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公开(公告)号：US11359029B2
公开(公告)日：2022-06-14
申请号：US16840830
申请日：2020-04-06
Applicant: Janssen Biotech, Inc.
IPC: C07K16/28
Abstract: The present invention relates to engineered anti-TNFR superfamily member antibodies having enhanced agonistic activity and methods of using them.
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公开(公告)号：US20220169741A1
公开(公告)日：2022-06-02
申请号：US17523058
申请日：2021-11-10
Applicant: Janssen Biotech, Inc.
Inventor： Thomas Nesspor
Abstract: The present disclosure relates to methods of modifying the isoelectric point of an antibody. The method includes providing an antibody comprising a first polypeptide comprising a heavy chain variable region and a second polypeptide comprising heavy chain variable region and substituting, in at least one of the first and second polypeptides of the antibody, one or more amino acid residues of the heavy chain variable region (VH) at positions 7, 9, 11, 14, 41, 70, 74, 82a, 84, and 113, according to the Kabat numbering system, wherein the substituting increases or decreases the isoelectric point of the antibody.
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公开(公告)号：US20220112282A1
公开(公告)日：2022-04-14
申请号：US17496057
申请日：2021-10-07
Applicant: Janssen Biotech, Inc.
Inventor： Frederic Lavie , Manuela Le Bars , Michael Plotnick , Sheldon Sloan
Abstract: Methods and compositions for clinical proven safe and effective treatment of Crohn's disease, particularly moderately to severely active Crohn's disease in patients, comprise intravenous initial dosing and subcutaneous maintenance dosing of an anti-IL12/IL23p40 antibody with maintenance dose intervals determined by evaluating clinical indicators.
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公开(公告)号：US20220090140A1
公开(公告)日：2022-03-24
申请号：US17595160
申请日：2020-04-21
Applicant: Janssen Biotech, Inc.
Inventor： Hsu-Feng Ko , Ravinder Bhatia , Soumya Mohanan Krishnathu , Vaishali Yannone , Jeffrey Edward Landau , Bas Diepenbroek , Guus Bjorn Erkens , Elisabeth Meulenbroek , Feras Nachmi Alazi
IPC: C12N15/86
Abstract: A method for purifying a viral vector from a solution including the viral vector and host cell proteins (HCP) is provided. The method includes circulating the solution across an ultrafiltration/diafiltration membrane using tangential flow filtration (TFF) mode with continuous addition of diafiltration buffer. The method further includes filtering the solution across the ultrafiltration/diafiltration membrane to provide a permeate and a retentate. The retentate is collected such that a purified viral vector solution is obtained and retained in the retentate. A volume of the retentate is kept constant by the continuous addition of diafiltration buffer and the HCP is filtered out via the permeate.
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公开(公告)号：US20220089737A1
公开(公告)日：2022-03-24
申请号：US17472237
申请日：2021-09-10
Applicant: JANSSEN BIOTECH, INC.
Inventor： Rajkumar GANESAN , Michael Riis HANSEN , Iqbal S. GREWAL , Sanjaya SINGH
Abstract: Provided herein are trispecific antibodies or antigen binding fragments thereof that bind to Vβ17, CD28 and another target (e.g., a cancer antigen, such as BCMA or PSMA) are described. Also described are nucleic acids encoding the antibodies, compositions comprising the antibodies, methods of producing the antibodies, and methods of using the antibodies for treating or preventing diseases.
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Patent Agency Ranking
公开(公告)号：US20220064306A1
公开(公告)日：2022-03-03
申请号：US17411158
申请日：2021-08-25
Applicant: Janssen Biotech, Inc.
Inventor： Roland Knoblauch , Sheri Moores
Abstract: The present invention relates to treatment of subjects having EGFR exon 20 insertion and other uncommon EGFR mutations.
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公开(公告)号：US20220064284A1
公开(公告)日：2022-03-03
申请号：US17376874
申请日：2021-07-15
Applicant: Janssen Biotech, Inc.
Inventor： Ellen CHI , Wilson EDWARDS , Matt HUSOVSKY , Ann LACOMBE , Christian MARTINEZ , H. Mimi ZHOU , John T. LEE
Abstract: In certain aspects, the disclosure relates to anti-idiotype antibodies and antigen-binding portions thereof that specifically bind a GP5B83 containing protein, e.g., an antibody or antigen-binding portions thereof. In some aspects, the anti-idiotype antibodies and antigen-binding portions of the present disclosure can be used in methods to detect and quantify cells expressing chimeric antigen receptors that include GP5B83.
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公开(公告)号：US20220062415A1
公开(公告)日：2022-03-03
申请号：US17524516
申请日：2021-11-11
Applicant: Janssen Biotech, Inc.
Inventor： Hong Xie , Andrew Cakana
IPC: A61K39/395 , A61K31/198 , A61K31/573 , C07K16/28 , A61K9/00 , A61K47/12 , A61K47/02 , A61K47/26 , A61K47/42 , A61K47/22 , A61K47/20 , A61P35/00 , A61K31/69 , G06Q30/00 , G06Q30/06 , G06Q30/02
Abstract: Described herein are methods of treating multiple myeloma with clinically proven safe and effective amounts of an antibody that specifically recognizes CD38 with bortezomib, melphalan, and prednisone. Also described are methods of selling or offering for sale an antibody that specifically recognizes CD38 or pharmaceutical compositions thereof with bortezomib, melphalan, and prednisone.
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公开(公告)号：US20220056109A1
公开(公告)日：2022-02-24
申请号：US17508026
申请日：2021-10-22
Applicant: Janssen Biotech, Inc.
Inventor： Hetal Sarvaiya , Nathaniel J. Washburn , Enrique Arevalo , Carlos J. Bosques
IPC: C07K16/00 , C12P21/00 , C07K1/107 , C07K14/435
Abstract: Glycoproteins having particular sialylation patterns, and methods of making and using such glycoproteins, are described.
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公开(公告)号：US20220054634A1
公开(公告)日：2022-02-24
申请号：US17522423
申请日：2021-11-09
Applicant: Janssen Biotech, Inc.
Inventor： Jacquelne Benson , Mark Cunningham , Cynthia Duchala , Jill Giles-Komar , Jinquan Luo , Michael Rycyzyn , Raymond Sweet
IPC: A61K39/395 , G01N33/68 , C07K16/24 , A61K45/06
Abstract: An anti-IL-23 antibody, including isolated nucleic acids that encode at least one anti-IL-23 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.
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