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    COATED MEDICAL DEVICE
    3.
    发明申请
    COATED MEDICAL DEVICE 审中-公开
    涂层医疗器械

    公开(公告)号：US20110015725A1

    公开(公告)日：2011-01-20

    申请号：US12892177

    申请日：2010-09-28

    申请人： Brian L. Bates ,  Scott E. Boatman ,  David G. Burton ,  Michael C. Hoffa ,  Darin G. Schaeffer ,  Jason S. Sturgeon ,  Anthony O. Ragheb

    发明人： Brian L. Bates ,  Scott E. Boatman ,  David G. Burton ,  Michael C. Hoffa ,  Darin G. Schaeffer ,  Jason S. Sturgeon ,  Anthony O. Ragheb

    IPC分类号： A61F2/82

    摘要： A coated medical device (10) including a structure (12) adapted for introduction into a passage or vessel of a patient. The structure is formed of preferably a non-porous base material (14) having a bioactive material layer (18) disposed thereon. The medical device is preferably an implantable stent or balloon (26) of which the bioactive material layer is deposited thereon. The stent can be positioned around the balloon and another layer of the bioactive material posited over the entire structure and extending beyond the ends of the positioned stent. The ends of the balloon extend beyond the ends of the stent and include the bioactive material thereon for delivering the bioactive material to the cells of a vessel wall coming in contact therewith. The balloon further includes a layer of hydrophilic material (58) positioned between the base and bioactive material layers of the balloon.

    摘要翻译： 一种涂覆的医疗装置（10），包括适于引入患者的通道或容器中的结构（12）。 该结构优选由其上设置有生物活性材料层（18）的无孔基材（14）形成。 该医疗装置优选为其上沉积有生物活性物质层的可植入支架或球囊（26）。 支架可以围绕气囊定位，另一层生物活性材料放置在整个结构上并延伸超过定位的支架的端部。 气囊的端部延伸超过支架的端部并且包括其上的生物活性材料，用于将生物活性材料输送到与其接触的血管壁的细胞。 气囊还包括位于气囊的基部和生物活性材料层之间的一层亲水材料（58）。

    Stent deployment device
    6.
    发明授权
    Stent deployment device 有权
    支架部署装置

    公开(公告)号：US09358141B2

    公开(公告)日：2016-06-07

    申请号：US11547020

    申请日：2005-03-22

    申请人： Scott E. Boatman ,  Michael C. Hoffa ,  Kimberly D. Roberts ,  Darin G. Schaeffer

    发明人： Scott E. Boatman ,  Michael C. Hoffa ,  Kimberly D. Roberts ,  Darin G. Schaeffer

    IPC分类号： A61F2/958 ,  A61F2/82

    CPC分类号： A61F2/958 ,  A61F2002/821

    摘要： A stent deployment device (110) is provided for deploying a stent in a lumen of a patient. The device can include a catheter (112), a first balloon (122) positioned near a distal end of the catheter and a second balloon (123) adjacent to the first balloon. Alternatively, the second balloon can be positioned over the first balloon. The device also includes an expandable stent (210) positioned over the first balloon and the second balloon. The first balloon comprises a semi-compliant material, a noncompliant material or a compliant material. Similarly, the second balloon comprises a semi-compliant material, a noncompliant material or a compliant material. The first balloon is expandable to a first diameter, while the second balloon can be expandable to a second diameter.

    摘要翻译： 提供支架展开装置（110）用于将支架展开在患者的内腔中。 该装置可以包括导管（112），定位在导管的远端附近的第一球囊（122）和邻近第一球囊的第二球囊（123）。 或者，第二气球可以位于第一气球上方。 该装置还包括位于第一球囊和第二球囊之上的可扩张支架（210）。 第一气囊包括半柔顺材料，不符合材料或柔顺材料。 类似地，第二气囊包括半柔顺材料，不合格材料或顺应性材料。 第一气囊可扩张至第一直径，而第二球囊可扩张至第二直径。

    Stent deployment device including splittable sleeve containing the stent
    7.
    发明授权
    Stent deployment device including splittable sleeve containing the stent 失效
    支架展开装置，包括含支架的可拆卸套筒

    公开(公告)号：US06447540B1

    公开(公告)日：2002-09-10

    申请号：US08971113

    申请日：1997-11-14

    申请人： Arthur B. Fontaine ,  Susan DosPassos ,  Brian L. Bates ,  Scott E. Boatman ,  Michael C. Hoffa ,  Thomas A. Osborne

    发明人： Arthur B. Fontaine ,  Susan DosPassos ,  Brian L. Bates ,  Scott E. Boatman ,  Michael C. Hoffa ,  Thomas A. Osborne

    IPC分类号： A61F206

    CPC分类号： A61F2/97 ,  A61F2/95 ,  A61F2/958 ,  A61F2002/9511 ,  A61F2002/9583 ,  A61M25/0668 ,  A61M25/10

    摘要： A stent deployment device (10) includes a catheter (12), a stent (14) positioned on the catheter (12), and a sleeve (16) carried on the catheter (12). The sleeve (16) has a portion (18) extending fully over and containing the stent (14). The stent deployment device (10) also includes a mechanism (20) for splitting at least the portion (18) of the sleeve (16) extending over the stent (14) and, preferably, for splitting the entire sleeve (16). Splitting of the sleeve portion (18) permits expansion of the stent (14). The mechanism (20) can include an inflatable, nondistending balloon (22) carried on the catheter (12), the stent (14) and the sleeve portion (18) being positioned over the balloon (22). The stent (14) can be self-expanding or can be expanded by the balloon (22) itself. Alternatively, the mechanism (20) can include a bulbous end (24) on the catheter (12). Longitudinal movement of the bulbous catheter end (24) with respect to the sleeve (16) splits at least the sleeve portion (18), permitting expansion of the stent (14). As further alternatives, the mechanism (20) can include a garrote (66) connected to the sleeve or a partial segment (62) of the sleeve (16) folded back alongside the stent (14). The sleeve (16) can be the same length as the catheter (12) or can be shorter than the catheter (12). In the former case, the mechanism (20) can include a pair of graspable wings (56) for splitting the full length of the sleeve (16). It is preferred that at least the portion (18) of the sleeve (16) extending over the stent (14) includes a longitudinally extending structure 46 for ensuring that the sleeve portion (18) will in fact split upon operation of the mechanism (20).

    摘要翻译： 支架展开装置（10）包括导管（12），定位在导管（12）上的支架（14）和承载在导管（12）上的套筒（16）。 套筒（16）具有完全延伸并且容纳支架（14）的部分（18）。 支架展开装置（10）还包括一个机构（20），用于至少分开延伸在支架（14）上的套筒（16）的部分（18），并且优选地用于分割整个套筒（16）。 套筒部分（18）的分裂允许支架（14）膨胀。 机构（20）可以包括承载在导管（12）上的可膨胀的非重排球囊（22），支架（14）和套筒部分（18）定位在球囊（22）上方。 支架（14）可以是自膨胀的，或者可以由气囊（22）自身扩张。 或者，机构（20）可以包括在导管（12）上的球根端（24）。 球根导管端部（24）相对于套筒（16）的纵向移动至少分开套筒部分（18），从而允许支架（14）的膨胀。 作为另外的替代方案，机构（20）可以包括连接到套筒的衣壳（66）或套管（16）的沿着支架（14）折回的部分段（62）。 套筒（16）可以与导管（12）的长度相同，或者可以比导管（12）短。 在前一种情况下，机构（20）可以包括用于分离套筒（16）的全长的一对可抓握翼（56）。 优选地，延伸在支架（14）上的套筒（16）的至少部分（18）包括纵向延伸的结构46，用于确保套筒部分（18）实际上将在

    Radially expandable stent
    8.
    发明授权
    Radially expandable stent 有权
    径向扩张支架

    公开(公告)号：US06231598B1

    公开(公告)日：2001-05-15

    申请号：US09160122

    申请日：1998-09-24

    申请人： Dale T. Berry ,  Coy M. Herald ,  Brian L. Bates ,  Scott E. Boatman ,  Michael C. Hoffa ,  Neal E. Fearnot ,  William D. Voorhees, III

    发明人： Dale T. Berry ,  Coy M. Herald ,  Brian L. Bates ,  Scott E. Boatman ,  Michael C. Hoffa ,  Neal E. Fearnot ,  William D. Voorhees, III

    IPC分类号： A61F206

    CPC分类号： A61F2/915 ,  A61F2/88 ,  A61F2/91 ,  A61F2002/91508 ,  A61F2002/91516 ,  A61F2002/91525 ,  A61F2002/91533 ,  A61F2002/91558 ,  A61F2002/91566 ,  A61F2002/91575 ,  A61F2002/91583 ,  A61F2230/0054 ,  A61F2250/0036 ,  A61F2250/0098 ,  A61L31/022 ,  A61L31/18

    摘要： A radially expandable stent (10) made from a cannula or sheet of biocompatible material that includes at least one longitudinal segment (14) comprised of a series of laterally interconnected closed cells (13). Each closed cell of a longitudinal segment is defined laterally by a pair of longitudinal struts (15, 16) that are interconnected at each end by a circumferentially adjustable member (19, 20). When the stent is expanded using a balloon (47), the opposing circumferentially adjustable members deform to allow circumferential expansion of the longitudinal segment, while the length of the segment, as defined by the longitudinal struts, is maintained. Self-expanding versions of the stent utilize a nickel-titanium alloy. Adjacent longitudinal segments are joined by flexible interconnection segments (21) that permit the stent to bend laterally. The flexible interconnection segment is comprised of curvilinear struts (22, 23) that form a series of serpentine bends (81) that distribute lateral bending forces. In a preferred embodiment, a short strut interconnects longitudinal segments and an adjacent interconnection segment. Each interconnection strut attaches to the longitudinal segment within a region (27) at the end (17) of a longitudinal strut (15) dividing two adjacent closed cells.

    摘要翻译： 一种由包括生物相容性材料的套管或片材制成的径向可扩张的支架（10），其包括由一系列横向互连的闭孔（13）构成的至少一个纵向段（14）。 纵向段的每个闭合单元由一对纵向支柱（15,16）侧向地限定，所述纵向支柱在每个端部由周向可调节构件（19,20）互连。 当使用球囊（47）扩张支架时，相对的周向可调部件变形以允许纵向段的周向膨胀，而由纵向支柱限定的段的长度保持。 自扩张型支架采用镍钛合金。 相邻的纵向段通过柔性互连段（21）连接，允许支架横向弯曲。 柔性互连部分由曲线支柱（22,23）组成，其形成分布横向弯曲力的一系列蛇形弯曲部（81）。 在优选实施例中，短支柱将纵向段和相邻互连段互连。 每个互连支柱在分开两个相邻闭孔的纵向支柱（15）的端部（17）处的区域（27）内附接到纵向段。

    Medical device including improved expandable balloon
    9.
    发明授权
    Medical device including improved expandable balloon 有权

    公开(公告)号：US06592550B1

    公开(公告)日：2003-07-15

    申请号：US09663747

    申请日：2000-09-15

    申请人： Scott E. Boatman ,  David G. Burton ,  Michael C. Hoffa ,  David R. Lessard ,  David A. Drewes, Jr. ,  Maggie A. Z. Hupcey

    发明人： Scott E. Boatman ,  David G. Burton ,  Michael C. Hoffa ,  David R. Lessard ,  David A. Drewes, Jr. ,  Maggie A. Z. Hupcey

    IPC分类号： A61M3100

    CPC分类号： C08G69/48 ,  A61L29/06 ,  C08F283/04 ,  C08L77/00 ,  C08F218/16

    摘要： A medical device (10) includes a catheter shaft (11) including inner and outer catheter shafts (12 and 14), and an expandable balloon (18) carried by the catheter shaft (11). The balloon (18) is made from an irradiation cross-linked mixture of a polyamide elastomer and at least one additional cross-linking reactant. The polyamide elastomer can be a polyester amide, a polyether ester amide or a polyether amide, and is preferably a nylon block copolymer. The cross-linking reactant can be: (a) a difunctional material, (b) a trifunctional material, (c) a tetrafunctional material, or (d) an aromatic molecule containing at least two ring substituents, each of the ring substituents having labile hydrogens at a benzylic site therein. The cross-linking reactant can also be diallyl phthalate or meta-phenylene dimaleimide. Irradiation is carried out by exposure to an electron beam or to ultraviolet, X- or gamma radiation, preferably at a total fluence of about 0.5 to about 20 megarads. The amount of the cross-linking reactant is selected to avoid the formation of gelling during the process by which the balloon (18) is made, and the amount of the cross-linking agent and the irradiation fluence are selected to give the balloon a strength generally about equal to that which would be obtained by mere irradiation.

    Medical device including improved expandable balloon
    10.
    发明授权
    Medical device including improved expandable balloon 有权
    医疗装置包括改进的可膨胀气囊

    公开(公告)号：US07485250B2

    公开(公告)日：2009-02-03

    申请号：US10463749

    申请日：2003-06-16

    申请人： Scott E. Boatman ,  David G. Burton ,  Michael C. Hoffa ,  David R. Lessard ,  David A. Drewes, Jr. ,  Maggie A. Z. Hupcey

    发明人： Scott E. Boatman ,  David G. Burton ,  Michael C. Hoffa ,  David R. Lessard ,  David A. Drewes, Jr. ,  Maggie A. Z. Hupcey

    IPC分类号： B29C35/08 ,  D01F1/02 ,  A61M29/00

    CPC分类号： C08G69/48 ,  A61L29/06 ,  C08F283/04 ,  C08L77/00 ,  C08F218/16

    摘要： A medical device (10) includes a catheter shaft (11) including inner and outer catheter shafts (12 and 14), and an expandable balloon (18) carried by the catheter shaft (11). The balloon (18) is made from an irradiation cross-linked mixture of a polyamide elastomer and at least one additional cross-linking reactant. The polyamide elastomer can be a polyester amide, a polyether ester amide or a polyether amide, and is preferably a nylon block copolymer. The cross-linking reactant can be: (a) a difunctional material, (b) a trifunctional material, (c) a tetrafunctional material, or (d) an aromatic molecule containing at least two ring substituents, each of the ring substituents having labile hydrogens at a benzylic site therein. The cross-linking reactant can also be diallyl phthalate or meta-phenylene dimaleimide. Irradiation is carried out by exposure to an electron beam or to ultraviolet, X- or gamma radiation, preferably at a total fluence of about 0.5 to about 20 megarads. The amount of the cross-linking reactant is selected to avoid the formation of gelling during the process by which the balloon (18) is made, and the amount of the cross-linking agent and the irradiation fluence are selected to give the balloon a strength generally about equal to that which would be obtained by mere irradiation.

    摘要翻译： 医疗装置（10）包括导管轴（11），其包括内导管轴和外导管轴（12和14）和由导管轴（11）承载的可膨胀气囊（18）。 球囊（18）由聚酰胺弹性体和至少一种另外的交联反应物的照射交联混合物制成。 聚酰胺弹性体可以是聚酯酰胺，聚醚酯酰胺或聚醚酰胺，优选为尼龙嵌段共聚物。 交联反应物可以是：（a）双官能材料，（b）三官能材料，（c）四官能材料，或（d）含有至少两个环取代基的芳族分子，每个环取代基具有不稳定性 在其苄基位点处的氢。 交联反应物也可以是邻苯二甲酸二烯丙酯或间亚苯基二马来酰亚胺。 照射通过暴露于电子束或紫外线，X射线或γ射线进行，优选以约0.5至约20兆拉德的总注量。 选择交联反应物的量以避免在制备气囊（18）的过程中形成胶凝，并且选择交联剂的量和照射注量以使球囊具有强度 通常大约等于仅通过照射获得的能量。