公开(公告)号：US20050176938A1

公开(公告)日：2005-08-11

申请号：US10501215

申请日：2003-01-14

Applicant: Kenji Kamada ,  Akira Hiraide ,  Kaichiro Koyama ,  Hitoshi Shimizu ,  Gary Ward ,  Vandana Cheruvallath ,  Stephan Parent

Inventor： Kenji Kamada ,  Akira Hiraide ,  Kaichiro Koyama ,  Hitoshi Shimizu ,  Gary Ward ,  Vandana Cheruvallath ,  Stephan Parent

IPC: A61K31/7048 ,  A61P1/00 ,  A61P31/00 ,  C07H17/08

CPC classification number: C07H17/08

Abstract: Crystal form F of [2S, 4R, 5R, 8R, 9S, 10S, 11R, 12R]-9-[(2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl)oxy]-5-ethyl-4-methoxy-2,4,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(isopropylmethylamino)-β-D-xylo-hexopyranosyl]oxy]-6,15-dioxabicyclo[10.2.1]pentadec-14(1)-ene-3,7-dione (E)-2-butenedioic acid salt (2:1) showing strong X-ray diffraction peaks at diffraction angles 2θ=6.6° and 8.5°, Crystal form D anhydrate of said compound showing strong X-ray diffraction peaks at diffraction angles 2θ=7.1°, 13.5° and 14.2°, Crystal form D X-hydrate of said compound showing strong X-ray diffraction peaks at diffraction angles 2θ=7.1° and 14.2° but not showing a strong X-ray diffraction peak at a diffraction angle 2θ=13.5°, Solvate Crystal forms G1, G2 and G3 of said compound characterized by 2-theta angle positions in the powder X-ray diffraction pattern of 5.4°, 10.4°, 10.7° and 12.1°. Crystal form D X-hydrate of said compound has more preferred properties for use as a pharmaceutical material such as higher stability as compared with Crystal form D anhydrate of said compound.

Abstract translation: [2S，4R，5R，8R，9S，10S，11R，12R] -9 - [（2,6-二脱氧-3-C-甲基-3-O-甲基-α-L- 己基吡喃糖基）氧基] -5-乙基-4-甲氧基-2,4,8,10,12,14-六甲基-11 - [[3,4,6-三脱氧-3-（异丙基甲基氨基）-β- - 六吡喃糖基]氧基] -6,15-二氧杂双环[10.2.1]十五烷-15（1） - 烯-3,7-二酮（E）-2-丁烯二酸盐（2:1） 在衍射角2θ= 6.6°和8.5°处的峰，所述化合物的晶型D无水物，在衍射角2θ= 7.1°，13.5°和14.2°处显示出强X射线衍射峰，所述化合物的晶型D X-水合物显示 在衍射角2θ= 7.1°和14.2°处的强X射线衍射峰，但在衍射角2θ= 13.5°处不显示强X射线衍射峰。溶剂化晶体形成所述化合物的G 1，G 2和G 3， 在粉末X射线衍射图中为2θ角位置为5.4°，10.4°，10.7°和12.1°。 与所述化合物的D型水合物相比，所述化合物的晶形DX-水合物具有更优选的用作药物材料的性质，例如更高的稳定性。

公开(公告)号：US20050123014A1

公开(公告)日：2005-06-09

申请号：US10958125

申请日：2004-10-05

Applicant: Hitoshi Shimizu ,  Setiagung Casimirus ,  Yasukazu Shiina ,  Takeshi Hama ,  Norihiro Iwai

Inventor： Hitoshi Shimizu ,  Setiagung Casimirus ,  Yasukazu Shiina ,  Takeshi Hama ,  Norihiro Iwai

IPC: H01S5/00 ,  H01S5/183 ,  H01S5/343

CPC classification number: B82Y20/00 ,  H01S5/02284 ,  H01S5/18305 ,  H01S5/18313 ,  H01S5/18347 ,  H01S5/18391 ,  H01S5/34313

Abstract: A surface emitting laser includes a lower semiconductor multilayer mirror formed of a plurality of pairs of a high-refractive-index area and a low-refractive-index area; an active layer vertically sandwiched by cladding layers; a current confinement layer of AlzGa1-zAs having an oxide area in a peripheral portion of the current confinement layer, where 0.95≦z≦1; and an upper semiconductor multilayer mirror formed of a plurality of pairs of a high-refractive-index area and a low-refractive-index area. The low-refractive-index area of at least one of the lower semiconductor multilayer mirror and the upper semiconductor multilayer mirror includes an Alz1Ga1-z1As layer with a thickness thinner than that of the current confinement layer, where z≦z1.

Abstract translation: 表面发射激光器包括由多对高折射率区域和低折射率区域形成的下半导体多层反射镜; 垂直夹层的有源层; 在电流限制层的外围部分中具有氧化物面积的Al z电流限制层，其中0.95 <= z <= 1; 以及由多对高折射率区域和低折射率区域构成的上半导体多层反射镜。 下半导体多层反射镜和上半导体多层反射镜中的至少一个的低折射率区域包括具有厚度的Al z 1 Ga 1-z 1 As层 薄于当前限制层，其中z <= z1。

公开(公告)号：US20050009201A1

公开(公告)日：2005-01-13

申请号：US10885753

申请日：2004-07-08

Applicant: Hitoshi Shimizu

Inventor： Hitoshi Shimizu

IPC: G01N33/53 ,  B01L3/00 ,  G01N35/10 ,  G01N37/00 ,  G01N1/10

CPC classification number: B01L3/5085 ,  B01L3/0255 ,  B01L2200/12 ,  B01L2300/069 ,  B01L2300/0819 ,  B01L2300/0829 ,  G01N35/1016 ,  G01N2035/1037 ,  Y10T436/2575

Abstract: A spotting pin contains a probe solution. The spot volume is determined such that the probe solution may not intrude into the neighboring spot area. A spot volume is calculated from a pore ratio of the membrane and the spot volume. The spotting time is determined from the spot volume. An end of the spotting pin is contacted to the spot area of the biochemical analysis unit, and the probe solution is spotted to the membrane which is pressed into the spot area. Then the spotted region becomes extended gradually. When the predetermined spotting time has passed, the spotting pin is upheld. The spot volume of the prove solution becomes uniform, and the mixing of the probe solution is prevented between the neighboring spot areas.

Abstract translation: 斑点针包含探针溶液。 确定点体积，使得探针溶液不会侵入到邻近斑点区域。 从膜的孔隙比和斑点体积计算斑点体积。 点样时间是从斑点体积确定的。 点针的端部与生化分析单元的点区域接触，将探针溶液点到被压入斑点区域的膜。 然后，斑点区逐渐扩大。 当预定的发现时间过去时，维护点。 证明溶液的斑点体积变得均匀，并且防止在相邻斑点区域之间的探针溶液的混合。

公开(公告)号：US06791691B2

公开(公告)日：2004-09-14

申请号：US10273270

申请日：2002-10-18

Applicant: Hisashi Ohtsuka ,  Hitoshi Shimizu ,  Toshihito Kimura

Inventor： Hisashi Ohtsuka ,  Hitoshi Shimizu ,  Toshihito Kimura

IPC: G01N2155

CPC classification number: G01N21/553 ,  G01N21/43

Abstract: A state of attenuation in total internal reflection is detected by the use of a measuring apparatus having a measuring unit and a reference unit and a measuring system which corrects result of detection by the measuring unit on the basis of result of detection by the reference unit and measures the change of a state of attenuation in total internal reflection on the basis of the corrected result of detection by the measuring unit. The difference in sensitivity between the measuring unit and the reference unit is detected before initiating the measurement of the change of a state of attenuation in total internal reflection, and result of measurement by the measuring system is calibrated on the basis of the difference in sensitivity between the measuring unit and the reference unit.

Abstract translation: 通过使用具有测量单元和参考单元的测量装置以及基于由参考单元的检测结果校正测量单元的检测结果的测量系统来检测全内反射的衰减状态，以及 根据校正检测结果，测量全内反射的衰减状态的变化。 在开始测量全内反射中的衰减状态的测量之前，检测测量单元和参考单元之间的灵敏度差异，并且基于测量系统的灵敏度差校正测量系统的结果， 测量单元和参考单元。

公开(公告)号：US06791618B1

公开(公告)日：2004-09-14

申请号：US09460433

申请日：1999-12-14

Applicant: Hitoshi Shimizu

Inventor： Hitoshi Shimizu

IPC: H04N5235

CPC classification number: H04N7/18 ,  H04N5/2351 ,  H04N5/2353

Abstract: A photographing system comprising a photographing-method input unit, a temporary exposure time setting unit, and an actual exposure time setting unit. The photographing-method input unit receives input of a photographing method. The temporary exposure time setting unit stores a look-up table in which the kind of photographing method is caused to correspond to a temporary-photographing exposure time that is used to obtain an appropriate actual-photographing exposure time. The temporary exposure time setting unit also obtains the temporary-photographing exposure time in accordance with the kind of input photographing method by making reference to the look-up table and inputs the obtained temporary-photographing exposure time to a camera controller. The actual exposure time setting unit sets an actual-photographing exposure time, based on a temporary-photographing image signal obtained in temporary photographing controlled by the camera controller in accordance with the temporary-photographing exposure time.

Abstract translation: 一种拍摄系统，包括拍摄方法输入单元，临时曝光时间设定单元和实际曝光时间设定单元。 拍摄方法输入单元接收拍摄方法的输入。 临时曝光时间设定单元存储一种查找表，其中拍摄方法的种类与用于获得适当的实际拍摄曝光时间的临时拍摄曝光时间相对应。 临时曝光时间设定单元还参照查找表，根据输入拍摄方法的种类获得临时拍摄曝光时间，并将获得的临时拍摄曝光时间输入到照相机控制器。 实际曝光时间设定单元根据临时拍摄曝光时间，根据由照相机控制器控制的临时拍摄中获得的临时摄影图像信号来设定实际摄影曝光时间。

公开(公告)号：US06654123B2

公开(公告)日：2003-11-25

申请号：US10026960

申请日：2001-12-27

Applicant: Hitoshi Shimizu

Inventor： Hitoshi Shimizu

IPC: G01N2155

CPC classification number: G01N21/553

Abstract: A sensor utilizing attenuated total reflection (ATR) is provided with a dielectric block, a thin film layer formed on a surface thereof, a light source for emitting a beam, and an optical system for making the beam enter the dielectric block at various angles of incidence so that a condition for total internal reflection is satisfied at an interface between the dielectric block and the thin film layer. The sensor is further provided with a photodetection section for detecting the ATR, a differentiation section for differentiating signals output from the light-receiving elements of the photodetection section, in a direction in which the light-receiving elements are juxtaposed, and an adjustment section for optically expanding the width of a dark line, corresponding to the ATR, of the beam which falls on the photodetection section, so that the width of the dark line becomes greater than a pitch between the light-receiving elements.

公开(公告)号：US06601959B2

公开(公告)日：2003-08-05

申请号：US10156816

申请日：2002-05-30

Applicant: Yasuyuki Miyata ,  Hitoshi Shimizu

Inventor： Yasuyuki Miyata ,  Hitoshi Shimizu

IPC: G03B2128

CPC classification number: H04N9/3141 ,  H04N5/7458 ,  H04N9/3102

Abstract: The thickness of the projector device can be reduced by making the direction of irradiation of a digital micromirror device (DMD) with illuminating light by an illuminating optical system variable depending on whether the projector device is used or not used. As an illuminating optical system is provided rotatably around an optical axis of a projecting optical system, the position of the illuminating optical system can be varied depending on whether the projector device is used or not used, and the overall thickness of the projector device can be thereby reduced.

Abstract translation: 通过照射光学系统照射具有照明光的数字微镜装置（DMD）的方向可以根据投影仪装置是否使用而变化，可以减小投影仪装置的厚度。 由于照明光学系统围绕投影光学系统的光轴可旋转地设置，所以照明光学系统的位置可以根据是否使用投影仪装置而变化，并且投影仪装置的总体厚度可以是 从而减少。

公开(公告)号：US5594519A

公开(公告)日：1997-01-14

申请号：US566953

申请日：1995-12-04

Applicant: Hitoshi Shimizu

Inventor： Hitoshi Shimizu

IPC: G03B9/22 ,  G03B9/00 ,  G03B9/02

CPC classification number: G03B9/22

Abstract: A blade mechanism includes a driving ring. At least two blades each have a pivot, a driving pin and an opening. The pivot of one blade is placed between the pivot and the driving pin of the other blade. The blades are rotated around the pivots by the driving ring. The opening is formed in the blades so as not to block the rotation of the other blades.

Abstract translation: 叶片机构包括驱动环。 至少两个叶片各具有枢轴，驱动销和开口。 一个叶片的枢轴放置在另一个叶片的枢轴和驱动销之间。 叶片通过驱动环围绕枢轴旋转。 开口形成在叶片中，以便不阻挡其它叶片的旋转。

公开(公告)号：US5266804A

公开(公告)日：1993-11-30

申请号：US868694

申请日：1992-04-15

Applicant: Hitoshi Shimizu

Inventor： Hitoshi Shimizu

IPC: G06T1/00 ,  H04N1/401 ,  G01N23/04

CPC classification number: H04N1/401

Abstract: A surface, on which uniform information has been recorded, is two-dimensionally scanned with light beam deflected by a rotating polygon mirror having reflecting surfaces. Light radiated out of the scanned surface is photoelectrically detected, and groups of reference signal components for correcting purposes are thereby obtained, each group corresponding to one reflecting surface. Each time the groups of reference signal components for correcting purposes, which groups correspond to the whole reflecting surfaces, are obtained while the rotating polygon mirror rotates one turn, an averaging process is carried out on these groups of reference signal components for correcting purposes. A group of correction signal components are generated from a group of reference signal components for correcting purposes, which have been obtained from the averaging process. After an image signal is detected from a surface having an image recorded thereon, each group of image signal components of the image signal corresponding to one reflecting surface are corrected with the group of correction signal components. An averaging process is then carried out on the groups of image signal components of the image signal, which correspond to the whole reflecting surfaces and which have thus been corrected.

Abstract translation: 已经记录了均匀信息的表面被具有由具有反射表面的旋转多面镜偏转的光束二维地扫描。 从扫描面射出的光被光电检测，从而获得用于校正目的的一组参考信号分量，每组对应于一个反射面。 每当旋转多面反射镜旋转一圈时，每一组参考信号分量用于校正目的，哪些组对应于整个反射表面，则对这些参考信号分量组进行平均处理以进行校正。 从用于校正目的的一组参考信号分量生成一组校正信号分量，其从平均处理获得。 在从其上记录有图像的表面检测到图像信号之后，用一组校正信号分量校正与一个反射表面相对应的图像信号的每组图像信号分量。 然后对与整个反射面对应的图像信号的图像信号分量组进行平均处理，并且由此被校正。

公开(公告)号：US5238827A

公开(公告)日：1993-08-24

申请号：US677176

申请日：1991-03-29

Applicant: Hitoshi Shimizu ,  Chiharu Fujita ,  Takakazu Endo ,  Ichiro Watanabe

Inventor： Hitoshi Shimizu ,  Chiharu Fujita ,  Takakazu Endo ,  Ichiro Watanabe

IPC: C12P13/04 ,  C12R1/01 ,  C12R1/05 ,  C12R1/06 ,  C12R1/15 ,  C12R1/38 ,  C12R1/545

CPC classification number: C12P13/04

Abstract: A process for preparing glycine from glycinonitrile by reacting glycinonitrile with a hydrolase produced by a microorganism, wherein the microorganism is a member of a genus selected from the group consisting of Rhodococcus, Arthrobacter, Caseobacter, Pseudomonas, Enterobacter, Acinetobacter, Alcaliqenes, and Streptomyces. The process involves no by-production, and the microorganism has high hydrolizing activity to convert glycinonitrile to glycine.