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113 条记录 (耗时 0.016 秒)

    Process for the manufacture of alkenylated hydroxylated aromatic compounds, of chroman compounds and of their acylated derivatives
    61.
    发明申请
    Process for the manufacture of alkenylated hydroxylated aromatic compounds, of chroman compounds and of their acylated derivatives 有权
    烯基化羟基化芳族化合物，色满化合物及其酰化衍生物的制备方法

    公开(公告)号：US20050171362A1

    公开(公告)日：2005-08-04

    申请号：US11005402

    申请日：2004-12-06

    申请人： Werner Bonrath ,  Yann Foricher ,  Thomas Netscher ,  Angela Wildermann

    发明人： Werner Bonrath ,  Yann Foricher ,  Thomas Netscher ,  Angela Wildermann

    IPC分类号： C07C37/11 ,  C07D311/58 ,  C07D311/72 ,  C07D311/74

    CPC分类号： C07D311/72 ,  Y02P20/582

    摘要： The present invention relates to a novel process for the manufacture of alkenylated aromatic compounds featuring at least one hydroxy group, their ring-closure reactions to chroman derivatives, as well as the acylation of the latter and the aromatic compounds featuring at least one hydroxy group themselves. The present invention relates especially to a process for the manufacture of tocol, tocopherols and their alkanoates such as α-tocopherol (TCP) and alkanoates (TCPA) thereof, preferably α-tocopheryl acetate (TCPAc). The processes of the present invention are characterized in that at least one step of the processes is carried out in the presence of an indium salt as the catalyst. Thus, an object of the present invention is the use of an indium salt as the catalyst in Friedel-Crafts alkylation reactions of aromatic compounds featuring at least one hydroxy group and ring-closure reactions of the latter to produce chroman-ring compounds in organic solvents. According to another aspect of the invention indium salts can be used as the catalyst in processes for the manufacture of tocyl alkanoates, tocopheryl alkanoates and alkanoates of aromatic compounds featuring at least one hydroxy group by reacting tocols, tocopherol and aromatic compounds featuring at least one hydroxy group, respectively, with an acylating agent. Suitable indium salts are indium(III) salts, especially indium trichloride, indium tribromide or indium triiodide, indium(III) triflate, indium(III) bis(trifluoromethanesulfonamide) and indium(III) acetate. In preferred embodiments of the invention the processes are carried out at a pressure of at least 0.96 bar, whereby the acylation can be carried out at an absolute pressure of at least 0.02 bar.

    摘要翻译： 本发明涉及一种制备具有至少一个羟基的烯基化芳族化合物的新方法，它们对苯并二氢吡喃衍生物的闭环反应以及后者的酰化反应和具有至少一个羟基的芳族化合物本身 。 本发明尤其涉及一种生产托生物，生育酚及其链烷酸酯如α-生育酚（TCP）和链烷酸酯（TCPA），优选醋酸α-生育酚酯（TCPAc）的方法。 本发明的方法的特征在于，在作为催化剂的铟盐存在下进行至少一个步骤。 因此，本发明的目的是在Friedel-Crafts烷基化反应中使用铟盐作为催化剂，其特征在于具有至少一个羟基和后者的闭环反应，在有机溶剂中产生苯并二氢吡喃酮化合物 。 根据本发明的另一方面，铟盐可以用作制备烷基链烷酸酯，生育酚基链烷酸酯和具有至少一个羟基的芳族化合物的链烷酸酯的方法，所述芳族化合物是通过使醇，生育酚和具有至少一个羟基的芳香族化合物 分别与酰化剂。 合适的铟盐是铟（III）盐，特别是三氯化铟，三溴化铟或三碘化铟，三氟甲磺酸铟（III），三（三氟甲烷磺酰胺）铟（III）和乙酸铟（III））。 在本发明的优选实施方案中，该方法在至少0.96巴的压力下进行，由此酰化可以在至少0.02巴的绝对压力下进行。

    Production of ionic liquids
    62.
    发明申请
    Production of ionic liquids 审中-公开
    离子液体的生产

    公开(公告)号：US20050005840A1

    公开(公告)日：2005-01-13

    申请号：US10497806

    申请日：2002-11-29

    申请人： Werner Bonrath ,  Jean-Marc Leveque ,  Jean-Louis Luche ,  Christian Petrier

    发明人： Werner Bonrath ,  Jean-Marc Leveque ,  Jean-Louis Luche ,  Christian Petrier

    IPC分类号： C07D233/06 ,  B01J19/10 ,  C07B61/00 ,  C07D521/00 ,  C30B1/00

    CPC分类号： C07D231/12 ,  C07D233/56 ,  C07D249/08

    摘要： A process for the manufacture of ionic liquids by an anion exchange reaction of a quaternary ammonium, phosphonium, imidazolium, or pyridinium halide, providing the appropriate cation component, with an acid or a salt thereof, providing the appropriate anion component, involves carrying out said reaction under ultrasonication. Ionic liquids belong to a known class of chemical compounds and are useful as solvents for organic syntheses; they are of particular interest in view of their capability of replacing classical solvents and avoiding the toxicological and disposal problems associated with such latter solvents.

    摘要翻译： 通过季铵，鏻，咪唑鎓或卤化吡啶鎓与提供合适的阳离子成分的阴离子交换反应制备离子液体的方法与提供合适的阴离子组分的酸或其盐包括进行所述 超声波反应。 离子液体属于已知类别的化合物，可用作有机合成的溶剂; 鉴于其替代古典溶剂的能力并避免与这种后者溶剂相关的毒理学和处置问题，它们是特别有意义的。

    Process for concentrating epigallocatechin gallate
    63.
    发明授权
    Process for concentrating epigallocatechin gallate 有权
    浓缩表没食子儿茶素没食子酸酯的方法

    公开(公告)号：US06383392B1

    公开(公告)日：2002-05-07

    申请号：US09709123

    申请日：2000-11-08

    申请人： Werner Bonrath ,  David Carl Burdick ,  Peter Schirg ,  Andreas Thum

    发明人： Werner Bonrath ,  David Carl Burdick ,  Peter Schirg ,  Andreas Thum

    IPC分类号： B01D6100

    CPC分类号： C07D311/62

    摘要： The present invention is a process for concentrating aqueous epigallocatechin gallate (EGCG) solutions by feeding an aqueous EGCG solution to at least one membrane module under pressure to provide a permeate purge and a retentate return so that in the latter the concentration of EGCG is increased. The permeate purge and the retentate return are then collected.

    摘要翻译： 本发明是一种通过在压力下将EGCG水溶液加入至少一个膜组件来浓缩表没食子儿茶素没食子酸酯水溶液（EGCG）溶液的方法，以提供渗透物清除和滞留物返回，使得在后者中EGCG的浓度增加。 然后收集渗透物吹扫和滞留物返回。

    Process for the manufacture of 5-cyano-4-lower alkyl-oxazoles
    64.
    发明授权
    Process for the manufacture of 5-cyano-4-lower alkyl-oxazoles 失效
    制备5-氰基-4-低级烷基 - 恶唑的方法

    公开(公告)号：US5910594A

    公开(公告)日：1999-06-08

    申请号：US8793

    申请日：1998-01-20

    申请人： Klaus Behringer ,  Werner Bonrath ,  Horst Pauling

    发明人： Klaus Behringer ,  Werner Bonrath ,  Horst Pauling

    IPC分类号： B01J31/02 ,  C07B61/00 ,  C07D263/34 ,  C07D263/30 ,  C07D263/36 ,  C07D263/44

    CPC分类号： C07D263/34

    摘要： A process for the manufacture of a 5-cyano-4-lower alkyl-oxazole by the dehydration of a 5-carbamoyl-4-lower alkyl-oxazole is disclosed. The reaction is carried out by dehydrating the oxazole with silicon tetrachloride in the presence of an amine in an aprotic organic solvent. 5-Carbamoyl-4-methyl-oxazole may be dehydrated by the process in accordance with the invention to obtain 5-cyano-4-methyl-oxazole, which is a valuable intermediate in the synthesis of pyridoxine.

    摘要翻译： 公开了通过5-氨基甲酰基-4-低级烷基 - 恶唑脱水制备5-氰基-4-低级烷基恶唑的方法。 该反应通过在胺存在下在四氢呋喃中在非质子有机溶剂中脱水来进行。 5-氨基甲酰基-4-甲基恶唑可以通过本发明的方法脱水得到5-氰基-4-甲基恶唑，它是合成吡哆醇的有价值的中间体。

    Manufacture of gamma-delta-unsaturated ketones
    67.
    发明授权
    Manufacture of gamma-delta-unsaturated ketones 有权
    制造γ-δ-不饱和酮

    公开(公告)号：US08664450B2

    公开(公告)日：2014-03-04

    申请号：US13125083

    申请日：2009-09-28

    申请人： Fabrice Aquino ,  Werner Bonrath ,  Rolf Kuenzi

    发明人： Fabrice Aquino ,  Werner Bonrath ,  Rolf Kuenzi

    IPC分类号： C07C49/20

    CPC分类号： C07C45/511 ,  C07C49/203

    摘要： A process for the manufacture of gamma-delta-unsaturated ketones of formula (R1)(R2)C═CH—CH2—CH2—CO—R3 (I), wherein R1 is methyl or ethyl; R2 is a saturated or unsaturated linear or cyclic hydrocarbon residue and R3 is methyl or ethyl, by reacting a tertiary vinyl carbinol of formula (R1)(R2)C(OH)—CH═CH2 (II) with an isopropenyl methyl or ethyl ether of formula H3C—C(OR3)═CH2 (III) in the pre-sence of an ammonium salt as catalyst.

    摘要翻译： 制备式（R1）（R2）C = CH-CH2-CH2-CO-R3（Ⅰ）的γ-δ-不饱和酮的方法，其中R1是甲基或乙基; 通过使式（R1）（R2）C（OH）-CH = CH2（II）的叔乙烯基甲醇与异丙烯基甲基或乙基醚反应，R2是饱和或不饱和的直链或环状烃残基，R3是甲基或乙基 的式IIIC-C（OR3）= CH2（Ⅲ）的铵盐作为催化剂。