公开(公告)号：US07301018B2

公开(公告)日：2007-11-27

申请号：US10332622

申请日：2001-07-10

申请人： Koji Suzuki ,  Yoshio Suzuki

发明人： Koji Suzuki ,  Yoshio Suzuki

IPC分类号： G01N27/62 ,  G01N30/72 ,  H01J49/00

CPC分类号： H01J49/0431 ,  G01N2458/15

摘要： Disclosed is a probe for mass spectrometry of liquid samples, which may effectively ionize the sample without adding a protic solvent to the mobile phase in the ionization method in mass spectrometry of liquid samples. The probe according to the present invention has a structure represented by the Formula [I]: R2-A-R1[I] (wherein R1 represents an ionic functional group which becomes an ion in a solvent, R2 represents a structure which can bind to other substance, and A represents an arbitrary spacer moiety).

摘要翻译： 公开了一种用于液体样品的质谱分析的探针，其可以在液体样品的质谱法中的离子化方法中将样品有效地离子化而不向流动相中添加质子溶剂。 根据本发明的探针具有由式[I]表示的结构：<？in-line-formula description =“In-line Formulas”end =“lead”？> R 2 - （I-1）<？in-line-formula description =“In-line Formulas”end =“tail”？>（其中R 1表示离子官能团 其在溶剂中成为离子，R 2表示可结合其它物质的结构，A表示任意的间隔基部分）。

公开(公告)号：US07247137B2

公开(公告)日：2007-07-24

申请号：US11432430

申请日：2006-05-12

申请人： Takao Tsuda ,  Ken Naitoh ,  Kazutoshi Nose

发明人： Takao Tsuda ,  Ken Naitoh ,  Kazutoshi Nose

IPC分类号： A61B5/00

CPC分类号： G01N1/24 ,  A61B5/00 ,  A61B5/145 ,  A61B5/441 ,  G01N2001/2244 ,  G01N2001/247

摘要： An apparatus for measuring skin permeable gas, which can be used to obtain clinical information by noninvasive and bloodless operations and are useful for in-home medical care and health management. The device for collecting skin permeable gas includes a cylindrical member including a spiral groove, a cover disposed on the upper surface of the cylindrical member, a gas-introducing section connected to the cover, a gas delivery section connected to the cover, and a sealing member for sealing the groove of the cylindrical member and for maintaining air contained in the groove at a predetermined temperature. After components in the air maintained at a predetermined temperature are analyzed, the sealing member is detached from the cylindrical member and the cylindrical member from which the sealing member is detached is then brought into intimate contact with skin of a subject to collect the skin permeable gas.

摘要翻译： 用于测量皮肤可渗透气体的装置，其可用于通过无创和无血液操作获得临床信息，并且可用于家庭内医疗和健康管理。 用于收集皮肤可渗透气体的装置包括：圆柱形构件，包括螺旋槽，设置在圆柱形构件的上表面上的盖，连接到盖的气体导入部，连接到盖的气体输送部， 用于密封圆柱形构件的凹槽并用于将包含在凹槽中的空气保持在预定温度的构件。 在保持在预定温度的空气中的组分被分析之后，将密封构件从圆柱形构件上分离，然后将密封构件脱离的圆柱形构件与受试者的皮肤紧密接触以收集皮肤可渗透气体 。

公开(公告)号：US20070155657A1

公开(公告)日：2007-07-05

申请号：US11633899

申请日：2006-12-04

申请人： Yoshitane Kojima ,  Hiromu Sakurai ,  Yutaka Yoshikawa

发明人： Yoshitane Kojima ,  Hiromu Sakurai ,  Yutaka Yoshikawa

IPC分类号： A61K31/555 ,  A61K31/315

CPC分类号： C07K5/1002 ,  A61K31/315 ,  A61K31/341 ,  A61K31/555 ,  A61K38/00 ,  C07C51/412 ,  C07C229/76 ,  C07D307/58 ,  C07K5/06008 ,  C07K5/08 ,  C07K5/0802 ,  C07C59/08

摘要： A zinc(II) complex which is lowly toxic, has high insulin-like activity, and is effectively usable as a hypoglycemic agent for the prevention or treatment of diabetes; a hypoglycemic agent containing the complex; a medicinal preparation which contains the complex and is useful as a preventive/remedy for diabetes; and a food containing the complex, such as a health food or supplementary health food. The hypoglycemic agent contains an organic zinc(II) complex having as a ligand a compound selected among aminoalkylpyridines, bis-optically active amino acids, bisaminoalkylcarboxylic acids, oligopeptides, oligopseudopeptides, di-substituted aminocarboxylic acids, α- and β-hydroxycarboxylic acids, vitamins, glutamine derivatives, etc.

公开(公告)号：US07229773B1

公开(公告)日：2007-06-12

申请号：US09958215

申请日：2000-04-05

申请人： Yoshihide Tsujimoto ,  Shigeomi Shimizu

发明人： Yoshihide Tsujimoto ,  Shigeomi Shimizu

IPC分类号： G01N33/53

CPC分类号： G01N33/5076 ,  G01N33/6872 ,  G01N2500/00 ,  G01N2510/00

摘要： To provide a screening method for an apoptosis-suppressing substance or an apoptosis-promoting substance, the application of which substances to pharmaceuticals or diagnostic drugs are expected, also to provide an apoptosis-suppressing substance or an apoptosis-promoting substance, since Bcl-2 family having apoptosis-suppressing or -promoting activities is deeply involved in many diseases.To attain the above object, VDAC-liposomes, an indicator substance such as fluorescent-labeled cytochrome c or isotope-labeled sucrose etc. capable of passing through VDAC (voltage-dependent anion channel), and a subject substance are incubated, and then concentration changes in the indicator substance, inside and outside the VDAC-liposomes before and after the incubation, are detected in order to estimate presence or absence of the apoptosis-suppressing activity or -promoting activity of the subject substance.

摘要翻译： 为了提供细胞凋亡抑制物质或细胞凋亡促进物质的筛选方法，由于Bcl-2可以提供抑制物质或细胞凋亡促进物质的作用，因此预期使用药物或诊断药物的物质 具有细胞凋亡抑制或促进活性的家族深深地涉及许多疾病。 为了达到上述目的，将VDAC-脂质体，能够通过VDAC（电压依赖性阴离子通道）的荧光标记的细胞色素c或同位素标记的蔗糖等指示物质和受试物质孵育，然后浓缩 检测VDAC-脂质体内外指示物质的变化，以便估计存在或不存在目标物质的凋亡抑制活性或促进活性。

公开(公告)号：US07226997B2

公开(公告)日：2007-06-05

申请号：US11529217

申请日：2006-09-29

申请人： Ryo Goitsuka

发明人： Ryo Goitsuka

IPC分类号： C07K1/00

CPC分类号： C07K14/47

摘要： The present invention provides a signal transducer specifically expressed in mouse mast cells that has the amino acid sequence of SEQ ID No. 2, a signal transducer specifically expressed in human mast cells that has the amino acid sequence of SEQ ID No. 4, polynucleotides encoding these proteins, an expression vector involving these polynucleotides, transformed cells induced by these expression vectors, and antibodies against the foregoing proteins. The signal transducer provided in the present invention is useful for screening of novel medicines against allergic diseases.

摘要翻译： 本发明提供了特异性表达于具有SEQ ID No.2的氨基酸序列的小鼠肥大细胞中的信号转导体，特异性表达于具有SEQ ID No.4的氨基酸序列的人肥大细胞中的信号转导体，编码 这些蛋白质，涉及这些多核苷酸的表达载体，由这些表达载体诱导的转化细胞，以及针对上述蛋白质的抗体。 本发明提供的信号转导体可用于筛选抗过敏性疾病的新型药物。

公开(公告)号：US07221005B2

公开(公告)日：2007-05-22

申请号：US10561530

申请日：2001-09-28

申请人： Mutsuo Ogura ,  Takeyoshi Sugaya ,  Kee-Youn Jang ,  Yoshinobu Sugiyama

发明人： Mutsuo Ogura ,  Takeyoshi Sugaya ,  Kee-Youn Jang ,  Yoshinobu Sugiyama

IPC分类号： H01L31/00

CPC分类号： B82Y10/00 ,  H01L29/045 ,  H01L29/125 ,  H01L29/775

摘要： A negative resistance field-effect element that is a negative differential resistance field-effect element capable of achieving negative resistance at a low power supply voltage (low drain voltage) and also enabling securement of a high PVCR is formed on its InP substrate 11 having an asymmetrical V-groove whose surface on one side is a (100) plane and surface on the other side is a (011) plane with an InAlAs barrier layer (12) that has a trench (TR) one of whose opposed lateral faces is a (111) A plane and the other of which is a (331) B plane. An InGaAs quantum wire (13) that has a relatively narrow energy band gap is formed at the trench bottom surface as a high-mobility channel. An InAlAs modulation-doped layer (20) having a relatively wide energy band gap is formed on the quantum wire as a low-mobility channel. A source electrode (42) and a drain electrode (43) each in electrical continuity with the quantum wire (13) constituting the high-mobility channel through a contact layer (30) and extending in the longitudinal direction of the quantum wire (13) as spaced from each other, and a gate electrode (41) provided between the source electrode (42) and the drain electrode (43) to face the low-mobility channel (20) through an insulating layer or a Schottky junction, are provided. Owing to the foregoing configuration, a very narrow-width quantum wire whose lateral confinement size can, without restriction by the lithographic technology limit, be made 100 nm or less is usable as a high-mobility channel, whereby there can be obtained a negative resistance field-effect element that develops a negative characteristic at a low power supply voltage and enables securement of a high PVCR.

摘要翻译： 作为能够在低电源电压（低漏极电压）下实现负电阻并且还能够确保高PVCR的负的差分电阻场效应元件的负电阻场效应元件形成在其具有 非对称V槽，其一侧的表面为（100）面，另一侧的表面为具有InAlAs阻挡层（12）的（011）平面，所述InAlAs势垒层具有沟槽（TR），所述沟槽（TR）的相对侧面之一为 （111）一个平面，另一个是（331）B平面。 在沟槽底面形成具有较窄能带隙的InGaAs量子线（13）作为高迁移率通道。 在量子线上形成具有相对宽的能带隙的InAlAs调制掺杂层（20）作为低迁移率信道。 每个与构成高迁移率通道的量子线（13）导电连接的源电极（42）和漏电极（43）通过接触层（30）沿量子线（13）的纵向方向延伸， 并且设置在源电极（42）和漏电极（43）之间通过绝缘层或肖特基结面对低迁移率通道（20）的栅电极（41）。 由于上述结构，可以使绝缘尺寸大小不受光刻技术限制的极窄宽度量子线作为100nm以下，作为高​​迁移率通道，由此可以获得负电阻 场效应元件在低电源电压下产生负特性并且能够确保高PVCR。

公开(公告)号：US07214827B2

公开(公告)日：2007-05-08

申请号：US11194554

申请日：2005-08-02

申请人： Shu Kobayashi

发明人： Shu Kobayashi

IPC分类号： C07C215/00

CPC分类号： C07C269/06 ,  C07C231/12 ,  C07C303/40 ,  C07C311/08 ,  C07C233/33 ,  C07C271/28

摘要： An anilide is reacted with an acylating agent by using as a catalyst a tri(perfluoroalkane sulfonate) compound of any of the elements belonging to groups 3 to 5 and groups 13 to 15 in periods 4 to 6 of the periodic table, thereby bonding an acyl group to the benzene ring. Thus, ketoaniline derivatives, which are useful as physiologically active compounds or intermediates in synthesizing the same, are synthesized in high reaction yield by catalytic acylation.

摘要翻译： 通过在周期表第4-6周期中使用属于3至5族和13至15族的任何元素的三（全氟烷基磺酸酯）化合物作为催化剂使酰苯胺与酰化剂反应，从而将酰基 组成苯环。 因此，作为生理活性化合物或其合成中间体的酮苯胺衍生物通过催化酰化以高反应收率合成。

公开(公告)号：US07204984B2

公开(公告)日：2007-04-17

申请号：US10471475

申请日：2002-03-13

申请人： Yasuhiko Komatsu ,  Minoru Yoshida

发明人： Yasuhiko Komatsu ,  Minoru Yoshida

IPC分类号： C12N15/13 ,  A61K39/395

CPC分类号： C07K16/44

摘要： Anti-acetyllysine monoclonal antibody capable of recognizing Nε-acetyllysine regardless of the types of the adjacent amino acids. Namely, a monoclonal antibody having a light chain comprising a constant region having the amino acid sequence represented by SEQ ID NO:1 and a variable region having the amino acid sequence represented by SEQ ID NO:2 or an amino acid sequence derived from this amino acid sequence by deletion, substitution or addition of one to several amino acids, and a heavy chain comprising a constant region having the amino acid sequence represented by SEQ ID NO:3 and a variable region having the amino acid sequence represented by SEQ ID NO:4 or an amino acid sequence derived from this amino acid sequence by deletion, substitution or addition of one to several amino acids, and being capable of recognizing Nε-acetyllysine in a protein regardless of the types of the adjacent amino acids, i.e., being capable of accepting adjacent amino acids over a broad range; and a process for producing this monoclonal antibody characterized by using a chemically acetylated protein as an antigen.

摘要翻译： 能够识别Nε - 乙酰赖氨酸的抗乙酰赖氨酸单克隆抗体，不管相邻氨基​​酸的类型如何。 即，具有包含具有由SEQ ID NO：1表示的氨基酸序列的恒定区和具有由SEQ ID NO：2表示的氨基酸序列的可变区的氨基酸序列的轻链的单克隆抗体或由该氨基 通过缺失，取代或添加一至几个氨基酸的酸序列，以及包含具有SEQ ID NO：3所示氨基酸序列的恒定区的重链和具有由SEQ ID NO：3表示的氨基酸序列的可变区。 4或由该氨基酸序列衍生的氨基酸序列，通过缺失，取代或添加一至几个氨基酸，并且能够识别蛋白质中的Nε - 乙酰赖氨酸，而不管 相邻的氨基酸，即能够在宽范围内接受相邻的氨基酸; 其特征在于使用化学乙酰化蛋白作为抗原的该单克隆抗体的制备方法。

公开(公告)号：US07204263B2

公开(公告)日：2007-04-17

申请号：US10432897

申请日：2001-11-08

申请人： Shouichirou Tsukita ,  Takashi Funatsu ,  Shuichi Shouji

发明人： Shouichirou Tsukita ,  Takashi Funatsu ,  Shuichi Shouji

IPC分类号： E03B1/00 ,  F15B21/00 ,  C01F1/40

CPC分类号： B01F13/0076 ,  B01F13/001 ,  B01F13/0059 ,  B01F2215/0431 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00853 ,  B01J2219/00873 ,  B01J2219/00891 ,  B01J2219/00945 ,  B01J2219/0095 ,  B01L3/502738 ,  B01L2400/0677 ,  F15C1/04 ,  F16K99/0001 ,  F16K99/0028 ,  F16K99/0036 ,  F16K99/0044 ,  F16K2099/0074 ,  F16K2099/0084 ,  G05D7/0186 ,  Y10T137/0324 ,  Y10T137/2082 ,  Y10T137/2196

摘要： A method of simply controlling the flow of fluid in a micro system without using a complicated value structure, comprising the steps of adding the substance transformed from sol-gel by stimulation to the fluid flowing through the micro flow passage of the micro system, and adding the stimulation to the fluid at a desired position on the micro flow passage to transform the fluid into gel for flow control.

摘要翻译： 一种在不使用复杂的价值结构的情况下简单地控制微系统中的流体流动的方法，包括以下步骤：通过刺激将从溶胶 - 凝胶转变的物质加入到流过微系统微流道的流体中， 在微流道上的期望位置处对流体的刺激，以将流体转化成凝胶以进行流量控制。

公开(公告)号：US07195698B2

公开(公告)日：2007-03-27

申请号：US10318124

申请日：2002-12-13

申请人： Yoshihide Hayashizaki ,  Shin Nakamura ,  Makoto Hazama ,  Hideshi Fujiwake

发明人： Yoshihide Hayashizaki ,  Shin Nakamura ,  Makoto Hazama ,  Hideshi Fujiwake

IPC分类号： G01N27/447 ,  G01N27/453

CPC分类号： G01N27/44782 ,  G01N27/44743

摘要： An electrode plate of a sample plate is set on the body of an electrophoretic apparatus, while a plug is inserted into a migration high voltage line connection hole and connected to a high-tension distribution cable. Each well of a base plate is inserted into a through hole of a well guide and further press-fit and engaged into a cavity of an electrode plate, for fixing the base plate to the electrode plate. Thereafter a sample is introduced into each well of the base plate and an end of a capillary column is dipped into each well for applying a migration voltage and electrophoretically injecting the sample into the capillary column.

摘要翻译： 将样品板的电极板放置在电泳装置的主体上，同时将插头插入迁移高压线路连接孔并连接到高压配电电缆。 基板的每个孔插入井导向件的通孔中，并进一步压配合并接合到电极板的空腔中，用于将基板固定到电极板。 然后将样品引入基板的每个孔中，并将毛细管柱的末端浸入每个孔中以施加迁移电压并将样品电泳注入毛细管柱中。