公开(公告)号：US06573371B2

公开(公告)日：2003-06-03

申请号：US09879833

申请日：2001-06-12

申请人： Neon-Cheol Jung ,  Jin-Man Kim ,  Seung-Suh Hong ,  Hyun-Soo Lee ,  Young-Rim Seong ,  Jae-Ho Lee

发明人： Neon-Cheol Jung ,  Jin-Man Kim ,  Seung-Suh Hong ,  Hyun-Soo Lee ,  Young-Rim Seong ,  Jae-Ho Lee

IPC分类号： C07H2102

CPC分类号： C12Q1/6886 ,  C12Q2600/156 ,  C12Q2600/158

摘要： The present invention relates to a diagnosis method of cancer using SYG972 gene and to the genomic DNA and to a promoter regulating transcription of the gene. Expression of SYG972 gene is greatly reduced in breast cancer cells compared to normal breast cells. Therefore the present invention provides a method of diagnosis method by using the gene of the present invention or its fragments as a probe. SYG972 genomic according to the present invention is composed of 4 exons and 3 introns. Promoter is 3 kb long from the transcription initiating site in the 5′ direction. SYG972 genomic DNA and promoter can be used to design and screen drugs to promote or to inhibit apoptosis and differentiation of cells, especially to screen drugs to treat cancer, a disease wherein cell growth and differentiation is abnormal.

摘要翻译： 本发明涉及使用SYG972基因和基因组DNA的癌症诊断方法以及调节基因转录的启动子。 与正常乳腺细胞相比，乳腺癌细胞中SYG972基因的表达大大降低。 因此，本发明提供了通过使用本发明的基因或其片段作为探针的诊断方法。 根据本发明的SYG972基因组由4个外显子和3个内含子组成。 启动子距5'方向的转录起始位点长3 kb。 SYG972基因组DNA和启动子可用于设计和筛选药物，以促进或抑制细胞的凋亡和分化，特别是筛选药物以治疗癌症，其中细胞生长和分化异常。

公开(公告)号：US06479701B1

公开(公告)日：2002-11-12

申请号：US09937747

申请日：2001-09-28

申请人： Seung-Hwan Kim ,  Jeong-Ho Park ,  Jin-Man Kim ,  Soon-Jong Hahn ,  Ki-Seung Choi ,  Myung-Ho Cho

发明人： Seung-Hwan Kim ,  Jeong-Ho Park ,  Jin-Man Kim ,  Soon-Jong Hahn ,  Ki-Seung Choi ,  Myung-Ho Cho

IPC分类号： C07C23305

CPC分类号： C07D275/03 ,  C07C319/20 ,  C07C319/24 ,  C07C323/60

摘要： A method of preparing N,N-disubstituted-3,3′-dithiodipropionamide of formula (2) is provided. In the method, 3-mercaptopropionamide of formula (4) reacts with an aqueous solution of amine to prepare N-substituted-3-mercaptopropionamide of formula (3) and N-substituted-3-mercaptopropionamide reacts with an aqueous solution of hydrogen peroxide. In addition, a method of preparing substituted 3-isothiazolone is provided. In the method, the produced N,N-disubstituted-3,3′-dithiodipropionamide reacts with a halogenating agent, wherein X and Z are same or different and each selected from the group consisting of hydrogen or a lower alkyl group; Y is selected from the group consisting of hydrogen, an alkyl group of 1 to 18 carbon atoms, a cycloalkyl group of up to 10 carbon atoms, an aralkyl group of up to 10 carbon atoms, an aryl group of up to 10 carbon atoms, a halogen-, lower alkyl- or lower alkoxy-substituted aryl group, a cyano alkyl group, a carboalkoxyalkyl group, a haloalkyl group, an alkoxyalkyl group, an aryloxyalkyl group of up to 12 carbon atoms, an aralkoxyalkyl group of up to 12 carbon atoms, a dialkylaminoalkyl group, an alkylacyl group of up to 8 carbon atoms, a lower alkylsulfonyl group, an arylsulfonyl group of up to 10 carbon atoms, a cyano group and a carbamoyl group.

摘要翻译： 提供制备式（2）的N，N-二取代-3,3'-二硫代二丙酰胺的方法。 在该方法中，式（4）的3-巯基丙酰胺与胺水溶液反应制备式（3）的N-取代-3-巯基丙酰胺，N-取代-3-巯基丙酰胺与过氧化氢水溶液反应。 此外，提供了制备取代的3-异噻唑酮的方法。 在该方法中，所制备的N，N-二取代-3,3'-二硫代二丙酰胺与卤化剂反应，其中X和Z相同或不同，各自选自氢或低级烷基; Y选自氢，1至18个碳原子的烷基，至多10个碳原子的环烷基，至多10个碳原子的芳烷基，至多10个碳原子的芳基， 卤素，低级烷基或低级烷氧基取代的芳基，氰基烷基，碳烷氧基烷基，卤代烷基，烷氧基烷基，至多12个碳原子的芳氧基烷基，至多12个碳原子的芳烷氧基烷基 原子，二烷基氨基烷基，至多8个碳原子的烷基酰基，低级烷基磺酰基，至多10个碳原子的芳基磺酰基，氰基和氨基甲酰基。

公开(公告)号：US6005345A

公开(公告)日：1999-12-21

申请号：US844584

申请日：1997-04-21

申请人： Nak-Heon Choi ,  Do-Young Ok ,  Jin-Man Kim ,  Deuk-Soo Pyun

发明人： Nak-Heon Choi ,  Do-Young Ok ,  Jin-Man Kim ,  Deuk-Soo Pyun

IPC分类号： H01J9/02 ,  H01J11/12 ,  H01J11/22 ,  H01J11/24 ,  H01J11/32 ,  H01J11/34 ,  H01J11/36 ,  H01J11/42 ,  H01J11/44 ,  H01J11/48 ,  H01J17/16 ,  H01J61/30 ,  H01J61/067

CPC分类号： H01J17/492 ,  H01J61/305

摘要： A plasma display panel is disclosed including a transparent insulating substrate having a plurality of striped grooves, whose portions between the grooves serve as barrier ribs; vertical transparent electrodes each of which is formed in each groove; a fluorescent layer formed on the vertical transparent electrode; horizontal electrodes in strip arrangement having a predetermined distance between one another, and being perpendicular to the transparent vertical electrodes; and supporting means which are respectively located on the edge portions of the substrate for supporting the horizontal electrodes.

摘要翻译： 公开了一种等离子体显示面板，其包括具有多个条纹槽的透明绝缘基板，其间的槽部分用作阻挡肋; 每个凹槽中形成垂直透明电极; 形成在垂直透明电极上的荧光层; 带状布置的水平电极在彼此之间具有预定距离并且垂直于透明垂直电极; 以及分别位于用于支撑水平电极的基板的边缘部分上的支撑装置。

公开(公告)号：US5925262A

公开(公告)日：1999-07-20

申请号：US840525

申请日：1997-04-21

申请人： Nak-Heon Choi ,  Do-Young Ok ,  Jin-Man Kim ,  Deuk-Soo Pyun

发明人： Nak-Heon Choi ,  Do-Young Ok ,  Jin-Man Kim ,  Deuk-Soo Pyun

IPC分类号： H01J9/02 ,  H01J9/18 ,  H01J9/24 ,  H01J11/12 ,  H01J11/22 ,  H01J11/24 ,  H01J11/32 ,  H01J11/34 ,  H01J11/36 ,  H01J11/42 ,  H01J17/16 ,  B44C1/22

CPC分类号： H01J9/242 ,  H01J17/492 ,  H01J9/185

摘要： A plasma display panel is disclosed including: a transparent insulating substrate; a plurality of transparent electrodes in a strip arrangement with each electrode having a groove that runs along the median of its surface and has a predetermined width and depth at its center, and side walls on both sides of the groove, the side walls serving as barrier ribs; a fluorescent layer formed in each groove; and a plurality of electrodes in strip arrangement having a predetermined distance between one another and perpendicular to the transparent electrodes, the electrodes being supported by supporting means formed on a predetermined portion of barrier rib located on the edge portion of the substrate.

摘要翻译： 公开了一种等离子体显示面板，包括：透明绝缘基板; 多个带状排列的透明电极，每个电极具有沿着其表面的中间延伸的凹槽，并且在其中心具有预定的宽度和深度，并且在两侧的侧壁上作为屏障 肋骨; 形成在每个槽中的荧光层; 以及带状排列的多个电极，其彼此之间具有预定的距离并垂直于所述透明电极，所述电极由形成在位于所述基板的所述边缘部分上的隔壁的预定部分上的支撑装置支撑。

公开(公告)号：US5542674A

公开(公告)日：1996-08-06

申请号：US403944

申请日：1995-03-14

申请人： Jin-Man Kim

发明人： Jin-Man Kim

IPC分类号： A63B21/02 ,  A63B69/00 ,  A63B69/36

CPC分类号： A63B24/0003 ,  A63B69/365 ,  A63B21/025 ,  A63B2209/08 ,  A63B2225/093 ,  A63B2225/12 ,  A63B69/3608 ,  A63B69/3652

摘要： A golf swing correcting health apparatus is disclosed, in which, when a golfer performs a swing within a room, the head-up movement is prevented, further the apparatus can be adjusted in accordance with the physical conditions of the golfer in an accurate manner, and further, the force of the golf club can be adjusted, so that not only the swinging posture can be corrected, but also the athletic exercising effect can be maximized.

摘要翻译： 公开了一种高尔夫挥杆校正健康装置，其中，当高尔夫球手在房间内进行摆动时，可以防止平视向上运动，并且还可以根据高尔夫球手的身体状况以准确的方式调整装置， 此外，可以调节高尔夫球杆的力，使得不仅可以校正摆动姿势，而且可以使运动锻炼效果最大化。