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61.发明申请METHOD AND STRUCTURE FOR SEMICONDUCTOR DEVICES WITH SILICON-GERMANIUM DEPOSITS 审中-公开具有硅锗沉积物的半导体器件的方法和结构公开(公告)号：US20090152590A1
公开(公告)日：2009-06-18
申请号：US11955488
申请日：2007-12-13
申请人： Thomas N. Adam , Linda Black , Huajie Chen , Dureseti Chidambarrao , Robert E. Davis , Judson R. Holt , Randolph F. Knarr , Christian Lavoie , Robert J. Purtell , Dominic J. Schepis
发明人： Thomas N. Adam , Linda Black , Huajie Chen , Dureseti Chidambarrao , Robert E. Davis , Judson R. Holt , Randolph F. Knarr , Christian Lavoie , Robert J. Purtell , Dominic J. Schepis
IPC分类号： H01L29/78 , H01L21/336
CPC分类号： H01L29/7848 , H01L29/165 , H01L29/665 , H01L29/6656 , H01L29/66636
摘要： A method of forming a semiconductor device including forming a second deposit of silicon-germanium on a first deposit of silicon-germanium, the first deposit formed in a conduction terminal region of a substrate of the semiconductor device and having a first percentage of germanium, and the second deposit having a second percentage of germanium that is less than the first percentage and supports forming a silicide deposit on the second deposit. A structure is also provided.
摘要翻译： 一种形成半导体器件的方法，包括在硅 - 锗的第一沉积物上形成硅 - 锗的第二沉积物，所述第一沉积物形成在所述半导体器件的衬底的导电末端区域中并且具有第一百分比的锗，以及 所述第二沉积物具有小于所述第一百分比的第二百分比的锗，并且在所述第二沉积物上支持形成硅化物沉积物。 还提供了一种结构。
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62.发明授权公开(公告)号：US06906174B2
公开(公告)日：2005-06-14
申请号：US09809827
申请日：2001-03-16
IPC分类号： G01N33/50 , A61K31/704 , A61K31/7048 , A61K31/7056 , A61K31/7064 , A61K45/00 , A61P3/00 , A61P3/10 , A61P17/06 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/28 , A61P27/16 , A61P35/00 , A61P43/00 , C07H15/256 , C07H15/26 , C07K1/22 , C07K14/47 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12N15/62 , C12P21/02 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/566 , C07K1/00 , C07K14/00
CPC分类号： C07K14/47 , C07K2319/00 , C07K2319/07 , C07K2319/21 , C07K2319/23 , C12N15/62 , C12N2799/021
摘要： Compositions and methods are provided for producing adenine nucleotide translocator (ANT) polypeptides and fusion proteins, including the production and use of recombinant expression constructs having a regulated promoter. ANT ligands and compositions and methods for identifying ANT ligands, agents that bind ANT and agents that interact with ANT are also disclosed.
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63.发明授权公开(公告)号：US06906173B2
公开(公告)日：2005-06-14
申请号：US09185904
申请日：1998-11-03
CPC分类号： C12N15/62 , C07K14/47 , C07K2319/00 , C07K2319/07 , C07K2319/21 , C07K2319/23 , C12N2799/021
摘要： Compositions and methods are provided for producing adenine nucleotide translocator (ANT) polypeptides and fusion proteins, including the production and use of recombinant expression constructs having a regulated promoter. ANT ligands and compositions and methods for identifying ANT ligands, agents that bind ANT and agents that interact with ANT are also disclosed.
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公开(公告)号：US06900197B2
公开(公告)日：2005-05-31
申请号：US10020867
申请日：2001-12-14
IPC分类号： A61K31/409 , A61K33/24 , A61P3/04 , C07D487/22 , C07F15/06 , A61K31/555 , A61K31/40 , A61K31/415
CPC分类号： C07D487/22
摘要： Cobalt-porphyrin (Co-P) complexes for use as anti-obesity agents, and compositions and methods related thereto. The Co-P complexes exhibit reduced redox activity compared to cobalt mesoporphyrin (Co-MP) and cobalt protoporphyrin (Co-PP), which alleviates the deleterious effects associated with administration of Co-P associated with oxidative stress, particularly in the context of injection site toxicity.
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公开(公告)号：US06867197B1
公开(公告)日：2005-03-15
申请号：US09448312
申请日：1999-11-23
CPC分类号： C07D219/08 , A61K38/00 , A61K47/541 , A61K47/545 , C07K14/4711 , C07K14/4713 , C12N9/0053 , C12Q1/6806 , C12Q2527/101
摘要： The present invention relates to genetic mutations in mitochondrial cytochrome c oxidase genes that segregate with Alzheimer's disease (AD). The invention provides methods for detecting such mutations, as a diagnostic for Alzheimer's Disease, either before or after the onset of clinical symptoms. The invention further provides treatment of cytochrome c oxidase dysfunction.
摘要翻译： 本发明涉及与阿尔茨海默氏病（AD）分离的线粒体细胞色素c氧化酶基因中的遗传突变。 本发明提供了在临床症状发作之前或之后检测这种突变作为阿尔茨海默病诊断的方法。 本发明进一步提供细胞色素c氧化酶功能障碍的治疗。
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公开(公告)号：US06653094B2
公开(公告)日：2003-11-25
申请号：US09924313
申请日：2001-08-07
IPC分类号： C12Q132
CPC分类号： C12Q1/6883 , G01N33/6893 , G01N2800/042
摘要： The present invention relates to improved diagnostic methods for early detection of a risk for developing type 2 diabetes mellitus in humans, and screening assays for therapeutic agents useful in the treatment of type 2 diabetes mellitus, by comparing the levels of one or more indicators of altered mitochondrial function. Indicators of altered mitochondrial function include enzymes such as mitochondrial enzymes and ATP biosynthesis factors. Other indicators of altered mitochondrial function include mitochondrial mass, mitochondrial number and mitochondrial DNA content, cellular responses to elevated intracellular calcium and to apoptogens, and free radical production. Methods of treating, and of stratifying, human patients as such methods relate to disclosed indicators of altered mitchondrial function are also provided.
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67.发明授权Compositions and mehtods for determining interactions of mitochondrial components, and for identifying agents that alter such interactions 失效用于确定线粒体组分相互作用的组合物和方法，以及用于鉴定改变这种相互作用的试剂公开(公告)号：US06562563B1
公开(公告)日：2003-05-13
申请号：US09434354
申请日：1999-11-03
申请人： Anne N. Murphy , William Clevenger , Sandra Eileen Wiley , Alexander Y. Andreyev , Luciano G. Frigeri , Gonul Velecelebi , Robert E. Davis
发明人： Anne N. Murphy , William Clevenger , Sandra Eileen Wiley , Alexander Y. Andreyev , Luciano G. Frigeri , Gonul Velecelebi , Robert E. Davis
IPC分类号： C12N500
CPC分类号： G01N33/5079 , C07K14/43595 , C07K2319/00 , C07K2319/21 , C07K2319/23 , C07K2319/50 , C07K2319/60 , C12N9/90 , C12N15/62 , G01N33/542
摘要： Compositions and methods are provided for identifying agents that alter mitochondrial membrane permeability transition. The screening methods generally detect agents that alter the interaction between the mitochondrial adenine nucleotide translocator and cyclophilin D. Such agents may be used, for example, in the treatment of a variety of conditions associated with altered mitochondrial function.
摘要翻译： 提供组合物和方法用于鉴定改变线粒体膜通透性转换的药剂。 筛选方法通常检测改变线粒体腺嘌呤核苷酸转运体和亲环蛋白D之间的相互作用的试剂。这种试剂可用于例如治疗与线粒体功能改变相关的多种病症。
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公开(公告)号：US06511966B2
公开(公告)日：2003-01-28
申请号：US09933911
申请日：2001-08-20
IPC分类号： A01N4304
CPC分类号： A61K31/155 , A61K31/00 , A61K31/05 , A61K31/06 , A61K31/136 , C07C39/08 , C07C39/11 , C07C39/19 , C07C69/017 , C07C215/78 , C07C215/80 , C07C217/84 , C07C279/18 , C07D215/20 , C07D311/72
摘要： The present invention relates generally to mitochondria protecting agents for treating diseases in which mitochondrial dysfunction leads to tissue degeneration and, more specifically, to compounds, compositions and methods related to the same. The methods of this invention involve administration of a pharmaceutically effective amount of a mitochondria protecting agent to a warm-blooded animal in need thereof, and composition of this invention contain a mitochondria protecting agent in combination with a pharmaceutically acceptable carrier or diluent. Mitochondrial associated diseases which may be treated by the present invention include (but are not limited to) Alzheimer's Disease, diabetes mellitus. Parkinson's Disease, neuronal and cardiac ischemia. Huntington's disease and stroke.
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公开(公告)号：US06489095B2
公开(公告)日：2002-12-03
申请号：US09098079
申请日：1998-06-15
IPC分类号： C12Q168
CPC分类号： C12Q1/6883 , C12Q1/6827 , C12Q2600/156 , C12Q2600/172
摘要： Compositions and methods based on quantification of extramitochondrial DNA (exmtDNA) sequences are provided that are useful for detecting the presence of or risk for having a disease associated with altered mitochondrial function, and for identifying agents suitable for treating such diseases. The exmtDNA sequences have strong homology to authentic mitochondrial DNA (mtDNA) sequences.
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公开(公告)号：US06291172B1
公开(公告)日：2001-09-18
申请号：US09302682
申请日：1999-04-30
IPC分类号： C12P1934
CPC分类号： C07D219/08 , A61K38/00 , C07K14/4711 , C07K14/4713 , C12N9/0053 , C12Q1/6806 , C12Q1/6883 , C12Q2600/156 , C12Q2527/101
摘要： The present invention relates to genetic mutations in mitochondrial genes that segregate with diabetes mellitus. The invention provides methods for detecting such mutations, as a diagnostic for diabetes mellitus, either before or after the onset of clinical symptoms. Examples of specific mutations in the ATP synthase 8/6 sequence and tRNALys sequence are given. The invention also provides treatments for dysfunctions due to genes for mitochondrial functions that segregate with diabetes mellitus. Cybrid cell lines are described which are useful as model systems for the study of the mitochondrial metabolic disorders that are associated with diabetes mellitus, and for identifying therapeutic compounds and treatments for this disease.
摘要翻译： 本发明涉及与糖尿病分离的线粒体基因中的遗传突变。 本发明提供在临床症状发作之前或之后检测这种突变作为糖尿病诊断的方法。 给出了ATP合酶8/6序列和tRNALys序列中特异性突变的实例。 本发明还提供了由于与糖尿病分离的线粒体功能的基因引起的功能障碍的治疗。 描述了杂交细胞系，其可用作研究与糖尿病相关的线粒体代谢紊乱的模型系统，并且用于鉴定该疾病的治疗化合物和治疗。
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