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1.发明授权Laser-induced mass transfer imaging materials and methods utilizing colorless sublimable compounds 失效激光诱导的质量转移成像材料和方法利用无色升华化合物
公开(公告)号：US5747217A
公开(公告)日：1998-05-05
申请号：US627305
申请日：1996-04-03
CPC分类号： B41M5/38207 , B41M5/392 , Y10S430/146
摘要： The invention relates to a method of increasing the sensitivity of laser induced thermal imaging by using certain sublimable compounds. The invention is useful in the field of thermal transfer imaging for the production of various graphic arts media.
摘要翻译： 本发明涉及通过使用某些可升华化合物来增加激光诱导热成像的灵敏度的方法。 本发明在用于生产各种图形艺术介质的热转印成像领域中是有用的。
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2.发明授权
公开(公告)号：US5691098A
公开(公告)日：1997-11-25
申请号：US627160
申请日：1996-04-03
IPC分类号： G03F7/00 , B41C1/10 , B41M5/382 , B41M5/385 , B41M5/388 , B41M5/39 , B41M5/392 , B41M5/46 , C07C245/14 , C07C245/18 , C08F20/36 , C08F220/36 , G03F3/10 , G11B7/244 , G03F7/11
CPC分类号： B41M5/392 , B41C1/1091 , C07C245/18 , G03F3/108
摘要： The invention relates to a method of increasing the sensitivity of laser induced thermal imaging by using certain diazo compounds. The diazo compounds contain functional groups adjacent the diazo substituent capable of stabilizing these compounds. The invention is useful in the field of thermal transfer imaging for the production of various graphic arts media.
摘要翻译： 本发明涉及通过使用某些重氮化合物来增加激光诱导热成像的灵敏度的方法。 重氮化合物含有邻近能稳定这些化合物的重氮取代基的官能团。 本发明在用于生产各种图形艺术介质的热转印成像领域中是有用的。
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公开(公告)号：US5756689A
公开(公告)日：1998-05-26
申请号：US858307
申请日：1997-05-19
IPC分类号： G03F7/00 , B41C1/10 , B41M5/382 , B41M5/385 , B41M5/388 , B41M5/39 , B41M5/392 , B41M5/46 , C07C245/14 , C07C245/18 , C08F20/36 , C08F220/36 , G03F3/10 , G11B7/244 , C07C245/00
CPC分类号： B41M5/392 , B41C1/1091 , C07C245/18 , G03F3/108
摘要： The invention relates to a method of increasing the sensitivity of laser induced thermal imaging by using certain diazo compounds. The diazo compounds contain functional groups adjacent the diazo substituent capable of stabilizing these compounds. The invention is useful in the field of thermal transfer imaging for the production of various graphic arts media.
摘要翻译： 本发明涉及通过使用某些重氮化合物来增加激光诱导热成像的灵敏度的方法。 重氮化合物含有邻近能稳定这些化合物的重氮取代基的官能团。 本发明在用于生产各种图形艺术介质的热转印成像领域中是有用的。
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4.再颁专利Composition comprising photochemical acid progenitor and specific squarylium dye 有权组合物包含光化学酸性祖细胞和特定方酸染料公开(公告)号：USRE38251E1
公开(公告)日：2003-09-16
申请号：US09512423
申请日：2000-02-23
申请人： Stanley C. Busman , Richard J. Ellis , Jeanne E. Haubrich , William D. Ramsden , Tran Van Thien , Gregory D. Cuny
发明人： Stanley C. Busman , Richard J. Ellis , Jeanne E. Haubrich , William D. Ramsden , Tran Van Thien , Gregory D. Cuny
IPC分类号： G03F7021
CPC分类号： G03F7/0045 , C09B57/007 , G03F7/0382 , G03F7/0392 , Y10S430/121 , Y10S430/127 , Y10S430/145 , Y10S430/146
摘要： Photochemical acid progenitors in combination with dihydroperimidine squarylium dyes have been found to be particularly effective at generating acid upon irradiation with new-infrared radiation. It has been found that dihydroperimidine squarylium dyes that are particularly useful in this invention have an oxidation potential greater than about 0.5 V relative to SCE as measured in dichloromethane.
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公开(公告)号：US06605416B2
公开(公告)日：2003-08-12
申请号：US09017001
申请日：1998-02-02
申请人： Stanley C. Busman , Richard J. Ellis , Jeanne E. Haubrich , William D. Ramsden , Tran Van Thien , Gregory D. Cuny
发明人： Stanley C. Busman , Richard J. Ellis , Jeanne E. Haubrich , William D. Ramsden , Tran Van Thien , Gregory D. Cuny
IPC分类号： G03F730
CPC分类号： G03F7/0045 , C09B57/007 , G03F7/0382 , G03F7/0392 , Y10S430/121 , Y10S430/127 , Y10S430/145 , Y10S430/146
摘要： Photochemical acid progenitors in combination with dihydroperimidine squarylium dyes have been found to be particularly effective at generating acid upon irradiation with near-infrared radiation. It has been found that dihydroperimidine squarylium dyes that are particularly useful in this invention have an oxidation potential greater than about 0.5 V relative to SCE as measured in dichloromethane.
摘要翻译： 已经发现光化学酸性祖细胞与二氢嘧啶方菁染料的组合在用近红外辐射照射时产生酸是特别有效的。 已经发现在本发明中特别有用的二氢嘧啶方酸菁染料相对于在二氯甲烷中测得的SCE，其氧化势大于约0.5V。
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6.发明授权Composition comprising photochemical acid progenitor and specific squarylium dye 失效组合物包含光化学酸性祖细胞和特定方酸染料
公开(公告)号：US5763134A
公开(公告)日：1998-06-09
申请号：US645303
申请日：1996-05-13
申请人： Stanley C. Busman , Richard J. Ellis , Jeanne E. Haubrich , William D. Ramsden , Tran Van Thien , Gregory D. Cuny
发明人： Stanley C. Busman , Richard J. Ellis , Jeanne E. Haubrich , William D. Ramsden , Tran Van Thien , Gregory D. Cuny
IPC分类号： C08K5/00 , C08K5/3465 , C08K5/5399 , C08K5/55 , C08L101/00 , C09B57/00 , G03F7/00 , G03F7/004 , G03F7/021 , G03F7/038 , G03F7/039
CPC分类号： G03F7/0045 , C09B57/007 , G03F7/0382 , G03F7/0392 , Y10S430/121 , Y10S430/127 , Y10S430/145 , Y10S430/146
摘要： Photochemical acid progenitors in combination with dihydroperimidine squarylium dyes have been found to be particularly effective at generating acid upon irradiation with near-infrared radiation. It has been found that dihydroperimidine squarylium dyes that are particularly useful in this invention have an oxidation potential greater than about 0.5 V relative to SCE as measured in dichloromethane.
摘要翻译： 已经发现光化学酸性祖细胞与二氢嘧啶方菁染料的组合在用近红外辐射照射时产生酸是特别有效的。 已经发现在本发明中特别有用的二氢嘧啶方酸菁染料相对于在二氯甲烷中测得的SCE，其氧化势大于约0.5V。
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7.发明申请Compounds and Methods for Treating Mammalian Gastrointestinal Microbial Infections 有权用于治疗哺乳动物胃肠道微生物感染的化合物和方法公开(公告)号：US20120101096A1
公开(公告)日：2012-04-26
申请号：US13257418
申请日：2010-03-22
申请人： Lizbeth K. Hedstrom , Gregory D. Cuny , Deviprasad R. Gollapalli , Sivapriya Kirubakaran , Sushil Kumar Maurya , Boris Striepen , Suresh Kumar Gorla , Corey Robert Johnson , Mandapati Kavitha , Jihan Khan
发明人： Lizbeth K. Hedstrom , Gregory D. Cuny , Deviprasad R. Gollapalli , Sivapriya Kirubakaran , Sushil Kumar Maurya , Boris Striepen , Suresh Kumar Gorla , Corey Robert Johnson , Mandapati Kavitha , Jihan Khan
IPC分类号： A61K31/535
CPC分类号： C07D401/12 , C07C233/15 , C07C235/24 , C07C235/38 , C07C237/20 , C07C255/60 , C07C275/28 , C07C275/30 , C07C275/42 , C07C309/15 , C07D209/08 , C07D209/12 , C07D209/30 , C07D215/38 , C07D235/26 , C07D237/32 , C07D249/06 , C07D263/56 , C07D263/57 , C07D295/192 , C07D401/04 , C07D401/14 , C07D409/04 , C07D413/04 , C07D417/04 , C07D417/14 , C07D471/08 , C07D491/052
摘要： Described herein are compounds, and pharmaceutically acceptable salts and prodrugs thereof, which are useful as inhibitors of IMPDH. In certain embodiments, a compound of the invention selectively inhibits a parasitic IMPDH versus a host IMPDH. Further, the invention provides pharmaceutical compositions comprising one or more compounds of the invention. The invention also relates to methods of treating various parasitic and bacterial infections in mammals. Moreover, the compounds may be used alone or in combination with other therapeutic or prophylactic agents, such as anti-virals, anti-inflammatory agents, antimicrobials and immunosuppressants.
摘要翻译： 本文描述了可用作IMPDH抑制剂的化合物及其药学上可接受的盐和前药。 在某些实施方案中，本发明的化合物选择性地抑制寄生IMPDH相对于宿主IMPDH。 此外，本发明提供包含一种或多种本发明化合物的药物组合物。 本发明还涉及治疗哺乳动物中各种寄生虫和细菌感染的方法。 此外，化合物可以单独使用或与其它治疗或预防剂如抗病毒剂，抗炎剂，抗微生物剂和免疫抑制剂组合使用。
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公开(公告)号：US20100183658A1
公开(公告)日：2010-07-22
申请号：US12593659
申请日：2008-03-28
IPC分类号： A61K39/385 , A61K31/41 , A61K31/47 , A61K31/4439 , A61K31/433 , A61K31/427 , A61K31/506 , A61K31/497 , A61K31/405 , A61K38/02 , A61P37/06
CPC分类号： A61K31/405 , C07D209/42 , C07D401/12 , C07D403/04 , C07D403/12 , C07D417/12 , Y02A50/387 , Y02A50/463 , Y02A50/465 , Y02A50/471 , Y02A50/483
摘要： The invention provides classes of novel compounds that accelerate peptide loading to DR in the absence of DM and related pharmaceutical compositions. The invention also provides conjugates of these compounds with peptides, antigens or other MHC-based therapeutics, including peptides that self-catalyze their loading onto MHC Class II molecules. Methods are provided for modulating an immune response in a subject. Also disclosed are methods of using the novel compounds, e.g., in combination with MHC-based therapeutics, for the treatment of autoimmune diseases and for the manufacture of medicaments. Methods of improving loading of viral peptides and tumor peptides for enhancing the CD4 T cell response following vaccination against viruses or tumors, and related vaccines, are also provided.
摘要翻译： 本发明提供了在不存在DM和相关药物组合物的情况下加速肽向DR加载的新类化合物。 本发明还提供了这些化合物与肽，抗原或其他基于MHC的治疗剂的缀合物，包括自身催化其在MHC II类分子上的载体的肽。 提供用于调节受试者的免疫应答的方法。 还公开了使用新化合物的方法，例如与基于MHC的治疗剂组合用于治疗自身免疫性疾病和用于制备药物。 还提供了改善病毒肽和肿瘤肽负荷以增强针对病毒或肿瘤疫苗接种后的CD4T细胞应答的方法以及相关疫苗。
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公开(公告)号：US20100143404A1
公开(公告)日：2010-06-10
申请号：US10585216
申请日：2004-12-29
申请人： Li-An Yeh , Gregory D. Cuny , Melissa Call , Kai Wucherpfennig , Ross L. Stein
发明人： Li-An Yeh , Gregory D. Cuny , Melissa Call , Kai Wucherpfennig , Ross L. Stein
IPC分类号： A61K31/381 , A61K39/12 , A61K39/02 , A61K39/00 , C07D333/40 , C12N5/00 , G01N33/53 , A61P37/02
CPC分类号： G01N33/5011 , C07D333/40 , G01N33/5008 , G01N33/502 , G01N33/5047 , G01N33/6863 , G01N2500/10
摘要： Compounds of formula (I), compositions, methods and kits are provided. The compounds and compositions may be particularly useful for modulating immunological responses. Formula (I) wherein, R1 is alkyl, aryl, or heterocyclyl; R2 is H, alkyl, aryl, heterocyclyl, OR3 or N(R3)2, R3 is H, alkyl, aryl, or heterocyclyl; R4 is H, CN, halogen, CF3, CO2R3, or C(O)N(R3)2; X is S, SO2, O, or NR3; and Y is S, O, or NR3.
摘要翻译： 提供式（I）化合物，组合物，方法和试剂盒。 化合物和组合物可特别用于调节免疫应答。 式（I）其中，R 1是烷基，芳基或杂环基; R2是H，烷基，芳基，杂环基，OR3或N（R3）2，R3是H，烷基，芳基或杂环基; R4是H，CN，卤素，CF3，CO2R3或C（O）N（R3）2; X是S，SO 2，O或NR 3; Y是S，O或NR 3。
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10.发明授权公开(公告)号：US07517892B2
公开(公告)日：2009-04-14
申请号：US09951130
申请日：2001-09-12
申请人： Brian M. Aquila , Thomas D. Bannister , Gregory D. Cuny , James R. Hauske , Joanne M. Holland , Paul E. Persons , Heike Radeke , Fengjiang Wang , Liming Shao
发明人： Brian M. Aquila , Thomas D. Bannister , Gregory D. Cuny , James R. Hauske , Joanne M. Holland , Paul E. Persons , Heike Radeke , Fengjiang Wang , Liming Shao
IPC分类号： A61P25/00 , A61K31/445 , C07D211/00 , C07D401/00
CPC分类号： C40B40/04 , C07B2200/11 , C07C255/46 , C07C2601/04 , C07D205/02 , C07D207/06 , C07D207/08 , C07D207/09 , C07D211/12 , C07D211/16 , C07D211/18 , C07D211/20 , C07D211/26 , C07D211/32 , C07D211/40 , C07D211/42 , C07D211/60 , C07D233/04 , C07D233/10 , C07D265/30 , C07D267/10 , C07D303/08 , C07D401/06 , C07D401/12 , C07D405/06 , C07D405/12 , C07D413/06 , C40B30/04 , C40B50/14
摘要： One aspect of the present invention relates to heterocyclic compounds. A second aspect of the present invention relates to the use of the heterocyclic compounds as ligands for various mammalian cellular receptors, including dopamine, serotonin, or norepinephrine transporters. The compounds of the present invention will find use in the treatment of numerous ailments, conditions and diseases which afflict mammals, including but not limited to addiction, anxiety, depression, sexual dysfunction, hypertension, migraine, Alzheimer's disease, obesity, emesis, psychosis, schizophrenia, Parkinson's disease, inflammatory pain, neuropathic pain, Lesche-Nyhane disease, Wilson's disease, and Tourette's syndrome. An additional aspect of the present invention relates to the synthesis of combinatorial libraries of the heterocyclic compounds, and the screening of those libraries for biological activity, e.g., in assays based on dopamine transporters.
摘要翻译： 本发明的一个方面涉及杂环化合物。 本发明的第二方面涉及杂环化合物作为各种哺乳动物细胞受体（包括多巴胺，5-羟色胺或去甲肾上腺素转运蛋白）的配体的用途。 本发明的化合物可用于治疗多种疾病，疾病，其包括但不限于成瘾，焦虑，抑郁，性功能障碍，高血压，偏头痛，阿尔茨海默病，肥胖，呕吐，精神病， 精神分裂症，帕金森病，炎症性疼痛，神经性疼痛，Lesche-Nyhane病，Wilson氏病和Tourette综合征。 本发明的另一方面涉及杂环化合物的组合文库的合成，以及用于生物活性的那些文库的筛选，例如在基于多巴胺转运蛋白的测定中。
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