公开(公告)号：US20160257672A1

公开(公告)日：2016-09-08

申请号：US15028164

申请日：2014-10-06

Applicant: TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION ,  SHIFA BIOMEDICAL CORPORATION

Inventor： Magid Abou-Gharbia ,  Wayne E. Childers ,  Rogelio Martinez ,  Victor P. Ghidu ,  Harold Meyers ,  Shaker A. Mousa ,  Nabil Elshourbagy

IPC: C07D405/12 ,  C07D487/08 ,  C07D471/08

CPC classification number: C07D405/12 ,  C07D307/66 ,  C07D471/08 ,  C07D487/08

Abstract: The present invention relates to pharmaceutical compositions comprising furan-2-sulfonamide derivatives. The present invention further relates to methods of treatment of diseases or conditions associated with endothelial lipase activity, including coronary artery disease and low HDL-C.

Abstract translation: 本发明涉及包含呋喃-2-磺酰胺衍生物的药物组合物。 本发明还涉及治疗与内皮脂肪酶活性相关的疾病或病症的方法，包括冠状动脉疾病和低HDL-C。

公开(公告)号：US20160250300A1

公开(公告)日：2016-09-01

申请号：US15148261

申请日：2016-05-06

Applicant: TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

Inventor： Kamel KHALILI ,  Wenhui HU

IPC: A61K38/46

CPC classification number: A61K38/465 ,  A61K9/0034 ,  A61K35/12 ,  A61K45/06 ,  A61K48/00 ,  A61K48/005 ,  C12N7/00 ,  C12N9/22 ,  C12N15/111 ,  C12N2310/20 ,  C12N2320/30 ,  C12N2740/16063 ,  C12Y301/21

Abstract: A method of inactivating a proviral DNA integrated into the genome of a host cell latently infected with a retrovirus by treating the host cell with a composition comprising a Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)-associated endonuclease, and two or more different guide RNAs (gRNAs), wherein each of the at least two gRNAs is complementary to a different target nucleic acid sequence in a long terminal repeat (LTR) in the proviral DNA, and inactivating the proviral DNA. A composition for use in inactivating a proviral DNA integrated into the genome of a host cell latently infected with a retrovirus including isolated nucleic acid sequences comprising a CRISPR-associated endonuclease and a guide RNA, wherein the guide RNA is complementary to a target sequence in a human immunodeficiency virus.

公开(公告)号：US20160213700A1

公开(公告)日：2016-07-28

申请号：US15081073

申请日：2016-03-25

Applicant: TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

Inventor： Salim Merali ,  Steven G. Kelsen ,  Carlos A. Barrero

IPC: A61K31/7072 ,  A61K31/365 ,  G01N33/68

CPC classification number: A61K31/7072 ,  A61K31/365 ,  G01N33/6893 ,  G01N2800/122 ,  G01N2800/50 ,  G01N2800/56 ,  G01N2800/60

Abstract: The methods described herein are based on the discovery that the plasma level of a panel of specific proteins differs between two subject populations: 1) subjects at risk for chronic obstructive pulmonary disease (“COPD”) but not manifesting clinical symptoms of COPD; and 2) subjects having very severe COPD. The difference in plasma levels is statistically significant for each protein. The identification of these proteins thus facilitates susceptibility detection, early disease detection, disease severity assessment, disease progression monitoring, and therapy efficacy monitoring.

Abstract translation: 本文描述的方法基于以下发现：一组特异性蛋白质的血浆水平在两个受试者群体之间不同：1）具有慢性阻塞性肺疾病（“COPD”）风险的受试者但不显示COPD的临床症状; 和2）COPD非常严重的受试者。 血浆水平的差异对于每种蛋白质具有统计学意义。 因此，鉴定这些蛋白质有助于敏感性检测，早期疾病检测，疾病严重程度评估，疾病进展监测和治疗功效监测。

公开(公告)号：US20160152952A1

公开(公告)日：2016-06-02

申请号：US14900809

申请日：2014-06-25

Applicant: TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

Inventor： Steven R. Houser ,  Hajime Kubo ,  Jason Mathew Duran ,  Thomas E. Sharp

IPC: C12N5/0775 ,  A61K35/28

CPC classification number: C12N5/0662 ,  A61K35/28 ,  C12N5/0668 ,  C12N2500/25 ,  C12N2501/11 ,  C12N2501/115 ,  C12N2501/235

Abstract: The present invention provides an isolated population of cortical bone-derived stem cells (CBSCs) and cells derived thereof. The CBSCs can survive when injected into the ischemic heart and have the potential to differentiate into cardiac myocytes with mature function and to secrete factors that promote endogenous repair.

Abstract translation: 本发明提供了皮质骨干细胞（CBSCs）的分离群体及其衍生的细胞。 当注射到缺血性心脏中时，CBSCs可以存活，并且具有分化成具有成熟功能的心肌细胞的潜力并分泌促进内源性修复的因子。

公开(公告)号：US20160089391A1

公开(公告)日：2016-03-31

申请号：US14864000

申请日：2015-09-24

Applicant: Temple University-of the Commonwealth System of Higher Education

Inventor： Hong Wang

IPC: A61K31/713 ,  G01N33/573 ,  A61K38/06 ,  A61K45/06 ,  A61K38/05

CPC classification number: A61K31/713 ,  A61K31/12 ,  A61K31/445 ,  A61K38/05 ,  A61K38/06 ,  A61K45/06 ,  G01N33/573 ,  G01N2333/96466 ,  G01N2800/32 ,  A61K2300/00

Abstract: The invention relates to methods and compositions for treating and preventing cardiovascular disease, including but not limited to treating and preventing endothelial dysfunction in subjects having hyperhomocysteinemia, hyperglycemia, or a combination of hyperhomocysteinemia and hyperglycemia. As endothelial dysfunction is an indicator for atherosclerosis and cardiovascular disease, this treatment has general impact for early prevention and treatment for all cardiovascular disease. In particular, the present invention relates to methods and compositions for inhibiting calpain activity.

Abstract translation: 本发明涉及用于治疗和预防心血管疾病的方法和组合物，包括但不限于治疗和预防具有高同型半胱氨酸血症，高血糖或高同型半胱氨酸血症和高血糖症的组合的受试者的内皮功能障碍。 由于内皮功能障碍是动脉粥样硬化和心血管疾病的指标，这种治疗对所有心血管疾病的早期预防和治疗具有一般影响。 特别地，本发明涉及抑制钙蛋白酶活性的方法和组合物。

公开(公告)号：US20160017301A1

公开(公告)日：2016-01-21

申请号：US14838057

申请日：2014-08-29

Applicant: TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

Inventor： Kamel Khalili ,  Wenhui Hu

IPC: C12N9/22 ,  C12N7/00 ,  A61K48/00 ,  A61K35/12 ,  A61K9/00 ,  A61K45/06

CPC classification number: A61K38/465 ,  A61K9/0034 ,  A61K35/12 ,  A61K45/06 ,  A61K48/00 ,  A61K48/005 ,  C12N7/00 ,  C12N9/22 ,  C12N15/111 ,  C12N2310/20 ,  C12N2320/30 ,  C12N2740/16063 ,  C12Y301/21

Abstract: A method of inactivating a proviral DNA integrated into the genome of a host cell latently infected with a retrovirus by treating the host cell with a composition comprising a Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)-associated endonuclease, and two or more different guide RNAs (gRNAs), wherein each of the at least two gRNAs is complementary to a different target nucleic acid sequence in a long terminal repeat (LTR) in the proviral DNA, and inactivating the proviral DNA. A composition for use in inactivating a proviral DNA integrated into the genome of a host cell latently infected with a retrovirus including isolated nucleic acid sequences comprising a CRISPR-associated endonuclease and a guide RNA, wherein the guide RNA is complementary to a target sequence in a human immunodeficiency virus.

Abstract translation: 通过用包含聚集的定期间隔短回文序列（CRISPR）相关内切核酸酶的组合物和两种或更多种不同的引导RNA来处理宿主细胞，使整合到潜伏感染逆转录病毒的宿主细胞基因组中的前病毒DNA失活的方法 （gRNA），其中所述至少两个gRNA中的每一个与前病毒DNA中的长末端重复（LTR）中的不同靶核酸序列互补，并使前病毒DNA失活。 用于灭活整合到潜伏感染逆转录病毒的宿主细胞的基因组中的前病毒DNA的组合物，包括分离的包含CRISPR相关内切核酸酶和引导RNA的核酸序列，其中所述指导RNA与 人类免疫缺陷病毒。

公开(公告)号：US09198446B2

公开(公告)日：2015-12-01

申请号：US14708361

申请日：2015-05-11

Applicant: Temple University—of the Commonwealth System of Higher Education

Inventor： Rongjia Tao ,  Hong Tang

IPC: A23C3/07 ,  A23G1/00

CPC classification number: A23G1/0006 ,  A23G1/0046 ,  A23G1/18 ,  A23V2002/00

Abstract: The present invention relates to a method and an apparatus for producing a chocolate product. The method includes delivering liquid chocolate having a viscosity through a pipe along a delivery path to a production station for producing the chocolate product. The liquid chocolate includes solid particles suspended within the liquid chocolate. The method changes the viscosity of the liquid chocolate by applying an electric field to the liquid chocolate in a direction along the delivery path of a strength and duration determined to aggregate the suspended solid particles into streamlined shapes extending along the direction of the delivery path.

公开(公告)号：US20150291539A1

公开(公告)日：2015-10-15

申请号：US14646290

申请日：2013-11-26

Applicant: TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

Inventor： Daniel J. Canney ,  Richie R. Bhandare ,  Benjamin E. Blass ,  Magid Abou-Gharbia

IPC: C07D263/20

CPC classification number: C07D263/20 ,  C07D263/24 ,  C07D413/06

Abstract: Pharmaceutical compositions of the invention comprise disubstituted oxazolidin-2-ones derivatives having a disease-modifying action in the treatment of diseases associated with dysregulation of 5-hydroxytryptamine receptor 2b activity.

Abstract translation: 本发明的药物组合物包含在治疗与5-羟色胺受体2b活性失调相关的疾病中具有疾病改变作用的二取代的恶唑烷-2-酮衍生物。

公开(公告)号：US20150266819A1

公开(公告)日：2015-09-24

申请号：US14429223

申请日：2013-09-18

Applicant: TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

Inventor： M. V. Ramana Reddy ,  E. Premkumar Reddy

IPC: C07D207/337 ,  C07C319/20 ,  C07C317/10 ,  C07C231/12 ,  C07C317/28 ,  C07C317/18 ,  C07C317/24 ,  C07C235/38 ,  C07C323/07 ,  C07C315/04

CPC classification number: C07D207/337 ,  C07C231/12 ,  C07C235/38 ,  C07C311/27 ,  C07C315/04 ,  C07C317/10 ,  C07C317/18 ,  C07C317/24 ,  C07C317/28 ,  C07C319/20 ,  C07C323/07 ,  C07C2601/02

Abstract: Compounds according to Formula I are provided: and salts thereof, wherein Q1, Q2, R3, R4, X, and Y are as defined herein. Methods for preparing compounds of Formula I are also provided, as well as methods of treating cellular proliferative disorders, such as cancer, using compounds of Formula (I). Q2-X—Y—CHR3—CHR4-Q1  (I)

Abstract translation: 提供了根据式I的化合物及其盐，其中Q 1，Q 2，R 3，R 4，X和Y如本文所定义。 还提供了制备式I化合物的方法，以及使用式（I）的化合物治疗细胞增殖性疾病如癌症的方法。 Q2-X-Y-CHR3-CHR4-Q1（I）

公开(公告)号：US20150237880A1

公开(公告)日：2015-08-27

申请号：US14708361

申请日：2015-05-11

Applicant: Temple University - of the Commonwealth System of Higher Education

Inventor： Rongjia Tao ,  Hong Tang

IPC: A23G1/00

CPC classification number: A23G1/0006 ,  A23G1/0046 ,  A23G1/18 ,  A23V2002/00

Abstract: The present invention relates to a method and an apparatus for producing a chocolate product. The method includes delivering liquid chocolate having a viscosity through a pipe along a delivery path to a production station for producing the chocolate product. The liquid chocolate includes solid particles suspended within the liquid chocolate. The method changes the viscosity of the liquid chocolate by applying an electric field to the liquid chocolate in a direction along the delivery path of a strength and duration determined to aggregate the suspended solid particles into streamlined shapes extending along the direction of the delivery path.

Abstract translation: 本发明涉及巧克力制品的制造方法和装置。 该方法包括将通过管道的粘度的液体巧克力沿着输送路径输送到用于生产巧克力产品的生产站。 液体巧克力包括悬浮在液体巧克力中的固体颗粒。 该方法通过将液体巧克力沿着输送路径的方向施加电场来改变液体巧克力的粘度，强度和持续时间确定为将悬浮固体颗粒聚集成沿着输送路径的方向延伸的流线型。