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112 条记录 (耗时 0.078 秒)

    Cyclised alpha-conotoxin peptides
    61.
    发明授权
    Cyclised alpha-conotoxin peptides 有权
    循环α-芋螺毒素肽

    公开(公告)号：US08354372B2

    公开(公告)日：2013-01-15

    申请号：US12297110

    申请日：2007-04-03

    申请人： Richard Clark ,  David James Craik

    发明人： Richard Clark ,  David James Craik

    IPC分类号： A61K38/00 ,  A61K38/16 ,  A61K38/12 ,  C07K5/00 ,  C07K7/00 ,  C07K16/00 ,  C07K17/00

    CPC分类号： A61K38/17 ,  A61K38/12

    摘要： This invention relates to an oral or enteral pharmaceutical preparation comprising at least one synthetically cyclised alpha-conotoxin peptide having an amide cyclised backbone such that the peptide has no free N- or C-terminus, said peptide having the ability to inhibit a nicotinic acetylcholine receptor and comprising four cysteine residues bonded in pairs to form two disulfide bonds, wherein the N-terminus of the corresponding linear/non-cyclised conotoxin peptide is linked to the C-terminus by a peptide linker, in a vehicle which is pharmaceutically suitable for oral or enteral administration.

    摘要翻译： 本发明涉及口服或肠内药物制剂，其包含至少一种具有酰胺环化主链的合成环化的α-芋螺毒素肽，使得肽不具有游离的N-或C-末端，所述肽具有抑制烟碱乙酰胆碱受体的能力 并且包含成对结合以形成两个二硫键的四个半胱氨酸残基，其中相应的线性/非环化的芋螺毒素肽的N-末端通过肽接头在C末端连接，其药学上适用于口服 或肠内管理。

    CYCLISED ALPHA-CONOTOXIN PEPTIDES
    67.
    发明申请
    CYCLISED ALPHA-CONOTOXIN PEPTIDES 有权

    公开(公告)号：US20100120670A1

    公开(公告)日：2010-05-13

    申请号：US12297110

    申请日：2007-04-03

    申请人： Richard Clark ,  David James Craik

    发明人： Richard Clark ,  David James Craik

    IPC分类号： A61K38/12 ,  C07K7/50 ,  A61P25/00 ,  A61P9/00

    CPC分类号： A61K38/17 ,  A61K38/12

    摘要： This invention relates to an oral or enteral pharmaceutical preparation comprising at least one synthetically cyclised alpha-conotoxin peptide having an amide cyclised backbone such that the peptide has no free N- or C-terminus, said peptide having the ability to inhibit a nicotinic acetylcholine receptor and comprising four cysteine residues bonded in pairs to form two disulfide bonds, wherein the N-terminus of the corresponding linear/non-cyclised conotoxin peptide is linked to the C-terminus by a peptide linker, in a vehicle which is pharmaceutically suitable for oral or enteral administration.

    摘要翻译： 本发明涉及口服或肠内药物制剂，其包含至少一种具有酰胺环化主链的合成环化的α-芋螺毒素肽，使得肽不具有游离的N-或C-末端，所述肽具有抑制烟碱乙酰胆碱受体的能力 并且包含成对结合以形成两个二硫键的四个半胱氨酸残基，其中相应的线性/非环化的芋螺毒素肽的N-末端通过肽接头在C末端连接，其药学上适用于口服 或肠内管理。

    Method and system for reporting cashflows to clients
    68.
    发明授权
    Method and system for reporting cashflows to clients 有权
    向客户报告现金流量的方法和系统

    公开(公告)号：US07693784B2

    公开(公告)日：2010-04-06

    申请号：US11514206

    申请日：2006-09-01

    申请人： Serge Rivest ,  Michael King ,  Richard Clark

    发明人： Serge Rivest ,  Michael King ,  Richard Clark

    IPC分类号： G06Q40/00

    CPC分类号： G06Q40/06 ,  G06Q20/10 ,  G06Q20/102 ,  G06Q30/08 ,  G06Q40/00 ,  G06Q40/02 ,  G06Q40/025

    摘要： A system and method of providing a client with cashflow monitoring during a transfer of services (e.g. pre-authorized debits and credits) from a first account to a second account, the method comprising the steps of: (i) determining an effective date for the transfer of each service, said effective dates creating a transfer window; (ii) determining cashflows for said first account and said second account during said transfer window; (iii) adjusting effective dates for transfer of each services to avoid cashflow interruptions in said first and said second accounts; and (iv) providing a cashflow analysis to the client that lists all the effective dates for each service transfer and predicted cashflows for said first and said second account during said transfer window.

    摘要翻译： 一种在从第一帐户转移到第二帐户的服务转移（例如预授权借记和信用）期间向客户提供现金流监视的系统和方法，所述方法包括以下步骤：（i）确定所述客户端的生效日期 传输每个服务，表示生效日期创建一个转移窗口; （ii）在所述传送窗口期间确定所述第一帐户和所述第二帐户的现金流; （iii）调整每个服务的转移的生效日期以避免所述第一和第二帐户中的现金流中断; 以及（iv）向所述客户提供现金流分析，列出在所述转移窗口期间所述第一帐户和所述第二账户的每个服务转移的所有生效日期和所述预测的现金流。

    Cyclic compound and PPAR agonist
    70.
    发明授权
    Cyclic compound and PPAR agonist 失效
    环状化合物和PPAR激动剂

    公开(公告)号：US07371777B2

    公开(公告)日：2008-05-13

    申请号：US10486396

    申请日：2002-08-16

    申请人： Richard Clark ,  Fumiyoshi Matsuura ,  Eita Emori ,  Masanobu Shinoda ,  Shunji Kasai ,  Hideki Yoshitomi ,  Kazuto Yamazaki ,  Takashi Inoue ,  Sadakazu Miyashita ,  Taro Hihara

    发明人： Richard Clark ,  Fumiyoshi Matsuura ,  Eita Emori ,  Masanobu Shinoda ,  Shunji Kasai ,  Hideki Yoshitomi ,  Kazuto Yamazaki ,  Takashi Inoue ,  Sadakazu Miyashita ,  Taro Hihara

    IPC分类号： A61K31/341 ,  C07D307/04

    CPC分类号： C07D213/53 ,  C07C233/87 ,  C07C251/60 ,  C07C2601/02 ,  C07C2601/14 ,  C07D263/32 ,  C07D277/56 ,  C07D307/24 ,  C07D307/30 ,  C07D317/32 ,  C07D339/08 ,  C07D405/06 ,  C07D405/12 ,  C07D407/12 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14

    摘要： The present invention provides a novel compound having an excellent PPAR agonist action. More specifically, it provides a compound represented by the following formula, a salt thereof, an ester thereof or a hydrate of them. Wherein a, b and c are the same as or different from one another and each represents 0 to 4; R1 to R6 are the same as or different from one another and each represents a hydrogen atom, a hydroxyl group, a cyano group, a halogen atom, etc.; A1 and A2 are the same as or different from each other and each represents a single bond, an oxygen atom, etc.; L, M and T each represent a single bond, an alkylene group having one to six carbon atoms, etc.; W represents a carboxyl group; the partial structure represented by the formula: represents a single bond or a double bond; X represents a single bond, an oxygen atom, —NRx1CQ1O—, etc.; Y represents Y1—Y2— (wherein Y1 represents a 5 to 14-membered aromatic ring having one to four substituents, etc.; and Y2 represents a single bond or a 5 to 14-membered aromatic ring); and the ring Z represents a 5 to 14-membered aromatic ring which have one to four substituents selected form the above-mentioned Group A, may have one or more hetero atoms and may be partially saturated.

    摘要翻译： 本发明提供具有优异的PPAR激动剂作用的新化合物。 更具体地，它提供由下式表示的化合物，其盐，其酯或它们的水合物。 其中a，b和c彼此相同或不同，各自表示0〜4; R 1至R 6彼此相同或不同，并且各自表示氢原子，羟基，氰基，卤素原子等; A＆lt; 1＆gt;和＆lt; 2＆gt;相同或不同，各自表示单键，氧原子等; L，M和T各自表示单键，具有1〜6个碳原子的亚烷基等; W表示羧基; 由式表示的部分结构表示单键或双键; X表示单键，氧原子，-O- O 1等。 Y表示Y 1 -Y 2 - （其中Y 1表示具有1〜4个取代基的5〜14元芳香环等。 ; Y 2代表单键或5至14元芳环）; 并且环Z表示具有一至四个选自上述A组的取代基的5至14元芳环，可具有一个或多个杂原子并且可部分饱和。