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公开(公告)号：US11701437B2
公开(公告)日：2023-07-18
申请号：US16612648
申请日：2018-05-14
申请人： President and Fellows of Harvard College , Massachusetts Institute of Technology , The Brigham and Women's Hospital, Inc. , The General Hospital Corporation
发明人： Denitsa M. Milanova , George M. Church , Noah Davidsohn , Carl Schoellhammer , Robert S. Langer , Anna I. Mandinova , Carlo Giovanni Traverso
CPC分类号： A61K48/0075 , A61K47/6901 , A61N7/00 , C12N15/86 , A61K9/7023 , C12N2750/14143 , C12N2750/14145 , C12N2750/14151 , C12N2810/859
摘要： A method for the systemic delivery of a polypeptide within a subject is provided by creating genetically modified skin cells via topical introduction of a genetically engineered virus which delivers a nucleic acid encoding a therapeutic polypeptide for expression by the skin cells, wherein the expressed therapeutic polypeptide is secreted by the skin cells and is introduced into the circulatory system of the subject.
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公开(公告)号：US20200375868A1
公开(公告)日：2020-12-03
申请号：US16612632
申请日：2018-05-14
申请人： President and Fellows of Harvard College , Massachusetts Institute of Technology , The Brigham and Women's Hospital, Inc. , The General Hospital Corporation
发明人： Denitsa M. Milanova , George M. Church , Noah Davidsohn , Carl Schoellhammer , Robert S. Langer , Anna I. Mandinova , Carlo Giovanni Traverso , Li Li
摘要： A method of delivering a recombinant virus to a skin tissue is provided. The method includes applying ultrasound to the skin tissue, and administering the recombinant virus to the skin tissue.
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公开(公告)号：US20240091384A1
公开(公告)日：2024-03-21
申请号：US18325332
申请日：2023-05-30
申请人： President and Fellows of Harvard College , Massachusetts Institute of Technology , The Brigham and Women's Hospital, Inc. , The General Hospital Corporation
发明人： Denitsa M. Milanova , George M. Church , Noah Davidsohn , Carl Schoellhammer , Robert S. Langer , Anna I. Mandinova , Carlo Giovanni Traverso
CPC分类号： A61K48/0075 , A61K47/6901 , A61N7/00 , C12N15/86 , A61K9/7023
摘要： A method for the systemic delivery of a polypeptide within a subject is provided by creating genetically modified skin cells via topical introduction of a genetically engineered virus which delivers a nucleic acid encoding a therapeutic polypeptide for expression by the skin cells, wherein the expressed therapeutic polypeptide is secreted by the skin cells and is introduced into the circulatory system of the subject.
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公开(公告)号：US20220001027A1
公开(公告)日：2022-01-06
申请号：US17293507
申请日：2019-11-14
申请人： President and Fellows of Harvard College , Massachusetts Institute of Technology , The General Hospital Corporation
发明人： Denitsa M. Milanova , George M. Church , Isaac Han , James Gorman , Robert S. Langer , Anna I. Mandinova , Kristina Aleksandrova Todorova
摘要： A method for the systemic delivery of an enzyme to treat lysosomal storage disease of a subject is provided by creating genetically modified skin cells via topical introduction of a genetically engineered virus which delivers a nucleic acid encoding an enzyme or factor for expression by the skin cells, wherein the expressed enzyme or factor is secreted by the skin cells and is introduced into the circulatory system of the subject.
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公开(公告)号：US20180066307A1
公开(公告)日：2018-03-08
申请号：US15790830
申请日：2017-10-23
申请人： THE BROAD INSTITUTE INC. , MASSACHUSETTS INSTITUTE OF TECHNOLOGY , PRESIDENT AND FELLOWS OF HARVARD COLLEGE
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6806 , A61K9/0019 , A61K9/5176 , C12N15/1003 , C12N15/1006 , C12N15/1013 , C12N15/1017 , C12Q1/6804 , C12Q1/6851 , C12Q1/686 , C12Q2563/131 , C12Q2563/137 , C12Q2563/143 , C12Q2565/629
摘要： The present invention relates to the isolation and purification of exosomes from biological samples, and to methods for extracting RNA contained therein. The present invention provides methods and uses for the purification of exosomes, as well as compositions comprising same.
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公开(公告)号：US20230022775A1
公开(公告)日：2023-01-26
申请号：US17784899
申请日：2020-12-11
发明人： Luis Ruben Soenksen Martinez , Nicolaas Angenent-Mari , Alexander S. Garruss , James J. Collins , George M. Church , Katherine Collins , Diogo M. Camacho
IPC分类号： C12Q1/6816 , C12Q1/6886 , C12Q1/70 , C12N15/10
摘要： This disclosure provides riboregulators specific for particular viruses or for particular human transcription factors. The viral-specific riboregulators may be used to detect the presence of the particular virus, and this may enable diagnosis of an infection. The transcription factor specific riboregulators may be used to detect the presence and/or measure the level of the particular transcription factor, and this may enable diagnosis or prognosis of a particular condition such as cancer.
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公开(公告)号：US20240254437A1
公开(公告)日：2024-08-01
申请号：US18437775
申请日：2024-02-09
IPC分类号： C12N5/0735 , C12N15/86 , C12N15/90
CPC分类号： C12N5/0606 , C12N15/86 , C12N15/90 , C12N2501/602 , C12N2501/603 , C12N2506/45 , C12N2800/90
摘要： Provided herein are pluripotent stem cells comprising particular combinations of transcription factor for the production of oligodendrocyte progenitor cells (OPCs). Also provided herein are methods of producing the pluripotent stem cells and methods of using the pluripotent stem cells to produce (OPCs) and oligodendrocytes.
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公开(公告)号：US11976318B2
公开(公告)日：2024-05-07
申请号：US18064956
申请日：2022-12-13
发明人： George M. Church , Jehyuk Lee , Daniel Levner , Michael Super
IPC分类号： C12Q1/68 , C12P19/34 , C12Q1/6804 , C12Q1/6806 , C12Q1/6816 , C12Q1/6837 , C12Q1/6844 , C12Q1/6869 , C12Q1/6874 , G01N33/53
CPC分类号： C12Q1/6806 , C12P19/34 , C12Q1/6804 , C12Q1/6816 , C12Q1/6837 , C12Q1/6844 , C12Q1/6869 , C12Q1/6874 , G01N33/53 , G01N2458/10
摘要： Methods of analyzing nucleic acids of a cell are provided.
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公开(公告)号：US20240141387A1
公开(公告)日：2024-05-02
申请号：US18279582
申请日：2022-03-01
CPC分类号： C12N15/907 , C12N9/22 , C12N15/11 , C12N15/86 , C12N2310/20 , C12N2750/14143 , C12N2800/80 , C12N2800/90
摘要： Provided herein, in some embodiments, are engineered nucleic acid targeting vectors that include a sequence of interest flanked by homology arms, each homology arm comprising a sequence homologous to a sequence in a safe harbor site in the human genome in any one of the following loci: 1q31, 3p24, 7q35, and Xq21. Also provided herein are methods of using and compositions the comprising engineered nucleic acid targeting vectors.
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公开(公告)号：US11900191B2
公开(公告)日：2024-02-13
申请号：US17235196
申请日：2021-04-20
发明人： George M. Church
CPC分类号： G06K19/022 , G06K19/00 , G06N3/123 , G16B30/00 , G16B30/20
摘要： The present invention relates to methods of storing data using one or more nucleic acids.
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