公开(公告)号：US20100168205A1

公开(公告)日：2010-07-01

申请号：US12605299

申请日：2009-10-23

申请人： Rachel Meyers ,  Rene Alvarez ,  Geoff Cole ,  Sayda Elbashir

发明人： Rachel Meyers ,  Rene Alvarez ,  Geoff Cole ,  Sayda Elbashir

IPC分类号： A61K31/713 ,  C07H21/02 ,  A61P31/14

CPC分类号： C12N15/1131 ,  A61K9/0073 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2320/30 ,  C12N2310/3521 ,  C12N2310/3533

摘要： Methods and compositions are provided for the prevention or treatment of RSV infection in a human. The methods include administering one or more doses of a composition comprising an siRNA. The dose can be formulated for topical or parenteral administration. Topical administration includes administration as a nasal spray, or by inhalation of respirable particles or droplets. The siRNA preferably comprises a sense strand and antisense strand with modified nucleotides.

摘要翻译： 提供了用于预防或治疗人体RSV感染的方法和组合物。 所述方法包括施用一种或多种剂量的包含siRNA的组合物。 剂量可以配制用于局部或肠胃外给药。 局部给药包括作为鼻喷雾给药，或通过吸入可吸入颗粒或液滴。 siRNA优选包含具有修饰的核苷酸的有义链和反义链。

公开(公告)号：US07704711B1

公开(公告)日：2010-04-27

申请号：US11901873

申请日：2007-09-19

申请人： Rachel Meyers ,  Rosana Kapeller-Libermann ,  Mark Williamson

发明人： Rachel Meyers ,  Rosana Kapeller-Libermann ,  Mark Williamson

IPC分类号： C07H21/04 ,  C12P21/04 ,  C12P21/06 ,  C07K14/00

CPC分类号： C12N9/1205 ,  A61K38/00 ,  C07C51/215 ,  C07C57/04

摘要： The invention relates to novel kinase nucleic acid sequences and proteins. Also provided are vectors, host cells, and recombinant methods for making and using the novel molecules.

摘要翻译： 本发明涉及新型激酶核酸序列和蛋白质。 还提供了用于制备和使用新分子的载体，宿主细胞和重组方法。

公开(公告)号：US20090233984A1

公开(公告)日：2009-09-17

申请号：US12326867

申请日：2008-12-02

申请人： Rachel Meyers

发明人： Rachel Meyers

IPC分类号： A61K31/7105

CPC分类号： C12N15/1131 ,  A61K9/0078 ,  A61K31/713 ,  A61M11/06 ,  A61M15/00 ,  A61M16/14 ,  A61M2202/04 ,  A61M2202/064 ,  C12N2310/14 ,  C12N2320/31 ,  C12N2320/32

摘要： The present invention is based on the in vivo demonstration that RSV can be inhibited through intranasal administration of iRNA agents as well as by parenteral administration of such agents. Further, it is shown that effective viral reduction can be achieved with more than one virus being treated concurrently. Based on these findings, the present invention provides general and specific compositions and methods that are useful in reducing RSV mRNA levels, RSV protein levels and viral titers in a subject, e.g., a mammal, such as a human. These findings can be applied to other respiratory viruses.

摘要翻译： 本发明基于体内证据，可以通过鼻内施用iRNA试剂以及通过肠胃外给药这种试剂来抑制RSV。 此外，显示可以同时治疗多于一种的病毒来实现有效的病毒降低。 基于这些发现，本发明提供了可用于减少受试者例如哺乳动物（例如人）中的RSV mRNA水平，RSV蛋白水平和病毒滴度的一般和特定组合物和方法。 这些发现可以应用于其他呼吸道病毒。

公开(公告)号：US07507809B2

公开(公告)日：2009-03-24

申请号：US11326956

申请日：2006-01-06

申请人： Rachel Meyers

发明人： Rachel Meyers

IPC分类号： C07H21/04

CPC分类号： C12N15/1131 ,  A61K9/0078 ,  A61K31/713 ,  A61M11/06 ,  A61M15/00 ,  A61M16/14 ,  A61M2202/04 ,  A61M2202/064 ,  C12N2310/14 ,  C12N2320/31 ,  C12N2320/32

摘要： The present invention is based on the in vivo demonstration that RSV can be inhibited through intranasal administration of iRNA agents as well as by parenteral administration of such agents. Further, it is shown that effective viral reduction can be achieved with more than one virus being treated concurrently. Based on these findings, the present invention provides general and specific compositions and methods that are useful in reducing RSV mRNA levels, RSV protein levels and viral titers in a subject, e.g., a mammal, such as a human. These findings can be applied to other respiratory viruses.

摘要翻译： 本发明基于体内证据，可以通过鼻内施用iRNA试剂以及通过肠胃外给药这种试剂来抑制RSV。 此外，显示可以同时治疗多于一种的病毒来实现有效的病毒降低。 基于这些发现，本发明提供了可用于减少受试者例如哺乳动物（例如人）中的RSV mRNA水平，RSV蛋白水平和病毒滴度的一般和特定组合物和方法。 这些发现可以应用于其他呼吸道病毒。

公开(公告)号：US20080108093A1

公开(公告)日：2008-05-08

申请号：US11981786

申请日：2007-10-31

申请人： Rosana Kapeller-Libermann ,  David White ,  Keith Robison ,  Kyle MacBeth ,  Joseph Carroll ,  William Cook ,  Rachel Meyers ,  Miyoung Chun ,  Mark Williamson

发明人： Rosana Kapeller-Libermann ,  David White ,  Keith Robison ,  Kyle MacBeth ,  Joseph Carroll ,  William Cook ,  Rachel Meyers ,  Miyoung Chun ,  Mark Williamson

IPC分类号： G01N33/53 ,  G01N33/68

CPC分类号： G01N33/5008 ,  A61K38/00 ,  C12N9/1007 ,  C12N9/16 ,  C12N9/6489 ,  C12Q1/37 ,  C12Q1/6883 ,  C12Q2600/158 ,  C12Y301/04017 ,  G01N33/5011 ,  G01N33/502 ,  G01N33/56983 ,  G01N33/56994 ,  G01N33/57426 ,  G01N33/5761 ,  G01N33/5767 ,  G01N33/68 ,  G01N2333/916 ,  G01N2333/96486 ,  G01N2500/04

摘要： The invention provides isolated nucleic acids molecules, designated 27875, 22025, 27420, 16319, 55092 and 10218 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 27875, 22025, 27420, 16319, 55092 and 10218 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 27875, 22025, 27420, 16319, 55092 and 10218 gene has been introduced or disrupted. The invention still further provides isolated 27875, 22025, 27420, 17906, 16319, 55092 or 10218 proteins, fusion proteins, antigenic peptides and anti-27875, 22025, 27420, 17906, 16319, 55092 or 10218 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.

公开(公告)号：US07214374B2

公开(公告)日：2007-05-08

申请号：US10682739

申请日：2003-10-09

申请人： Rachel Meyers ,  Martin R. Hodge ,  Mark Williamson

发明人： Rachel Meyers ,  Martin R. Hodge ,  Mark Williamson

IPC分类号： A61K39/00 ,  G01N33/53

CPC分类号： C12N9/1205 ,  A61K38/00 ,  A61K48/00 ,  C07K16/40 ,  C12Q1/6886 ,  C12Q2600/136

摘要： Novel human kinase-like polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length kinase-like proteins, the invention further provides isolated kinase-like fusion proteins, antigenic peptides, and anti-kinase-like antibodies. The invention also provides kinase-like nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a kinase-like gene has been introduced or disrupted. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.

摘要翻译： 公开了新的人激酶样多肽，蛋白质和核酸分子。 除了分离的全长激酶样蛋白之外，本发明还提供了分离的激酶样融合蛋白，抗原肽和抗激酶样抗体。 本发明还提供激酶样核酸分子，含有本发明的核酸分子的重组表达载体，已经引入了表达载体的宿主细胞和其中已经引入或破坏了类似激酶的基因的非人类转基因动物 。 还提供了利用本发明组合物的诊断，筛选和治疗方法。

公开(公告)号：US20070099230A1

公开(公告)日：2007-05-03

申请号：US11636665

申请日：2006-12-08

申请人： Rajasekhar Bandaru ,  Maria Glucksmann ,  Rachel Meyers ,  Laura Rudolph-Owen

发明人： Rajasekhar Bandaru ,  Maria Glucksmann ,  Rachel Meyers ,  Laura Rudolph-Owen

IPC分类号： C12Q1/68 ,  G01N33/574 ,  C07H21/04 ,  C12P21/06 ,  C07K14/82

CPC分类号： G01N33/5743 ,  A01K2217/05 ,  A01K2217/075 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  C07K14/47 ,  C07K14/4748 ,  C07K2319/00 ,  C12N9/1029 ,  C12N9/1096 ,  C12N9/14 ,  C12N9/90

摘要： The invention provides isolated nucleic acids molecules that encode novel polypeptides. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a sequence of the invention has been introduced or disrupted. The invention still further provides isolated proteins, fusion proteins, antigenic peptides and antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

摘要翻译： 本发明提供编码新多肽的分离的核酸分子。 本发明还提供了反义核酸分子，含有本发明的核酸分子的重组表达载体，已经引入了表达载体的宿主细胞，以及本发明的序列已被引入或破坏的非人类转基因动物。 本发明还进一步提供分离的蛋白质，融合蛋白，抗原肽和抗体。 还提供了利用本发明组合物的诊断方法。

公开(公告)号：US20060258608A1

公开(公告)日：2006-11-16

申请号：US11411291

申请日：2006-04-26

申请人： Rachel Meyers

发明人： Rachel Meyers

IPC分类号： A61K48/00

CPC分类号： C12N15/1131 ,  A61K9/0078 ,  A61K31/713 ,  A61M11/06 ,  A61M15/00 ,  A61M16/14 ,  A61M2202/04 ,  A61M2202/064 ,  C12N2310/14 ,  C12N2320/31 ,  C12N2320/32

摘要： The present invention is based on the in vivo demonstration that RSV can be inhibited through intranasal administration of iRNA agents as well as by parenteral administration of such agents. Further, it is shown that effective viral reduction can be achieved with more than one virus being treated concurrently. Based on these findings, the present invention provides general and specific compositions and methods that are useful in reducing RSV mRNA levels, RSV protein levels and viral titers in a subject, e.g., a mammal, such as a human. These findings can be applied to other respiratory viruses.

公开(公告)号：US07094565B1

公开(公告)日：2006-08-22

申请号：US09464039

申请日：1999-12-15

申请人： Rachel Meyers

发明人： Rachel Meyers

IPC分类号： C12P21/06 ,  C12N5/00 ,  C12N15/00 ,  C12N15/63 ,  C07H21/02 ,  C07H21/04 ,  C07K1/00

CPC分类号： C12N9/0006 ,  A61K38/00

摘要： The present invention relates to newly identified human ADHs belonging to the superfamily of mammalian alcohol dehydrogenases. The invention also relates to polynucleotides encoding the ADHs. The invention further relates to methods using the ADH polypeptides and polynucleotides as a target for diagnosis and treatment in ADH-mediated or -related disorders. The invention further relates to drug-screening methods using the ADH polypeptides and polynucleotides to identify agonists and antagonists for diagnosis and treatment. The invention further encompasses agonists and antagonists based on the ADH polypeptides and polynucleotides. The invention further relates to procedures for producing the ADH polypeptides and polynucleotides.

摘要翻译： 本发明涉及属于哺乳动物醇脱氢酶超家族的新鉴定的人ADH。 本发明还涉及编码ADH的多核苷酸。 本发明还涉及使用ADH多肽和多核苷酸作为ADH介导或相关疾病中的诊断和治疗靶标的方法。 本发明还涉及使用ADH多肽和多核苷酸鉴定用于诊断和治疗的激动剂和拮抗剂的药物筛选方法。 本发明还包括基于ADH多肽和多核苷酸的激动剂和拮抗剂。 本发明还涉及产生ADH多肽和多核苷酸的方法。

公开(公告)号：US20060009632A1

公开(公告)日：2006-01-12

申请号：US11226701

申请日：2005-09-14

申请人： Rosana Kapeller-Libermann ,  David White ,  Keith Robison ,  Kyle MacBeth ,  Joseph Carroll ,  William Cook ,  Rachel Meyers ,  Miyoung Chun ,  Mark Williamson

发明人： Rosana Kapeller-Libermann ,  David White ,  Keith Robison ,  Kyle MacBeth ,  Joseph Carroll ,  William Cook ,  Rachel Meyers ,  Miyoung Chun ,  Mark Williamson

IPC分类号： C07H21/04

CPC分类号： G01N33/5008 ,  A61K38/00 ,  C12N9/1007 ,  C12N9/16 ,  C12N9/6489 ,  C12Q1/37 ,  C12Q1/6883 ,  C12Q2600/158 ,  C12Y301/04017 ,  G01N33/5011 ,  G01N33/502 ,  G01N33/56983 ,  G01N33/56994 ,  G01N33/57426 ,  G01N33/5761 ,  G01N33/5767 ,  G01N33/68 ,  G01N2333/916 ,  G01N2333/96486 ,  G01N2500/04

摘要： The invention provides isolated nucleic acids molecules, designated 27875, 22025, 27420, 16319, 55092 and 10218 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 27875, 22025, 27420, 16319, 55092 and 10218 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 27875, 22025, 27420, 16319, 55092 and 10218 gene has been introduced or disrupted. The invention still further provides isolated 27875, 22025, 27420, 17906, 16319, 55092 or 10218 proteins, fusion proteins, antigenic peptides and anti-27875, 22025, 27420, 17906, 16319, 55092 or 10218 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.

摘要翻译： 本发明提供分离的核酸分子，命名为27875,22025,27420,16319,55092和10218核酸分子。 本发明还提供反义核酸分子，含有27875,22025,27420,16319,55092和10218核酸分子的重组表达载体，已经引入表达载体的宿主细胞，以及非人类转基因动物，其中27875,22025， 27420,16319,55092和10218基因已被引入或破坏。 本发明还进一步提供了分离的27875,22025,27420,17906,16319,55092或10218蛋白，融合蛋白，抗原肽和抗27875,22025,27420,17906,16319,55092或10218抗体。 还提供了利用本发明组合物的诊断和治疗方法。