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98 条记录 (耗时 0.036 秒)

    Quantification analysis of immobilized contrast agent in medical imaging applications
    61.
    发明授权
    Quantification analysis of immobilized contrast agent in medical imaging applications 有权
    医学成像应用中固定化造影剂的定量分析

    公开(公告)号：US09072492B2

    公开(公告)日：2015-07-07

    申请号：US12811089

    申请日：2008-12-23

    申请人： Marcel Arditi ,  Tristan Messager ,  Michel Schneider ,  Peter Frinking

    发明人： Marcel Arditi ,  Tristan Messager ,  Michel Schneider ,  Peter Frinking

    IPC分类号： A61B8/14 ,  A61B8/08 ,  G06F19/12

    CPC分类号： A61B8/481 ,  A61B8/14 ,  A61B8/5223 ,  G06F19/12

    摘要： An embodiment analyzes a body part of a patient, which patient is perfused with a contrast agent that is capable of circulating within the patient and of being substantially immobilized on a biological target. An embodiment of a corresponding system provides an echo signal that is indicative of a response over time to an interrogation signal of the body part, fits the echo signal with a time model function that models an evolution over time of the contrast agent in the body part, the time model function including a combination of a circulation function that models the circulation of the contrast agent and a decay function that models a decay of the echo signal from the immobilized contrast agent, and estimates at least one kinetics indicator of the contrast agent from the time model function.

    摘要翻译： 一个实施方案分析患者的身体部分，该患者被灌注了能够在患者体内循环并且基本上固定在生物靶上的造影剂。 对应系统的一个实施例提供一个回波信号，其指示随着时间的推移对身体部位的询问信号的响应，将回波信号与时间模型函数拟合，该时间模型函数对身体部位中造影剂的时间演化进行建模 时间模型功能包括对造影剂的循环进行建模的循环功能和对来自固定的造影剂的回波信号的衰减进行建模的衰减函数的组合，并估计造影剂的至少一个动力学指标 时间模型功能。

    Liposomal assembly for therapeutic and/or diagnostic use
    62.
    发明授权
    Liposomal assembly for therapeutic and/or diagnostic use 有权
    用于治疗和/或诊断用途的脂质体组装

    公开(公告)号：US07749485B2

    公开(公告)日：2010-07-06

    申请号：US11596447

    申请日：2005-05-31

    申请人： Herve Tournier ,  Roland Hyacinthe ,  Michel Schneider

    发明人： Herve Tournier ,  Roland Hyacinthe ,  Michel Schneider

    IPC分类号： A61K51/00 ,  A61M36/14 ,  B32B5/16 ,  B01F3/00

    CPC分类号： A61K9/1075 ,  A61K9/1271 ,  A61K48/0091 ,  A61K49/1812 ,  C12N15/88 ,  Y10S977/907 ,  Y10T428/2982

    摘要： Composition for diagnostic or therapeutic use which comprises an assembly comprising an active agent. The assembly comprises a liposome and a plurality of micellar components associated thereto, said micellar components being associated to the outer surface of the envelope of said liposome through a substantially electrostatic interaction, When an active compound is incorporated into the micelles, a substantial amount of said active compound can be linked to a singe liposome. Furthermore, the presence of the outer micellar layer allows to increase the residence time of said liposome in the blood stream.

    摘要翻译： 用于诊断或治疗用途的组合物，其包含包含活性剂的组合物。 组合物包含脂质体和与其相关联的多个胶束组分，所述胶束组分通过基本上静电的相互作用与所述脂质体的外壳的外表面结合。当将活性化合物并入胶束中时，大量的所述 活性化合物可以连接到单个脂质体。 此外，外胶束层的存在允许增加所述脂质体在血流中的停留时间。

    Gas- Filled Microvesicles Composition for Contrast Imaging
    63.
    发明申请
    Gas- Filled Microvesicles Composition for Contrast Imaging 有权
    气体填充的微泡组合物用于对比成像

    公开(公告)号：US20080008657A1

    公开(公告)日：2008-01-10

    申请号：US11660188

    申请日：2005-08-17

    申请人： Philippe Bussat ,  Peter Frinking ,  Christian Guillot ,  Michel Schneider

    发明人： Philippe Bussat ,  Peter Frinking ,  Christian Guillot ,  Michel Schneider

    IPC分类号： A61K49/22

    CPC分类号： A61K49/223

    摘要： The present invention relates to a new composition comprising gas-filled microvesicles for contrast imaging which are particularly suitable for providing an effective echo response to at least two selected ultrasound waves having different frequencies. Said composition preferably comprises at least two different preparations of gas-filled microvesicles, which preferably have respective different mean sizes. In particular, said preparations preferably have respective Dv values differing from each other by at least 0.5 μm, more preferably at least 1.0 μm. Alternatively, said composition has a volume size distribution showing a value of Bowley skewness of 0.16 or higher. According to a preferred embodiment, at least 95% of the total volume of gas contained in said microvesicles, calculated on the population of microvesicles up to a diameter of 10 μm, is contained in microvesicles having a diameter of 8 micron or less. The composition of the invention can be effectively employed at rather different ultrasound transmission frequencies differing by about 8 MHz.

    摘要翻译： 本发明涉及一种新的组合物，其包括用于对比成像的气体填充微泡，其特别适合于向至少两个具有不同频率的选定超声波提供有效的回波响应。 所述组合物优选包含至少两种气体填充微泡的不同制剂，其优选具有不同的平均尺寸。 特别地，所述制剂优选具有彼此不同的至少0.5μm，更优选至少1.0μm的相应的D V值。 或者，所述组合物具有显示Bowley偏度值为0.16或更高的体积大小分布。 根据一个优选实施方案，所述微泡中包含的气体的总体积的至少95％是以直径为10微米的微泡总数计算的，包含在直径为8微米或更小的微泡中。 本发明的组合物可以以不同于约8MHz的相当不同的超声波传播频率有效地使用。

    Method of imaging using encapsulated magnetite particles
    67.
    发明授权
    Method of imaging using encapsulated magnetite particles 失效
    使用封装的磁铁矿颗粒成像的方法

    公开(公告)号：US5545395A

    公开(公告)日：1996-08-13

    申请号：US421330

    申请日：1995-04-13

    申请人： Herve Tournier ,  Roland Hyacinthe ,  Michel Schneider

    发明人： Herve Tournier ,  Roland Hyacinthe ,  Michel Schneider

    IPC分类号： A61K9/127 ,  A61B5/055 ,  A61K20060101 ,  A61K49/00 ,  A61K49/18

    CPC分类号： A61K49/1806 ,  A61K49/1839 ,  Y10S977/838 ,  Y10S977/904 ,  Y10S977/905 ,  Y10S977/927 ,  Y10S977/96 ,  Y10T428/2991 ,  Y10T428/2998 ,  Y10T436/24

    摘要： Magnetite particles suitable for injection into the blood stream of patients having enhanced resistance against agglomeration and uptake by the RES of the liver and spleen. The particles essentially consist of an iron oxide core and a phosphoric acid mono alkyl or alkenyl ester or glycerophospholipid/surfactant three dimensional shell surrounding the core. The core and the monoester or a micellar glycerophospholipid form an urchin-like structure which is further interlaced or intertwined with a non-ionic surfactant to produce a protective three dimensional shell which renders particles almost undetectable by the macrophages. Particles prepared according to the invention are kept in the blood circulation for long periods and represent excellent long lasting blood pool agents. Key components in the shell are (a) a polybasic mineral-organic species such as glycero phosphatidic acid in micellar form and (b) a block copolymer having successive hydrophilic and hydrophobic segments.

    摘要翻译： 适合于注射到患有肝脏和脾脏的RES的聚集和摄取的抗性的患者血液中的磁铁矿颗粒。 颗粒基本上由氧化铁芯和磷酸单烷基或链烯基酯或包含核心的甘油磷脂/表面活性剂三维壳组成。 核心和单酯或胶束甘油磷脂形成海胆样结构，其进一步与非离子表面活性剂交织或交织在一起，以产生保护性三维壳，其使颗粒几乎不被巨噬细胞检测到。 根据本发明制备的颗粒长时间保持在血液循环中并且代表优异的持久的血液池剂。 壳中的关键组分是（a）多元矿物有机物质，例如胶束形式的甘油磷脂酸，和（b）具有连续亲水和疏水链段的嵌段共聚物。