公开(公告)号：US3717642A

公开(公告)日：1973-02-20

申请号：US3717642D

申请日：1971-06-09

申请人： WARNER LAMBERT CO

发明人： VON STRANDTMANN M

IPC分类号： C07D209/40 ,  C07D213/75 ,  C07D215/38 ,  C07D239/42 ,  C07D257/06 ,  C07D263/48 ,  C07D277/82 ,  C07D85/44

CPC分类号： C07D213/75 ,  C07D209/40 ,  C07D215/38 ,  C07D239/42 ,  C07D257/06 ,  C07D263/48 ,  C07D277/82

摘要： The present invention is concerned with compounds of Formula I: wherein R1 is heteroaryl and R2 is alkyl, aryl, or heteroaryl. Compounds of this invention exhibit central nervous system depressant properties.

公开(公告)号：US3586693A

公开(公告)日：1971-06-22

申请号：US3586693D

申请日：1969-07-07

申请人： AMERICAN HOME PROD

发明人： BELL STANLEY C

IPC分类号： C07D209/40 ,  C07D57/02

CPC分类号： C07D209/40

摘要： THIS INVENTION RELATES TO NEW IMIDAZO(1,2-A)INDOLIN-9OLS WHICH HAVE DEMONSTRATED PHARMACOLOGICAL ACTIVITY AS CENTRAL NEVOUS SYSTEM DEPRESSANTS.

公开(公告)号：US3577435A

公开(公告)日：1971-05-04

申请号：US3577435D

申请日：1968-08-14

申请人： AMERICAN HOME PROD

发明人： BELL STANLEY C ,  GOCHMAN CARL

IPC分类号： C07D209/40 ,  C07D27/38

CPC分类号： C07D209/40

摘要： A NEW PROCESS IS DISCLOSED REACTING A 2-BENZOYL ACYLANILIDE WITH IONIC CYANIDES TO FORM NEW 3-ARYL-2-IMINO-3INDOLINOLS AND 2-AMINO-3-ARYL-3H-INDOL-3-OLS. THESE PRODUCTS MAY BE FURTHER REACTED TO FORM A NUMBER OF NEW DERIVATIVES WHICH HAVE PHARMACOLOGICAL ACITIVITY AS CENTRAL NERVOUS SYSTEM DEPRESSANTS.

公开(公告)号：US3576001A

公开(公告)日：1971-04-20

申请号：US3576001D

申请日：1967-12-28

申请人： AMERICAN HOME PROD

发明人： BELL STANLEY C ,  GOCHMAN CARL

IPC分类号： C07D209/40 ,  C07D27/36

CPC分类号： C07D209/40

摘要： A NEW PROCESS IS DISCLOSED REACTING A 2-BENZOYL ACYLANILIDE WITH IONIC CYANIDES TO FORM NEW 3-ARYL-2-IMINO3-INDOLINOLS AND 2-AMINO-3-ARYL-3H-INDOL-3-OLS. THE PRODUCTS MAY BE FURTHER PROCESSED INTO A NUMBER OF NEW DERIVATIVES WHICH HAVE THERAPEUTIC ACTIVITY IN EXPERIMENTAL AND COMPARATIVE PHARMACOLOGY.

公开(公告)号：US3253991A

公开(公告)日：1966-05-31

申请号：US32579063

申请日：1963-11-22

申请人： BURROUGHS WELLCOME CO

发明人： JOHN BAUER DENIS ,  WILLIAM SADLER PETER

IPC分类号： A61K31/00 ,  C07D209/40

CPC分类号： A61K31/00 ,  C07D209/40

公开(公告)号：US12065459B2

公开(公告)日：2024-08-20

申请号：US16672114

申请日：2019-11-01

申请人： Achillion Pharmaceuticals, Inc.

发明人： Jason Allan Wiles ,  Venkat Rao Gadhachanda ,  Qiuping Wang ,  Godwin Pais ,  Akihiro Hashimoto ,  Dawei Chen ,  Xiangzhu Wang ,  Atul Agarwal ,  Milind Deshpande ,  Avinash S. Phadke

IPC分类号： C07F9/572 ,  A61K9/00 ,  A61K31/404 ,  A61K31/4045 ,  A61K31/407 ,  A61K31/4162 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/4188 ,  A61K31/4192 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/501 ,  A61K31/506 ,  A61K31/519 ,  A61K31/549 ,  A61K31/55 ,  A61K31/675 ,  A61K31/683 ,  C07B59/00 ,  C07D209/12 ,  C07D209/14 ,  C07D209/30 ,  C07D209/40 ,  C07D209/42 ,  C07D209/44 ,  C07D209/88 ,  C07D401/14 ,  C07D403/06 ,  C07D403/08 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14 ,  C07D413/06 ,  C07D413/14 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D471/08 ,  C07D487/04 ,  C07D487/14 ,  C07D491/113 ,  C07D495/04 ,  C07D513/04 ,  C07F5/02 ,  C07F7/08 ,  C07F9/6558 ,  C07F9/6561

CPC分类号： C07F9/5728 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/0048 ,  A61K9/0053 ,  A61K31/404 ,  A61K31/4045 ,  A61K31/407 ,  A61K31/4162 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/4188 ,  A61K31/4192 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/501 ,  A61K31/506 ,  A61K31/519 ,  A61K31/549 ,  A61K31/55 ,  A61K31/675 ,  A61K31/683 ,  C07B59/002 ,  C07D209/12 ,  C07D209/14 ,  C07D209/30 ,  C07D209/40 ,  C07D209/42 ,  C07D209/44 ,  C07D209/88 ,  C07D401/14 ,  C07D403/06 ,  C07D403/08 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14 ,  C07D413/06 ,  C07D413/14 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D471/08 ,  C07D487/04 ,  C07D487/14 ,  C07D491/113 ,  C07D495/04 ,  C07D513/04 ,  C07F5/025 ,  C07F5/027 ,  C07F7/0812 ,  C07F9/65583 ,  C07F9/6561 ,  C07F9/65616 ,  C07B2200/05

摘要： Compounds, methods of use, and processes for making inhibitors of complement factor D comprising Formula I, or a pharmaceutically acceptable salt or composition thereof wherein R12 or R13 on the A group is an aryl, heteroaryl or heterocycle (R32) are provided. The inhibitors described herein target factor D and inhibit or regulate the complement cascade at an early and essential point in the alternative complement pathway, and reduce factor D's ability to modulate the classical and lectin complement pathways. The inhibitors of factor D described herein are capable of reducing the excessive activation of complement, which has been linked to certain autoimmune, inflammatory, and neurodegenerative diseases, as well as ischemia-reperfusion injury and cancer.

公开(公告)号：US20240190821A1

公开(公告)日：2024-06-13

申请号：US18275382

申请日：2022-02-01

申请人： Triana Biomedicines, Inc.

发明人： William J. Greenlee ,  Nicholas Calandra ,  Soumya Ray ,  Arthur F. Kluge

IPC分类号： C07D209/40 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D471/04 ,  C07D471/18 ,  C07D487/04 ,  C07D487/10 ,  C07D498/10

CPC分类号： C07D209/40 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D471/04 ,  C07D471/18 ,  C07D487/04 ,  C07D487/10 ,  C07D498/10

摘要： The present application discloses novel compounds of formula (I), pharmaceutical compositions containing these compounds and methods of inducing degradation of a protein, comprising contacting the protein with an effective amount of a compound of the disclosure. Methods of treating disease and disorders that results from abnormal activity of a target protein in a subject, are also disclosed.

公开(公告)号：US20230121798A1

公开(公告)日：2023-04-20

申请号：US17960015

申请日：2022-10-04

申请人： SHIN-ETSU CHEMICAL CO., LTD.

发明人： Daisuke KORI ,  Naoki KOBAYASHI ,  Yasuyuki YAMAMOTO

IPC分类号： G03F7/039 ,  H01L21/027 ,  C07D209/40

摘要： A material for forming an organic film, containing: a compound shown by formula (1); and an organic solvent. In formula (1), R1 represents one of the following formulae (2), R2 represents a nitro group, a halogen atom, a hydroxy group, an alkyloxy group, an alkynyloxy group, an alkenyloxy group, a linear, branched, or cyclic alkyl group, a trifluoromethyl group, or a trifluoromethyloxy group, “n” represents 0 or 1, “m” represents an integer of 1 to 3, “p” represents 0 or 1, “1” represents an integer of 0 to 2, and W represents a divalent organic group having 2 to 40 carbon atoms. The objective: a compound which allows the formation of an organic underlayer film having excellent heat resistance and properties of filling and planarizing a pattern formed on a substrate, favorable film-formability and adhesiveness to a substrate; and a material for forming an organic film containing the compound.

公开(公告)号：US20220388957A1

公开(公告)日：2022-12-08

申请号：US17422397

申请日：2020-01-16

申请人： IFM Due, Inc.

发明人： Hans Martin Seidel ,  William R. Roush ,  Shankar Venkatraman

IPC分类号： C07D209/40 ,  A61K31/404 ,  C07D471/04 ,  A61K31/437 ,  A61K31/415 ,  C07D231/42 ,  C07D498/04 ,  A61K31/5383 ,  A61K31/4439 ,  A61K31/4545 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12

摘要： This disclosure features chemical entities (e.g., a compound or a pharmaceutically acceptable salt, and/or hydrate, and/or cocrystal, and/or drug combination of the compound) that inhibit (e.g., antagonize) Stimulator of Interferon Genes (STING). Said chemical entities are useful, e.g., for treating a condition, disease or disorder in which increased (e.g., excessive) STING activation (e.g., STING signaling) contributes to the pathology and/or symptoms and/or progression of the condition, disease or disorder (e.g., cancer) in a subject (e.g., a human). This disclosure also features compositions containing the same as well as methods of using and making the same.

公开(公告)号：US11465989B2

公开(公告)日：2022-10-11

申请号：US15304798

申请日：2015-04-17

申请人： IMMUNOMET THERAPEUTICS INC.

发明人： Sung Wuk Kim ,  Hong Woo Kim ,  Sang Hee Yoo ,  Ji Sun Lee ,  Hye Jin Heo ,  Hong Bum Lee ,  Ji Ae Kook ,  Young Woo Lee ,  Mi Jeong Kim ,  Woong Cho

IPC分类号： C07D295/13 ,  C07D213/38 ,  C07D213/40 ,  C07D333/20 ,  C07D333/16 ,  C07D249/14 ,  C07D251/18 ,  C07D251/48 ,  C07D211/14 ,  C07D211/54 ,  C07D209/44 ,  C07D209/40 ,  C07D233/88 ,  C07D233/91 ,  C07D207/46 ,  C07D279/08 ,  C07D203/12 ,  C07D239/42 ,  C07D263/48 ,  C07D319/18 ,  C07D317/58 ,  C07D277/46 ,  A61P3/00 ,  A61P3/04 ,  A61P3/10 ,  A61P3/06 ,  A61P5/50 ,  A61P13/00 ,  A61P21/00 ,  A61P35/00 ,  A61P35/04 ,  A61P9/00 ,  A61P19/10 ,  A61P1/16 ,  A61P15/00 ,  C07C279/16 ,  C07C311/47 ,  C07C311/49 ,  C07C279/12 ,  C07C279/26 ,  C07C279/24 ,  C07C279/08 ,  C07C279/04 ,  C07C279/06 ,  C07D403/12 ,  C07D207/16

摘要： The present invention relates to guanidine compounds for inhibiting mitochondrial oxidative phosphorylation (OXPHOS) and use thereof. More specifically, the present invention relates to a pharmaceutical composition for preventing or treating a OXPHOS-related disease, particularly cancer, by inhibiting mitochondrial oxidative phosphorylation and reprogramming cellular metabolism.