公开(公告)号：US20210372540A1

公开(公告)日：2021-12-02

申请号：US17404495

申请日：2021-08-17

Applicant: Repligen Corporation

Inventor： Michael C. Gagne ,  Dean C. Richards ,  Steven V. Cates ,  Scott Bendon

IPC: F16K27/00 ,  F16K7/07 ,  F16L3/24 ,  A61M5/14 ,  F16L3/13 ,  A23C7/00 ,  A61J3/00

Abstract: A system for managing flexible conduit or tubing used in pharmaceutical, bioprocess, or food/dairy applications includes a segment of flexible conduit or tubing and a plurality of conduit tracks, each conduit track including a conduit channel disposed on a first side thereof and extending along the length of each respective conduit track and dimensioned to receive the segment of flexible conduit or tubing therein, each conduit track further including a connector channel disposed on a second, opposing side and extending along the length of each respective conduit track and containing the one or more connectors that connect adjacent conduit tracks. The conduit tracks can be connected to each other or other process components.

公开(公告)号：US20210231470A1

公开(公告)日：2021-07-29

申请号：US17229457

申请日：2021-04-13

Applicant: Repligen Corporation

Inventor： Michael C. Gagne ,  Steven V. Cates ,  Dean C. Richards ,  Scott Bendon

IPC: G01D11/24 ,  G01L19/14 ,  G01D11/30 ,  G01F15/14 ,  G01N27/07

Abstract: A fluid monitoring assembly includes a conduit having a wall defining a lumen for carrying fluid. A sensor mount is integrally formed with the wall of the conduit and extends generally transverse with respect to a longitudinal axis of the conduit, the sensor mount including an aperture defining an inner surface extending to the lumen. The assembly includes a sensor configured to be removably secured within the sensor mount, the sensor having an elongate body terminating at one end thereof in a sensing portion, the elongate body having a male projection on a portion thereof and configured to rest within the inner surface of the sensor mount. The assembly further includes a housing having first and second portions connected to one another, the housing defining an interior portion configured to encapsulate the conduit, at least a portion of the elongate body of the sensor, and the sensor mount.

公开(公告)号：US20210214669A1

公开(公告)日：2021-07-15

申请号：US17218563

申请日：2021-03-31

Applicant: REPLIGEN CORPORATION

Inventor： Michael Bransby ,  Derek Carroll

IPC: C12M1/00 ,  B01D61/18 ,  B01D71/26 ,  B01D71/48 ,  B01D69/08 ,  C12M1/26

Abstract: The present disclosure relates to hollow fiber tangential flow filters, including hollow fiber tangential flow depth filters, for various applications, including bioprocessing and pharmaceutical applications, systems employing such filters, and methods of filtration using the same.

公开(公告)号：US20210131601A1

公开(公告)日：2021-05-06

申请号：US17147667

申请日：2021-01-13

Applicant: Repligen Corporation

Inventor： Michael C. Gagne

IPC: F16L55/11 ,  A61L2/07 ,  A61L2/08 ,  A61L2/20

Abstract: A fluid plug for use with sterile processes such as the manufacture or production of pharmaceuticals and biologics is disclosed. The fluid plug is made of a material or materials that will tolerate sterilizing processes such as gamma irradiation. The fluid plug is used to selectively plug the ends of flexible polymer conduits that may be connected to fluids, reagents, or products used or generated as part of the manufacturing process. Also disclosed is the use of the plugs in combination with a series of valves in a block-and-bleed arrangement to enable the sterile transfer and connection of fluids, reagents, or products within a process flow.

公开(公告)号：US10799816B2

公开(公告)日：2020-10-13

申请号：US15856210

申请日：2017-12-28

Applicant: REPLIGEN CORPORATION

Inventor： Rudolf Pavlik

IPC: B01D29/90 ,  B01D35/26 ,  B01D29/11 ,  F04B43/02 ,  B01D63/02 ,  C12M1/00 ,  B01D69/08 ,  B01D37/04 ,  C12M1/12 ,  F04B43/00 ,  F04B43/067 ,  F04B53/20

Abstract: A fluid filtration assembly includes a filter housing having a first end for fluid connection with a fluid storage vessel. A filter cartridge is disposable within the filter housing, and a plunger pump is coupled at a second end of the filter housing. The plunger pump includes a housing having a rigid portion and a flexible portion. The flexible portion has a plunger-engaging portion for coupling to the plunger of an actuator. The flexible portion selectively movable with respect to the rigid portion via the actuator. The filter cartridge can be a hollow fiber filter. The plunger pump can be configured to induce alternating tangential flow in at least a portion a the assembly. The fluid filtration assembly can be provided as a disposable single-use arrangement.

公开(公告)号：US20190300568A1

公开(公告)日：2019-10-03

申请号：US16324842

申请日：2017-08-07

Applicant: Repligen Corporation

Inventor： Paul Knick ,  Erik Fiedler ,  Ulrich Haupts ,  Maren Meysing

IPC: C07K1/22 ,  C07K14/31

Abstract: The present invention relates to Fc binding proteins comprising one or more Fc binding domains wherein at least one domain comprises of an amino acid sequence selected from the group consisting of SEQ ID NOs: 1-6 or 21. The invention further relates to affinity matrices comprising the Fc binding proteins of the invention. The invention also relates to a use of these Fc binding proteins or affinity matrices for affinity purification of immunoglobulins and to methods of affinity purification using the Fc binding proteins of the invention.

公开(公告)号：US20190240622A1

公开(公告)日：2019-08-08

申请号：US16263466

申请日：2019-01-31

Applicant: REPLIGEN CORPORATION

Inventor： Rudolf Pavlik

IPC: B01D61/18 ,  B01D69/08 ,  F04B43/04 ,  B01D61/22 ,  C07K1/34

CPC classification number: B01D61/18 ,  B01D61/22 ,  B01D69/08 ,  C07K1/34 ,  C12N7/02 ,  F04B43/04

Abstract: A single-use fluid storage and filtration system includes a process vessel, a filter module including a hollow fiber filter element, and a drive module coupled to the filter module. The filter module is fixed to the process vessel and is in fluid communication with the process vessel for filtering a fluid received from the process vessel. The drive module includes a pump to induce flow of the fluid between the filter module and the process vessel. The process vessel, filter module and drive module comprise a single integrated and sterilized assembly.

公开(公告)号：US20190201820A1

公开(公告)日：2019-07-04

申请号：US15856210

申请日：2017-12-28

Applicant: REPLIGEN CORPORATION

Inventor： Rudolf Pavlik

IPC: B01D29/90 ,  B01D35/26 ,  B01D29/11 ,  B01D69/08 ,  B01D37/04 ,  C12M1/12 ,  C12M1/00

CPC classification number: B01D29/908 ,  B01D29/11 ,  B01D35/26 ,  B01D37/04 ,  B01D63/02 ,  B01D69/08 ,  B01D2313/243 ,  B01D2313/58 ,  B01D2313/90 ,  C12M25/02 ,  C12M29/10 ,  F04B43/0063 ,  F04B43/0081 ,  F04B43/067 ,  F04B53/20

Abstract: A fluid filtration assembly includes a filter housing having a first end for fluid connection with a fluid storage vessel. A filter cartridge is disposable within the filter housing, and a plunger pump is coupled at a second end of the filter housing. The plunger pump includes a housing having a rigid portion and a flexible portion. The flexible portion has a plunger-engaging portion for coupling to the plunger of an actuator. The flexible portion selectively movable with respect to the rigid portion via the actuator. The filter cartridge can be a hollow fiber filter. The plunger pump can be configured to induce alternating tangential flow in at least a portion a the assembly. The fluid filtration assembly can be provided as a disposable single-use arrangement.

公开(公告)号：US20190127678A1

公开(公告)日：2019-05-02

申请号：US16171867

申请日：2018-10-26

Applicant: Repligen Corporation

Inventor： Michael Bransby ,  Philip Yuen

IPC: C12M1/00 ,  C12M1/26 ,  B01D61/14 ,  B01D61/18

Abstract: A micro alternating tangential flow (microATF) perfusion filter includes a hollow cylinder having a proximal end and a distal end. The proximal end is connected in series to a permeate chamber, followed by a retentate chamber. The proximal end either (i) terminates in or at the permeate chamber, or (ii) terminates in or at the retentate chamber. The portion of the proximal end within the permeate chamber, in a case of (ii), possesses at least one opening allowing fluid communication between an inside of the hollow cylinder and the permeate chamber. The microATF perfusion filter further includes an inlet, positioned over the retentate chamber, for communication with a source of positive or negative pressure, and an outlet, positioned in a wall of the permeate chamber, which can be connected to a check valve, which, in turn, can be connected to a hydrophobic fluid vent filter.

公开(公告)号：US20190040859A1

公开(公告)日：2019-02-07

申请号：US15892214

申请日：2018-02-08

Applicant: Repligen Corporation

Inventor： Rudolf Pavlik

IPC: F04B49/20 ,  F04B43/02 ,  F04B43/06 ,  F04B51/00 ,  F04B53/20 ,  F04B23/04 ,  C12M1/00 ,  C12M1/34

Abstract: A control unit includes a first connector configured to connect a proportional pressure regulator to a positive pressure supply and a second connector configured to connect the proportional pressure regulator to a negative pressure supply. The control unit further includes at least one sensor configured to detect an amount of air flow (volume per unit of time), positive or negative, within an air flow line connected to an output of the proportional pressure regulator, and a third connector configured to connect the air flow line to an air side of a diaphragm. Additionally, the control unit includes a controller programmed to control at least an opening and closing function of the proportional pressure regulator to attain a desired amount of air flow (volume per unit of time), positive or negative, within the air flow line.