公开(公告)号：US09782516B2

公开(公告)日：2017-10-10

申请号：US13842445

申请日：2013-03-15

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC.

Inventor： Stephen D. Pacetti ,  John Stankus

IPC: A61F2/00 ,  A61L27/36 ,  A61L31/16

CPC classification number: A61L27/3695 ,  A61L27/3604 ,  A61L31/16 ,  A61L2400/06 ,  A61L2430/34

Abstract: A therapeutic formulation is described for a drug delivery balloon comprising a therapeutic formulation which includes a therapeutic agent and an adhesion additive. The adhesion additive promotes adhesion of the therapeutic formulation a vessel wall of a subject. A system and a method of manufacturing a system including an expandable member having a working length with the therapeutic formulation disposed along at least a portion of the working length is also provided.

公开(公告)号：US09757258B2

公开(公告)日：2017-09-12

申请号：US14859170

申请日：2015-09-18

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： Rommel Lumauig ,  Stephen D. Pacetti ,  Ni Ding ,  Joel Harrington ,  Xiao Ma ,  James P. Oberhauser ,  Jill McCoy ,  Chad J. Abunassar ,  Senthil Eswaran ,  Diem Ta

IPC: A61F2/82 ,  A61F2/91 ,  A61F2/915 ,  C08G63/08 ,  B29C71/02 ,  A61L31/06 ,  A61L31/14 ,  B29K67/00 ,  B29L31/00 ,  B29C35/04 ,  B29C35/08

Abstract: Methods are disclosed including thermally processing a scaffold to increase the radial strength of the scaffold when the scaffold is deployed from a crimped state to a deployed state such as a nominal deployment diameter. The thermal processing may further maintain or increase the expansion capability of the scaffold when expanded beyond the nominal diameter.

公开(公告)号：US20170231790A1

公开(公告)日：2017-08-17

申请号：US15045849

申请日：2016-02-17

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： Chad J. Abunassar ,  Stephen D. Pacetti

IPC: A61F2/915 ,  A61F2/844 ,  A61F2/958

Abstract: Delivery systems are disclosed for bioresorbable scaffolds that decrease in length when expanded to a deployment diameter that allow accurate positioning of the scaffold at a lesion. The scaffolds are mounted on a catheter that includes marker bands that are positioned interior to the proximal and distal edges of the crimped scaffold to anticipate the shortening of the scaffold upon deployment. Delivery systems are further disclosed for bioresorbable scaffolds that increase in length when expanded to a deployment diameter that allow accurate positioning of the scaffold at a lesion. The scaffolds are mounted on a catheter that includes marker bands that are positioned exterior to the proximal and distal edges of the crimped scaffold to anticipate the lengthening of the scaffold upon deployment.

公开(公告)号：US09675483B2

公开(公告)日：2017-06-13

申请号：US13924421

申请日：2013-06-21

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： Stephen D. Pacetti ,  Annie P. Liu ,  Mark C. Johnson

IPC: A61F2/962 ,  A61F2/958 ,  A61F2/82 ,  A61L31/14 ,  A61L31/04 ,  A61L31/06 ,  A61F2/95 ,  A61F2/966 ,  A61F2/00 ,  A61F2/97

CPC classification number: A61F2/958 ,  A61F2/0095 ,  A61F2/82 ,  A61F2/95 ,  A61F2/962 ,  A61F2/966 ,  A61F2/97 ,  A61F2002/9583 ,  A61F2210/0004 ,  A61F2250/0059 ,  A61L31/048 ,  A61L31/06 ,  A61L31/14 ,  A61L31/148

Abstract: A medical device includes a polymer scaffold crimped to a catheter having an expansion balloon. A sheath is placed over the crimped scaffold after crimping to reduce recoil of the crimped polymer scaffold and maintain scaffold-balloon engagement relied on to hold the scaffold to the balloon when the scaffold is being delivered to a target in a body. The sheath is removed by a health professional either by removing the sheath directly or using a tube containing the catheter.

公开(公告)号：US09592323B2

公开(公告)日：2017-03-14

申请号：US14109795

申请日：2013-12-17

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC.

Inventor： Florencia Lim ,  Mikael O. Trollsas ,  Syed F.A. Hossainy ,  Stephen D. Pacetti

IPC: A61L31/10 ,  A61L31/16 ,  A61L31/14

CPC classification number: A61L31/10 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/604 ,  A61L2300/606 ,  Y10T24/258 ,  C08L67/04

Abstract: The present invention provides a coating comprising a reservoir layer comprising a semi-crystalline polymer and a primer layer comprising an amorphous polymer on an implantable device and methods of making and using the same.

Abstract translation: 本发明提供一种包含储存层的涂层，其包含半结晶聚合物和在可植入装置上包含无定形聚合物的底漆层及其制备和使用该涂层的方法。

公开(公告)号：US09566147B2

公开(公告)日：2017-02-14

申请号：US13830404

申请日：2013-03-14

Applicant: Abbott Cardiovascular Systems, Inc.

Inventor： Pamela A. Kramer-Brown ,  Kayla L. Calvert ,  John A. Simpson ,  Stephen D. Pacetti ,  Austin M. Leach

IPC: C22C19/07 ,  A61F2/06 ,  A61L31/02 ,  A61L31/18 ,  C22C1/04 ,  C22C19/05 ,  C22C27/00 ,  C22C27/04 ,  C22C27/06

CPC classification number: A61F2/82 ,  A61F2/06 ,  A61F2250/0098 ,  A61L31/022 ,  A61L31/18 ,  C22C1/0433 ,  C22C19/05 ,  C22C19/07 ,  C22C27/00 ,  C22C27/04 ,  C22C27/06

Abstract: Embodiments are directed to radiopaque implantable structures (e.g., stents) formed of cobalt-based alloys that comprise cobalt, chromium and one or more platinum group metals, refractory metals, precious metals, or combinations thereof. Platinum group metals include platinum, palladium, ruthenium, rhodium, osmium, and iridium. Refractory metals include zirconium, niobium, rhodium, molybdenum, hafnium, tantalum, tungsten, rhenium, and precious metals include silver and gold. In one embodiment, the one or more included platinum group or refractory metals substitute at least partially for nickel, such that the alloy exhibits reduced nickel content, or is substantially nickel free. The stents exhibit improved radiopacity as compared to similar alloys including greater amounts of nickel.

Abstract translation: 实施例涉及由包含钴，铬和一种或多种铂族金属，难熔金属，贵金属或其组合的钴基合金形成的不透射线的可植入结构（例如，支架）。 铂族金属包括铂，钯，钌，铑，锇和铱。 耐火金属包括锆，铌，铑，钼，铪，钽，钨，铼，贵金属包括银和金。 在一个实施方案中，所述一种或多种包括的铂族或难熔金属至少部分地代替镍，使得该合金显示出降低的镍含量或基本上不含镍。 与包括更大量的镍的类似合金相比，支架表现出改善的射线不透性。

公开(公告)号：US20160374838A1

公开(公告)日：2016-12-29

申请号：US14754479

申请日：2015-06-29

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： Stephen D. Pacetti ,  Alexander J. Sheehy ,  Chad J. Abunassar

IPC: A61F2/915

CPC classification number: A61F2/915 ,  A61F2002/91558 ,  A61F2002/91566 ,  A61F2210/0004 ,  A61F2210/0076 ,  A61F2250/0067 ,  A61L31/06 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/606 ,  A61L2300/608 ,  A61L2420/02 ,  A61L2420/08 ,  C08L67/04

Abstract: Stents including a poly(D,L-lactide)(PDLLA)-based scaffold and PDLLA based therapeutic layer are disclosed. The PDLLA based scaffold may be amorphous and may include a primer layer. Methods of applying the PDLLA-based coating to the scaffold are disclosed with solvent processing methods using a solvent blend are also disclosed. Methods of removing residual solvent from a PDLLA-base coating that also condition the scaffold are disclosed. Methods of treating restenosis that release drugs to prevent restenosis without interfering with the natural positive remodeling of a vessel are disclosed.

Abstract translation: 公开了包含基于聚（D，L-丙交酯）（PDLLA）的支架和基于PDLLA的治疗层的支架。 基于PDLLA的支架可以是无定形的，并且可以包括底漆层。 公开了使用溶剂共混物的溶剂处理方法将基于PDLLA的涂层施用于支架的方法。 公开了从处于支架状态的PDLLA基底涂层除去残余溶剂的方法。 公开了治疗释放药物以预防再狭窄而不干扰血管的天然阳性重塑的再狭窄的方法。

公开(公告)号：US09492295B2

公开(公告)日：2016-11-15

申请号：US14985141

申请日：2015-12-30

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： Stephen D. Pacetti

IPC: A61F2/91 ,  B05D7/22 ,  A23G9/28 ,  B05D3/04 ,  B05D1/18

CPC classification number: A61F2/91 ,  A23G9/283 ,  A61F2240/001 ,  A61F2250/0068 ,  B05D1/18 ,  B05D3/0486 ,  B05D3/0493 ,  B05D7/22

Abstract: An apparatus for loading material into a stent strut can comprise a cover sleeve. The cover sleeve is elastic so that it can reduce in diameter so as to press against the stent strut, and expand in diameter so as to be spaced apart from the stent strut. The stent strut can include a lumen into which material is injected. When pressed against the stent strut, the cover sleeve seals side openings to the lumen and prevents injected material from leaking out of the side openings during the injection process.

Abstract translation: 用于将材料装载到支架支柱中的装置可以包括盖套筒。 盖套是弹性的，使得其可以减小直径以便压靠支架支柱，并且直径扩大以与支架支柱间隔开。 支架支架可以包括注射材料的内腔。 当压靠支架支柱时，盖套筒将侧开口密封到内腔，并防止在注射过程中注入材料从侧开口泄漏出来。

公开(公告)号：US09492294B2

公开(公告)日：2016-11-15

申请号：US14034953

申请日：2013-09-24

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： Stephen D. Pacetti

IPC: A61F2/91 ,  A61F2/90 ,  A61F2/915

CPC classification number: A61F2/90 ,  A61F2/915 ,  A61F2002/91575 ,  A61F2210/0004 ,  A61F2230/0054 ,  A61F2240/001 ,  A61F2250/0068 ,  B33Y80/00

Abstract: A prosthesis for intraluminal drug delivery can comprise a plurality of interconnected struts and links that form a tubular structure. The struts and links can have luminal surfaces facing radially inward, abluminal surfaces facing radially outward, and side surfaces connecting the luminal surfaces to the abluminal surfaces. At least some of the struts and links have through-holes in the side surfaces. At least some of the through-holes contain a drug, which can be carried in a polymer matrix.

公开(公告)号：US09486559B2

公开(公告)日：2016-11-08

申请号：US13889259

申请日：2013-05-07

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： Terry B. Mazer ,  Stephen D. Pacetti ,  Brenna H. Lord

IPC: A61F2/06 ,  A61L31/14 ,  A61L33/00 ,  A61L31/06 ,  A61L31/16

CPC classification number: A61L31/148 ,  A61L31/06 ,  A61L31/146 ,  A61L31/16 ,  A61L33/0011 ,  A61L33/0047 ,  A61L2300/254 ,  A61L2300/256 ,  A61L2300/416 ,  A61L2300/45 ,  A61L2300/604 ,  C08L67/04

Abstract: Bioresorbable scaffolds and methods of treatment with such scaffolds for neurologic disorders including Parkinson's disease, Huntington's disease, Alzheimer's disease, and brain neoplasms are disclosed. The bioresorbable scaffold includes a bioresorbable body and an active agent or drug associated with the body for treating or ameliorating the neurological disorder. The bioresorbable scaffold is implanted in the neurological vasculature brain or brain tissue to provide localized delivery of the drug or active agent. Embodiments of the invention include scaffolds that are partially bioresorbable or completely bioresorbable.

Abstract translation: 公开了生物可吸收支架和用这种支架治疗包括帕金森病，亨廷顿病，阿尔茨海默氏病和脑肿瘤的神经障碍的方法。 生物可吸收支架包括生物可吸收体和与身体相关联的用于治疗或改善神经障碍的活性剂或药物。 将生物可吸收的支架植入神经系统的脉管系统脑或脑组织中以提供药物或活性剂的局部递送。 本发明的实施方案包括部分生物可再吸收或完全生物可再吸收的支架。