公开(公告)号：US20190380830A1

公开(公告)日：2019-12-19

申请号：US16525439

申请日：2019-07-29

Applicant: Edwards Lifesciences Corporation

Inventor： Ziv Yohanan ,  Tamir S. Levi ,  Netanel Benichou ,  Michael Bukin ,  Nikolay Gurovich ,  Elena Sherman

IPC: A61F2/24

Abstract: A method of implanting a prosthetic heart valve within a patient can comprise inserting a distal end portion of a delivery apparatus and a prosthetic heart valve into the patient and advancing the prosthetic heart valve to a deployment location within the heart of the patient and inflating one or more of a plurality of differently-sized balloons in a balloon-assembly on the distal end portion of the delivery apparatus. The prosthetic heart valve can be mounted on the balloon assembly in a crimped state and the inflating of the one or more of the plurality of differently-sized balloons can expand the prosthetic heart valve from the crimped state to a radially expanded state having a non-cylindrical shape.

公开(公告)号：US20190192296A1

公开(公告)日：2019-06-27

申请号：US16252890

申请日：2019-01-21

Applicant: Edwards Lifesciences Corporation

Inventor： Evan T. Schwartz ,  Sean Chow ,  Sandip Vasant Pawar ,  Darshin S. Patel ,  Chambory Chhe ,  Arpit Laddha ,  Ngoc Huong Thi Nguyen ,  Waina Michelle Chu ,  Yuanlong Du ,  Michael Bukin ,  Boaz Manash ,  Sara Haivatov ,  Tamir S. Levi

IPC: A61F2/24

CPC classification number: A61F2/2442 ,  A61F2/2433 ,  A61F2/2436 ,  A61F2220/0075 ,  A61F2230/0091 ,  A61F2250/006

Abstract: A prosthetic heart valve includes a frame having an inflow end and an outflow end, and defining a longitudinal axis. The prosthetic heart valve further includes a leaflet structure situated at least partially within the frame, and a covering disposed around the frame. The covering includes a first woven portion extending circumferentially around the frame and including a plurality of texturized strands or yarns extending along the longitudinal axis of the frame. The covering further includes a second woven portion extending circumferentially around the frame and spaced apart from the first woven portion along the longitudinal axis of the frame. The texturized strands extend along the longitudinal axis of the frame from the first woven portion to the second woven portion and form a floating portion between the first woven portion and the second woven portion.

公开(公告)号：US20180078367A1

公开(公告)日：2018-03-22

申请号：US15709355

申请日：2017-09-19

Applicant: Edwards Lifesciences Corporation

Inventor： Tomer Saar ,  Michael Bukin ,  Elena Sherman ,  Alexander Barash ,  Yana Mayatskaya

IPC: A61F2/24

Abstract: An implantable prosthetic valve that is radially collapsible to a collapsed configuration and radially expandable to an expanded configuration includes an annular frame including a plurality of angled strut members, and a skirt member secured to the frame. The skirt member includes a plurality of extension portions wrapped around at least one strut member adjacent the extension portions. The prosthetic valve further includes a cord member threaded through at least a portion of the plurality of extension portions to secure the skirt member to the at least one strut member.

公开(公告)号：US20170014229A1

公开(公告)日：2017-01-19

申请号：US15209642

申请日：2016-07-13

Applicant: Edwards Lifesciences Corporation

Inventor： Diana Nguyen-Thien-Nhon ,  Timothy A. Geiser ,  Larry L. Wood ,  Dinesh L. Sirimanne ,  Son Nguyen ,  Tamir S. Levi ,  Nikolay Gurovich ,  Michael Bukin

IPC: A61F2/24

CPC classification number: A61F2/2418 ,  A61F2002/072 ,  A61F2210/0076 ,  A61F2220/0075 ,  A61F2230/0026 ,  A61F2230/0093 ,  A61F2250/0003 ,  A61F2250/0039 ,  A61F2250/0069

Abstract: An implantable prosthetic valve can comprise an annular frame comprising an inflow end and an outflow end and being radially collapsible and expandable between a radially collapsed configuration and a radially expanded configuration, the frame defining an axial direction extending from the inflow end to the outflow end, a leaflet structure positioned within the frame and secured thereto, and an annular outer skirt positioned around an outer surface of the frame, wherein the outer skirt comprises an inflow edge secured to the frame at a first location, an outflow edge comprising a plurality of alternating projections and notches, wherein the projections are secured to the frame at a second location, and the notches are not directly secured to the frame, an intermediate portion between the inflow edge and the outflow edge that comprises a plurality of openings.

Abstract translation: 可植入假体瓣膜可以包括环形框架，其包括流入端和流出端，并且在径向折叠构型和径向扩张构型之间径向可折叠并且可扩张，所述框架限定从流入端延伸到流出端的轴向方向， 定位在框架内并固定到其上的小叶结构以及围绕框架的外表面定位的环形外裙部，其中外裙部包括在第一位置处固定到框架的流入边缘，流出边缘包括多个交替 突起和凹口，其中突起在第二位置处固定到框架，并且凹口不直接固定到框架，入口边缘和流出边缘之间的中间部分包括多个开口。

公开(公告)号：US12290436B2

公开(公告)日：2025-05-06

申请号：US17316885

申请日：2021-05-11

Applicant: Edwards Lifesciences Corporation

Inventor： Nikolai Gurovich ,  Michael Bukin ,  Elena Sherman ,  Tamir S. Levi ,  Ziv Yohanan ,  Gil Senesh ,  Dikla Kersh ,  Alexey Tsypenyuk ,  Waina Michelle Chu ,  Alexander Barash

IPC: A61F2/24 ,  A61F2/90

Abstract: A prosthetic heart valve can include a radially expandable and compressible frame having an inflow end portion and an outflow end portion, the frame comprising a plurality of struts defining openings between them. The prosthetic valve can further include a valvular structure comprising a plurality of leaflets, each leaflet comprising a main body, opposing tabs on opposite sides of the main body, a coaptation edge portion, and a cusp edge portion. Each tab can be paired with an adjacent tab of an adjacent leaflet to form a plurality of commissures that are fixed relative to the frame, and each leaflet can have opposing edge portions between the opposing tabs and the cusp edge portion that are unattached to the frame, each unattached edge portion defining a gap that extends radially into the main body of the leaflet.

公开(公告)号：US20250127616A1

公开(公告)日：2025-04-24

申请号：US19007924

申请日：2025-01-02

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Noam Nir ,  Elena Sherman ,  Michael Bukin ,  Tomer Saar

IPC: A61F2/24

Abstract: A prosthetic valve can include a radially expandable and compressible frame having a plurality of struts, each strut having a first end, a second end, and a length extending from the first end to the second end. Each strut further including a plurality of recesses disposed on one or more longitudinal edges of the strut and extending into a width of the strut. The prosthetic valve further including a valvular structure disposed within and coupled to the frame, the valvular structure comprising a plurality of leaflets, and a skirt mounted to the frame via one or more sutures. The recesses retain the one or more sutures and prevent the one or more sutures from sliding along the length of the strut.

公开(公告)号：US12226312B2

公开(公告)日：2025-02-18

申请号：US18316942

申请日：2023-05-12

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Nikolai Gurovich ,  Michael Bukin ,  Elena Sherman ,  Tamir S. Levi ,  Ziv Yohanan ,  Gil Senesh ,  Dikla Kersh ,  Alexey Tsypenyuk ,  Waina Michelle Chu ,  Alexander Barash

IPC: A61F2/24 ,  A61F2/90

Abstract: A prosthetic heart valve can include a radially expandable and compressible frame having an inflow end, an outflow end, and a plurality of struts. The prosthetic valve can further include a valvular structure comprising a plurality of leaflets, each leaflet comprising a coaptation edge portion and a cusp edge portion. The cusp edge portion of each leaflet can be folded toward the outflow end of the frame along a bending axis and a reinforcing member extends along an outflow surface of the cusp edge portion along the bending axis. The prosthetic heart valve can include a plurality of connecting skirts, each disposed between the cusp edge portion of an adjacent leaflet and the frame. First stitching secures the reinforcing member and the connecting skirts to the cusp edge portions and second stitching secures the connecting skirts to selected struts of the frame.

公开(公告)号：US20250041053A1

公开(公告)日：2025-02-06

申请号：US18920663

申请日：2024-10-18

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Tamir S. Levi ,  Shahram Zamani ,  Michael Bukin ,  Ziv Yohanan ,  Noam Nir ,  Tyler Dale O'Dell ,  Elena Sherman

IPC: A61F2/24

Abstract: A method of assembling a valvular structure can include folding an upper tab of a first leaflet onto a lower tab of the first leaflet, disposing a first end of a reinforcing member on the upper tab, disposing a commissure member adjacent the lower tab, and coupling the first end of the reinforcing member, the tabs of the first leaflet, and the commissure member to one another. The method can further include folding an upper tab of a second leaflet onto a lower tab of the second leaflet, disposing the second leaflet adjacent the first leaflet such that the commissure member is positioned between the lower tabs, disposing a second end of the reinforcing member on the upper tab of the second leaflet, and coupling the reinforcing member, the upper and lower tabs of the second leaflet, and the commissure member to one another to form a commissure.

公开(公告)号：US20250009503A1

公开(公告)日：2025-01-09

申请号：US18891007

申请日：2024-09-20

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Noa Axelrod Manela ,  Michael Bukin ,  Noam Nir ,  Eran Goldberg

IPC: A61F2/24 ,  A61F2/00 ,  A61F2/852

Abstract: The present disclosure relates to prosthetic valves that include valvular structures retained between two frames coupled to each other. In an example, the prosthetic valve includes a main frame, an inner frame which is disposed radially inwardly from, and is coupled to, the main frame, and a valvular structure disposed between the main frame and the inner frame. The main frame is movable between a radially compressed state and a radially expanded state. The inner frame comprises a plurality of struts and a plurality of spikes extending from at least some of the plurality of struts. The plurality of spikes are engaged with the valvular structure.

公开(公告)号：US20240382306A1

公开(公告)日：2024-11-21

申请号：US18787184

申请日：2024-07-29

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Diana Nguyen-Thien-Nhon ,  Timothy A. Geiser ,  Larry L. Wood ,  Dinesh L. Sirimanne ,  Son V. Nguyen ,  Tamir S. Levi ,  Nikolai Gurovich ,  Michael Bukin

IPC: A61F2/24 ,  A61F2/07

Abstract: A prosthetic valve includes an annular frame with a plurality of inflow apices and a plurality of outflow apices. Each one of the outflow apices can be circumferentially offset from a respective inflow apex. The prosthetic valve can further include a leaflet structure positioned within the frame and secured thereto. The prosthetic valve can further include an outer skirt secured to the frame. The outer skirt can include an upper edge portion disposed around an outer surface of the frame, a lower edge portion wrapped around the inflow apices, and a plurality of creases. Each crease can be circumferentially aligned with a corresponding outflow apex and can extend from the lower edge portion towards the upper edge portion. The inner skirt can be secured to an inner surface of the frame and can include a lower edge portion attached to the lower edge portion of the outer skirt.