公开(公告)号：US20100216246A1

公开(公告)日：2010-08-26

申请号：US12727720

申请日：2010-03-19

申请人： Ahmet Konya ,  Herbert Harttig

发明人： Ahmet Konya ,  Herbert Harttig

IPC分类号： G01N35/00 ,  G01N33/50 ,  G01N33/49 ,  G01N35/10

CPC分类号： A61B5/1411 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/150022 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/15109 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/15123 ,  A61B5/15128 ,  A61B5/15132 ,  A61B5/15153 ,  A61B5/15169 ,  A61B5/15171 ,  A61B5/157 ,  A61B2562/0295 ,  Y10T436/11

摘要： A sampling system for collecting a liquid sample, having at least one analytic auxiliary means is proposed. The sampling system has a coupling element for coupling onto the analytic auxiliary means and at least one drive unit for driving a movement of the coupling element from a rest position into a deflected position. The drive unit comprises an energy transducer which is designed to generate a rotational movement with different rotational directions. The drive unit furthermore has a coupling device with at least one rotational-direction sensitive element, wherein the coupling device is designed to couple the energy transducer to a first system function in a first rotational direction, and to couple said transducer to a second system function which differs from the first system function in a second rotational direction which differs from the first rotational direction.

摘要翻译： 提出了一种用于收集具有至少一个分析辅助装置的液体样品的采样系统。 采样系统具有用于耦合到分析辅助装置的耦合元件和用于驱动耦合元件从静止位置移动到偏转位置的至少一个驱动单元。 驱动单元包括能量转换器，其被设计成产生具有不同旋转方向的旋转运动。 所述驱动单元还具有一个具有至少一个旋转方向敏感元件的联接装置，其中所述耦合装置被设计成在第一旋转方向上将所述能量换能器耦合到第一系统功能，并且将所述换能器耦合到第二系统功能 其与第一旋转方向不同的第一旋转方向与第一系统功能不同。

公开(公告)号：US20100094325A1

公开(公告)日：2010-04-15

申请号：US12619420

申请日：2009-11-16

申请人： Ahmet Konya ,  Herbert Harttig

发明人： Ahmet Konya ,  Herbert Harttig

IPC分类号： A61B17/32

CPC分类号： A61B5/157 ,  A61B5/150022 ,  A61B5/150175 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/15117 ,  A61B5/15128 ,  A61B5/1513 ,  A61B5/15146

摘要： A pricking system includes lancets for producing a prick wound, sampling devices for collecting a sample of a body fluid from the prick wound, a housing having an opening for application of a body part in which the prick wound is to be produced, a drive arranged in the housing for moving one of the lancets to produce the prick wound and to then move one of the sampling devices to the prick wound so produced, a coupling part for coupling to the drive one of the lancets for a pricking movement and then coupling to the drive one of the sampling devices for a sampling movement, the coupling part being moved, during the pricking movement and the sampling movement, respectively, from a starting position into an end position by an advancing movement, and from the end position back into the starting position by a reversing movement, respectively, and a motion control which, during the sampling movement, causes the coupling part to reach an end position that differs from the end position reached by the coupling part during the pricking movement, wherein the end position reached by the coupling part in the sampling movement is laterally displaced relative to the end position reached by the coupling part in the prickling movement.

摘要翻译： 穿刺系统包括用于产生刺伤的刺血针，用于从刺伤缠绕收集体液样本的取样装置，具有用于施加要产生刺伤的身体部位的开口的壳体，布置成 在用于移动其中一个刺血针以产生刺伤并且然后将其中一个取样装置移动到如此产生的刺伤的壳体中的一个联接部分，用于联接到驱动器之一的刺血针用于穿刺运动，然后耦合到 用于采样运动的采样装置中的一个驱动器，耦合部分在穿刺运动和采样运动期间分别从进位运动的起始位置移动到结束位置，并且从终端位置返回到 分别通过反转运动的起始位置和运动控制，在运动控制期间，在取样运动期间，使联接部件到达不同于最终位置的终点位置 d，其中在取样运动中由联接部件到达的端部位置相对于穿刺运动中的联接部件所达到的端部位置横向移位。

公开(公告)号：US20090182289A1

公开(公告)日：2009-07-16

申请号：US12341088

申请日：2008-12-22

申请人： Hans List ,  Otto Fuerst ,  Hans-Peter Haar ,  Ulrich Haueter ,  Herbert Harttig ,  Johannes Pill

发明人： Hans List ,  Otto Fuerst ,  Hans-Peter Haar ,  Ulrich Haueter ,  Herbert Harttig ,  Johannes Pill

IPC分类号： A61M37/00

CPC分类号： A61B17/3421 ,  A61B5/0002 ,  A61B5/14865 ,  A61B5/6848 ,  A61B17/3417 ,  A61B17/3468 ,  A61B2017/2905 ,  A61B2017/3405 ,  A61B2017/3492

摘要： An introducing device for introduction of a medical device into a body is described which has a distal region with a tip region for generating an opening in the skin, and a segment region which comprises at least two sections which, in a rigid state, are essentially rigidly connected at least to one another and to the distal region and which are movable relative to one another in a flexible state. Furthermore, a system is described in which a sensor is integrated into the device for introduction into a body.

摘要翻译： 描述了一种用于将医疗装置引入到身体中的引入装置，其具有具有用于在皮肤中产生开口的尖端区域的远侧区域，以及包括至少两个部分的区段，所述区段处于刚性状态基本上是 至少彼此刚性地连接并且连接到远侧区域并且能够以柔性状态相对于彼此移动。 此外，描述了一种系统，其中将传感器集成到用于引入身体的装置中。

公开(公告)号：US07449326B2

公开(公告)日：2008-11-11

申请号：US09780206

申请日：2001-02-09

申请人： Michael Fritz ,  Volker Gerstle ,  Herbert Harttig ,  Juergen Schwab ,  Joachim Steinbiss ,  Andreas Rauscher

发明人： Michael Fritz ,  Volker Gerstle ,  Herbert Harttig ,  Juergen Schwab ,  Joachim Steinbiss ,  Andreas Rauscher

IPC分类号： C12M3/00 ,  C12Q1/68 ,  C12P19/34 ,  C07H21/02

CPC分类号： B01L7/525 ,  B01L7/52 ,  C12N15/101

摘要： A system for simple nucleic acid analysis is described in which the amplification space contains at least a part of the binding space. An additional improvement is achieved by the design of the binding or/and amplification space which is optionally surrounded by a heatable metal layer.

摘要翻译： 描述了用于简单核酸分析的系统，其中放大空间包含至少一部分结合空间。 通过设计由可加热金属层任选地包围的结合或/和放大空间来实现另外的改进。

公开(公告)号：US07371830B2

公开(公告)日：2008-05-13

申请号：US11041750

申请日：2005-01-24

申请人： Jörg Kleiber ,  Thomas Walter ,  Herbert Harttig ,  Christop Lesniak ,  Martin Mennig ,  Michael Riedling ,  Helmut Schmidt

发明人： Jörg Kleiber ,  Thomas Walter ,  Herbert Harttig ,  Christop Lesniak ,  Martin Mennig ,  Michael Riedling ,  Helmut Schmidt

IPC分类号： C07K1/22 ,  C12N13/00 ,  C12N1/02 ,  C12P19/34 ,  C12P1/00 ,  C07H21/00

CPC分类号： C23C30/00 ,  C12Q1/6806 ,  Y10S428/90 ,  Y10S435/814 ,  Y10T428/12042 ,  Y10T428/2996 ,  C12Q2563/149 ,  C12Q2563/143

摘要： Magnetic particles are prepared containing a magnetic core coated with a glass layer having a substantially pore-free glass surface or having pores with a diameter of less than 10 nm. The particles are used for separating biological material such as nucleic acids. A preferred process of preparing the particles is by forming a mixture of magnetic cores with a sol formed from an alcohol and a metal alkoxide, spray-drying the mixture to coat the cores with a layer of gelled sol, and heating the coated cores to obtain the magnetic glass particles. Preferably, the particles have an average particle size of less than 100 μm. The magnetic core may be a composite material containing a mica core and magnetite particles immobilized on the mica core, and the glass layer may contain boron oxide. Magnetic core materials include magnetite (Fe3O4) and Fe2O3.

摘要翻译： 制备磁性颗粒，其包含涂覆有具有基本无孔玻璃表面或具有小于10nm直径的孔的玻璃层的磁芯。 颗粒用于分离生物材料如核酸。 制备颗粒的优选方法是通过用由醇和金属醇盐形成的溶胶形成磁芯的混合物，喷雾干燥混合物以用一层凝胶溶胶涂覆芯，并加热涂覆的芯以获得 磁性玻璃颗粒。 优选地，颗粒的平均粒度小于100μm。 磁芯可以是包含固定在云母芯上的云母芯和磁铁矿颗粒的复合材料，并且玻璃层可以含有氧化硼。 磁芯材料包括磁铁矿（Fe 3 O 4 O 4）和Fe 2 O 3 O 3。

公开(公告)号：US20080082023A1

公开(公告)日：2008-04-03

申请号：US11849280

申请日：2007-09-01

申请人： Frank Deck ,  Ortrud Quarder ,  Thomas Weiss ,  Christian Horauf ,  Michael Keil ,  Ahmet Konya ,  Herbert Harttig ,  Felix Baader ,  Hans List ,  Karl-Peter Ebert

发明人： Frank Deck ,  Ortrud Quarder ,  Thomas Weiss ,  Christian Horauf ,  Michael Keil ,  Ahmet Konya ,  Herbert Harttig ,  Felix Baader ,  Hans List ,  Karl-Peter Ebert

IPC分类号： A61B5/157 ,  A61B5/151

CPC分类号： A61B5/15148 ,  A61B5/150022 ,  A61B5/15019 ,  A61B5/150198 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/150572 ,  A61B5/150832 ,  A61B5/150916 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/15128 ,  A61B5/1519 ,  A61B5/15194 ,  A61B5/15196

摘要： The present invention provides a puncturing system for withdrawing body fluid. The puncturing system comprises a disposable puncturing unit, which includes a needle element for piercing into skin and a puncturing depth reference element with a skin contact area. The system includes a puncturing instrument which has a puncturing drive, wherein the puncturing drive is coupled by a coupling mechanism to the puncturing unit for driving the needle element to a puncturing depth, the puncturing depth being determined by the distance in the piercing direction between the skin contact area and the position of the tip of the needle at a reversal point of the puncturing movement. The puncturing depth reference element is connected to the needle element such that the puncturing depth reference element moves with the needle element during at least part of the puncturing movement. The puncturing depth reference element has a defined longitudinal position in the piercing direction relative to the needle element at least at the reversal point of the puncturing movement.

摘要翻译： 本发明提供一种用于抽出体液的穿刺系统。 穿刺系统包括一次性穿刺单元，其包括用于刺入皮肤的针元件和具有皮肤接触区域的穿刺深度参考元件。 该系统包括具有穿刺驱动器的穿刺器具，其中穿刺驱动器通过联接机构联接到穿刺单元，用于将针元件驱动到穿刺深度，穿刺深度由穿刺方向上的距离确定 皮肤接触区域和针的尖端在穿刺运动的反转点处的位置。 穿刺深度参考元件连接到针元件，使得穿刺深度参考元件在穿刺运动的至少一部分期间与针元件一起移动。 穿刺深度参考元件至少在穿刺运动的反转点处具有相对于针元件在穿刺方向上的限定的纵向位置。

公开(公告)号：US20070077175A1

公开(公告)日：2007-04-05

申请号：US11533894

申请日：2006-09-21

申请人： Herbert Harttig

发明人： Herbert Harttig

IPC分类号： G01N33/00

CPC分类号： G01N33/4875 ,  Y10T436/144444

摘要： An analytical system comprising a replaceable magazine (12) for providing a plurality of test units that react to an analyte and a measuring device (14) for processing the test units, wherein the magazine (12) is provided with a code (26) that can be registered by the measuring device (14). In order to enable the simplest possible coding, it is proposed that the code (26) comprises an unique magazine identifier (28) for the magazine (12) and that the measuring device (14) has a magazine-independent test counter (16) which registers the processing of a test unit and a counter memory (18) to store the magazine identifier (28) and a corresponding count of the test counter (16).

摘要翻译： 一种分析系统，包括用于提供与分析物反应的多个测试单元和用于处理所述测试单元的测量装置（14）的可替换盒（12），其中所述盒（12）设置有代码（26），所述代码 可以由测量装置（14）登记。 为了实现最简单的可能的编码，提出了代码（26）包括用于盒（12）的唯一杂志标识符（28），并且测量装置（14）具有独立于杂志的测试计数器（16） 其记录测试单元和计数器存储器（18）的处理，以存储盒标识符（28）和测试计数器（16）的相应计数。

公开(公告)号：US20050266429A1

公开(公告)日：2005-12-01

申请号：US11041750

申请日：2005-01-24

申请人： Jorg Kleiber ,  Thomas Walter ,  Herbert Harttig ,  Christoph Lesniak ,  Martin Mennig ,  Michael Riedling ,  Helmut Schmidt

发明人： Jorg Kleiber ,  Thomas Walter ,  Herbert Harttig ,  Christoph Lesniak ,  Martin Mennig ,  Michael Riedling ,  Helmut Schmidt

IPC分类号： C03C14/00 ,  C12Q1/68 ,  C23C30/00

CPC分类号： C23C30/00 ,  C12Q1/6806 ,  Y10S428/90 ,  Y10S435/814 ,  Y10T428/12042 ,  Y10T428/2996 ,  C12Q2563/149 ,  C12Q2563/143

摘要： Magnetic particles with an outer glass surface being essentially poreless or having pores of a diameter of less then 10 nm as well as ferromagnetic particles with a glass surface are preferentially useful for the isolation of biological material from samples. They provide a quick and reliable purification.

摘要翻译： 具有基本上无孔隙或具有小于10nm直径的孔的外部玻璃表面的磁性颗粒以及具有玻璃表面的铁磁颗粒优选用于从样品中分离生物材料。 它们提供快速可靠的净化。

公开(公告)号：US20050137471A1

公开(公告)日：2005-06-23

申请号：US10740056

申请日：2003-12-18

申请人： Hans-Peter Haar ,  Hans List ,  Felix Baader ,  Herbert Harttig ,  George Meacham

发明人： Hans-Peter Haar ,  Hans List ,  Felix Baader ,  Herbert Harttig ,  George Meacham

IPC分类号： A61B5/00 ,  G01N35/00 ,  A61K9/22

CPC分类号： A61B5/14528 ,  A61B5/14532 ,  A61B5/686 ,  A61B2562/0295 ,  Y10T436/110833

摘要： The present invention is generally directed towards devices for sensing a concentration of chemical constituents in body fluid such as interstitial fluid, including but not limited to glucose. The devices also relates to systems for measuring and reporting the concentration of body fluid constituents at time intervals shorter than the physiological response time, thereby providing effectively continuous concentration measurements. The device according to the present invention comprises a probe, a reservoir with perfusion fluid connected to an inlet of the probe, at least one test zones which comprise a reagent, to react with the analyte to produce a detectable change, a reader unit which reads test zones wetted with fluid containing the analyte, where the reader unit produces signals according to the concentration of the analyte in the fluid; and a processing unit for processing the signals and the concentration of the analyte.

摘要翻译： 本发明通常涉及用于感测体液中诸如间质液体（包括但不限于葡萄糖）的化学成分浓度的装置。 这些装置还涉及用于在比生理反应时间短的时间间隔测量和报告体液组分的浓度的系统，从而提供有效的连续浓度测量。 根据本发明的装置包括探针，具有连接到探针的入口的灌注流体的储存器，包含试剂的至少一个测试区域，以与分析物反应以产生可检测的变化;读取器单元，其读取 用含有分析物的流体润湿的测试区域，其中读取器单元根据流体中分析物的浓度产生信号; 以及用于处理信号和分析物浓度的处理单元。

公开(公告)号：US06872315B2

公开(公告)日：2005-03-29

申请号：US10912705

申请日：2004-08-05

申请人： Carlo Effenhauser ,  Herbert Harttig ,  Peter Kraemer

发明人： Carlo Effenhauser ,  Herbert Harttig ,  Peter Kraemer

IPC分类号： F04B17/00 ,  F04B43/06 ,  B01D29/00

CPC分类号： F04B43/06 ,  F04B17/00 ,  Y10T436/2575

摘要： The present invention concerns a method of producing flow rates of a transport liquid of about 1 to 1000 nl/min. The method provides a pump having a housing defining a space and including a channel and a wettable membrane positioned in the housing, the membrane including a first side facing toward the channel and a second side facing the space. The method further includes at least partially filling the channel with the transport liquid, contacting the wettable membrane with the transport liquid to generate an underpressure in the channel,evaporating the transport liquid at the wettable membrane to remove the transport liquid from the channel and to create an underpressure in the channel, and maintaining a generally constant vapor pressure of the transport liquid in the space.

摘要翻译： 本发明涉及一种产生约1至1000nl / min的输送液体的流速的方法。 该方法提供一种泵，其具有限定空间的壳体，并且包括定位在壳体中的通道和可湿性膜，所述膜包括面向通道的第一侧和面向空间的第二侧。 该方法还包括至少部分地与输送液体填充通道，使可湿性膜与输送液体接触以在通道中产生负压，蒸发可渗透膜上的输送液体以从通道移除输送液体并产生 通道中的负压，并保持空间中输送液体的蒸汽压大体上恒定。