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    Thermoplastic polyurethane method of making same and forming a medical article therefrom
    62.
    发明授权
    Thermoplastic polyurethane method of making same and forming a medical article therefrom 失效
    热塑性聚氨酯制造方法，从其形成医用制品

    公开(公告)号：US5545708A

    公开(公告)日：1996-08-13

    申请号：US91702

    申请日：1993-07-14

    申请人： Theo O. Onwunaka ,  Mutlu Karakelle

    发明人： Theo O. Onwunaka ,  Mutlu Karakelle

    IPC分类号： A61L29/06 ,  A61M25/16 ,  C08G18/66 ,  A61M25/00 ,  C08G18/32 ,  C08G18/48 ,  C08G18/76

    CPC分类号： C08G18/6674 ,  A61L29/06

    摘要： A thermoplastic polyurethane having inherent softness properties is formed from a diisocyanate, a polyetherglycol and a mixture of diol chain extenders. The mixture of chain extenders includes a first diol and a second diol which has side chain branching. A method for making the polyurethane of the present invention includes mixing the components to induce an exothermic reaction, followed by curing. The polyurethane formed is suitable for melt processing into medical devices such as catheters, other tubing, hubs and the like.

    摘要翻译： 具有固有柔软性的热塑性聚氨酯由二异氰酸酯，聚醚二醇和二醇增链剂的混合物形成。 扩链剂的混合物包括具有侧链支化的第一二醇和第二二醇。 制备本发明的聚氨酯的方法包括将组分混合以引发放热反应，随后固化。 所形成的聚氨酯适合于熔融加工成诸如导管，其它管，轮毂等医疗装置。

    Blood electrolyte sensors including crosslinked polyetherurethane membranes
    65.
    发明授权
    Blood electrolyte sensors including crosslinked polyetherurethane membranes 失效
    血液电解质传感器包括交联聚醚聚氨酯膜

    公开(公告)号：US4816130A

    公开(公告)日：1989-03-28

    申请号：US133767

    申请日：1987-12-14

    申请人： Mutlu Karakelle ,  Richard J. Zdrahala

    发明人： Mutlu Karakelle ,  Richard J. Zdrahala

    IPC分类号： B01D71/54 ,  C08G18/12 ,  C08G18/48 ,  C08G18/66 ,  G01N27/40 ,  G01N21/00 ,  G01N27/00

    CPC分类号： G01N27/40 ,  B01D71/54 ,  C08G18/12 ,  C08G18/4833 ,  C08G18/6677

    摘要： Partition membranes which are permeable to blood electrolytes fabricated from crosslinked polyetherurethane compositions having from 20 to 50% hard segments. The membranes absorb from 50 to 120% of their dry weight of water and have electrolyte diffusion constants of up to 1.times.10.sup.-6 cm.sup.2 /sec. The membranes are included in electrochemical, fiber optic and solid state blood electrolyte sensors to provide blood compatible surfaces and to ensure that blood components deleterious to analysis of electrolyte in the blood remain separated from the sensing elements.

    摘要翻译： 由具有20至50％硬链段的交联聚醚聚氨酯组合物制备的可渗透血液电解质的分隔膜。 膜吸收其干重量的50至120％，电解质扩散常数高达1×10-6cm2 / sec。 膜被包括在电化学，光纤和固态血液电解质传感器中，以提供血液相容性表面，并确保对血液中电解质分析有害的血液成分与感测元件分离。

    Intraocular lens delivery device having a cartridge with an internal coating
    67.
    发明授权
    Intraocular lens delivery device having a cartridge with an internal coating 有权
    具有具有内部涂层的盒的人工晶状体输送装置

    公开(公告)号：US08821572B2

    公开(公告)日：2014-09-02

    申请号：US12620639

    申请日：2009-11-18

    申请人： Mutlu Karakelle ,  David A. Downer ,  Sushant Muchhala

    发明人： Mutlu Karakelle ,  David A. Downer ,  Sushant Muchhala

    IPC分类号： A61F2/16

    CPC分类号： A61F2/1678 ,  A61F2/1675

    摘要： An intraocular lens (IOL) delivery device is disclosed. The device includes an intraocular lens cartridge having an internal coating wherein the coating includes a polymeric material that is compatible with a polymeric material of a material that forms the cartridge. Preferably, the polymeric material of the coating, the cartridge or both is a polyurethane material.

    摘要翻译： 公开了一种眼内透镜（IOL）输送装置。 该装置包括具有内部涂层的眼内透镜盒，其中涂层包括与形成盒的材料的聚合物材料相容的聚合物材料。 优选地，涂层的聚合材料，筒或两者都是聚氨酯材料。

    EXTENDED DEPTH OF FOCUS (EDOF) LENS TO INCREASE PSEUDO-ACCOMMODATION BY UTILIZING PUPIL DYNAMICS
    68.
    发明申请
    EXTENDED DEPTH OF FOCUS (EDOF) LENS TO INCREASE PSEUDO-ACCOMMODATION BY UTILIZING PUPIL DYNAMICS 有权
    聚焦深度（EDOF）镜头通过利用PUPIL动态增加PSEUDO-ACCOMMODATION

    公开(公告)号：US20120290085A1

    公开(公告)日：2012-11-15

    申请号：US13562143

    申请日：2012-07-30

    申请人： Xin Hong ,  Mutlu Karakelle ,  Xiaoxiao Zhang ,  Michael Simpson ,  Myoung Choi ,  Yan Zhang

    发明人： Xin Hong ,  Mutlu Karakelle ,  Xiaoxiao Zhang ,  Michael Simpson ,  Myoung Choi ,  Yan Zhang

    IPC分类号： A61F2/16

    CPC分类号： G02C7/044 ,  A61F2/1613 ,  G02C7/042

    摘要： In one aspect, the present invention provides an ophthalmic lens (e.g., an IOL) that includes an optic having an anterior surface and a posterior surface disposed about an optical axis. At least one of the surfaces (e.g., the anterior surface) has a profile characterized by superposition of a base profile and an auxiliary profile. The auxiliary profile can include an inner region, an outer region and a transition region between the inner and the outer regions, where an optical path difference across the transition region (i.e., the optical path difference between the inner and the outer radial boundaries of the transition region) corresponds to a non-integer fraction (e.g., ½) of a design wavelength (e.g., a wavelength of about 550 nm).

    摘要翻译： 一方面，本发明提供一种眼科镜片（例如，IOL），其包括具有围绕光轴设置的前表面和后表面的光学元件。 至少一个表面（例如，前表面）具有由基体轮廓和辅助轮廓叠加来表征的轮廓。 辅助轮廓可以包括内部区域，外部区域和内部区域和外部区域之间的过渡区域，其中穿过过渡区域的光程差（即，内部和外部径向边界之间的光程差） 过渡区域）对应于设计波长（例如，约550nm的波长）的非整数分数（例如，1/2）。

    Accommodative IOL with dynamic spherical aberration
    69.
    发明授权
    Accommodative IOL with dynamic spherical aberration 有权
    适应性IOL具有动态球面像差

    公开(公告)号：US07998198B2

    公开(公告)日：2011-08-16

    申请号：US12365609

    申请日：2009-02-04

    申请人： Robert Angelopoulos ,  Xin Hong ,  Xiaoxiao Zhang ,  Mutlu Karakelle

    发明人： Robert Angelopoulos ,  Xin Hong ,  Xiaoxiao Zhang ,  Mutlu Karakelle

    IPC分类号： A61F2/16

    CPC分类号： A61F2/1613 ,  A61F2/1629 ,  A61F2/1637 ,  A61F2/1648

    摘要： The present invention is generally directed to accommodative intraocular lenses (IOLs) that exhibit a dynamic spherical aberration as a function of accommodative power. By way of example, in one aspect, the present invention provides an intraocular lens (IOL) having an anterior optical element, a posterior optical element, and a mechanism for coupling the anterior and posterior elements so as to allow axial movement of those elements relative to one another for providing accommodation when the lens is implanted in a patient's eye. Each of the anterior and the posterior elements includes at least one aspherical surface, where the asphericities of the surfaces are adapted to provide a combined spherical aberration that varies with accommodation.

    摘要翻译： 本发明通常涉及作为调节功率的函数的动态球面像差的调节性眼内透镜（IOL）。 作为示例，在一个方面，本发明提供了一种具有前光学元件，后部光学元件和用于联接前部元件和后部元件的机构的眼内透镜（IOL），以允许这些元件相对于轴向移动 当镜片植入患者眼睛时，提供住宿。 前部和后部元件中的每一个包括至少一个非球面，其中表面的非球面度适于提供随调节而变化的组合球面像差。

    Correction of higher order aberrations in intraocular lenses
    70.
    发明授权
    Correction of higher order aberrations in intraocular lenses 有权
    矫正眼内透镜高阶像差

    公开(公告)号：US07879089B2

    公开(公告)日：2011-02-01

    申请号：US11435905

    申请日：2006-05-17

    申请人： Xin Hong ,  Mutlu Karakelle ,  Xiaoxiao Zhang

    发明人： Xin Hong ,  Mutlu Karakelle ,  Xiaoxiao Zhang

    IPC分类号： A61F2/16

    CPC分类号： A61F2/141 ,  A61B3/0025 ,  A61F2/1637 ,  A61F2240/001 ,  A61F2240/008

    摘要： In one aspect, the present invention provides a method of designing an intraocular lens (IOL) to address variations of at least one ocular parameter in a population of patient eyes. The method can include establishing at least one eye model in which the ocular parameter can be varied over a range exhibited by the population. The eye model can be employed to evaluate a plurality of IOL designs in correcting visual acuity for eyes in the patient population. An IOL design that provides a best fit for visual performance over at least a portion of the parameter range can then be selected.

    摘要翻译： 一方面，本发明提供一种设计眼内透镜（IOL）以解决患者眼睛中的至少一个眼睛参数的变化的方法。 该方法可以包括建立至少一个眼睛模型，其中眼睛参数可以在群体表现的范围上变化。 可以使用眼睛模型来评估多个IOL设计，以校正患者群体中的眼睛的视力。 然后可以选择提供最适合视觉性能的IOL设计，至少部分参数范围。