显示库筛选和显示库筛选期间显示蛋白质的价态的方法和组合物。 在一个实施方案中，它们可应用于基于噬菌体的噬菌体和噬菌体文库，例如丝状噬菌体。

公开(公告)号：US20210270842A1

公开(公告)日：2021-09-02

申请号：US17141690

申请日：2021-01-05

Applicant: Dyax Corp.

Inventor： Daniel J. Sexton ,  Ryan Faucette ,  Janja Cosic

IPC: G01N33/68 ,  G01N33/86 ,  C07K16/36 ,  G01N33/543

Abstract: The present disclosure provides immunoassay methods of detecting a cleaved high molecular weight kininogen (HMWK) with high sensitivity and specificity and isolated antibodies that specifically bind cleaved HMWK.

公开(公告)号：US20210025898A1

公开(公告)日：2021-01-28

申请号：US16062734

申请日：2016-12-15

Applicant: Dyax Corp.

Inventor： Jiang Wu ,  Guodong Zhang ,  Daniel J. Sexton ,  Ryan Faucette ,  Gul M. Mustafa ,  Mark Szewc

IPC: G01N33/68 ,  G01N30/88 ,  G01N30/72

Abstract: Methods for differentiating full-length high molecular weight kininogen (HMWK) and cleaved HMWK in a sample are provided herein. Such methods may comprise treating a biological sample with a protease to generate a plurality of digested peptides, and measuring one or more signature peptides, which are indicative of cleaved HMWK and/or full-length HMWK.

公开(公告)号：US20200348311A1

公开(公告)日：2020-11-05

申请号：US16849601

申请日：2020-04-15

Applicant: Dyax Corp.

Inventor： Priya Sethu Chockalingam ,  Yongquan Lai ,  Jiang Wu ,  Guodong Zhang ,  Zhiwei Zhou

IPC: G01N33/68

Abstract: Methods for quantitation of fC1-INH from dried blood spot are provided herein. Such methods may comprise spotting and drying a blood sample on a support member, extracting protein from the dried blood sample and measuring the level of fC1-INH in the extracted proteins.