公开(公告)号：US20120055253A1

公开(公告)日：2012-03-08

申请号：US13226444

申请日：2011-09-06

Applicant: Dipen N. Sinha

Inventor： Dipen N. Sinha

IPC: G01N29/04

CPC classification number: G01N29/024 ,  G01F1/74 ,  G01N29/222 ,  G01N29/348 ,  G01N29/4454 ,  G01N29/50 ,  G01N2291/0222 ,  G01N2291/0224 ,  G01N2291/048 ,  G01N2291/102

Abstract: A method for determining the composition of fluids flowing through pipes from noninvasive measurements of acoustic properties of the fluid is described. The method includes exciting a first transducer located on the external surface of the pipe through which the fluid under investigation is flowing, to generate an ultrasound chirp signal, as opposed to conventional pulses. The chirp signal is received by a second transducer disposed on the external surface of the pipe opposing the location of the first transducer, from which the transit time through the fluid is determined and the sound speed of the ultrasound in the fluid is calculated. The composition of a fluid is calculated from the sound speed therein. The fluid density may also be derived from measurements of sound attenuation. Several signal processing approaches are described for extracting the transit time information from the data with the effects of the pipe wall having been subtracted.

Abstract translation: 描述了通过流体的声学性质的非侵入性测量来确定流过管道的流体的组成的方法。 该方法包括激励位于管道的外表面上的第一换能器，所述第一换能器与正在进行的脉冲相反地产生超声线性调频脉冲信号。 啁啾信号被设置在与第一换能器的位置相对的管的外表面上的第二换能器接收，从该位置确定通过流体的通过时间，并且计算流体中超声波的声速。 从其中的声速计算流体的组成。 流体密度也可以从声衰减的测量中导出。 描述了几个信号处理方法，用于从已经减去管壁效应的数据中提取渡越时间信息。

公开(公告)号：US20110246099A1

公开(公告)日：2011-10-06

申请号：US13066354

申请日：2011-04-13

Applicant: Herbert Estrada ,  Calvin R. Hastings ,  Donald R. Augenstein

Inventor： Herbert Estrada ,  Calvin R. Hastings ,  Donald R. Augenstein

IPC: G06F19/00 ,  G01N11/00

CPC classification number: G01N27/18 ,  G01N29/024 ,  G01N33/2847 ,  G01N2291/011 ,  G01N2291/0222 ,  G01N2291/0224 ,  G01N2291/0226

Abstract: An apparatus for measuring the mass fractions of water and oil in a flowing mixture of oil and water through a pipe includes a sensor portion that measures sound velocity and temperature of the flowing oil water mixture at a first time and at a second time. The apparatus includes a temperature changer in thermal communication with the flowing fluid which changes the temperature of the flowing oil water mixture by a measurable amount between the first time and the second time. A method for measuring water mass fraction in a flowing mixture of oil and water through a pipe includes the steps of measuring sound velocity and temperature of the flowing oil water mixture at a first time with a sensor portion. There is the step of changing the temperature of the flowing oil water mixture by a measurable amount with a temperature changer in thermal communication with the flowing fluid. There is the step of measuring sound velocity and temperature of the flowing oil water mixture at a second time with the sensor portion.

Abstract translation: 用于通过管道测量油和水的流动混合物中的水和油的质量分数的装置包括传感器部分，其在第一时间和第二时间测量流动的油水混合物的声速和温度。 该装置包括与流动流体热连通的温度变换器，其在第一时间和第二时间之间改变流动的油水混合物的温度可测量的量。 通过管道测量油和水的流动混合物中的水质量分数的方法包括以下步骤：首先用传感器部分测量流动油水混合物的声速和温度。 通过与流动的流体热连通的温度更换器，可以将流动的油水混合物的温度改变可测量的步骤。 传感器部分第二次测量流动的油水混合物的声速和温度的步骤。

公开(公告)号：US20110020834A1

公开(公告)日：2011-01-27

申请号：US12721978

申请日：2010-03-11

Applicant: Harold G. Craighead ,  Bojan (Rob) Ilic ,  David Alan Czaplewski ,  Robert H. Hall

Inventor： Harold G. Craighead ,  Bojan (Rob) Ilic ,  David Alan Czaplewski ,  Robert H. Hall

IPC: G01N33/53 ,  C12M1/34

CPC classification number: G01N29/022 ,  G01N29/036 ,  G01N29/2418 ,  G01N29/348 ,  G01N33/54373 ,  G01N33/569 ,  G01N2291/0224 ,  G01N2291/0256 ,  G01N2291/0427 ,  Y10S435/808

Abstract: A system and method for detecting mass based on a frequency differential of a resonating micromachined structure, such as a cantilever beam. A high aspect ratio cantilever beam is coated with an immobilized binding partner that couples to a predetermined cell or molecule. A first resonant frequency is determined for the cantilever having the immobilized binding partner. Upon exposure of the cantilever to a solution that binds with the binding partner, the mass of the cantilever beam increases. A second resonant frequency is determined and the differential resonant frequency provides the basis for detecting the target cell or molecule. The cantilever may be driven externally or by ambient noise. The frequency response of the beam can be determined optically using reflected light and two photodetectors or by interference using a single photodetector.

Abstract translation: 一种用于基于谐振微加工结构（例如悬臂梁）的频率差来检测质量的系统和方法。 高尺寸比悬臂梁涂覆有固定的结合配偶体，其结合到预定的细胞或分子。 确定具有固定的结合配偶体的悬臂的第一共振频率。 当将悬臂暴露于与结合配偶体结合的溶液时，悬臂梁的质量增加。 确定第二谐振频率，并且差分谐振频率为检测靶细胞或分子提供依据。 悬臂可能被外部驱动或环境噪声驱动。 光束的频率响应可以使用反射光和两个光电检测器或通过使用单个光电检测器的干涉光学地确定。

公开(公告)号：US20090308161A1

公开(公告)日：2009-12-17

申请号：US12298514

申请日：2007-04-25

Applicant: Jostein Jacobsen ,  Ashild Bergh ,  Stale Vilming

Inventor： Jostein Jacobsen ,  Ashild Bergh ,  Stale Vilming

IPC: G01N29/12

CPC classification number: G01N29/036 ,  G01N29/11 ,  G01N29/12 ,  G01N29/348 ,  G01N29/4454 ,  G01N29/46 ,  G01N2291/0224 ,  G01N2291/0427 ,  G01N2291/2634

Abstract: An acoustic method and apparatus detects or characterizes a medium in a structure which may be a container, such as a pipeline for transportation of oil, gas, or hydrocarbon condensate. A pulse of broadband acoustic energy is emitted towards the structure by a first transducer. A return signal is generating by a second transducer from acoustic energy returned from the structure in response to the emission of acoustic energy. A return signal spectrum representing acoustic spectral components of the acoustic energy returned from the structure is derived from the return signal, and the medium is detected or characterized by applying a return signal processing medium detection or characterization algorithm to the return signal spectrum.

Abstract translation: 声学方法和装置检测或表征可以是容器的结构中的介质，例如用于输送油，气体或烃冷凝物的管道。 宽带声能的脉冲通过第一换能器向结构发射。 响应于声能的发射，由结构返回的声能由第二换能器产生返回信号。 从返回信号导出表示从结构返回的声能的声频分量的返回信号频谱，并且通过对返回信号频谱应用返回信号处理介质检测或表征算法来检测或表征介质。

公开(公告)号：US07493798B2

公开(公告)日：2009-02-24

申请号：US11274566

申请日：2005-11-14

Applicant: Raviprakash Thotadakumbri ,  James Z T Liu

Inventor： Raviprakash Thotadakumbri ,  James Z T Liu

IPC: G01N11/00

CPC classification number: G01N29/022 ,  G01N2291/014 ,  G01N2291/0224 ,  G01N2291/0226 ,  G01N2291/0258 ,  G01N2291/02818 ,  G01N2291/02863 ,  G01N2291/0422 ,  G01N2291/0423 ,  G01N2291/0426 ,  G01N2291/0427

Abstract: A relaxation time constant associated with a fluid can be determined and then compared with a stored reference value. The difference between the relaxation time constant and the stored reference value can then be calculated in order to provide qualitative and/or quantitative data indicative of an adulteration of the fluid. The relaxation time constant associated with the fluid can be determined by first generating a static charge and then injecting the static charge into the fluid. The charge can then be collected from the fluid and utilized to determine the relaxation time constant.

Abstract translation: 可以确定与流体相关联的松弛时间常数，然后与存储的参考值进行比较。 然后可以计算松弛时间常数与存储的参考值之间的差异，以便提供指示流体掺假的定性和/或定量数据。 与流体相关的松弛时间常数可以通过首先产生静电荷然后将静电注入流体来确定。 然后可以从流体中收集电荷并用于确定弛豫时间常数。

公开(公告)号：US07380438B2

公开(公告)日：2008-06-03

申请号：US11227713

申请日：2005-09-15

Applicant: Daniel L. Gysling ,  Douglas H. Loose

Inventor： Daniel L. Gysling ,  Douglas H. Loose

IPC: G01N9/24 ,  G01N9/26 ,  G01N33/18

CPC classification number: G01N22/00 ,  G01N9/36 ,  G01N29/024 ,  G01N29/222 ,  G01N33/28 ,  G01N33/2823 ,  G01N2291/0224 ,  G01N2291/024 ,  G01N2291/02433 ,  G01N2291/02827 ,  G01N2291/02836 ,  G01N2291/02872

Abstract: An apparatus for determining a fluid cut measurement of a multi-liquid mixture includes a first device configured to sense at least one parameter of the mixture to determine a fluid cut of a liquid in the mixture. A second device is configured to determine a concentration of gas in the mixture in response to a speed of sound in the mixture; and a signal processor is configured to adjust the fluid cut of the liquid using the concentration of the gas to determine a compensated fluid cut of the liquid. The parameter of the mixture sensed by the first device may include a density of the mixture (e.g., by way of a Coriolis meter), a permittivity of the mixture (e.g., by way of a resonant microwave oscillator), or an amount of microwave energy absorbed by the mixture (e.g., by way of a microwave absorption watercut meter). The signal processor may employ different correction factors depending on the type of fluid cut device used. The second device may include a gas volume fraction meter.

Abstract translation: 用于确定多液体混合物的流体切割测量的装置包括构造成感测混合物的至少一个参数以确定混合物中液体的流体切割的第一装置。 第二装置被配置为响应混合物中的声速来确定混合物中气体的浓度; 并且信号处理器被配置为使用气体的浓度调节液体的液体切割以确定液体的补偿流体切割。 由第一装置感测的混合物的参数可以包括混合物的密度（例如，通过科里奥利计），混合物的介电常数（例如通过谐振微波振荡器）或微波的量 由混合物吸收的能量（例如，通过微波吸收水切割仪）。 信号处理器可以根据所使用的流体切割装置的类型使用不同的校正因子。 第二装置可以包括气体体积分数计。

公开(公告)号：US20070033990A1

公开(公告)日：2007-02-15

申请号：US11581472

申请日：2006-10-17

Applicant: Hasin Francois Grey ,  Tove Maria Jensenius ,  Jacob Thaysen ,  Anja Boisen

Inventor： Hasin Francois Grey ,  Tove Maria Jensenius ,  Jacob Thaysen ,  Anja Boisen

IPC: G01N11/00 ,  G01N33/487

CPC classification number: G01N9/002 ,  G01N11/00 ,  G01N11/16 ,  G01N29/022 ,  G01N29/036 ,  G01N29/222 ,  G01N29/30 ,  G01N2035/00237 ,  G01N2291/0215 ,  G01N2291/0224 ,  G01N2291/0255 ,  G01N2291/0256 ,  G01N2291/02818 ,  G01N2291/0427

Abstract: The present invention relates to integrated micro-cantilevers, micro-bridges or micro-membranes in micro-liquid handling systems. Such micro-liquid handling systems provide novel detection mechanisms for monitoring the physical, chemical and biological properties of fluids in such systems. The present invention further relates to micro-cantilever, micro-bridge or micro-membrane type sensors having integrated readout. Such constructions allow laminated flows of different liquids to flow in a channel without mixing, which opens up for new type of experiments and which reduces noise related to the liquid movement. The present invention even further relates to sensors having adjacent or very closely spaced micro-cantilevers, micro-bridges or micro-membranes which can be exposed to different chemical environments at the same time.

Abstract translation: 本发明涉及微液体处理系统中的集成微悬臂，微桥或微膜。 这种微液体处理系统提供用于监测这种系统中的流体的物理，化学和生物性质的新型检测机制。 本发明还涉及具有集成读出的微悬臂，微桥或微膜型传感器。 这样的结构允许不同液体的层压流在通道中流动而不混合，这开启了新型实验，并且减少了与液体运动相关的噪声。 本发明还涉及具有相邻或非常紧密间隔的微悬臂，微桥或微膜的传感器，其可以同时暴露于不同的化学环境。

公开(公告)号：US07073370B2

公开(公告)日：2006-07-11

申请号：US10686444

申请日：2003-10-15

Applicant: Leonid Matsiev ,  James Bennett ,  Eric McFarland

Inventor： Leonid Matsiev ,  James Bennett ,  Eric McFarland

IPC: G01N29/02

CPC classification number: G01H13/00 ,  B01J2219/00704 ,  G01N9/002 ,  G01N9/34 ,  G01N11/16 ,  G01N29/022 ,  G01N29/036 ,  G01N29/30 ,  G01N29/348 ,  G01N29/42 ,  G01N29/4418 ,  G01N29/4427 ,  G01N29/4436 ,  G01N2009/006 ,  G01N2291/014 ,  G01N2291/0224 ,  G01N2291/0255 ,  G01N2291/0256 ,  G01N2291/02818 ,  G01N2291/0422 ,  G01N2291/0423 ,  G01N2291/0427 ,  G10K11/02

Abstract: A method and apparatus for measuring properties of a liquid composition includes a mechanical resonator, such as a cantilever, connected to a measurement circuit. The mechanical resonator can be covered with a coating to impart additional special detection propertied to the resonator, and multiple resonators can be attached together as a single sensor to obtain multiple frequency responses. The invention is particularly suitable for combinatorial chemistry applications, which require rapid analysis of chemical properties for screening. In one embodiment, the resonator is operated at a frequency of less than 1 MHz.

Abstract translation: 用于测量液体组合物性质的方法和装置包括连接到测量电路的诸如悬臂的机械谐振器。 可以用涂层覆盖机械谐振器以赋予谐振器附加的特殊检测，并且多个谐振器可以作为单个传感器附接在一起以获得多个频率响应。 本发明特别适用于组合化学应用，其需要快速分析筛选的化学性质。 在一个实施例中，谐振器以小于1MHz的频率工作。

公开(公告)号：US06996478B2

公开(公告)日：2006-02-07

申请号：US10799185

申请日：2004-03-11

Applicant: Steven A. Sunshine ,  M. Gregory Steinthal ,  Ajoy Roy

Inventor： Steven A. Sunshine ,  M. Gregory Steinthal ,  Ajoy Roy

IPC: G01N33/497

CPC classification number: H04L29/06 ,  B82Y15/00 ,  G01N29/022 ,  G01N33/0032 ,  G01N2001/021 ,  G01N2291/0215 ,  G01N2291/0217 ,  G01N2291/0224 ,  G01N2291/0226 ,  G01N2291/0256 ,  G01N2291/02827 ,  G01N2291/0423 ,  G01N2291/0426 ,  G01N2291/106 ,  H04L67/12 ,  H04L69/329

Abstract: The present invention provides a distributed sensing system in a networked environment for identifying an analyte, including a first sensor array connected to the network comprising sensors capable of producing a first response in the presence of a chemical stimulus; a second sensor array connected to the network comprising sensors capable of producing a second response in the presence of a physical stimulus; and a computer comprising a resident algorithm. The algorithm indicates or selects the most relevant sensor in the network to identify the analyte. The sensors can be separated over large spatial areas, wherein the sensor arrays are networked. Suitable networks include a computer local area network, an intranet or the Internet.

公开(公告)号：US06849460B2

公开(公告)日：2005-02-01

申请号：US10183306

申请日：2002-06-25

Applicant: Eric W. McFarland ,  William Archibald

Inventor： Eric W. McFarland ,  William Archibald

IPC: B01J19/00 ,  C07B61/00 ,  C07F15/00 ,  C07F15/04 ,  C08F10/00 ,  C40B30/08 ,  C40B40/14 ,  C40B40/18 ,  C40B50/14 ,  C40B60/14 ,  G01H13/00 ,  G01J4/00 ,  G01N3/00 ,  G01N9/00 ,  G01N21/21 ,  G01N21/25 ,  G01N21/64 ,  G01N21/66 ,  G01N29/02 ,  G01N29/036 ,  G01N29/24 ,  G01N29/34 ,  G01N29/42 ,  G01N29/44 ,  G01N33/53 ,  G01N33/543 ,  H01J49/00 ,  H01J49/04 ,  H03H9/19 ,  G01N21/62 ,  G01N21/35 ,  G01N25/18

CPC classification number: G01N29/2425 ,  B01J19/0046 ,  B01J2219/00315 ,  B01J2219/00317 ,  B01J2219/00364 ,  B01J2219/00378 ,  B01J2219/0043 ,  B01J2219/00443 ,  B01J2219/00497 ,  B01J2219/005 ,  B01J2219/00511 ,  B01J2219/00515 ,  B01J2219/0052 ,  B01J2219/00527 ,  B01J2219/00536 ,  B01J2219/00583 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00621 ,  B01J2219/00626 ,  B01J2219/00628 ,  B01J2219/00637 ,  B01J2219/00641 ,  B01J2219/00659 ,  B01J2219/00675 ,  B01J2219/00689 ,  B01J2219/00702 ,  B01J2219/00704 ,  B01J2219/00722 ,  B01J2219/00738 ,  B01J2219/00745 ,  B01J2219/00747 ,  B01J2219/0075 ,  B01J2219/00754 ,  B82Y30/00 ,  C07F15/0066 ,  C07F15/045 ,  C40B20/08 ,  C40B30/08 ,  C40B40/14 ,  C40B40/18 ,  C40B50/14 ,  C40B60/12 ,  C40B60/14 ,  G01H13/00 ,  G01J4/00 ,  G01N9/002 ,  G01N11/16 ,  G01N21/211 ,  G01N21/253 ,  G01N21/6402 ,  G01N21/6452 ,  G01N21/66 ,  G01N25/4813 ,  G01N29/022 ,  G01N29/036 ,  G01N29/2418 ,  G01N29/30 ,  G01N29/348 ,  G01N29/42 ,  G01N29/4418 ,  G01N29/4427 ,  G01N31/10 ,  G01N2009/006 ,  G01N2203/0094 ,  G01N2291/014 ,  G01N2291/0224 ,  G01N2291/0255 ,  G01N2291/0256 ,  G01N2291/02818 ,  G01N2291/02827 ,  G01N2291/02863 ,  G01N2291/0422 ,  G01N2291/0423 ,  G01N2291/0427 ,  G01N2291/106 ,  H01J49/0409 ,  H01J49/0468

Abstract: Methods and apparatus for screening diverse arrays of materials using infrared imaging techniques are provided. Typically, each of the individual materials on the array will be screened or interrogated for the same material characteristic. Once screened, the individual materials may be ranked or otherwise compared relative to each other with respect to the material characteristic under investigation. According to one aspect, infrared imaging techniques are used to identify the active sites within an array of compounds by monitoring the temperature change resulting from a reaction. This same technique can also be used to quantify the stability of each new material within an array of compounds. According to another aspect, identification and characterization of condensed phase products is achieved, wherein library elements are activated by a heat source serially, or in parallel. According to another aspect, a Fourier transform infrared spectrometer is used to rapidly characterize a large number of chemical reactions contained within a combinatorial library.

Abstract translation: 提供了使用红外成像技术筛选各种材料阵列的方法和装置。 通常，对于相同的材料特性，阵列上的每个单独的材料将被筛选或询问。 一旦筛选，单个材料可以相对于被调查的材料特性相对于彼此进行排序或以其他方式比较。 根据一个方面，红外成像技术用于通过监测由反应产生的温度变化来鉴定化合物阵列内的活性位点。 也可以使用相同的技术来量化化合物阵列内的每种新材料的稳定性。 根据另一方面，实现冷凝相产物的鉴定和表征，其中文库元素被串联或并联的热源活化。 根据另一方面，使用傅里叶变换红外光谱仪来快速表征包含在组合文库中的大量化学反应。