公开(公告)号：US09822154B2

公开(公告)日：2017-11-21

申请号：US14652078

申请日：2013-12-14

Applicant: VIRGINIA COMMONWEALTH UNIVERSITY ,  HEALTH RESEARCH, INC.

Inventor： Xiang-Yang Wang ,  Xiaofei Yu ,  John R. Subjeck

IPC: C12N15/00 ,  A61K39/00 ,  C07K14/47 ,  C12N5/0783 ,  A61K39/112 ,  A61K35/17 ,  C07K14/255 ,  A61K35/761

CPC classification number: C07K14/47 ,  A61K35/17 ,  A61K35/761 ,  A61K39/0011 ,  A61K39/0275 ,  A61K2039/57 ,  A61K2039/572 ,  A61K2039/585 ,  A61K2039/6068 ,  A61K2039/70 ,  C07K14/255 ,  C07K2319/00 ,  C07K2319/40 ,  C12N5/0636 ,  C12N2710/10343 ,  C12Y306/03044 ,  Y02A50/466

Abstract: A recombinant Flagrp170 protein and pharmaceutical compositions comprising a Flagrp170 protein and related molecules encoding same, and cells presenting such a protein are provided. The Flagrp170 protein comprises an NF-KB-activating domain of Flagellin and an ATP-binding domain truncated Grp170. The pharmaceutical compositions of the invention can be used for the treatment or prevention of cancer or infectious disease.

公开(公告)号：US09777123B2

公开(公告)日：2017-10-03

申请号：US14889870

申请日：2014-05-29

Applicant: VIRGINIA COMMONWEALTH UNIVERSITY

Inventor： Umesh R. Desai ,  Jay Thakkar ,  Akul Mehta

IPC: C07G1/00 ,  C08H7/00 ,  C07C305/22

CPC classification number: C08H6/00 ,  C07C305/22

Abstract: Low molecular weight sulfated beta-O4 lignin (SbO4L) are potent inhibitors of coagulation with high selectivity.

公开(公告)号：USD797944S1

公开(公告)日：2017-09-19

申请号：US29548722

申请日：2015-12-16

Applicant: Virginia Commonwealth University

Designer： Kristie Bonovitch ,  Sharon Brinkley ,  Gauri Gulati ,  Lisa Rettig

公开(公告)号：US20170260146A1

公开(公告)日：2017-09-14

申请号：US15529615

申请日：2015-12-01

Applicant: VIRGINIA COMMONWEALTH UNIVERSITY

Inventor： Frank GUPTON ,  Alex MARTIN ,  Ali SIAMAKI ,  Katherine BELECKI

IPC: C07D235/20 ,  B01J35/00 ,  B01J31/22 ,  B01J31/24 ,  B01J23/44 ,  B01J21/18

CPC classification number: C07D235/20 ,  A61K31/4184 ,  B01J21/18 ,  B01J23/44 ,  B01J31/2295 ,  B01J31/2409 ,  B01J35/0006 ,  B01J2231/4211 ,  B01J2531/824 ,  B01J2531/842 ,  C07D403/04

Abstract: Methods of synthesizing the angiotensin II receptor antagonist telmisartan in high yield and purity are provided. The methods involve the coupling of two structurally distinct benzimidazole units via a Suzuki cross-coupling reaction. Methods of regioselectively synthesizing one of the benzimidazole units are also provided.

公开(公告)号：US20170252355A1

公开(公告)日：2017-09-07

申请号：US15517395

申请日：2015-10-13

Applicant: VIRGINIA COMMONWEALTH UNIVERSITY

Inventor： Shunlin REN ,  Jin Koung KIM

IPC: A61K31/56 ,  A61K31/58 ,  A61K31/575

CPC classification number: A61K31/56 ,  A61K31/575 ,  A61K31/58 ,  G01N2800/044

Abstract: Methods and compositions are provided for the prevention and/or treatment of symptoms associated with lipid accumulation disorders caused by attenuated leptin activity and by lipid storage disorders. The methods involve administering at least one oxygenated cholesterol sulfate (OCS) to a subject with the disorder. The disorder may be acquired or congenital (hereditary).

公开(公告)号：US20170224693A1

公开(公告)日：2017-08-10

申请号：US15480242

申请日：2017-04-05

Applicant: Virginia Commonwealth University

Inventor： Ruey-min Lee ,  Peck-sun Lin

IPC: A61K31/53 ,  A61K47/46 ,  A61K39/395 ,  C07K16/22 ,  A61K9/00 ,  A61K45/06

CPC classification number: A61K31/53 ,  A61K9/0019 ,  A61K31/135 ,  A61K31/167 ,  A61K39/3955 ,  A61K39/39558 ,  A61K45/06 ,  A61K47/46 ,  C07K16/22 ,  C07K2317/24 ,  A61K2300/00

Abstract: Methods and compositions for enhancing the ability of hypoxia-activated bioreductive agents to kill tumor cells within solid tumors are provided. Local regions of hypoxia are created within a tumor, or within a region containing a tumor, resulting in enhanced activation of hypoxia-activated bioreductive agents (e.g. tirapazamine) within the local region. The activated hypoxia-activated bioreductive agents kill tumor cells in the hypoxic region by catalyzing DNA stand breakage within the tumor cells. Because the activity is localized, side effects that typically occur as a result of systemic administration of bioreductive agents are reduced.

公开(公告)号：US20170218160A1

公开(公告)日：2017-08-03

申请号：US15500376

申请日：2015-07-31

Applicant: Massimo BERTINO ,  Virginia Commonwealth University

Inventor： Massimo Bertino

IPC: C08J9/28 ,  C01B33/158 ,  B01J13/00

CPC classification number: C08J9/28 ,  B01J13/0091 ,  C01B33/1585 ,  C08J9/286 ,  C08J2201/022 ,  C08J2201/026 ,  C08J2201/0522 ,  C08J2201/0524 ,  C08J2205/026 ,  C08J2205/042 ,  C08J2333/08 ,  C08J2383/06 ,  C08L33/08 ,  Y02P20/544

Abstract: A method of synthesizing aerogels and cross-linked aerogels in a single step and in a single pot without requiring any solvent exchange is described. Porous matrices are synthesized through a modification of hydrolysis condensation of alkoxides in which addition of water is minimized. The reaction occurs in an ethanol-water azeotrope mixture; the water in the azeotrope slowly hydrolyzes the alkoxide. Additionally, after gelation, the porous matrix is dried in supercritical ethanol rather than liquid CO2, which allows for elimination of solvent exchange steps. These modifications allow for the preparation of aerogel monoliths in any size in one step and in one pot and much faster than conventional procedures. In addition, the method provides for custom aerogel parts with large dimensions, as well as high volume fabrication of aerogels. The custom aerogel parts may be used in a variety of thermal insulation applications.

公开(公告)号：US09687037B1

公开(公告)日：2017-06-27

申请号：US14616381

申请日：2015-02-06

Applicant: Virginia Commonwealth University

Inventor： Raymond J. Colello ,  Rebecca E. Caffrey

IPC: A42B3/04 ,  A42B3/06

CPC classification number: A42B3/069

Abstract: Helmets which harness magnetic forces to reduce the force of impact collisions to helmets during contact sports, thus reducing the likelihood that athletes sustain a physical injury such as a traumatic brain injury and/or a neck injury, are described. The helmets incorporate strong magnets into the shell such that a repulsive magnetic force is generated between opposing helmets, thus reducing impact forces. Each helmet includes a protective shell and at least one magnet which is arranged or configured to provide for a spatially modulated magnetic array.

公开(公告)号：US09649316B2

公开(公告)日：2017-05-16

申请号：US14043661

申请日：2013-10-01

Applicant: Virginia Commonwealth University

Inventor： Ruey-min Lee ,  Peck-sun Lin

IPC: A61K31/53 ,  A61K31/167 ,  A61K39/395 ,  C07K16/22 ,  A61K31/135

CPC classification number: A61K31/53 ,  A61K9/0019 ,  A61K31/135 ,  A61K31/167 ,  A61K39/3955 ,  A61K39/39558 ,  A61K45/06 ,  A61K47/46 ,  C07K16/22 ,  C07K2317/24 ,  A61K2300/00

Abstract: Methods and compositions for enhancing the ability of hypoxia-activated bioreductive agents to kill tumor cells within solid tumors are provided. Local regions of hypoxia are created within a tumor, or within a region containing a tumor, resulting in enhanced activation of hypoxia-activated bioreductive agents (e.g. tirapazamine) within the local region. The activated hypoxia-activated bioreductive agents kill tumor cells in the hypoxic region by catalyzing DNA stand breakage within the tumor cells. Because the activity is localized, side effects that typically occur as a result of systemic administration of bioreductive agents are reduced.

公开(公告)号：US20170087363A1

公开(公告)日：2017-03-30

申请号：US15247010

申请日：2016-08-25

Applicant: VIRGINIA COMMONWEALTH UNIVERSITY

Inventor： Richard M. Costanzo ,  Woon-Hong Yeo

IPC: A61N1/36 ,  A61B5/07 ,  A61B5/00 ,  A61N1/05

Abstract: The system includes various embodiments of components, including (1) a sensor array, (2) a processor, (3) a transmitter, (4) a receiver-stimulator, and (5) an implantable electrode array. The gustatory implant system generates tastant fingerprints by detecting tastants with an array of chemical sensors and then transmitting variable spatiotemporal stimulation patterns for an electrode array with electrode stimulating points positioned at different locations in the gustatory cortex (e.g., stimulating the chorda tympanic nerve). Different patterns of activity in the gustatory cortex are thereby generated which mimic the sense of taste in a subject. Once trained the system should be usable by a subject to detect or correctly identify or perceive one or more tastes. The system may also include an external electronic device for processing and displaying information to monitor ingestion of various substances in a subject.