公开(公告)号：US20190218232A1

公开(公告)日：2019-07-18

申请号：US16244637

申请日：2019-01-10

Applicant: California Institute Of Technology

Inventor： Anton A. Toutov ,  Kerry N. Betz ,  Andrew M. Romine ,  Robert H. Grubbs

IPC: C07F7/10

CPC classification number: C07F7/10

Abstract: The present disclosure is directed at methods of forming an N—Si silyl bond, the method comprising contacting an organic substrate comprising an aromatic amine having at least one N—H bond with a mixture comprising of (a) at least one hydrosilane or hydrosiloxane and (b) at least one hydroxide or alkoxide, under conditions sufficient to form the N—Si bond. The disclosure is further directed to the compositions involved in these methods and the products that result therefrom.

公开(公告)号：US20190048030A1

公开(公告)日：2019-02-14

申请号：US16159298

申请日：2018-10-12

Applicant: California Institute Of Technology

Inventor： Anton Toutov ,  Kerry Betz ,  Alexey Fedorov ,  Brian M. Stoltz ,  Wenbo Liu ,  Robert H. Grubbs

IPC: C07F7/08 ,  C07D209/12

Abstract: The present disclosure describes novel silylated heteroaromatic derivatives, including those prepared by methods comprising the use of hydrosilanes and at least one strong base, the definition of strong base now also including hydroxide, especially KOH.

公开(公告)号：US10081705B2

公开(公告)日：2018-09-25

申请号：US14698520

申请日：2015-04-28

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Yan Xia ,  Benjamin R. Sveinbjornsson ,  Robert H. Grubbs ,  Raymond Weitekamp ,  Garret M. Miyake ,  Victoria Piunova ,  Christopher Scot Daeffler

IPC: C08F297/02 ,  C08F297/00 ,  C08L53/00 ,  C08G61/12 ,  C08G81/00 ,  C08F222/04 ,  C08F222/40 ,  C08F293/00 ,  C08F299/00 ,  C08F232/08 ,  B82Y40/00 ,  C08G61/08

CPC classification number: C08G61/124 ,  B81C2201/0149 ,  B82Y40/00 ,  C08F222/04 ,  C08F222/40 ,  C08F232/08 ,  C08F293/00 ,  C08F299/00 ,  C08G61/08 ,  C08G81/00 ,  C08G2261/126 ,  C08G2261/128 ,  C08G2261/1426 ,  C08G2261/146 ,  C08G2261/148 ,  C08G2261/149 ,  C08G2261/3241 ,  C08G2261/3324 ,  C08G2261/418 ,  C08G2261/74

Abstract: The invention provides a class of wedge-type block copolymers having a plurality of chemically different blocks, at least a portion of which incorporates a wedge group-containing block providing useful properties. For example, use of one or more wedge group-containing blocks in some block copolymers of the invention significantly inhibits chain entanglement and, thus, the present block copolymers materials provide a class of polymer materials capable of efficient molecular self-assembly to generate a range of structures, such as periodic nanostructures and microstructures. Materials of the present invention include copolymers having one or more wedge group-containing blocks, and optionally for some applications copolymers also incorporating one or more polymer side group-containing blocks. The present invention also provides useful methods of making and using wedge-type block copolymers.

公开(公告)号：US20180254478A1

公开(公告)日：2018-09-06

申请号：US15903553

申请日：2018-02-23

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Simon C. Jones ,  Emmanuelle Despagnet-Ayoub ,  Brendon McNicholas ,  Harry B. Gray ,  Robert H. Grubbs

IPC: H01M4/36 ,  H01M8/18 ,  H01M8/0202 ,  C07F15/02 ,  C07F15/06 ,  C07F13/00 ,  C07F11/00

CPC classification number: H01M4/368 ,  C07F11/00 ,  C07F13/00 ,  C07F15/02 ,  C07F15/06 ,  H01M4/9008 ,  H01M8/0202 ,  H01M8/188 ,  H01M2300/0025 ,  Y02E60/528

Abstract: In an aspect, a redox flow battery comprises a catholyte and an anolyte; wherein at least one of said catholyte and said anolyte is a metal-coordination complex, said metal-coordination complex comprising: (i) a metal; (ii) one or more first ligands coordinated with said metal atom, wherein each of said first ligands is independently a Lewis basic ligand; and one or more second ligands associated with said one or more first ligands, wherein each of said second ligands is independently a Lewis acid ligand; and a nonaqueous solvent, wherein said catholyte, said anolyte or both are dissolved in said nonaqueous solvent. One or more first ligands may be provided in a primary coordination sphere of said metal-coordination complex and one or more second ligands may be provided in a secondary coordination sphere of said metal-coordination complex. The one or more first ligands independently may comprise a Lewis basic functional group and each of said one or more second ligands independently may comprise a Lewis acidic functional group.

公开(公告)号：US09890239B2

公开(公告)日：2018-02-13

申请号：US14915822

申请日：2014-09-04

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Robert Tuba ,  Robert H. Grubbs

IPC: C08G61/08 ,  C08G61/12 ,  C08L65/00

CPC classification number: C08G61/08 ,  C08G61/12 ,  C08G2261/142 ,  C08G2261/1422 ,  C08G2261/3321 ,  C08G2261/3342 ,  C08G2261/418 ,  C08G2261/419 ,  C08G2261/724 ,  C08G2261/80 ,  C08L65/00

Abstract: This invention relates to methods and compositions for preparing linear and cyclic polyolefins. More particularly, the invention relates to methods and compositions for preparing functionalized linear and cyclic polyolefins via olefin metathesis reactions. Polymer products produced via the olefin metathesis reactions of the invention may be utilized for a wide range of materials applications. The invention has utility in the fields of polymer and materials chemistry and manufacture.

公开(公告)号：US09676676B2

公开(公告)日：2017-06-13

申请号：US14789848

申请日：2015-07-01

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： John Hartung, Jr. ,  Brendan L. Quigley ,  Peter K. Dornan ,  Robert H. Grubbs

IPC: C07F15/00 ,  C07B37/02 ,  B01J31/22 ,  C07C67/293 ,  C07D207/46 ,  C07F7/18 ,  C07D211/94 ,  C07D471/04 ,  C07D317/12 ,  C07C6/04 ,  C07C29/32 ,  C07C67/343 ,  C07C67/475

CPC classification number: C07B37/02 ,  B01J31/2208 ,  B01J31/2278 ,  B01J2231/54 ,  B01J2231/543 ,  B01J2531/821 ,  C07B2200/09 ,  C07C6/04 ,  C07C29/32 ,  C07C67/293 ,  C07C67/343 ,  C07C67/475 ,  C07C2531/22 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2602/08 ,  C07D207/46 ,  C07D211/94 ,  C07D317/12 ,  C07D471/04 ,  C07F7/1892 ,  C07F15/0046 ,  C07C69/145 ,  C07C69/63 ,  C07C69/78 ,  C07C33/025 ,  C07C69/593 ,  C07C69/608 ,  C07C15/50

Abstract: This invention relates generally to C—H activated ruthenium olefin metathesis catalyst compounds which are stereogenic at the ruthenium center, to their preparation, and the use of such catalysts in the metathesis of olefins and olefin compounds. In particular, the invention relates to the use of C—H activated ruthenium olefin metathesis catalyst compounds in Z-selective olefin metathesis reactions, enantio-selective olefin metathesis reactions, and enantio-Z-selective olefin metathesis reactions. The invention has utility in the fields of catalysis, organic synthesis, polymer chemistry, and industrial and fine chemicals chemistry.

公开(公告)号：US09593425B2

公开(公告)日：2017-03-14

申请号：US14603332

申请日：2015-01-22

Applicant: The California Institute of Technology

Inventor： Oana R. Luca ,  Raymond Weitekamp ,  Robert H. Grubbs ,  Harry A. Atwater ,  Slobodan Mitrovic

IPC: C25B11/00 ,  C25B3/04 ,  C25B11/04

CPC classification number: C25B3/04 ,  C25B1/003 ,  C25B11/0405 ,  C25B11/0489

Abstract: A CO2 reduction electrode includes an active layer on an electrode base. The active layer includes a polymer that includes one or more reaction components selected from a group consisting of a CO2 reduction catalyst and an activator that bonds CO2 so as to form a CO2 reduction intermediate.

Abstract translation: CO 2还原电极在电极基体上具有活性层。 活性层包括聚合物，其包含一种或多种选自CO 2还原催化剂和键合CO 2的活化剂的反应组分以形成CO 2还原中间体。

公开(公告)号：US09586981B2

公开(公告)日：2017-03-07

申请号：US14649725

申请日：2013-12-12

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Lauren E. Rosebrugh ,  Myles B. Herbert ,  Vanessa M. Marx ,  Benjamin K. Keitz ,  Robert H. Grubbs

IPC: C07F15/00 ,  B01J31/22 ,  C08G61/08 ,  C07C2/34 ,  C07C29/00 ,  C07C45/67 ,  C07C67/293 ,  C07D313/00 ,  C08F110/14

CPC classification number: C07F15/0046 ,  B01J31/2265 ,  B01J31/2278 ,  B01J2231/20 ,  B01J2231/32 ,  B01J2531/821 ,  C07C2/34 ,  C07C29/00 ,  C07C45/673 ,  C07C67/293 ,  C07D313/00 ,  C08F110/14 ,  C08G61/08 ,  C08G2261/418

Abstract: A novel chelated ruthenium-based metathesis catalyst bearing an N-2,6-diisopropylphenyl group is reported and displays near-perfect selectivity for the Z-olefin (>95%), as well as unparalleled TONs of up to 7,400, in a variety of homodimerization and industrially relevant metathesis reactions. This derivative and other new catalytically-active species were synthesized using an improved method employing sodium carboxylates to induce the salt metathesis and C—H activation of these chelated complexes. All of these new ruthenium-based catalysts are highly Z-selective in the homodimerization of terminal olefins.

Abstract translation: 报道了一种新型的具有N-2,6-二异丙基苯基的螯合钌基复分解催化剂，并显示了Z-烯烃（> 95％）的近乎完美的选择性，以及多达7400种无与伦比的TON 的同型二聚化和工业相关复分解反应。 该衍生物和其他新的催化活性物质使用羧酸钠诱导盐复分解和这些螯合络合物的C-H活化的改进方法合成。 所有这些新的钌基催化剂在末端烯烃的同二聚化中是高度Z选择性的。

公开(公告)号：US09556080B2

公开(公告)日：2017-01-31

申请号：US14972653

申请日：2015-12-17

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Anton Toutov ,  Wenbo Liu ,  Brian M. Stoltz ,  Robert H. Grubbs ,  Kerry Betz ,  David P. Schuman

IPC: C07B47/00 ,  C07F7/08 ,  C07D209/12

CPC classification number: C07B47/00 ,  C07D209/12 ,  C07F5/04 ,  C07F7/0827

Abstract: The present invention describes chemical systems and methods for silylating heteroaromatic organic substrates, said system consisting essentially of a mixture of (a) at least one organodisilane and (b) at least alkoxide base, preferably a potassium alkoxide base, and said methods comprising contacting a quantity of the organic substrate with a mixture consisting essentially of (a) at least one organodisilane and (b) at least one alkoxide base, preferably a potassium alkoxide, under conditions sufficient to silylate the heteroaromatic substrate.

Abstract translation: 本发明描述了用于甲硅烷基化杂芳族有机底物的化学系统和方法，所述系统基本上由（a）至少一种有机硅烷和（b）至少烷氧基，优选烷醇钾碱的混合物组成，所述方法包括使 基本上由（a）至少一种有机硅烷和（b）至少一种醇盐碱，优选烷氧基钾，在足以使所述杂芳族底物甲硅烷基化的条件下混合的混合物的有机底物的量。

公开(公告)号：US09440891B2

公开(公告)日：2016-09-13

申请号：US14091466

申请日：2013-11-27

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Yiyang Liu ,  Brian M. Stoltz ,  Robert H. Grubbs ,  Alexey Fedorov ,  Kelly E. Kim

IPC: C07C1/24 ,  C07C1/207

CPC classification number: C07C1/24 ,  C07C1/2078 ,  C07C2531/24 ,  C07C2531/30 ,  C07C11/02

Abstract: The present invention is directed to methods of forming olefins, especially linear alpha olefins from fatty acids or anhydrides, each method comprising: contacting an amount of precursor carboxylic acid anhydride with a palladium catalyst comprising a bidentate bis-phosphine ligand in a reaction mixture so as to form an olefin in a product with the concomittant formation and removal of CO and water from the reaction mixture, either directly or indirectly, wherein the reaction mixture is maintained with a sub-stoichiometric excess of a sacrificial carboxylic acid anhydride, an organic acid, or both, said sub-stoichiometric excess being relative to the amount of the precursor carboxylic acid anhydride. The precursor carboxylic acid anhydride may be added to the reaction mixture directly or formed in situ by the reaction between at least one precursor carboxylic acid with a stoichiometric amount of the sacrificial acid anhydride.

Abstract translation: 本发明涉及从脂肪酸或酸酐形成烯烃，特别是直链α-烯烃的方法，每种方法包括：将一定量的前体羧酸酐与包含二齿双膦配体的钯催化剂反应在反应混合物中，以便 在直接或间接从反应混合物中伴随形成和除去CO和水的产物中形成烯烃，其中反应混合物用亚化学计量过量的牺牲羧酸酐，有机酸， 或两者，所述亚化学计量过量相对于前体羧酸酐的量。 可以将前体羧酸酐直接加入到反应混合物中或通过至少一种前体羧酸与化学计量的牺牲酸酐之间的反应原位形成。