Microfluidic element for analyzing a liquid sample
    1.
    发明授权
    Microfluidic element for analyzing a liquid sample 有权
    用于分析液体样品的微流体元件

    公开(公告)号:US08911684B2

    公开(公告)日:2014-12-16

    申请号:US13487707

    申请日:2012-06-04

    摘要: A microfluidic element for analyzing a bodily fluid sample for an analyte contained therein is provided, the element having a substrate, a channel structure that is enclosed by the substrate, and a cover layer, and is rotatable around a rotational axis. The channel structure of the microfluidic element includes a feed channel having a feed opening, a ventilation channel having a ventilation opening, and at least two reagent chambers. The reagent chambers are connected to one another via two connection channels in such a manner that a fluid exchange is possible between the reagent chambers, one of the reagent chambers having an inlet opening, which has a fluid connection to the feed channel, so that a liquid sample can flow into the rotational-axis-distal reagent chamber. At least one of the reagent chambers contains a reagent, which reacts with the liquid sample.

    摘要翻译: 提供了用于分析其中​​包含的分析物的体液样品的微流体元件,所述元件具有衬底,由衬底包围的沟道结构和覆盖层,并且可围绕旋转轴线旋转。 微流体元件的通道结构包括具有进料口的进料通道,具有通风口的通风通道和至少两个试剂室。 试剂室通过两个连接通道彼此连接,使得可以在试剂室之间进行流体交换,其中一个试剂室具有与进料通道的流体连接的入口,从而使得 液体样品可以流入旋转轴远端试剂室。 至少一个试剂室含有与液体样品反应的试剂。

    Micro chamber
    5.
    发明授权
    Micro chamber 有权
    微室

    公开(公告)号:US08911683B2

    公开(公告)日:2014-12-16

    申请号:US12142019

    申请日:2008-06-19

    IPC分类号: B01J19/00 B01L3/00 B01F13/00

    摘要: A microfluidic device is provided including at least one chamber accessible by microfluidic channels characterized in that the surface of the channels and the chambers are patterned and comprise hydrophilic and hydrophobic areas. The surface energy in correspondence of the areas, i.e., the capillary force, being such that a liquid can be guided along the hydrophilic path, enter the chamber from one side, wet part of one surface of the chamber as a thin layer without touching the opposite surface of the chamber, thus avoiding to fill the volume inside the chamber in correspondence of the hydrophilic pattern until a second liquid, either sequentially or in parallel, comes to wet part of the opposite surface of the chamber and eventually touches the first liquid layer, resulting in a sudden coalescence and efficient mixing between the liquids.

    摘要翻译: 提供了一种微流体装置,其包括至少一个可由微流体通道访问的腔室,其特征在于通道和腔室的表面被图案化并且包括亲水和疏水区域。 对应于面积的表面能,即毛细管力,使得液体可以沿着亲水路径被引导,从一侧进入腔室,将腔室的一个表面的湿部分作为薄层而不接触 因此避免了填充室内的体积,与亲水图形相对应,直到第二液体顺序地或平行地到达室的相对表面的湿润部分,并最终接触第一液体层 ,导致液体之间突然的聚结和有效的混合。

    Method and apparatus for analyzing a dry-chemical test element
    10.
    发明授权
    Method and apparatus for analyzing a dry-chemical test element 有权
    用于分析干化学试验元件的方法和装置

    公开(公告)号:US07760346B2

    公开(公告)日:2010-07-20

    申请号:US12206803

    申请日:2008-09-09

    IPC分类号: G01J1/00

    CPC分类号: G01N21/253 G01N21/8483

    摘要: The invention relates to a method and an apparatus for analyzing a dry-chemical test element, in particular an immunological test element, wherein, in the method, a dry-chemical test element is analyzed by optical scanning, whereby measurement light beams leaving assay regions of the test element, which are loaded with one or more immobilized optically active substances, with a respective measurement light intensity are detected by a detector device. The method comprises the following steps: during the optical scanning of a first assay region, from which the measurement light beams leave with a first measurement light intensity, a first quantity of light from measurement light beams which impinges on the detector device and a working range of the detector device are adapted to one another by selecting scanning parameters according to a first set of scanning parameters, and during the optical scanning of a second assay region, from which the measurement light beams leave with a second measurement light intensity which differs from the first measurement light intensity, a second quantity of light from measurement light beams which impinges on the detector device and the working range of the detector device are adapted to one another by selecting scanning parameters according to a second set of scanning parameters which differs from the first set of scanning parameters.

    摘要翻译: 本发明涉及一种用于分析干化学测试元件,特别是免疫测试元件的方法和设备,其中在该方法中,通过光学扫描分析干化学测试元件,由此测量光束离开测定区域 通过检测器装置检测装载有一个或多个固定的光学活性物质的各个测量光强度的测试元件。 该方法包括以下步骤:在第一测定区域的光学扫描期间,测量光束以第一测量光强度离开,来自测量光束的第一数量的光照射在检测器装置上,工作范围 通过根据第一组扫描参数选择扫描参数,并且在第二测定区域的光学扫描期间,通过与第二测量光束不同的第二测量光强度离开测量光束而使检测器设备彼此适配 通过根据与第一测量光强度不同的第二组扫描参数选择扫描参数,第一测量光强度,撞击检测器装置的测量光束的第二数量的光和检测器装置的工作范围彼此适配 扫描参数集。