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    Coated implantable medical device
    62.
    发明授权
    Coated implantable medical device 失效
    涂层可植入医疗器械

    公开(公告)号：US07611533B2

    公开(公告)日：2009-11-03

    申请号：US10223415

    申请日：2002-08-19

    申请人： Brian L. Bates ,  Anthony O. Ragheb ,  Neal E. Fearnot ,  Thomas G. Kozma ,  William D. Voorhees, III ,  Thomas A. Osborne

    发明人： Brian L. Bates ,  Anthony O. Ragheb ,  Neal E. Fearnot ,  Thomas G. Kozma ,  William D. Voorhees, III ,  Thomas A. Osborne

    IPC分类号： A61F2/06

    CPC分类号： A61K51/1282 ,  A61F2/24 ,  A61F2/82 ,  A61F2250/0068 ,  A61L27/306 ,  A61L27/54 ,  A61L29/085 ,  A61L29/106 ,  A61L29/16 ,  A61L31/088 ,  A61L31/10 ,  A61L31/16 ,  A61L33/022 ,  A61L2300/256 ,  A61L2300/416 ,  A61L2300/602 ,  A61L2300/606 ,  A61L2300/608 ,  A61L2420/08 ,  A61N5/1002 ,  C08L65/04

    摘要： A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract, and at least one layer 18 of an immunosuppressive agent posited over at least one surface of the structure 12. Optionally, the device 10 can include at least one porous, preferably polymeric layer 20 posited over the layer 18 of immunosuppressive agent, and can alternatively or additionally include at least one coating layer 16 posited on one surface of the structure 12, the at least one layer 18 of immunosuppessive agent being posited in turn on at least a portion of the coating layer 16. The porous layer 20 and the coating layer 16 each provide for the controlled release of the bioactive material from the device 10. The structure 12 is preferably configured as a coronary stent. The polymer of the porous layer 20 is preferably applied by vapor or plasma deposition. It is particularly preferred that the polymer is a polyamide, parylene or a parylene derivative which is deposited without solvents, heat or catalysts, but rather by condensation of a monomer vapor.

    摘要翻译： 涂覆的可植入医疗装置10包括适于引入到血管系统，食管，气管，结肠，胆管或尿道中的结构12，以及至少一个位于结构的至少一个表面上的免疫抑制剂层18 任选地，装置10可以包括位于免疫抑制剂的层18上的至少一个多孔的，优选的聚合物层20，并且可以替代地或另外包括至少一个涂覆层16，该涂层16位于结构12的一个表面上， 至少一层18的免疫抑制剂依次放置在涂层16的至少一部分上。多孔层20和涂层16各自提供生物活性材料从装置10的受控释放。结构12是 优选构造为冠状动脉支架。 多孔层20的聚合物优选通过蒸气或等离子体沉积来施加。 特别优选的是聚合物是聚酰胺，聚对二甲苯或聚对二甲苯衍生物，它们不用溶剂，加热或催化剂沉积，而是通过单体蒸气的冷凝而沉积。

    Radially expandable stent
    65.
    发明授权
    Radially expandable stent 有权
    径向扩张支架

    公开(公告)号：US06231598B1

    公开(公告)日：2001-05-15

    申请号：US09160122

    申请日：1998-09-24

    申请人： Dale T. Berry ,  Coy M. Herald ,  Brian L. Bates ,  Scott E. Boatman ,  Michael C. Hoffa ,  Neal E. Fearnot ,  William D. Voorhees, III

    发明人： Dale T. Berry ,  Coy M. Herald ,  Brian L. Bates ,  Scott E. Boatman ,  Michael C. Hoffa ,  Neal E. Fearnot ,  William D. Voorhees, III

    IPC分类号： A61F206

    CPC分类号： A61F2/915 ,  A61F2/88 ,  A61F2/91 ,  A61F2002/91508 ,  A61F2002/91516 ,  A61F2002/91525 ,  A61F2002/91533 ,  A61F2002/91558 ,  A61F2002/91566 ,  A61F2002/91575 ,  A61F2002/91583 ,  A61F2230/0054 ,  A61F2250/0036 ,  A61F2250/0098 ,  A61L31/022 ,  A61L31/18

    摘要： A radially expandable stent (10) made from a cannula or sheet of biocompatible material that includes at least one longitudinal segment (14) comprised of a series of laterally interconnected closed cells (13). Each closed cell of a longitudinal segment is defined laterally by a pair of longitudinal struts (15, 16) that are interconnected at each end by a circumferentially adjustable member (19, 20). When the stent is expanded using a balloon (47), the opposing circumferentially adjustable members deform to allow circumferential expansion of the longitudinal segment, while the length of the segment, as defined by the longitudinal struts, is maintained. Self-expanding versions of the stent utilize a nickel-titanium alloy. Adjacent longitudinal segments are joined by flexible interconnection segments (21) that permit the stent to bend laterally. The flexible interconnection segment is comprised of curvilinear struts (22, 23) that form a series of serpentine bends (81) that distribute lateral bending forces. In a preferred embodiment, a short strut interconnects longitudinal segments and an adjacent interconnection segment. Each interconnection strut attaches to the longitudinal segment within a region (27) at the end (17) of a longitudinal strut (15) dividing two adjacent closed cells.

    摘要翻译： 一种由包括生物相容性材料的套管或片材制成的径向可扩张的支架（10），其包括由一系列横向互连的闭孔（13）构成的至少一个纵向段（14）。 纵向段的每个闭合单元由一对纵向支柱（15,16）侧向地限定，所述纵向支柱在每个端部由周向可调节构件（19,20）互连。 当使用球囊（47）扩张支架时，相对的周向可调部件变形以允许纵向段的周向膨胀，而由纵向支柱限定的段的长度保持。 自扩张型支架采用镍钛合金。 相邻的纵向段通过柔性互连段（21）连接，允许支架横向弯曲。 柔性互连部分由曲线支柱（22,23）组成，其形成分布横向弯曲力的一系列蛇形弯曲部（81）。 在优选实施例中，短支柱将纵向段和相邻互连段互连。 每个互连支柱在分开两个相邻闭孔的纵向支柱（15）的端部（17）处的区域（27）内附接到纵向段。

    Medical radiation treatment device
    66.
    发明授权
    Medical radiation treatment device 失效
    医疗放射治疗装置

    公开(公告)号：US06162165A

    公开(公告)日：2000-12-19

    申请号：US203947

    申请日：1998-12-02

    申请人： Marc G. Apple ,  Brian L. Bates ,  John A. DeFord ,  Neal E. Fearnot

    发明人： Marc G. Apple ,  Brian L. Bates ,  John A. DeFord ,  Neal E. Fearnot

    IPC分类号： A61M36/04 ,  A61N5/10 ,  A61N5/00

    CPC分类号： A61N5/1002 ,  A61N2005/1021

    摘要： A catheter apparatus and radiation dosimetry unit indicator for delivery of a prescribed radiation dose to a patient. The catheter is filled with a radiation carrier material such as an inert radioactive gas for the treatment of, for example, restenosis after angioplasty, and malignancies. The inflated catheter includes a plurality of discrete chambers for transporting the radioactive carrier material, and a plurality of discrete chambers enabling substantial blood flow through the artery during treatment with the prescribed radiation. The inflated catheter can also comprise a one-unit balloon. A specific metal coating enhances the radiation dose delivered to the target. The wall of the inflation lumen attenuates transmission dose to the blood circulating through the hollow inner lumen of the catheter device. The system also creates increased by-product radiation, from the impact of beta particles and gamma protons traveling toward the lumen wall. A radiation dosimetry unit indicator is positioned, disposed, or affixed to a calibrated catheter to assist the physician in prescribing radiation activity and exposure times.

    摘要翻译： 导管装置和放射剂量测定单元指示器，用于向患者输送规定的辐射剂量。 导管填充有诸如惰性放射性气体的辐射载体材料，用于治疗例如血管成形术后的再狭窄和恶性肿瘤。 充气导管包括用于运输放射性载体材料的多个离散室，以及多个分立的腔室，其能够在用规定的辐射治疗期间使血液能够通过动脉。 充气导管还可以包括一个单一的气囊。 特定的金属涂层增强了传递给靶的辐射剂量。 充气腔的壁衰减通过导管装置的中空内腔循环的血液的透射剂量。 该系统还产生增加的副产物辐射，从β粒子和γ质子向腔壁行进的影响。 放射剂量测定单元指示器被定位，设置或固定到校准的导管上，以帮助医生规定辐射活动和暴露时间。

    Vessel closure device
    70.
    发明授权
    Vessel closure device 有权
    容器关闭装置

    公开(公告)号：US09398902B2

    公开(公告)日：2016-07-26

    申请号：US13497708

    申请日：2010-09-20

    申请人： Ram H. Paul, Jr. ,  Brian L. Bates ,  Cleon Stanley

    发明人： Ram H. Paul, Jr. ,  Brian L. Bates ,  Cleon Stanley

    IPC分类号： A61B17/128 ,  A61B17/122 ,  A61B17/00 ,  A61B17/29 ,  A61B17/14 ,  A61B17/30

    CPC分类号： A61B17/0057 ,  A61B17/29 ,  A61B2017/0034 ,  A61B2017/00473 ,  A61B2017/00575 ,  A61B2017/2905 ,  A61B2017/2931 ,  A61B2017/303

    摘要： A device and system for closure of an opening formed in a body vessel includes a bioabsorbable grasping member and locking member. The grasping member includes grasping lingers that are radially collapsible to the closed positions by movement of the locking member over the fingers. A distal portion of the fingers is configured to grasp an outer wall portion of the body vessel surrounding the opening when the fingers are in the open position. Movement of the locking member can cause the fingers to at least substantially close the vessel opening. Structural features on the fingers and/or locking member can inhibit proximal or distal movement of the locking member when in a locking position. A detachable arm can be coupled to the grasping member to facilitate placement of the grasping member. A sheath can fit over the detachable arm and be configured to move the locking member over the fingers.

    摘要翻译： 用于封闭形成在体容器中的开口的装置和系统包括生物可吸收的抓持构件和锁定构件。 抓持构件包括通过锁定构件通过手指的移动而径向可折叠到关闭位置的抓握件。 手指的远端部分构造成当手指处于打开位置时抓住围绕开口的身体血管的外壁部分。 锁定构件的运动可导致手指至少基本上关闭容器开口。 手指和/或锁定构件上的结构特征可以在锁定位置时阻止锁定构件的近端或远端运动。 可拆卸臂可以联接到抓握构件以便于抓握构件的放置。 护套可以装配在可拆卸臂上方并且被配置成使锁定构件移动超过手指。