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71 条记录 (耗时 0.039 秒)

    Metformin-Cysteine Prodrug
    65.
    发明申请
    Metformin-Cysteine Prodrug 有权
    二甲双胍半胱氨酸前药

    公开(公告)号：US20110257432A1

    公开(公告)日：2011-10-20

    申请号：US13087673

    申请日：2011-04-15

    申请人： Thomas M. DiMauro

    发明人： Thomas M. DiMauro

    IPC分类号： C07C323/58 ,  C07C323/59

    CPC分类号： C07C323/58 ,  C07C323/59 ,  C07C381/00

    摘要： A metformin-cysteine prodrug. It is believed that the prodrug of the present invention will transport in the LAT1 and LAT2 transporter system. Because the LAT1 and LAT2 transporters are important and effective transporters of amino acids in both the small intestine and colon, it is believed that the LAT-transportable prodrugs of the present invention will be effectively absorbed both in small intestine and in the colon. The increased absorption window provided by the present invention should result in highly sustained plasma concentrations of metformin, thereby increasing the effectiveness of the medication and allowing for a single daily dose.

    摘要翻译： 二甲双胍半胱氨酸前药。 据信本发明的前药将在LAT1和LAT2转运体系中运输。 因为LAT1和LAT2转运蛋白是小肠和结肠中氨基酸的重要且有效的转运蛋白，所以相信本发明的LAT可转运前体药物将被有效地吸收在小肠和结肠中。 由本发明提供的增加的吸收窗口应该导致二甲双胍的高度持续的血浆浓度，从而增加药物的有效性并允许单次日剂量。

    Device for removing deleterious charged molecules from brain tissue
    66.
    发明授权
    Device for removing deleterious charged molecules from brain tissue 有权
    从脑组织中去除有害带电分子的装置

    公开(公告)号：US08010201B2

    公开(公告)日：2011-08-30

    申请号：US12371438

    申请日：2009-02-13

    申请人： Thomas M. DiMauro

    发明人： Thomas M. DiMauro

    IPC分类号： A61N1/30

    CPC分类号： A61N1/32 ,  A61N1/306

    摘要： A system for removing charged particles from the brain in which a cannula with a distal anode, a proximal cathode and a vacuum are used. The cannula also comprises a fluid delivery port that is functionally connected to a vacuum, and holes with the distal end of the cannula. The charged species in the brain tissue are drawn to the anode that is on the distal end of the probe, when a cathode is placed on the skull of the patient and an appropriate electric field is applied between the anode and cathode. The use of a vacuum within the device to remove the destructive charged particles.

    摘要翻译： 用于从脑中去除带电粒子的系统，其中使用具有远端阳极，近端阴极和真空的套管。 套管还包括在功能上连接到真空的流体输送口和与套管远端的孔。 当阴极被放置在患者的颅骨上并且在阳极和阴极之间施加适当的电场时，脑组织中的带电物质被吸引到探针的远端上的阳极。 在设备内使用真空去​​除破坏性带电粒子。

    Cervical Motion Disc Inserter
    68.
    发明申请
    Cervical Motion Disc Inserter 有权
    颈动脉片插入器

    公开(公告)号：US20100249795A1

    公开(公告)日：2010-09-30

    申请号：US12414591

    申请日：2009-03-30

    申请人： Thomas M. DiMauro ,  Edward B. Zalenski

    发明人： Thomas M. DiMauro ,  Edward B. Zalenski

    IPC分类号： A61B17/58 ,  A61F2/44

    CPC分类号： A61F2/4611 ,  A61F2002/4622 ,  A61F2002/4624 ,  A61F2002/4628

    摘要： A novel inserter for inserting a prosthetic cervical motion disc, wherein the distal end portion of the inserter features a pair of projections that are adapted to move slidably and transversely relative to one another (like a wrench) in order to engage a prosthetic cervical motion disc.

    摘要翻译： 一种用于插入假体颈动脉盘的新型插入器，其中插入器的远端部分具有一对突起，其适于相对于彼此（如扳手）可滑动和横向移动，以便接合假体子宫颈运动盘 。