公开(公告)号：US5637591A

公开(公告)日：1997-06-10

申请号：US460649

申请日：1995-06-02

申请人： Mitsunori Ono ,  Y.-S. Edmond Cheng ,  Douglas F. Marks, Jr. ,  Hiroshi Kataguchi

发明人： Mitsunori Ono ,  Y.-S. Edmond Cheng ,  Douglas F. Marks, Jr. ,  Hiroshi Kataguchi

IPC分类号： C07D241/52 ,  A61C15/02 ,  A61C15/04 ,  A61K8/00 ,  A61K8/49 ,  A61K9/20 ,  A61K31/495 ,  A61K31/498 ,  A61P1/02 ,  A61P31/04 ,  A61P43/00 ,  A61Q11/00

CPC分类号： A61K31/498

摘要： Disclosed are chemical agents with unexpected antimicrobial activity against the microbes, especially Porphyromonas gingivalis, known to be important in the cause and progression of gingivitis, periodontitis, and destruction of hard and soft oral tissues leading to tooth loss. The agents have additional unexpected anticollagenase activity useful in the direct mitigation of tissue damage. The agents can be formulated to produce various compositions and dental implements useful in management of peridental diseases, particularly those involving infection with certain gram-negative anaerobes.

摘要翻译： 公开了具有针对微生物，特别是牙龈卟啉单胞菌具有意想不到的抗微生物活性的化学试剂，其已知在牙龈炎，牙周炎的起因和进展中重要，以及导致牙齿损失的硬和软口腔组织的破坏。 这些试剂具有额外的意想不到的抗胶原酶活性，可用于直接缓解组织损伤。 可以配制这些药剂以产生用于治疗意外疾病的各种组合物和牙科用具，特别是那些涉及某些革兰氏阴性厌氧菌感染的组合物和牙科用具。

公开(公告)号：US5589510A

公开(公告)日：1996-12-31

申请号：US441219

申请日：1995-05-15

申请人： Mitsunori Ono ,  Yumiko Wada ,  Yaming Wu ,  Hiroshi Kitaguchi ,  Yumiko Jimbo ,  Ryoichi Nemori ,  Stephen Gillies ,  Kin-Ming Lo

发明人： Mitsunori Ono ,  Yumiko Wada ,  Yaming Wu ,  Hiroshi Kitaguchi ,  Yumiko Jimbo ,  Ryoichi Nemori ,  Stephen Gillies ,  Kin-Ming Lo

IPC分类号： A61K9/00 ,  A61K31/185 ,  A61K31/655 ,  A61P31/12 ,  A61P31/18 ,  A61P37/04 ,  A61K31/175 ,  A61K31/10 ,  A61K31/16

CPC分类号： A61K31/185 ,  Y10S514/934

摘要： A method for inhibiting retroviral infection in a subject comprising administering to said subject a therapeutically effective amount of a naphthalenesulfonic acid compound or a pharmaceutically acceptable salt thereof, as herein defined.

摘要翻译： 一种用于抑制受试者逆转录病毒感染的方法，包括向所述受试者施用治疗有效量的如本文所定义的萘磺酸化合物或其药学上可接受的盐。

公开(公告)号：US5169635A

公开(公告)日：1992-12-08

申请号：US873678

申请日：1992-04-24

申请人： Mitsunori Ono ,  Yoshihisa Tsukada

发明人： Mitsunori Ono ,  Yoshihisa Tsukada

IPC分类号： A61K9/127 ,  C07D309/10 ,  C07F9/09 ,  C07F9/10 ,  C07H13/06

CPC分类号： C07H13/06 ,  A61K9/1271 ,  A61K9/1272 ,  C07D309/10 ,  C07F9/091 ,  C07F9/094 ,  C07F9/10 ,  Y10S436/829 ,  Y10T428/2982

摘要： A photoresponsive liposome which comprises a compound represented by the following general formula (I): ##STR1## wherein R.sub.1 is an alkyl group; R.sub.2, R.sub.3, R.sub.4 and R.sub.5, which may be the same or different, are selected from the group consisting of an alkyl group, a substituted alkyl group, an alkoxy group, a substituted alkoxy group, a halogen atom and a hydrogen atom; R.sub.6 and R.sub.7, which may be the same or different, are an alkyl group or a hydrogen atom; n is an integer of 1 to 2; and X represents a hydrophilic group, a hydrophobic group or a combination of hydrophilic and hydrophobic groups, bonded through a connecting group, provided that any of these hydrophilic and hydrophobic groups has such properties that the compound represented by the general formula (I) becomes available as a component forming the membrane of liposome.

摘要翻译： 一种光响应性脂质体，其包含由以下通式（I）表示的化合物：其中R 1为烷基; R2，R3，R4和R5可以相同或不同，选自烷基，取代的烷基，烷氧基，取代的烷氧基，卤素原子和氢原子; R6和R7可以相同或不同，是烷基或氢原子; n为1〜2的整数， 并且X表示通过连接基团键合的亲水基团，疏水基团或亲水基团和疏水基团的组合，条件是这些亲水基团和疏水基团中的任何一个具有使通式（I）表示的化合物变得可用的性质 作为形成脂质体膜的成分。

公开(公告)号：US4966607A

公开(公告)日：1990-10-30

申请号：US339014

申请日：1989-04-14

申请人： Hiroshi Shinoki ,  Mitsunori Ono

发明人： Hiroshi Shinoki ,  Mitsunori Ono

IPC分类号： C08B31/00 ,  C08B31/12 ,  C09B62/78 ,  C09B69/10 ,  D06P3/00 ,  D06P3/58

CPC分类号： C09B69/10 ,  C08B31/00 ,  C08B31/12 ,  D06P3/58

摘要： A method of producing a dyed polysaccharide which comprises linking a dye, capable of linking to amino group or imino group, to a starch derivative having a glucose derivative unit shown in a general formula [I] as a partial structure of the starch derivative. ##STR1## In the formula [I], R represents an arylene group or an alkylene group, R.sub.1, represents hydrogen atom or an alkyl group, and X and Y represent linking portions to other portions of the starch molecule, respectively.According to the method of the invention, dyed polysaccharides can readily be obtained by using a commercial reactive dye at room temperature under neutral conditions.

摘要翻译： 染色多糖的制造方法，其特征在于，将通式[I]所示的具有葡萄糖衍生物单元的淀粉衍生物与淀粉衍生物的部分结构连接，将能够与氨基或亚氨基连接的染料连接。 [I]在式[I]中，R表示亚芳基或亚烷基，R 1表示氢原子或烷基，X和Y分别表示与淀粉分子的其它部分的连接部分。 根据本发明的方法，在室温下在中性条件下使用市售的活性染料可以容易地得到染色的多糖。

公开(公告)号：US4892811A

公开(公告)日：1990-01-09

申请号：US121242

申请日：1987-11-16

申请人： Morio Yagihara ,  Mitsunori Ono ,  Akihiko Ikegawa

发明人： Morio Yagihara ,  Mitsunori Ono ,  Akihiko Ikegawa

IPC分类号： G03C7/26 ,  G03C1/06 ,  G03C1/42 ,  G03C1/43 ,  G03C7/00 ,  G03C7/305 ,  G03C7/392 ,  G03C8/12

CPC分类号： G03C1/06 ,  G03C7/39208 ,  Y10S430/156 ,  Y10S430/158 ,  Y10S430/159 ,  Y10S430/16

摘要： A silver halide photographic material which comprises a support having coated thereon a light-sensitive silver halide emulsion layer, wherein the photographic material contains a blocked photographic agent represented by the following general formula (I): ##STR1## wherein A represents a photographic agent moiety which is bonded to a blocking moiety through a hetero atom, or a precursor thereof; R.sup.1 represents a hydrogen atom or a substituent group; and Z represents atoms necessary to form a carboxylic ring or a heterocyclic ring. The blocked photographic agent is completely stable upon storage of the photographic material, and releases a photographic agent at a desired time upon processing of the photographic material. The blocked photographic agent also exhibits its function to a substantial degree over a wide range.

摘要翻译： 一种卤化银照相材料，其包含其上涂覆有感光卤化银乳剂层的载体，其中所述照相材料含有由以下通式（I）表示的封闭的感光剂：其中A表示 通过杂原子键合到封闭部分的照相剂部分或其前体; R1表示氢原子或取代基; Z表示形成羧基或杂环所需的原子。 封存的照相剂在照相材料储存时是完全稳定的，并且在照相材料处理时在期望的时间释放照相剂。 封闭的摄影剂在很宽的范围内也显示出相当程度的功能。

公开(公告)号：US4740453A

公开(公告)日：1988-04-26

申请号：US813308

申请日：1985-12-24

申请人： Koki Nakamura ,  Shigeo Hirano ,  Tadashi Ikeda ,  Keiji Mihayashi ,  Mitsunori Ono ,  Toshiro Takahashi ,  Ken-ichi Kuwabara ,  Morio Yagihara ,  Isamu Itoh

发明人： Koki Nakamura ,  Shigeo Hirano ,  Tadashi Ikeda ,  Keiji Mihayashi ,  Mitsunori Ono ,  Toshiro Takahashi ,  Ken-ichi Kuwabara ,  Morio Yagihara ,  Isamu Itoh

IPC分类号： G03C1/43 ,  G03C7/305 ,  G03C1/40 ,  G03C5/54

CPC分类号： G03C1/43 ,  G03C7/305 ,  G03C2005/168 ,  Y10S430/156 ,  Y10S430/158 ,  Y10S430/16

摘要： A silver halide photosensitive material is described, comprising a support and at least one silver halide emulsion layer, wherein said emulsion layer or another layer contains a compound represented by formula (I) ##STR1## wherein X represents an atomic group forming a redox center of benzene type having substituents by linking with C.sub.A and C.sub.B, and which does not enable Time-PUG to be released until the redox center is oxidized during development processing; EWG represents an electron withdrawing group having a Hammet's .sigma. para value exceeding 0.3; C.sub.A and C.sub.B each represents a carbon atom; R.sub.1 and R.sub.2 each represents a hydrogen atom or a suitable substituent; Time represents a timing group connecting to C.sub.B through a sulfur, nitrogen, or selenium atom thereof, t is an integer of 0 or 1, and when t=0, Time is a chemical bond; PUG represents a photographically useful group and connects to C.sub.B through a sulfur, nitrogen, or selenium atom thereof when t=0; and n is an integer of 0 or 1.

摘要翻译： 描述了卤化银感光材料，其包括载体和至少一种卤化银乳剂层，其中所述乳剂层或另一层含有由式（I）表示的化合物（I），其中X表示形成 通过与CA和CB连接而具有取代基的苯类氧化还原中心，并且不能使Time-PUG释放直到氧化还原中心在显影处理期间被氧化; EWG代表Hammet sigma值超过0.3的吸电子基团; CA和CB各自表示碳原子; R1和R2各自表示氢原子或适当的取代基; 时间表示通过其硫，氮或硒原子与CB连接的定时基团，t为0或1的整数，当t = 0时，为化学键; PUG表示当t = 0时，通过其硫，氮或硒原子连接CB; n为0或1的整数。

公开(公告)号：US4618563A

公开(公告)日：1986-10-21

申请号：US641101

申请日：1984-08-15

申请人： Mitsunori Ono ,  Isamu Itoh ,  Keiji Mihayashi

发明人： Mitsunori Ono ,  Isamu Itoh ,  Keiji Mihayashi

IPC分类号： G03C7/26 ,  C07D401/12 ,  C07D403/12 ,  C07D403/14 ,  C07D413/12 ,  C07D417/12 ,  G03C1/06 ,  G03C7/00 ,  G03C7/305 ,  G03C8/08 ,  G03C8/10 ,  G03C1/40 ,  G03C1/08 ,  G03C1/34 ,  G03C5/54

CPC分类号： G03C7/30511 ,  G03C8/10 ,  Y10S430/156 ,  Y10S430/158 ,  Y10S430/159 ,  Y10S430/16

摘要： A silver halide photographic light-sensitive material is described, comprising a support having thereon a light-sensitive silver halide emulsion layer having associated therewith a blocked photographic agent represented by formula (I) ##STR1## wherein A represents a photographically useful agent moiety, which may have a timing group; X.sup.1 and X.sup.2 each represents a carbonyl group, a sulfonyl group, or a sulfinyl group; Z represents an atomic group forming a 5-membered, 6-membered, or 7-membered ring; R.sup.1 and R.sup.2, which may be the same or different, each represents a hydrogen atom, a halogen atom, an alkyl group, an alkenyl group, a cycloalkyl group, an aryl group, an alkoxy group, an acyl group, a sulfonyl group, or a heterocyclic group; R.sup.3 represents an alkyl group, an alkenyl group, a cycloalkyl group, a heterocyclic group, an aryl group, or an aralkyl group; m represents 0, 1, or 2; n represents 0 or 1; and the total of m+n is 1, 2, or 3. The precursor of photographic agent is completely stable during the preservation of the photographic light-sensitive material and releases a photographically useful agent at a desired time during processing of the photographic light-sensitive material. The precursor can exhibit its function to a substantial degree under mild conditions, such as in a pH range of from 9 to 12.

摘要翻译： 描述了一种卤化银照相感光材料，其包括其上具有感光卤化银乳剂层的载体，其具有与式（I）表示的封闭的感光剂相关联，其中A表示摄影有用的试剂部分，其中 可能有一个时间组; X1和X2各自表示羰基，磺酰基或亚磺酰基; Z表示形成5元，6元或7元环的原子团; R 1和R 2可以相同或不同，各自表示氢原子，卤素原子，烷基，烯基，环烷基，芳基，烷氧基，酰基，磺酰基， 或杂环基; R3表示烷基，烯基，环烷基，杂环基，芳基或芳烷基; m表示0,1或2; n表示0或1; 并且m + n的总和为1,2或3.照相剂的前体在照相感光材料的保存期间是完全稳定的，并且在照相感光材料的处理期间在期望的时间释放照相用的试剂， 敏感材料。 前体可以在温和条件下，例如在9至12的pH范围内显着地发挥其功能。

公开(公告)号：US09107955B2

公开(公告)日：2015-08-18

申请号：US12692895

申请日：2010-01-25

申请人： Keizo Koya ,  Lijun Sun ,  Shoujun Chen ,  Noriaki Tatsuta ,  Yaming Wu ,  Mitsunori Ono

发明人： Keizo Koya ,  Lijun Sun ,  Shoujun Chen ,  Noriaki Tatsuta ,  Yaming Wu ,  Mitsunori Ono

IPC分类号： A61K31/16 ,  A61K31/165 ,  A61K47/48 ,  A61K31/381 ,  A61K31/277 ,  A61K31/337 ,  A61K31/44 ,  A61K31/505 ,  A61K31/53 ,  C07C327/56 ,  C07D209/42 ,  C07D209/44 ,  C07D213/83 ,  C07D261/18 ,  C07D305/14 ,  C07D307/68 ,  C07D333/38 ,  C07D333/68 ,  C07D407/12

CPC分类号： A61K47/48176 ,  A61K31/16 ,  A61K31/165 ,  A61K31/277 ,  A61K31/337 ,  A61K31/381 ,  A61K31/44 ,  A61K31/505 ,  A61K31/53 ,  A61K47/58 ,  C07C327/56 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/14 ,  C07D209/42 ,  C07D209/44 ,  C07D213/83 ,  C07D261/18 ,  C07D305/14 ,  C07D307/68 ,  C07D333/38 ,  C07D333/68 ,  C07D407/12

摘要： Disclosed is a compound represented by the Structural Formula (I): Y is a covalent bond, a phenylene group or a substituted or unsubstituted straight chained hydrocarbyl group. In addition, Y, taken together with both >C═Z groups to which it is bonded, is a substituted or unsubstituted aromatic group. Preferably, Y is a covalent bond or —C(R7R8)—. R1 and R2 are independently an aryl group or a substituted aryl group, R3 and R4 are independently —H, an aliphatic group, a substituted aliphatic group, an aryl group or a substituted aryl group. R5-R6 are independently —H, an aliphatic group, a substituted aliphatic group, an aryl group or a substituted aryl group. R7 and R8 are each independently —H, an aliphatic or substituted aliphatic group, or R7 is —H and R8 is a substituted or unsubstituted aryl group, or, R7 and R8, taken together, are a C2-C6 substituted or unsubstituted alkylene group. Z is ═O or ═S. Also disclosed are pharmaceutical compositions comprising the compound of the present invention and a pharmaceutically acceptable carrier or diluent.Also disclosed is a method of treating a subject with cancer by administering to the subject a compound of Structural Formula (I) in combination with Paclitaxel or an analog of Paclitaxel.

摘要翻译： 公开了由结构式（I）表示的化合物：Y是共价键，亚苯基或取代或未取代的直链烃基。 此外，Y与它所键合的两个> C = Z基团一起是取代或未取代的芳族基团。 优选Y为共价键或-C（R 7 R 8） - 。 R 1和R 2独立地是芳基或取代的芳基，R 3和R 4独立地是-H，脂族基团，取代的脂族基团，芳基或取代的芳基。 R5-R6独立地是-H，脂族基团，取代的脂族基团，芳基或取代的芳基。 R 7和R 8各自独立地为-H，脂族或取代的脂族基团，或者R 7为-H且R 8为取代或未取代的芳基，或者R 7和R 8一起为C 2 -C 6取代或未取代的亚烷基 。 Z为═O或═S。 还公开了包含本发明化合物和药学上可接受的载体或稀释剂的药物组合物。 还公开了通过向受试者施用结合式（I）的化合物与紫杉醇或紫杉醇的类似物组合来治疗患有癌症的受试者的方法。

公开(公告)号：US08318225B2

公开(公告)日：2012-11-27

申请号：US12901991

申请日：2010-10-11

申请人： Thomas Christian Lines ,  Mitsunori Ono

发明人： Thomas Christian Lines ,  Mitsunori Ono

IPC分类号： A23L1/302

CPC分类号： A61K31/352 ,  A23L2/02 ,  A23L33/105 ,  A23L33/15 ,  A23V2002/00 ,  A61K31/185 ,  A61K31/353 ,  A61K31/355 ,  A61K31/375 ,  A61K31/4415 ,  A61K31/445 ,  A61K31/455 ,  A61K31/51 ,  A61K31/522 ,  A61K31/525 ,  A61K31/675 ,  A61K31/7048 ,  A61K31/714 ,  A61K36/16 ,  A61K36/185 ,  A61K36/48 ,  A61K45/06 ,  A61K2300/00 ,  A23V2250/214 ,  A23V2250/2116 ,  A23V2250/2108 ,  A23V2250/7042 ,  A23V2250/7044 ,  A23V2250/7046 ,  A23V2250/704 ,  A23V2250/7052 ,  A23V2250/706 ,  A23V2250/712 ,  A23V2250/70 ,  A23V2200/322 ,  A23V2250/21168 ,  A23V2200/33 ,  A23V2200/30

摘要： This invention relates to a composition that contains quercetin, vitamin B1, vitamin B2, vitamin B3, vitamin B6, vitamin B12, vitamin C, caffeine, epigallocatechin gallate, epicatechin, epicatechin gallate, and epigallocatechin.

公开(公告)号：US08142821B2

公开(公告)日：2012-03-27

申请号：US12422146

申请日：2009-04-10

申请人： Mitsunori Ono ,  Naoto Yamaguchi ,  Keiko Yamaguchi

发明人： Mitsunori Ono ,  Naoto Yamaguchi ,  Keiko Yamaguchi

IPC分类号： A01N65/00

CPC分类号： A61K36/185

摘要： A method for preparing a xanthohumol-rich hop composition. The method includes providing a solution that contains xanthohumol-containing hop substances and effecting precipitation of non-xanthohumol hop substances by adjusting both the salt concentration and pH value of the solution. The xanthohumol-rich hop composition prepared by this method can be used for treating various diseases, e.g., skin disorders, and bacterial infection.

摘要翻译： 一种制备富含黄腐酚的啤酒花组合物的方法。 该方法包括提供含有含黄腐酚的啤酒花物质的溶液，并通过调节溶液的盐浓度和pH值来实现非黄褐酮啤酒花物质的沉淀。 通过该方法制备的富含黄腐酚酸的啤酒花组合物可用于治疗各种疾病，例如皮肤病和细菌感染。