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    Polynucleotides encoding natural killer cell enhancing factor C
    61.
    发明授权
    Polynucleotides encoding natural killer cell enhancing factor C 失效
    编码天然杀伤细胞增强因子C的多核苷酸

    公开(公告)号：US06255079B1

    公开(公告)日：2001-07-03

    申请号：US08467265

    申请日：1995-06-06

    申请人： Jian Ni ,  Guo-Liang Yu ,  Reiner Gentz ,  Craig A. Rosen

    发明人： Jian Ni ,  Guo-Liang Yu ,  Reiner Gentz ,  Craig A. Rosen

    IPC分类号： C07K1452

    CPC分类号： C07K14/52 ,  A61K38/00 ,  Y10S514/885

    摘要： A human natural killer cell enhancing factor C and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for preventing and/or treating viral infections, inflammation, neoplasia and damage from superoxide radicals. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases, for example, cancer, are also disclosed.

    摘要翻译： 公开了一种编码这种多肽的人类天然杀伤细胞增强因子C和DNA（RNA），以及通过重组技术产生此类多肽的方法。 还公开了利用这种多肽预防和/或治疗病毒感染，炎症，瘤形成和超氧自由基损伤的方法。 还公开了用于鉴定编码本发明多肽的核酸序列中的突变并用于检测用于检测疾病例如癌症的本发明多肽的改变水平的诊断测定法。

    Polynucleotides encoding human G-protein coupled receptor GPR1
    62.
    发明授权
    Polynucleotides encoding human G-protein coupled receptor GPR1 失效
    编码人G蛋白偶联受体GPR1的多核苷酸

    公开(公告)号：US6090575A

    公开(公告)日：2000-07-18

    申请号：US467947

    申请日：1995-06-06

    申请人： Yi Li ,  Liang Cao ,  Jian Ni ,  Reiner Gentz ,  Carol J. Bult ,  Granger G. Sutton, III ,  Craig A. Rosen

    发明人： Yi Li ,  Liang Cao ,  Jian Ni ,  Reiner Gentz ,  Carol J. Bult ,  Granger G. Sutton, III ,  Craig A. Rosen

    IPC分类号： A61K48/00 ,  C07K14/705 ,  C12N15/12 ,  C12N5/10 ,  C12N15/62

    CPC分类号： C07K14/705 ,  A61K48/00

    摘要： Human G-protein coupled receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the G-protein coupled receptor polypeptides, respectively. Also disclosed are diagnostic methods for detecting a mutation in the G-protein coupled receptor nucleic acid sequences and an altered level of the soluble form of the receptors.

    摘要翻译： 公开了人G-蛋白偶联受体多肽和编码此类多肽的DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了利用这些多肽来鉴定此类多肽的拮抗剂和激动剂的方法，以及分别在治疗上使用激动剂和拮抗剂治疗与G蛋白偶联受体多肽的低表达和过表达相关的病症的方法。 还公开了用于检测G蛋白偶联受体核酸序列中的突变和受体的可溶形式的改变水平的诊断方法。

    Ubiquitin conjugating enzymes 8 and 9
    64.
    发明授权
    Ubiquitin conjugating enzymes 8 and 9 失效
    泛素缀合酶8和9

    公开(公告)号：US5968797A

    公开(公告)日：1999-10-19

    申请号：US903396

    申请日：1997-07-22

    申请人： Jian Ni ,  Reiner Gentz ,  Mark D. Adams

    发明人： Jian Ni ,  Reiner Gentz ,  Mark D. Adams

    IPC分类号： A61K38/00 ,  C07K16/40 ,  C12N9/00 ,  C12N9/10 ,  C07H21/04 ,  C12N15/00

    CPC分类号： C12N9/93 ,  C07K16/40 ,  A61K38/00

    摘要： Human UCE 7, UCE 8 and UCE 9 polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods of utilizing such polypeptide for the treatment of the proliferation of malignant cells. Antagonists against such polypeptides and their uses as a therapeutic to treat Alzheimer's disease, atrophying skeletal muscle, African swine fever virus and apoptotic cell death are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in UCE 7, 8 and 9 nucleic acid sequences and the concentration of polypeptides encoded by such sequences.

    摘要翻译： 公开了人类UCE 7，UCE 8和UCE 9多肽和编码这些多肽的DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了利用这种多肽来治疗恶性细胞增殖的方法。 还公开了抗这种多肽的拮抗剂及其作为治疗性阿尔茨海默氏病，萎缩性骨骼肌，非洲猪瘟病毒和凋亡性细胞死亡的治疗剂的用途。 还公开了用于检测与UCE 7,8和9核酸序列中的突变相关的疾病的诊断测定以及由这些序列编码的多肽的浓度。

    Polynucleotides encoding cytostatin I
    65.
    发明授权
    Polynucleotides encoding cytostatin I 失效
    编码细胞抑制素I的多核苷酸

    公开(公告)号：US5658758A

    公开(公告)日：1997-08-19

    申请号：US409731

    申请日：1995-03-24

    申请人： Jian Ni ,  Reiner Gentz ,  Guo-Liang Yu ,  Craig A. Rosen

    发明人： Jian Ni ,  Reiner Gentz ,  Guo-Liang Yu ,  Craig A. Rosen

    IPC分类号： A61K38/00 ,  C07K14/475 ,  C12N15/12

    CPC分类号： C07K14/475 ,  A61K38/00

    摘要： A human cytostatin I polypeptide and DNA encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for the treatment of cancers, particularly breast cancer, leukemias, and other matastases.

    摘要翻译： 公开了人类细胞抑素I多肽和编码这种多肽的DNA以及通过重组技术产生这种多肽的方法。 还公开了利用这种多肽治疗癌症，特别是乳腺癌，白血病和其它母细胞瘤的方法。

    Ubiquitin conjugating enzymes 8 and 9
    66.
    发明授权
    Ubiquitin conjugating enzymes 8 and 9 失效
    泛素缀合酶8和9

    公开(公告)号：US5650313A

    公开(公告)日：1997-07-22

    申请号：US464342

    申请日：1995-06-05

    申请人： Jian Ni ,  Reiner Gentz ,  Mark D. Adams

    发明人： Jian Ni ,  Reiner Gentz ,  Mark D. Adams

    IPC分类号： A61K38/00 ,  C07K16/40 ,  C12N9/00 ,  C12N9/10 ,  C07H21/04 ,  C12N1/20 ,  C12P21/06

    CPC分类号： C12N9/93 ,  C07K16/40 ,  A61K38/00

    摘要： Human UCE 7, UCE 8 and UCE 9 polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods of utilizing such polypeptide for the treatment of the proliferation of malignant cells. Antagonists against such polypeptides and their uses as a therapeutic to treat Alzheimer's disease, atrophying skeletal muscle, African swine fever virus and apoptotic cell death are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in UCE 7, 8 and 9 nucleic acid sequences and the concentration of polypeptides encoded by such sequences.

    摘要翻译： 公开了人类UCE 7，UCE 8和UCE 9多肽和编码这些多肽的DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了利用这种多肽来治疗恶性细胞增殖的方法。 还公开了抗这种多肽的拮抗剂及其作为治疗性阿尔茨海默氏病，萎缩性骨骼肌，非洲猪瘟病毒和凋亡性细胞死亡的治疗剂的用途。 还公开了用于检测与UCE 7,8和9核酸序列中的突变相关的疾病的诊断测定以及由这些序列编码的多肽的浓度。

    Human TNF receptor
    67.
    发明授权
    Human TNF receptor 失效
    人类TNF受体

    公开(公告)号：US08163522B1

    公开(公告)日：2012-04-24

    申请号：US08444791

    申请日：1995-05-19

    申请人： Manfred Brockhaus ,  Reiner Gentz ,  Dembic Zlatko ,  Werner Lesslauer ,  Hansruedi Lotscher ,  Ernst-Jurgen Schlaeger

    发明人： Manfred Brockhaus ,  Reiner Gentz ,  Dembic Zlatko ,  Werner Lesslauer ,  Hansruedi Lotscher ,  Ernst-Jurgen Schlaeger

    IPC分类号： C12N15/12 ,  C12N15/63 ,  C12N5/10 ,  C12P21/00

    CPC分类号： C07K14/7151 ,  C07K16/2866 ,  C12N2799/026 ,  Y10S930/144

    摘要： The present invention is concerned with non-soluble proteins and soluble or insoluble fragments thereof, which bind TNF, in homogeneous form, as well as their physiologically compatible salts, especially those proteins having a molecular weight of about 55 or 75 kD (non-reducing SDS-PAGE conditions), a process for the isolation of such proteins, antibodies against such proteins, DNA sequences which code for non-soluble proteins and soluble or non-soluble fragments thereof, which bind TNF, as well as those which code for proteins comprising partly of a soluble fragment, which binds TNF, and partly of all domains except the first of the constant region of the heavy chain of human immunoglobulins and the recombinant proteins coded thereby as well as a process for their manufacture using transformed pro- and eukaryotic host cells.

    摘要翻译： 本发明涉及不溶性蛋白质及其可溶性或不溶性片段，其以均质形式结合TNF，以及它们的生理相容性盐，特别是分子量为约55或75kD的蛋白质（非还原型 SDS-PAGE条件），分离这些蛋白质的方法，针对这些蛋白质的抗体，编码结合TNF的不溶性蛋白质的DNA序列和可溶性或非可溶性片段，以及编码蛋白质的蛋白质 其部分包含结合TNF的可溶性片段，以及部分除了人免疫球蛋白重链的恒定区域的第一个区域以外的所有结构域，以及由此编码的重组蛋白质以及其使用转化的真核和真核生物的方法 宿主细胞。

    Human TNF receptor fusion protein
    68.
    发明授权
    Human TNF receptor fusion protein 失效
    人TNF受体融合蛋白

    公开(公告)号：US08063182B1

    公开(公告)日：2011-11-22

    申请号：US08444790

    申请日：1995-05-19

    申请人： Manfred Brockhaus ,  Reiner Gentz ,  Dembic Zlatko ,  Werner Lesslauer ,  Hansruedi Lotscher ,  Ernst-Jurgen Schlaeger

    发明人： Manfred Brockhaus ,  Reiner Gentz ,  Dembic Zlatko ,  Werner Lesslauer ,  Hansruedi Lotscher ,  Ernst-Jurgen Schlaeger

    IPC分类号： C07K14/715 ,  A61P29/00 ,  A61K38/17 ,  C07K19/00 ,  C07H21/04

    CPC分类号： C07K14/7151 ,  C07K16/2866 ,  C12N2799/026 ,  Y10S930/144

    摘要： The present invention is concerned with non-soluble proteins and soluble or insoluble fragments thereof, which bind TNF, in homogeneous form, as well as their physiologically compatible salts, especially those proteins having a molecular weight of about 55 or 75 kD (non-reducing SDS-PAGE conditions), a process for the isolation of such proteins, antibodies against such proteins, DNA sequences which code for non-soluble proteins and soluble or non-soluble fragments thereof, which bind TNF, as well as those which code for proteins comprising partly of a soluble fragment, which binds TNF, and partly of all domains except the first of the constant region of the heavy chain of human immunoglobulins and the recombinant proteins coded thereby as well as a process for their manufacture using transformed pro- and eukaryotic host cells.

    摘要翻译： 本发明涉及不溶性蛋白质及其可溶性或不溶性片段，其以均质形式结合TNF，以及它们的生理相容性盐，特别是分子量为约55或75kD的蛋白质（非还原型 SDS-PAGE条件），分离这些蛋白质的方法，针对这些蛋白质的抗体，编码结合TNF的不溶性蛋白质的DNA序列和可溶性或非可溶性片段，以及编码蛋白质的蛋白质 其部分包含结合TNF的可溶性片段，以及部分除了人免疫球蛋白重链的恒定区域的第一个区域以外的所有结构域，以及由此编码的重组蛋白质以及其使用转化的真核和真核生物的方法 宿主细胞。

    Polynucleotides encoding a human chemotactic cytokine I
    69.
    发明授权
    Polynucleotides encoding a human chemotactic cytokine I 失效
    编码人趋化因子I的多核苷酸

    公开(公告)号：US07393943B1

    公开(公告)日：2008-07-01

    申请号：US08761289

    申请日：1996-12-06

    申请人： Jian Ni ,  Guo-Liang Yu ,  Pedro Alfonso ,  Reiner Gentz ,  Jeffrey Y. Su

    发明人： Jian Ni ,  Guo-Liang Yu ,  Pedro Alfonso ,  Reiner Gentz ,  Jeffrey Y. Su

    IPC分类号： C07H21/04 ,  C12P21/06 ,  C12N1/20 ,  C12N15/00 ,  C12N5/00 ,  C12N5/02 ,  C12N15/74

    CPC分类号： C07K14/52 ,  C07H21/04

    摘要： Human chemotactic cytokine I polypeptides and DNA (RNA) encoding such chemotactic cytokines and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemotactic cytokines for the treatment of leukemia, tumors, chronic infections, auto-immune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such chemotactic cytokines and their use as a therapeutic to treat rheumatoid arthritis, auto-immune and chronic and acute inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding the chemotactic cytokines and for detecting altered levels of the polypeptide in a host.

    摘要翻译： 公开了人类趋化性细胞因子I多肽和编码这种趋化性细胞因子的DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了利用这种趋化性细胞因子治疗白血病，肿瘤，慢性感染，自身免疫疾病，纤维化病症，伤口愈合和牛皮癣的方法。 还公开了抗这种趋化性细胞因子的拮抗剂及其作为治疗类风湿性关节炎，自身免疫，慢性和急性炎性和感染性疾病，过敏反应，前列腺素不依赖性发烧和骨髓衰竭的治疗剂的用途。 还公开了用于检测与核酸序列中的突变和多肽的改变的浓度相关的疾病的诊断测定。 还公开了用于检测编码趋化性细胞因子的多核苷酸中的突变并用于检测宿主中多肽的改变水平的诊断测定。