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    COMPONENTS WITH HIGH API LOADING
    62.
    发明申请
    COMPONENTS WITH HIGH API LOADING 审中-公开

    公开(公告)号：US20200324095A1

    公开(公告)日：2020-10-15

    申请号：US16614172

    申请日：2018-05-17

    Applicant: Massachusetts Institute of Technology ,  The Brigham and Women's Hospital, Inc.

    Inventor： Carlo Giovanni Traverso ,  Alex G. Abramson ,  Ester Caffarel Salvador ,  Niclas Roxhed ,  Minsoo Khang ,  Taylor Bensel ,  Robert S. Langer

    IPC: A61M37/00 ,  A61K9/00 ,  A61K38/28 ,  A61K9/48

    Abstract: Components with relatively high loading of active pharmaceutical ingredients are generally provided. In some embodiments, the component (e.g., a tissue interfacing component) comprises a solid therapeutic agent and a supporting material such that the solid therapeutic agent is present in the component in an amount of greater than or equal to 10 wt % versus the total weight of the tissue interfacing component. Such tissue-interfacing components may be useful for delivery of API doses e.g., to a subject. Advantageously, in some embodiments, the reduction of volume required to deliver the required API dose as compared to a liquid formulation permits the creation of solid needle delivery systems for a wide variety of drugs in a variety of places/tissues (e.g., tongue, GI mucosal tissue, skin) and/or reduces and/or eliminates the application of an external force in order to inject a drug solution through the small opening in the needle. In some cases, a physiologically relevant dose may be present in a single tissue interfacing component.

    TISSUE ANCHORING ARTICLES
    63.
    发明申请
    TISSUE ANCHORING ARTICLES 审中-公开

    公开(公告)号：US20200306515A1

    公开(公告)日：2020-10-01

    申请号：US16614299

    申请日：2018-05-17

    Applicant: Massachusetts Institute of Technology ,  The Brigham and Women's Hospital, Inc.

    Inventor： Carlo Giovanni Traverso ,  Alex G. Abramson ,  Ester Caffarel Salvador ,  Niclas Roxhed ,  Minsoo Khang ,  Taylor Bensel ,  David Dellal ,  Robert S. Langer

    IPC: A61M31/00 ,  A61M5/20 ,  A61M5/32 ,  A61M37/00 ,  A61K9/00 ,  A61K9/48

    Abstract: Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject). In some cases, upon contact of the tissue with the tissue engaging surface of the article, the self-righting article may be configured to release one or more tissue interfacing components. In some cases, the tissue interfacing component is associated with a self-actuating component. For example, the self-righting article may comprise a self-actuating component configured, upon exposure to a fluid, to release the tissue interfacing component from the self-righting article. In some cases, the tissue interfacing component may comprise and/or be associated with the pharmaceutical agent (e.g., for delivery to a location internal to a subject).

    Methods and Apparatus for Multi-Frequency Beamforming
    64.
    发明申请
    Methods and Apparatus for Multi-Frequency Beamforming 审中-公开

    公开(公告)号：US20200280356A1

    公开(公告)日：2020-09-03

    申请号：US16876068

    申请日：2020-05-17

    Applicant: Massachusetts Institute of Technology ,  The Brigham and Women's Hospital, Inc.

    Inventor： Yunfei Ma ,  Zhihong Luo ,  Christoph Steiger ,  Carlo Giovanni Traverso ,  Fadel Adib

    IPC: H04B7/06 ,  G06K7/10 ,  H04B13/00

    Abstract: Multiple antennas of a beamformer may simultaneously transmit wireless signals at different frequencies. The signals may comprise synchronized, identical wireless commands, each at a different carrier frequency. The transmitted signals may constructively and destructively interfere with each other at a receiver antenna, to form a beat signal. When the transmitted signals constructively interfere, the beat signal may cause a voltage in the receiver to exceed a threshold voltage. The threshold voltage may be a minimum voltage at which a device, which is operatively connected to the receiver antenna, is able to perform energy harvesting or wireless communication. The beamformer may operate under blind channel conditions, because the transmitted frequencies may be selected in such a way as to maximize peak power delivered under all possible channel conditions. The beamformer may deliver wireless power to a sensor or actuator that is located deep inside bodily tissue.

    Residence structures and related methods
    65.
    发明授权
    Residence structures and related methods 有权

    公开(公告)号：US10596110B2

    公开(公告)日：2020-03-24

    申请号：US16014549

    申请日：2018-06-21

    Applicant: Massachusetts Institute of Technology ,  The Brigham and Women's Hospital, Inc.

    Inventor： Andrew Bellinger ,  Shiyi Zhang ,  Carlo Giovanni Traverso ,  Robert S. Langer ,  Stacy Mo ,  Tyler Grant ,  Mousa Jafari ,  Dean Liang Glettig ,  Angela DiCiccio ,  Omar Abouzid ,  Ameya R. Kirtane

    IPC: A61K9/00 ,  A61K9/48 ,  A61K47/34 ,  A61K47/10 ,  A61K31/65 ,  A61K31/7048 ,  A61K47/32

    Abstract: Residence structures, systems, and related methods are generally provided. Certain embodiments comprise administering (e.g., orally) a residence structure to a subject (e.g., a patient) such that the residence structure is retained at a location internal to the subject for a particular amount of time (e.g., at least about 24 hours) before being released. The residence structure may be, in some cases, a gastric residence structure. In some embodiments, the structures and systems described herein comprise one or more materials configured for high levels of active substances (e.g., a therapeutic agent) loading, high active substance and/or structure stability in acidic environments, mechanical flexibility and strength in an internal orifice (e.g., gastric cavity), easy passage through the GI tract until delivery to at a desired internal orifice (e.g., gastric cavity), and/or rapid dissolution/degradation in a physiological environment (e.g., intestinal environment) and/or in response to a chemical stimulant (e.g., ingestion of a solution that induces rapid dissolution/degradation). In certain embodiments, the structure has a modular design, combining a material configured for controlled release of therapeutic, diagnostic, and/or enhancement agents with a structural material necessary for gastric residence but configured for controlled and/or tunable degradation/dissolution to determine the time at which retention shape integrity is lost and the structure passes out of the gastric cavity. For example, in certain embodiments, the residence structure comprises a first elastic component, a second component configured to release an active substance (e.g., a therapeutic agent), and, optionally, a linker. In some such embodiments, the linker may be configured to degrade such that the residence structure breaks apart and is released from the location internally of the subject after a predetermined amount of time.

    RESIDENCE STRUCTURES AND RELATED METHODS
    66.
    发明申请
    RESIDENCE STRUCTURES AND RELATED METHODS 审中-公开

    公开(公告)号：US20190175500A1

    公开(公告)日：2019-06-13

    申请号：US16277516

    申请日：2019-02-15

    Applicant: Massachusetts Institute of Technology ,  The Brigham and Women's Hospital, Inc.

    Inventor： Andrew Bellinger ,  Shiyi Zhang ,  Carlo Giovanni Traverso ,  Robert S. Langer ,  Stacy Mo ,  Tyler Grant ,  Mousa Jafari ,  Dean Liang Glettig ,  Angela DiCiccio ,  Lowell L. Wood, JR. ,  Philip A. Eckhoff

    IPC: A61K9/00 ,  A61K47/58 ,  A61K47/69 ,  A61K31/357 ,  A61K31/65 ,  A61K31/7048 ,  A61K47/10 ,  A61K47/32 ,  A61K47/34 ,  A61K47/40 ,  A61K47/42 ,  A61M31/00 ,  C08G18/42 ,  C08G18/73 ,  C08G63/08 ,  C08G83/00 ,  C08L33/02 ,  C08L33/08 ,  C08L33/14 ,  A61K9/48

    Abstract: Residence structures, systems, and related methods are generally provided. Certain embodiments comprise administering (e.g., orally) a residence structure to a subject (e.g., a patient) such that the residence structure is retained at a location internal to the subject for a particular amount of time (e.g., at least about 24 hours) before being released. The residence structure may be, in some cases, a gastric residence structure. In some embodiments, the structures and systems described herein comprise one or more materials configured for high levels of active substances (e.g., a therapeutic agent) loading, high active substance and/or structure stability in acidic environments, mechanical flexibility and strength in an internal orifice (e.g., gastric cavity), easy passage through the GI tract until delivery to at a desired internal orifice (e.g., gastric cavity), and/or rapid dissolution/degradation in a physiological environment (e.g., intestinal environment) and/or in response to a chemical stimulant (e.g., ingestion of a solution that induces rapid dissolution/degradation). In certain embodiments, the structure has a modular design, combining a material configured for controlled release of therapeutic, diagnostic, and/or enhancement agents with a structural material necessary for gastric residence but configured for controlled and/or tunable degradation/dissolution to determine the time at which retention shape integrity is lost and the structure passes out of the gastric cavity. For example, in certain embodiments, the residence structure comprises a first elastic component, a second component configured to release an active substance (e.g., a therapeutic agent), and, optionally, a linker. In some such embodiments, the linker may be configured to degrade such that the residence structure breaks apart and is released from the location internally of the subject after a predetermined amount of time.

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