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    POLYMERIC TISSUE SEALANT
    61.
    发明申请
    POLYMERIC TISSUE SEALANT 有权
    聚合组织密封剂

    公开(公告)号：US20080253987A1

    公开(公告)日：2008-10-16

    申请号：US12102157

    申请日：2008-04-14

    申请人： Annemie Rehor ,  Simona Cerritelli

    发明人： Annemie Rehor ,  Simona Cerritelli

    IPC分类号： A61K31/765 ,  C08L71/00 ,  A61P41/00

    CPC分类号： A61L24/046 ,  A61K47/34 ,  A61L24/0042 ,  A61L31/06 ,  A61L2400/04 ,  C08G63/00 ,  C08G65/3322 ,  C08G65/33306 ,  C08G65/3342 ,  C08G2650/58 ,  C08L71/02 ,  C08L2666/22

    摘要： Methods for making biomaterials for use as a tissue sealant, kits containing precursors for forming the biomaterials, and the resulting biomaterials are described herein. The biomaterials are formed from a composition comprising at least a first and a second precursor molecule, wherein: i) the first precursor molecule is a poly(ethylene glycol) based polymer having x nucleophilic groups selected from the group consisting of thiol or amino groups, wherein x is greater than or equal to 2 ii) the second precursor molecule is of the general formula: A-[(C3H6O)n—(C2H4O)m—B]i wherein m and n are integers from 1 to 200 i is greater than 2 A is a branch point B is a conjugated unsaturated group The precursors are selected based on the desired properties of the biomaterial. Optionally, the biomaterials contain additives, such as thixotropic agents, radiopaque agents, or bioactive agents. In the preferred embodiment, the biomaterials are used to reduce, inhibit, or contain loss of a biological fluid or gas in a patient.

    摘要翻译： 用于制备用作组织密封剂的生物材料的方法，包含用于形成生物材料的前体的试剂盒以及所得生物材料在本文中描述。 生物材料由包含至少第一和第二前体分子的组合物形成，其中：i）第一前体分子是具有选自硫醇或氨基的x个亲核基团的聚（乙二醇）基聚合物， 其中x大于或等于2 ii）第二前体分子具有以下通式：<？in-line-formula description =“In-line formula”end =“lead”？> A - [（C

    Ionic polyethers, process for preparing them and compositions in which they are present
    64.
    发明授权
    Ionic polyethers, process for preparing them and compositions in which they are present 失效
    离子聚醚，其制备方法和它们存在的组合物

    公开(公告)号：US4971789A

    公开(公告)日：1990-11-20

    申请号：US678405

    申请日：1984-12-05

    申请人： Guy Vanlerberghe ,  Henri Sebag

    发明人： Guy Vanlerberghe ,  Henri Sebag

    IPC分类号： C08L71/02 ,  A61K8/00 ,  A61K8/06 ,  A61K8/34 ,  A61K8/64 ,  A61K8/72 ,  A61K8/86 ,  A61K9/08 ,  A61K31/573 ,  A61K31/765 ,  A61K47/00 ,  A61K47/12 ,  A61K47/18 ,  A61K47/20 ,  A61K47/30 ,  A61K47/34 ,  A61Q5/02 ,  A61Q5/06 ,  A61Q5/10 ,  A61Q5/12 ,  C07C323/25 ,  C07C323/52 ,  C08G65/28 ,  C08G65/32 ,  C08G65/334 ,  C08G75/12 ,  C08L71/00 ,  C11D1/00 ,  D06M15/53 ,  D06M101/12 ,  D06P1/60

    CPC分类号： A61Q5/065 ,  A61K47/186 ,  A61K47/20 ,  A61K8/86 ,  A61K9/0014 ,  A61Q5/02 ,  A61Q5/10 ,  C07C323/00 ,  C08G65/3342

    摘要： Mixture of ionic polyethers of formula: ##STR1## where R denotes C.sub.1 -C.sub.20 alkyl or alkenyl or C.sub.6 14 C.sub.20 aryl or aralkyl;z=1 or 2; y=3-20; T=0 or S; u=0 or 1; m=3-11;n=0-11;n.noteq.0 when u=1 and m+n.gtoreq.4; B=OH or A; A is an ionic group --COOM; --(CH.sub.2).sub.u --S--(W)COOH (with W=--CH.sub.2 --, --CH.sub.2 --CH.sub.2 -- or --CH(CH.sub.3)-- and u'=u); --CH.sub.2 --O--S).sub.3 M, (M being an alkali metal or an ammonium ion optionally substituted by methyl, ethyl, hydroxyethyl, hydroxypropyol, methylhydroxypropyl or methyldihydroxypropyl); ##STR2## (where R.sub.1, R.sub.2 and R.sub.3 denotes methyl, ethyl, hydroxyethyl or dihydroxypropyl, R.sub.1 and R.sub.2 being capable of forming with N an amino or ammonio heterocyclic ring, HV is an inorganic or organic acid and Q- is an anion); ##STR3## HV (with R.sub.4 =methyl or ethyl and x=2 or 3) ##STR4## with the provision that when T=0 and u=0, A denotes only (b); and process for preparing them.The new polyethers can be employed in cosmetics, pharmacy and the textile industry as a result of their good solubilising and stabilising capacity.

    摘要翻译： 式（I）的离子聚醚的混合物，其中R表示C1-C20烷基或烯基或C614 C20芳基或芳烷基; z = 1或2; y = 3-20; T = 0或S; u = 0或1; m = 3-11; n = 0-11; n当u = 1和m + n> / = 4时，NOTEQUAL 0; B = OH或A; A是离子基团-COOM; - （CH 2）u -S-（W）COOH（其中W = -CH 2 - ， - CH 2 -CH 2 - 或-CH（CH 3） - 和u'= u）; -CH 2 -O-S）3M，（M是任选被甲基，乙基，羟基乙基，羟基丙基羟基，甲基羟丙基或甲基二羟基丙基取代的碱金属或铵离子）; （其中R1，R2和R3表示甲基，乙基，羟乙基或二羟基丙基，R1和R2能够与N形成氨基或铵杂环，HV是无机或有机酸，Q- 是阴离子）; （图中，R4 =甲基或乙基，x = 2或3） ，条件是当T = 0和u = 0时，A仅表示（b）; 及其准备过程。 新的聚醚可以用于化妆品，药​​学和纺织工业，因为它们具有良好的增溶和稳定能力。

    Process for the production and purification of SH-terminated prepolymers and use thereof
    65.
    发明授权
    Process for the production and purification of SH-terminated prepolymers and use thereof 失效
    用于生产和纯化SH-封端的预聚物的方法及其用途

    公开(公告)号：US4861863A

    公开(公告)日：1989-08-29

    申请号：US115225

    申请日：1987-10-30

    申请人： Rene-Andres A. Gonzalez ,  Winfried Emmerling ,  Werner Krause ,  Tore Podola ,  Klaus Neitzer

    发明人： Rene-Andres A. Gonzalez ,  Winfried Emmerling ,  Werner Krause ,  Tore Podola ,  Klaus Neitzer

    IPC分类号： C09K3/10 ,  C07C67/00 ,  C07C313/00 ,  C07C319/12 ,  C07C323/52 ,  C08G59/00 ,  C08G59/40 ,  C08G59/66 ,  C08G65/26 ,  C08G65/30 ,  C08G65/32 ,  C08G65/334 ,  C08L63/00

    CPC分类号： C08G65/3342 ,  C08G65/2609 ,  C08G65/30

    摘要： Process for the production and purification of SH-terminated prepolymers by reaction of polyhydroxy compounds with thioalkane carboxylic acids, wherein one or more adducts of ethylene oxide and/or propylene oxide with triols or tetraols corresponding to the following general formula ##STR1## in which m=1, 2 or 3,n=0, 1 or 2 andp=0 or 1,and having a molecular weight of from 400 to 10,000 are reacted with one or more thioalkane carboxylic acids corresponding to the following general formulaHS--R--COOH (II)in which R is a straight-chain or branched C.sub.1 -C.sub.8 alkylene radical, in such a molar ratio that, for every mole of thioalkane carboxylic acid (II), there is an equivalent of the OH groups in compound (I), a neutralizing agent is added to the reaction mixture in a quantity sufficient to neutralize the unreacted quantity of thioalkane carboxylic acid (II), one or more compounds which bind the water of neutralization and a precipitant in excess are added at the same time as or immediately after the neutralizing agent, the reaction mixture is freed in known manner from the precipitated solids and, if desired, the prepolymer is isolated.

    摘要翻译： 通过多羟基化合物与硫代烷基羧酸的反应来生产和纯化SH封端的预聚物的方法，其中环氧乙烷和/或环氧丙烷与三醇或四醇的一种或多种加合物对应于下列通式（I） 其中m = 1,2或3，n = 0,1或2和p = 0或1，并且分子量为400至10,000与一种或多种对应于下列通式HS的硫醇酸羧酸反应 -R-COOH（II），其中R是直链或支链的C 1 -C 8亚烷基，摩尔比使得对于每摩尔硫代烷基羧酸（II），存在等同的OH基团 化合物（I）中，以足以中和未反应量的硫代烷基羧酸（II）的量加入到反应混合物中，将一种或多种与中和水结合的化合物和过量的沉淀剂加入到 同时或立即 在中和剂之后，以已知方式从沉淀的固体中除去反应混合物，如果需要，分离预聚物。

    Polyethers having oxidized thioether side chains
    67.
    发明授权
    Polyethers having oxidized thioether side chains 失效
    具有氧化的三面体链的聚合物

    公开(公告)号：US4001310A

    公开(公告)日：1977-01-04

    申请号：US613150

    申请日：1975-09-15

    申请人： Hugh A. Farber

    发明人： Hugh A. Farber

    IPC分类号： C08G65/24 ,  C08G65/334 ,  C07C87/30

    CPC分类号： C08G65/24 ,  C08G65/3342 ,  C08G65/3348

    摘要： Polyethers having utility as adhesion promoters for various polymers to metals and other substrates comprise repeating monomer units represented by the general formula: ##STR1## wherein Z is --CH=CR.sub.1 R.sub.2, or ##STR2## wherein G is hydroxyl, halogen or amine, R.sub.1 and R.sub.2 are individually hydrogen or a monovalent organic radical and e is 1 or 2. Exemplary of Z are --C=CH.sub.2 ##STR3##

    Chromate curable sealant compositions
    70.
    发明授权
    Chromate curable sealant compositions 失效
    铬酸盐可固化密封剂组合物

    公开(公告)号：US3849381A

    公开(公告)日：1974-11-19

    申请号：US31551172

    申请日：1972-12-15

    申请人： PHILLIPS PETROLEUM CO

    发明人： DOSS R ,  GINGERICH L

    IPC分类号： C08G65/334 ,  C08G75/14 ,  C08L31/04 ,  C08L81/04 ,  C08G39/08 ,  C08G43/00

    CPC分类号： C08L81/04 ,  C08G65/3342 ,  C08G75/14 ,  C08L31/04

    摘要： 1. A COMPOSITION CURABLE TO A SEALANT COMPRISING (A) A POLY(OXYALKYLENE) - POLYESTER - POLY(MONOSULFIDE)-POLYTHIOL HAVING AN AVERAGE OF MORE THAN TWO MERCAPTO GROUPS PER MOLECULE AND (B) A CHROMATE SELECTED FROM THE GROUP CONSISTING OF AMMONIUM AND ALKALI METAL MONOCHROMATES, DICHROMATES, TRICHROMATES AND TETRACHROMATES IN AN AMOUNT SUFFICIENT TO CONVERT AT LEAST ABOUT 70 PERCENT OF THE PENDANT THIOL GROUPS TO POLYSULFIDE GROUPS AND THUS FORM A SEALANT, SAID (A) BEING THE ACIDIC, UNNEUTRALIZED POLYMERIC REACTION PRODUCT OF AT LEAST ONE MERCAPTOALKANOIC ACID, AT LEAST ONE THIODIALKANOIC ACID, AND AT LEAST ONE POLY(OXYALKYLENE)-POLYOL HAVING AN AVERAGE OF MORE THAN TWO HYDROXY GROUPS PER MOLECULE.