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公开(公告)号：US09498288B2
公开(公告)日：2016-11-22
申请号：US13950154
申请日：2013-07-24
Applicant: Edwards Lifesciences Corporation
Inventor： Jeffrey S. Dove , Bin Tian , Ralph Schneider , Jeffrey S. Cohen , Ivan Jankovic , John F. Migliazza , Gregory A. Wright , James Young , Louis A. Campbell
CPC classification number: A61F2/2415 , A61B18/20 , A61F2/02 , A61F2/24 , A61F2/2409 , A61F2/2418 , A61F2002/30324 , A61F2250/0036 , A61L27/3604 , A61L27/3625 , A61L27/3691 , A61L27/507 , A61L2300/60 , A61L2430/20 , B65B55/18 , B65B63/02
Abstract: Methods for the conditioning of bioprosthetic material employ bovine pericardial membrane. A laser directed at the fibrous surface of the membrane and moved relative thereto reduces the thickness of the membrane to a specific uniform thickness and smoothes the surface. The wavelength, power and pulse rate of the laser are selected which will smooth the fibrous surface as well as ablate the surface to the appropriate thickness. Alternatively, a dermatome is used to remove a layer of material from the fibrous surface of the membrane. Thinning may also employ compression. Stepwise compression with cross-linking to stabilize the membrane is used to avoid damaging the membrane through inelastic compression. Rather, the membrane is bound in the elastic compressed state through addition cross-linking. The foregoing several thinning techniques may be employed together to achieve strong thin membranes.
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公开(公告)号：US09492230B2
公开(公告)日：2016-11-15
申请号：US13621680
申请日：2012-09-17
Applicant: Edwards Lifesciences Corporation
Inventor： Ralph Schneider , Bin Tian , Jeffrey S. Dove , Jeff Cohen , Ivan Jankovic , John F. Migliazza , Gregory A. Wright , James Young , Louis A. Campbell
CPC classification number: A61F2/2415 , A61B18/20 , A61F2/02 , A61F2/24 , A61F2/2409 , A61F2/2418 , A61F2002/30324 , A61F2250/0036 , A61L27/3604 , A61L27/3625 , A61L27/3691 , A61L27/507 , A61L2300/60 , A61L2430/20 , B65B55/18 , B65B63/02
Abstract: Methods for the conditioning of bioprosthetic material employ bovine pericardial membrane. A laser directed at the fibrous surface of the membrane and moved relative thereto reduces the thickness of the membrane to a specific uniform thickness and smoothes the surface. The wavelength, power and pulse rate of the laser are selected which will smooth the fibrous surface as well as ablate the surface to the appropriate thickness. Alternatively, a dermatome is used to remove a layer of material from the fibrous surface of the membrane. Thinning may also employ compression. Stepwise compression with cross-linking to stabilize the membrane is used to avoid damaging the membrane through inelastic compression. Rather, the membrane is bound in the elastic compressed state through addition cross-linking. The foregoing several thinning techniques may be employed together to achieve strong thin membranes.
Abstract translation: 生物假体材料调理方法采用牛心包膜。 指向膜的纤维表面并相对于其移动的激光将膜的厚度减小到特定的均匀厚度并平滑表面。 选择激光器的波长，功率和脉冲速率，这将使纤维表面平滑，并将表面烧蚀到合适的厚度。 或者，使用皮肤表面从膜的纤维表面去除一层材料。 变薄也可能采用压缩。 使用交联以稳定膜的逐步压缩来避免通过非弹性压缩损伤膜。 相反，膜通过加成交联结合在弹性压缩状态。 上述几种稀释技术可以一起使用以获得强的薄膜。
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公开(公告)号：US09301835B2
公开(公告)日：2016-04-05
申请号：US13906166
申请日：2013-05-30
Applicant: Edwards Lifesciences Corporation
Inventor： Louis A. Campbell , Donald E. Bobo, Jr. , Gregory A. Wright , Tak G. Cheung
CPC classification number: A61F2/2418 , A61F2/0095 , A61F2/06 , A61F2/2409 , A61F2/2412 , A61F2/2415 , A61F2/2427 , A61F2210/0004 , A61F2220/0075 , A61F2310/00371 , A61F2310/00383 , A61L27/222 , A61L27/24 , A61L27/3625 , A61L27/3687 , A61L27/507 , A61L2430/20 , A61L2430/40
Abstract: A valved conduit including a bioprosthetic valve, such as a heart valve, and a tubular conduit sealed with a bioresorbable material. The bioprosthetic heart valve includes prosthetic tissue that has been treated such that the tissue may be stored dry for extended periods without degradation of functionality of the valve. The bioprosthetic heart valve may have separate bovine pericardial leaflets or a whole porcine valve. The sealed conduit includes a tubular matrix impregnated with a bioresorbable medium such as gelatin or collagen. The valved conduit is stored dry in packaging in which a desiccant pouch is supplied having a capacity for absorbing moisture within the packaging limited to avoid drying the bioprosthetic tissue out beyond a point where its ability to function in the bioprosthetic heart valve is compromised. The heart valve may be sewn within the sealed conduit or coupled thereto with a snap-fit connection.
Abstract translation: 包括生物假体瓣膜（例如心脏瓣膜）和用生物可再吸收材料密封的管状导管的阀门导管。 生物假体心脏瓣膜包括经过处理的假体组织，使得组织可以长时间保存干燥，而不会降低瓣膜的功能。 生物假体心脏瓣膜可以具有单独的牛心包瓣或整个猪瓣。 密封导管包括浸渍有生物可吸收介质如明胶或胶原的管状基质。 带阀的导管在包装中储存，其中提供干燥剂袋，其具有吸收包装内的水分的能力，以避免将生物假体组织干燥超过其在生物假体心脏瓣膜中起作用的能力受损的程度。 心脏瓣膜可以缝合在密封导管内或用卡扣配合连接在其上。
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公开(公告)号：US20150313590A1
公开(公告)日：2015-11-05
申请号：US14797112
申请日：2015-07-11
Applicant: Edwards Lifesciences Corporation
Inventor： Brian S. Conklin , Louis A. Campbell , Salvador Marquez , Donald E. Bobo, JR.
CPC classification number: A61B17/0487 , A61B17/0401 , A61B2017/0404 , A61B2017/0409 , A61B2017/0414 , A61B2017/0416 , A61B2017/0464 , A61B2017/0488 , A61B2017/0496 , A61F2/24 , A61F2/2409 , A61F2/2442
Abstract: Methods of deploying knotless suture locking clamps for securing prostheses such as heart valves or annuloplasty rings to facilitate implantation. The clamps have opposed clamp halves separated by a slot opening to one side and surrounded by a biasing member such as one or more C-clip springs. Sutures pass laterally into the slot which is held open by a retention member positioned between the clamp halves. The locking clamp slides along the sutures into position, the tension of the sutures is adjusted, and the retention member removed to allow the biasing member to clamp the sutures between the clamp halves. A delivery tool used to deliver and deploy the locking clamps contains a number of clamps within a delivery tube in a stack and bonded together for safety and a common retention member. The tool has a longitudinal channel on one side for entry of sutures.
Abstract translation: 部署用于固定假体（例如心脏瓣膜或瓣环成形术环）的无缝缝合锁定夹具的方法以便于植入。 夹具具有相对的夹具半部，该半部由通向一侧的狭槽分开，并被诸如一个或多个C形夹弹簧的偏置构件包围。 缝合线横向穿过狭槽，狭槽由位于夹子半部之间的保持构件保持打开。 锁定夹具沿着缝合线滑动到适当位置，调节缝合线的张力，并且移除保持构件以允许偏置构件将缝合线夹在夹具半部之间。 用于传送和展开锁定夹具的输送工具在堆叠中的输送管内包含多个夹具，并且为了安全而将其粘合在一起并具有公共保持构件。 该工具在一侧具有用于进入缝合线的纵向通道。
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公开(公告)号：US20150216656A1
公开(公告)日：2015-08-06
申请号：US14684267
申请日：2015-04-10
Applicant: EDWARDS LIFESCIENCES CORPORATION
Inventor： Rafael Pintor , Mark Chau , Travis Oba , August R. Yambao , Louis A. Campbell , Tammy Huntley , Qinggang Zeng , Carey L. Cristea , Faisal Kalam
IPC: A61F2/24
CPC classification number: A61F2/2418 , A61F2/2409 , A61F2/243 , A61F2/2433 , A61F2220/0016 , A61F2220/0025 , A61F2220/005 , A61F2220/0075 , A61F2220/0083 , A61F2230/0054 , A61F2230/0067 , A61F2230/0069 , A61F2230/0078 , A61F2250/006
Abstract: A heart valve prosthesis that can be quickly and easily implanted during a surgical procedure is provided. The prosthetic valve has a base stent that is deployed at a treatment site, and a valve component configured to quickly connect to the base stent. The base stent may take the form of a self- or balloon-expandable stent that expands outward against the native valve with or without leaflet excision. The valve component has a non-expandable prosthetic valve and a self- or balloon-expandable coupling stent for attachment to the base stent, thereby fixing the position of the valve component relative to the base stent. The prosthetic valve may be a commercially available to valve with a sewing ring and the coupling stent attaches to the sewing ring. The system is particularly suited for rapid deployment of heart valves in a conventional open-heart surgical environment. A catheter-based system and method for deployment is provided.
Abstract translation: 提供了可以在手术过程中快速且容易地植入的心脏瓣膜假体。 假体瓣膜具有部署在治疗部位的基部支架和构造成快速连接到基部支架的阀部件。 基底支架可以采取自体或球囊扩张的支架的形式，其在具有或不具有小叶切除的情况下相对于天然瓣膜向外扩张。 阀部件具有不可扩张的假体瓣膜和用于附接到基底支架的自支撑或球囊扩张的联接支架，由此固定阀部件相对于基底支架的位置。 人造瓣膜可以是市售的，具有缝合环的阀门，并且联接支架附接到缝合环。 该系统特别适用于在常规开心手术环境中快速部署心脏瓣膜。 提供了基于导管的系统和部署方法。
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Patent Agency Ranking
公开(公告)号：US09005277B2
公开(公告)日：2015-04-14
申请号：US13723799
申请日：2012-12-21
Applicant: Edwards Lifesciences Corporation
Inventor： Rafael Pintor , Mark Chau , Travis Zenyo Oba , August R. Yambao , Louis A. Campbell , Tammy Huntley , Qinggang Zeng , Carey L. Cristea , Faisal Kalam
IPC: A61F2/24
CPC classification number: A61F2/2427 , A61F2/2409 , A61F2/2418 , A61F2/2433 , A61F2/2439 , A61F2220/0008 , A61F2220/0016 , A61F2220/0025 , A61F2220/005 , A61F2220/0075 , A61F2220/0083 , A61F2230/005 , A61F2250/006
Abstract: A quick-connect heart valve prosthesis that can be quickly and easily implanted during a surgical procedure is provided. The heart valve includes a substantially non-expandable, non-compressible prosthetic valve and a plastically-expandable coupling stent, thereby enabling attachment to the annulus without sutures. A small number of guide sutures may be provided for aortic valve orientation. The prosthetic valve may be a commercially available valve with a sewing ring with the coupling stent attached thereto. The coupling stent may expand from a conical deployment shape to a conical expanded shape, and may include web-like struts connected between axially-extending posts. A system and method for deployment includes a hollow two-piece handle through which a balloon catheter passes. A valve holder is stored with the heart valve and the handle easily attaches thereto to improve valve preparation steps.
Abstract translation: 提供了一种快速连接的心脏瓣膜假体，可以在手术过程中快速方便地植入。 心脏瓣膜包括基本上不可膨胀的不可压缩的人造瓣膜和塑性可扩张的联接支架，从而使得能够在不缝合的情况下连接到环形空间。 可以提供少量的导向缝线用于主动脉瓣取向。 假体瓣膜可以是具有连接有联接支架的缝合环的市售阀。 联接支架可以从锥形展开形状扩展到圆锥形膨胀形状，并且可以包括连接在轴向延伸柱之间的腹板状支柱。 用于展开的系统和方法包括气球导管通过的中空两件式手柄。 与心脏瓣膜一起存储阀保持器，并且手柄容易地附接到其上以改善阀门准备步骤。
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公开(公告)号：US20140188219A1
公开(公告)日：2014-07-03
申请号：US14137501
申请日：2013-12-20
Applicant: Edwards Lifesciences Corporation
Inventor： Brian S. Conklin , Louis A. Campbell , Donald E. Bobo, Jr. , Steven M. Ford , Derrick Johnson
IPC: A61F2/24
CPC classification number: A61F2/2418 , A61F2/2409 , A61F2/2433 , A61F2/2445 , A61F2210/0004 , A61F2220/0033 , A61F2220/0075 , A61F2250/0004 , A61F2250/001 , A61F2250/006 , A61F2250/0063 , A61F2250/0071 , A61F2310/00011
Abstract: Disclosed herein is a prosthetic heart valve, and associated methods therefore, configured to replace a native heart valve, and having a support frame configured to be reshaped into an expanded form in order to receive and/or support an expandable prosthetic heart valve therein. The prosthetic heart valve is configured to have an expansion-resistant configuration when initially implanted to replace a native valve (or other prosthetic heart valve), but to assume a generally expanded form when subjected to an outward force such as that provided by a dilation balloon or other mechanical expander.
Abstract translation: 本文公开了一种假体心脏瓣膜，因此，相关联的方法被配置为替代天然心脏瓣膜，并且具有构造成重新成形为膨胀形式的支撑框架，以便在其中容纳和/或支撑可扩张的假体心脏瓣膜。 假体心脏瓣膜被配置为当最初植入时具有抗膨胀构造以替代天然瓣膜（或其他假体心脏瓣膜），但是当受到向外的力（例如由扩张气球 或其他机械膨胀机。
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公开(公告)号：US20130053949A1
公开(公告)日：2013-02-28
申请号：US13660780
申请日：2012-10-25
Applicant: Edwards Lifesciences Corporation
Inventor： Rafael Pintor , Mark Chau , Travis Zenyo Oba , August R. Yambao , Louis A. Campbell , Tammy Huntley , Quinggang Zeng , Carey L. Cristea , Faisal Kalam
IPC: A61F2/24
CPC classification number: A61F2/2418 , A61F2/2409 , A61F2/243 , A61F2/2433 , A61F2220/0016 , A61F2220/0025 , A61F2220/005 , A61F2220/0075 , A61F2220/0083 , A61F2230/0054 , A61F2230/0067 , A61F2230/0069 , A61F2230/0078 , A61F2250/006
Abstract: A heart valve prosthesis that can be quickly and easily implanted during a surgical procedure is provided. The prosthetic valve has a base stent that is deployed at a treatment site, and a valve component configured to quickly connect to the base stent. The base stent may take the form of a self- or balloon-expandable stent that expands outward against the native valve with or without leaflet excision. The valve component has a non-expandable prosthetic valve and a self- or balloon-expandable coupling stent for attachment to the base stent, thereby fixing the position of the valve component relative to the base stent. The prosthetic valve may be a commercially available valve with a sewing ring and the coupling stent attaches to the sewing ring. The system is particularly suited for rapid deployment of heart valves in a conventional open-heart surgical environment.
Abstract translation: 提供了可以在手术过程中快速且容易地植入的心脏瓣膜假体。 假体瓣膜具有部署在治疗部位的基部支架和构造成快速连接到基部支架的阀部件。 基底支架可以采取自体或球囊扩张的支架的形式，其在具有或不具有小叶切除的情况下相对于天然瓣膜向外扩张。 阀部件具有不可扩张的假体瓣膜和用于附接到基底支架的自支撑或球囊扩张的联接支架，由此固定阀部件相对于基底支架的位置。 假体阀可以是具有缝合环的市售阀，并且联接支架附接到缝合环。 该系统特别适用于在常规开心手术环境中快速部署心脏瓣膜。
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公开(公告)号：US20250057646A1
公开(公告)日：2025-02-20
申请号：US18934905
申请日：2024-11-01
Applicant: EDWARDS LIFESCIENCES CORPORATION
Inventor： Harvey H. Chen , Son V. Nguyen , Devin D. Nguyen , Diana Marie Edwards , August R. Yambao , Jyoti B. Rao , Alyssa E. Kornswiet , Lisong Ai , Stephen W. Tang , Edward Romero , Kevin K. Dang , Meena Francis , Louis A. Campbell , Grace Myong Kim
IPC: A61F2/24
Abstract: A hybrid heart valve prosthesis that can be quickly and easily implanted during a surgical procedure is provided. The hybrid heart valve includes a substantially non-expandable, non-compressible prosthetic valve member having a peripheral sealing ring and an expandable stent frame projecting from an inflow end, thereby enabling attachment to the annulus without sutures. The stent frame may be plastically-expandable and may have a thin fabric layer covering its entirety as well as secondary sealing structures around its periphery to prevent paravalvular leaking. Other sealing solutions include interactive steps at the time of valve implant to establish seals around the stent and especially between the stent and the sealing ring of the valve member.
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公开(公告)号：US12138153B2
公开(公告)日：2024-11-12
申请号：US17389771
申请日：2021-07-30
Applicant: Edwards Lifesciences Corporation
Inventor： Harvey H. Chen , Son V. Nguyen , Devin D. Nguyen , Diana Marie Edwards , August R. Yambao , Jyoti B. Rao , Alyssa E. Kornswiet , Lisong Ai , Stephen W. Tang , Edward Romero , Kevin K. Dang , Meena Francis , Louis A. Campbell , Grace Myong Kim
IPC: A61F2/24
Abstract: A hybrid heart valve prosthesis that can be quickly and easily implanted during a surgical procedure is provided. The hybrid heart valve includes a substantially non-expandable, non-compressible prosthetic valve member having a peripheral sealing ring and an expandable stent frame projecting from an inflow end, thereby enabling attachment to the annulus without sutures. The stent frame may be plastically-expandable and may have a thin fabric layer covering its entirety as well as secondary sealing structures around its periphery to prevent paravalvular leaking. Other sealing solutions include interactive steps at the time of valve implant to establish seals around the stent and especially between the stent and the sealing ring of the valve member.
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