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    Method for limiting the growth of microorganisms using metal-containing compounds
    68.
    发明授权
    Method for limiting the growth of microorganisms using metal-containing compounds 失效
    使用含金属化合物限制微生物生长的方法

    公开(公告)号：US06248733B1

    公开(公告)日：2001-06-19

    申请号：US09004892

    申请日：1998-01-09

    申请人： Kevin D. Landgrebe ,  Charles E. Shelburne ,  Terrance P. Smith ,  Gregory D. Cuny

    发明人： Kevin D. Landgrebe ,  Charles E. Shelburne ,  Terrance P. Smith ,  Gregory D. Cuny

    IPC分类号： C07D22900

    CPC分类号： C07F15/0093 ,  A01N55/02 ,  A01N59/16 ,  A01N59/20

    摘要： This invention relates to the use of compounds having the general structure: wherein: Z1 and Z2 each independently represent an arene nucleus, which has from 5 to 14 ring atoms; G1 and G2 each independently represent a metal ligating group; R represents a hydrogen atom, a halogen atom, an alkyl group, an acylamino group, an alkoxy group, a sulfonamido group, an aryl group, a thiol group, an alkylthio group, an arylthio group, an alkylamino group, an arylamino group, an amino group, an alkoxycarbonyl group, an acyloxy group, a nitro group, a cyano group, an alkylsulfonyl group, an arylsulfonyl group, an alkylsulfoxyl group, an arylsulfoxyl group, an aryloxyl group, a hydroxyl group, a thioamido group, a carbamoyl group, a suffamoyl group, a formyl group, an acyl group, a ureido group, an aryloxycarbonyl group, a silyl group, or a sulfoalkoxy group; L1 represents a nitrogen heterocycle; L2 represents a monodentate or polydentate (e.g., bidentate) ligand; X represents nitrogen or a methine (CH) group; M is a divalent or polyvalent transition metal ion where the coordination number is at least 4; and k, m, and n are whole numbers less than or equal to 3 as antimicrobial agents to inhibit the growth or replication of microorganisms such as viruses, bacteria, and fungi.

    摘要翻译： 本发明涉及具有以下通式结构的化合物的用途：其中：Z 1和Z 2各自独立地表示具有5至14个环原子的芳烃核; G1和G2各自独立地表示金属结合基团; R表示氢原子，卤素原子，烷基，酰氨基，烷氧基，亚磺酰氨基，芳基，硫醇基，烷硫基，芳硫基，烷基氨基，芳基氨基， 氨基，烷氧基羰基，酰氧基，硝基，氰基，烷基磺酰基，芳基磺酰基，烷基亚砜基，芳基亚砜基，芳氧基，羟基，硫代酰氨基，氨基甲酰基 氨基，酰基，脲基，芳氧基羰基，甲硅烷基或磺基烷氧基; L1表示氮杂环; L2表示单齿或多齿（例如双齿）配体; X表示氮或次甲基（CH）基团; M是配位数至少为4的二价或多价过渡金属离子; 和k，m和n是小于或等于3的整数作为抑制微生物如病毒，细菌和真菌的生长或复制的抗微生物剂。