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61.发明公开公开(公告)号：US20230228689A1
公开(公告)日：2023-07-20
申请号：US18061215
申请日：2022-12-02
CPC分类号： G01N21/8851 , G02B6/42 , G06T7/0002 , G06T7/62 , H04N23/56 , G01N2021/8874
摘要： A system for monitoring the tread of a shoe includes a frame member, a waveguide structured to support the shoe when an outer sole of shoe is in contact with a surface of the waveguide, a light source structured to provide light within an edge of the waveguide such that the light will be internally reflected within the waveguide, and an imaging device structured and configured to generate an image of the outer sole of the shoe when the outer sole of shoe is in contact with the waveguide and the light is being provided within the waveguide. The system also includes a controller structured and configured to: (i) receive image data based on the image of the outer sole; (ii) determine from the image data a largest worn region size for the shoe; and (iii) determine a slip risk for the shoe based on the largest worn region size.
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公开(公告)号：US11696976B2
公开(公告)日：2023-07-11
申请号：US15750219
申请日：2016-08-22
发明人： Prashant N. Kumta , Abhijit Roy , Da-Tren Chou , Daeho Hong , Vijay S. Gorantla
CPC分类号： A61L31/148 , A61L31/022 , C22C23/04 , A61L2430/02
摘要： The invention relates to biodegradable, magnesium alloys, compositions and composites, methods for their preparation and applications for their use as implantable medical devices in load-bearing conditions. The magnesium alloys are composed of alloying elements selected from yttrium, calcium, zirconium, zinc, and strontium, with the remainder being magnesium and impurities due to production, and are prepared by melting together the elements and casting the resulting melted mixture. In certain embodiments, the methods of preparation include solution treatment and hot extrusion.
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63.发明公开公开(公告)号：US20230211053A1
公开(公告)日：2023-07-06
申请号：US18113676
申请日：2023-02-24
发明人： PRASHANT N. KUMTA , SUNG JAE CHUNG , PARTHA SAHA , OLEG VELIKOKHATNYI , MONI KANCHAN DATTA , DAE HO HONG , DA-TREN CHOU
CPC分类号： A61L31/022 , A61L31/148 , C22C38/002
摘要： The invention relates to biodegradable iron alloy-containing compositions for use in preparing medical devices. In addition, biodegradable crystalline and amorphous compositions of the invention exhibit properties that make them suitable for use as medical devices for implantation into a body of a patient. The compositions include elemental iron and one or more elements selected from manganese, magnesium, zirconium, zinc and calcium. The compositions can be prepared using a high energy milling technique. The resulting compositions and the devices formed therefrom are useful in various surgical procedures, such as but not limited to orthopedic, craniofacial and cardiovascular.
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公开(公告)号：US11693014B2
公开(公告)日：2023-07-04
申请号：US16743610
申请日：2020-01-15
发明人： Kai Singbartl , John A. Kellum, Jr.
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , G01N2333/495 , G01N2333/70578 , G01N2400/40 , G01N2800/347 , G01N2800/50
摘要： This invention is related to the field of the prevention and treatment of kidney disease. The treatment of kidney disease may be tailored depending upon the need for, or expectation of, long-term dialysis. For example, prediction of long-term dialysis treatment can be determined by monitoring urine biomarkers related to the development of chronic kidney disease. For example, a normalized time course of approximately fourteen Days measuring hyaluronic acid, death receptor 5, and/or transforming growth factor β1 can be used to establish the risk of recovery versus non-recovery in patient's having suffered an acute kidney injury.
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公开(公告)号：US11673916B2
公开(公告)日：2023-06-13
申请号：US17494605
申请日：2021-10-05
CPC分类号： C07K7/06 , A61P25/00 , A61K38/00 , C07K2319/10
摘要： Neuroprotective peptides derived from the voltage-gated potassium channel Kv2.2 are described. The peptides promote dispersal of the cognate channel Kv2.1 in neurons, thereby blocking pro-apoptotic potassium efflux, and preserving cell viability after apoptotic injury. Methods of preventing and treating neuronal damage, such as neuronal damage following ischemic stroke, by administering the neuroprotective peptides are described. Fusion of the neuroprotective peptides to a cell-penetrating peptide to promote cellular uptake is also described.
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公开(公告)号：US11673853B2
公开(公告)日：2023-06-13
申请号：US17313577
申请日：2021-05-06
申请人： University of Pittsburgh—Of the Commonwealth System of Higher Education , The United States as represented by the Department of Veterans Affairs
发明人： Beibei Chen , Rama K. Mallampalli , Yuan Liu
IPC分类号： C07C217/34 , C07C215/08 , C07C215/18 , C07D205/04 , C07D217/04 , C07D311/88 , A61P29/00
CPC分类号： C07C217/34 , A61P29/00 , C07C215/08 , C07C215/18 , C07D205/04 , C07D217/04 , C07D311/88
摘要： Described herein are compounds that disrupt the interaction between Fbxo48 and phosphorylated-AMPK.
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公开(公告)号：US11672483B2
公开(公告)日：2023-06-13
申请号：US15360880
申请日：2016-11-23
发明人： Mingui Sun , Wenyan Jia , Robert Joseph Sclabassi
CPC分类号： A61B5/6839 , A61B5/291 , A61B5/7225 , A61N1/0488 , A61B5/0006 , A61B2562/0209 , A61B2562/125 , A61B2562/164
摘要： Electrodes providing excellent recording and physical stability. Electrodes are disclosed that may include a plurality of small teeth that possess a novel design shape and orientation. The shallow and relatively long teeth run parallel to the rim of the electrode that presses against the patient's skin. When the electrode is twisted onto skin, the tiny teeth penetrate the stratum corneum and move nearly horizontally under the stratum corneum, thus anchoring the electrode securely to the skin. The electrodes cause minimal discomfort to the patient since the small teeth do not extend to the pain fibers which are located in deeper layers of the skin. The electrodes may be fabricated in a variety of geometries including cylindrical, disk, and blunt bullet or top shapes. In some instances, the electrodes may be connected to detachable leads having magnetic properties.
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68.发明公开公开(公告)号：US20230163346A1
公开(公告)日：2023-05-25
申请号：US18100722
申请日：2023-01-24
IPC分类号： H01M10/054 , H01M4/58 , C01G39/06 , C01G39/00 , H01M10/052 , C01B19/00
CPC分类号： H01M10/054 , H01M4/581 , H01M4/5815 , C01G39/06 , C01G39/006 , H01M10/052 , C01B19/002 , C01B19/007 , H01M2004/028
摘要： The invention relates to Chevrel-phase materials and methods of preparing these materials utilizing a precursor approach. The Chevrel-phase materials are useful in assembling electrodes, e.g., cathodes, for use in electrochemical cells, such as rechargeable batteries. The Chevrel-phase materials have a general formula of Mo6Z8 (Z=sulfur) or Mo6Z18-yZ2y (Z1=sulfur; Z2=selenium), and partially cuprated Cu1Mo6S8 as well as partially de-cuprated Cu1-xMgxMo6S8 and the precursors have a general formula of MxMo6Z8 or MxMo6Z18-yZ2y, M=Cu. The cathode containing the Chevrel-phase material in accordance with the invention can be combined with a magnesium-containing anode and an electrolyte.
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公开(公告)号：US20230158504A1
公开(公告)日：2023-05-25
申请号：US18159284
申请日：2023-01-25
发明人： HONGYAO GENG , SUNG KWON CHO
IPC分类号： B01L3/00 , G01N27/06 , G01N27/447
CPC分类号： B01L3/502792 , G01N27/06 , G01N27/44769 , B01L2300/161 , B01L2400/0427
摘要： A digital microfluidic system includes a substrate, a plurality of electrode sets provided on the substrate, wherein each of the electrode sets includes two co-planar interdigitated finger electrodes, and a driving circuit including an AC/DC voltage source and a controller. Each of the electrode sets is individually addressable by the driving circuit under control of the controller such that an AC/DC voltage generated by the AC/DC voltage source may be selectively provided to one or more of the electrode sets. Also, an anti-biofouling electrode for a digital microfluidic system includes an electrode layer, and a slippery liquid infused porous surface structure provided on the electrode layer.
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公开(公告)号：US20230154465A1
公开(公告)日：2023-05-18
申请号：US17917429
申请日：2021-04-14
申请人： UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION , THE REGENTS OF THE UNIVERSITY OF COLORADO, a body corporate
发明人： SEAN P. KELLY , SIDNEY D'MELLO
IPC分类号： G10L15/26 , G10L15/01 , G10L21/0272
CPC分类号： G10L15/26 , G10L15/01 , G10L21/0272
摘要： A method of analyzing instructor discourse includes recording an audio signal representing speech of the instructor during a class session, converting the audio signal to a session transcript comprising speech data for the session using an automatic speech recognition tool and segmenting the transcript into utterances, extracting a set of features from the session transcript, filtering student talk out from the utterances, analyzing a first subset of the features to produce a number of local context predictions for each utterance of the session transcript, analyzing a second subset of the features to produce a number of global context predictions for the session transcript, and combining a subset of the number of local context predictions and the number of global context predictions into a classification that attends to differential reliability.
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