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403 条记录 (耗时 0.022 秒)

    Polymer encapsulation of hydrophobic materials
    61.
    发明授权
    Polymer encapsulation of hydrophobic materials 失效
    疏水材料的聚合物封装

    公开(公告)号：US06365146B1

    公开(公告)日：2002-04-02

    申请号：US09298729

    申请日：1999-04-23

    申请人： Kathryn E. Uhrich

    发明人： Kathryn E. Uhrich

    IPC分类号： A61K3174

    CPC分类号： C08G83/005 ,  A61K9/1075 ,  A61K9/127 ,  A61K9/5146 ,  C08L71/02

    摘要： Polymers are provided having a structure selected from: R(—O—R1,)x and R(—NH—R1)x wherein R(—O—)x is a polyol moiety and R(—NH—)x is a polyamine moiety, with the x being between 2 and 10, inclusive, and each R1 independently has the structure: wherein a divalent amino acid moiety with R2 being a covalent bond or having from 1 to 8 carbon atoms, and y and z are between 0 and 10, inclusive, provided that y and z are not both 0; is a divalent dicarboxylic acid moiety in which R3 is an alkylene or cyclolkylene group containing from 1 to about 15 carbon atoms substituted with a total of from 1 to about 10 hydroxyl groups, with at least a portion of the hydroxyl groups being acylated with 3 to 24 carbon atom carboxylic acids; and R4 is a poly(alkylene oxide) having the structure: R5—(R6—O—)a—R6—Q— with R5 selected from 1 to 40 carbon atom alkyl groups, —OH—, —OR7, —NH—, —NHR7, —NR7R8, —C—OH, —C—OR7, —C—O—C—R7, —C-NH2, —C—NHR7 and —C—NHR7R8; R6, R7 and R8 are independently selected from 2 to 40 carbon atom, straight-chain or branched alkylene groups; Q is a divalent linkage moiety; and a is between 2 and 110, inclusive. Polymer encapsulates of hydrophobic molecules are also disclosed, including pharmaceutical dosage forms containing the encapsulates in which the hydrophobic molecule has biological or pharmaceutical activity, as well as transdermal delivery devices. Methods of treating patients with the pharmaceutical dosage forms are also disclosed.

    摘要翻译： 提供具有选自以下结构的聚合物：其中R（-O-）x是多元醇部分，R（-NH-）x是多胺部分，x在2和10之间，并且每个R 1独立地具有 结构：其中具有R2是共价键或具有1至8个碳原子的二价氨基酸部分，y和z在0和10之间，包括端值，y和z不为0;是二价二羧酸 部分，其中R3是含有1至约15个碳原子的亚烷基或环烯基，其总共具有1至约10个羟基，其中至少一部分羟基被3至24个碳原子的羧酸酰化 ; 和R 4是具有以下结构的聚（烯化氧）：其中R 5选自1至40个碳原子烷基，-OH - ， - OR 7，-NH-，-NHR 7，-NR 7 R 8，-C-OH，-C-OR 7 ，-COC-R7，-C-NH2，-C-NHR7和-C-NHR7R8; R6，R7和R8独立地选自2至40个碳原子，直链或支链亚烷基; Q是二价连接部分; a为2至110（含）。 还公开了疏水性分子的聚合物包封物，包括含有疏水性分子具有生物或药学活性的包封物的药物剂型，以及透皮递送装置。 还公开了用药物剂型治疗患者的方法。

    Polymers with fractal structure
    62.
    发明授权
    Polymers with fractal structure 失效
    具有分形结构的聚合物

    公开(公告)号：US6001889A

    公开(公告)日：1999-12-14

    申请号：US29587

    申请日：1998-03-04

    申请人： Michel S. M. Lefebvre

    发明人： Michel S. M. Lefebvre

    IPC分类号： C08F2/00 ,  C08G83/00 ,  C08J3/09 ,  C08J3/12 ,  C08J5/00 ,  C08S9/00

    CPC分类号： C08G83/005 ,  C08G83/002 ,  C08J3/091 ,  C08J5/00

    摘要： A polymer having a fractal configuration of structure which is self-similar or is scale invariant at different scales. As a consequence of their fractal configuration, such polymers have superior properties as an interstitial material for the adsorption of substances, and are useful as an additive or adjunct to ion exchange, filtration and membrane separation of compounds.

    摘要翻译： PCT No.PCT / AU96 / 00550 Sec。 371日期：1998年3月4日 102（e）1998年3月4日PCT PCT 1996年9月4日PCT公布。 公开号WO97 / 09352 日期1997年3月13日具有分形结构的聚合物是自相似的或在不同尺度上是尺度不变的。 作为其分形构型的结果，这种聚合物具有作为用于吸附物质的间隙材料的优异性质，并且可用作化合物的离子交换，过滤和膜分离的添加剂或辅助剂。

    Polymerizable macromonomers and polymers prepared therefrom
    64.
    发明授权
    Polymerizable macromonomers and polymers prepared therefrom 失效
    可聚合的大分子单体和由其制备的聚合物

    公开(公告)号：US5830948A

    公开(公告)日：1998-11-03

    申请号：US810465

    申请日：1997-02-28

    申请人： Jean J.M. Frechet ,  Koji Yui

    发明人： Jean J.M. Frechet ,  Koji Yui

    IPC分类号： A61K47/48 ,  C08F290/06 ,  C08G73/02 ,  C08G73/04 ,  C08G83/00 ,  C08L79/04 ,  C08G73/06

    CPC分类号： C08G83/005 ,  A61K47/48207 ,  C08F290/06 ,  C08G73/0233

    摘要： Polyoxazolines having the structural formula: ##STR1## wherein R is phenylene or alkylene containing 2 to 18 carbon atoms, R.sup.2 is C.sub.1-4 alkyl and R.sub.1 is selected from the group consisting of C.sub.1-12 alkyl, vinyl, isopropylidene, pentafluoroethyl, phenyl, hydroxyphenyl which is optionally interrupted by up to 20 ethylene oxide groups, C.sub.1-2 -alkoxyphenyl which is optionally interrupted by up to 20 ethylene oxide groups and .paren open-st.CH.sub.2 CH.sub.2 --O.paren close-st..sub.r CH.sub.3 in which r ranges from 1-20, X is NH.sub.2 or OH, n ranges from 2 to 50 and m ranges from 0 to 50, wherein R.sub.1 is hydroxyphenyl optionally interrupted by up to 20 ethylene oxide groups only when X is NH.sub.2, are polymerizable to form hyperbranched polymers which have a number average molecular weight ranging from 5,000 to 150,000, a weight average molecular weight ranging from 5,500 to 5,000,000 and a polydispersity ranging from 1.1 to 300 and which are very polar and highly wettable and are useful as adhesives, biodegradable materials, biomaterials, carriers for chemicals, carriers for image contrast agents, coatings, components of blends, components of medical imaging formulations, crosslinkers, dispersants, drug carriers, imaging materials, resists for lighography, slow release agents, vectors for gene therapy, and viscosity modifiers.

    摘要翻译： 具有以下结构式的聚恶唑啉：其中R是亚苯基或含2至18个碳原子的亚烷基，R 2是C 1-4烷基，R 1选自C 1-12烷基，乙烯基，异亚丙基，五氟乙基 ，任选地被多达20个环氧乙烷基团间隔的苯基，羟基苯基，任选地被多达20个环氧乙烷基团间隔的C 1-2 - 烷氧基苯基和+545个CH 2 CH 2 -O + 546 rCH 3，其中r在1-20， X为NH 2或OH，n为2至50，m为0至50，其中R 1为仅在X为NH 2时任选地被至多20个环氧乙烷基团间隔的羟基苯基，可聚合形成数均分子量的超支化聚合物 分子量为5,000至150,000，重均分子量为5,500至5,000,000，多分散性为1.1至300，非极性和高度可湿性，可用作粘合剂，可生物降解材料，生物材料，载体 用于化学品，图像造影剂的载体，涂料，共混物组分，医学成像制剂的组分，交联剂，分散剂，药物载体，成像材料，用于光刻的抗蚀剂，缓释剂，用于基因治疗的载体和粘度调节剂。

    Hyperbranched macromolecule from epoxide nucleus and hydroxy-functional carboxylic acid chain extenders
    65.
    发明授权
    Hyperbranched macromolecule from epoxide nucleus and hydroxy-functional carboxylic acid chain extenders 失效
    来自环氧化物核的超支化大分子和羟基官能的羧酸增链剂

    公开(公告)号：US5663247A

    公开(公告)日：1997-09-02

    申请号：US547447

    申请日：1995-10-24

    申请人： Kent Sorensen ,  Bo Pettersson

    发明人： Kent Sorensen ,  Bo Pettersson

    IPC分类号： A61K6/08 ,  C08G20060101 ,  C08G18/42 ,  C08G59/14 ,  C08G63/20 ,  C08G63/42 ,  C08G63/48 ,  C08G63/49 ,  C08G63/82 ,  C08G83/00 ,  C08L61/06 ,  C08L61/24 ,  C08L61/28 ,  C08L101/00 ,  C10M107/00 ,  C08G59/16 ,  C08G63/66

    CPC分类号： C08G83/005 ,  C08G63/20 ,  C08G63/42 ,  C08G63/48 ,  Y10S424/16

    摘要： A hyperbranched macromolecule of polyester type comprising a central monomeric or polymeric nucleus and at least one generation of a branching chain extender having at least three reactive sites of which at least one is a hydroxyl or hydroxyalkyl substituted hydroxyl group and at least one is a carboxyl or terminal epoxide group. The nucleus is an epoxide compound having at least one reactive epoxide group. Optionally, the macromolecule comprises at least one generation consisting of at least one spacing chain extender having two reactive sites of which one is a hydroxyl or hydroxyalkyl substituted hydroxyl group and one is a carboxyl or terminal epoxide group. The macromolecule may be terminated by means of at least one chain stopper.

    摘要翻译： 包含中心单体或聚合物核的聚丙烯类型的超支化高分子和至少一代支链增链剂，其具有至少三个反应性位点，其至少一个是羟基或羟烷基取代的羟基，并且至少一个是羧基或 末端环氧基团。 核是具有至少一个活性环氧基团的环氧化合物。 任选地，大分子包含至少一个由至少一个具有两个反应性位点的间隔扩链剂组成的一代，其中一个是羟基或羟烷基取代的羟基，一个是羧基或末端环氧基。 大分子可以通过至少一个链塞终止。

    Process for preparing hyperbranched polymers
    67.
    发明授权
    Process for preparing hyperbranched polymers 失效
    制备超支化聚合物的方法

    公开(公告)号：US5591809A

    公开(公告)日：1997-01-07

    申请号：US516667

    申请日：1995-08-18

    申请人： Richard Vicari ,  Kathleen N. Juneau ,  Carl D. Murphy

    发明人： Richard Vicari ,  Kathleen N. Juneau ,  Carl D. Murphy

    IPC分类号： C08G63/123 ,  C08G63/20 ,  C08G63/60 ,  C08G64/14 ,  C08G83/00 ,  C08G63/00

    CPC分类号： C08G83/005 ,  C08G63/123 ,  C08G63/20 ,  C08G63/60 ,  C08G64/14

    摘要： The present invention provides novel one-step processes for preparing highly branched macromolecule polymers that have highly controlled molecular architectures. The process comprises the reaction of a branching monomer such as a substituted phenyl compound having the formula: ##STR1## wherein R.sub.1, R.sub.2, and R.sub.3 are defined herein, with a core monomer and an end-capping monomer, such as a phenolic ester, for a sufficient period of time and at a sufficient temperature to directly produce the highly branched polymer, in a single processing step.

    摘要翻译： 本发明提供了制备具有高度可控的分子结构的高支化高分子聚合物的新颖的一步法。 该方法包括支化单体例如具有下式的取代的苯基化合物：其中R 1，R 2和R 3在本文中定义的取代的苯基化合物与核心单体和封端单体如酚酯反应， 在足够的温度下直接生产高度支化的聚合物，在单一的加工步骤中。