中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

248 records (took 0.038 seconds)

    HIGH RESOLUTION INTRAOPERATIVE MRI IMAGES
    73.
    发明申请
    HIGH RESOLUTION INTRAOPERATIVE MRI IMAGES 审中-公开
    高分辨率内窥镜MRI图像

    公开(公告)号：US20170046826A1

    公开(公告)日：2017-02-16

    申请号：US15307012

    申请日：2015-04-28

    Applicant: Tel Hashomer Medical Research, Infrastructure and Services Ltd. ,  Ramot at Tel Aviv University Ltd.

    Inventor： Eli KONEN ,  Arnaldo MAYER ,  Moshe HADANI ,  Nahum KIRYATI ,  Ori WEBER

    IPC: G06T7/00 ,  G06T3/40 ,  A61B5/00 ,  G01R33/56 ,  G01R33/483

    CPC classification number: A61B5/0042 ,  G01R33/4835 ,  G01R33/5608 ,  G06T3/0068 ,  G06T3/4053 ,  G06T7/30 ,  G06T7/337 ,  G06T2207/10088 ,  G06T2207/20016 ,  G06T2207/30016

    Abstract: A method of providing an intraoperative magnetic resonance image of a target site of a patient body at which a medical procedure is performed, the method comprising: acquiring a high resolution preoperative magnetic resonance image (MRI), MRI0, of a first region of the patient comprising the target site, the MRI0 image comprising a plurality of slices MRI0 n having voxels; acquiring a preoperative, iMRI0 image of a second region of the patient comprising the target site, using an iMRI scanner having a field of view (FOV), the iMRI0 image comprising plurality of slices iMRI0 m having voxels; registering the MRI0 image to the iMRI0 image to provide a rigid body transform (RT0) that transforms the MRI0 to the iMRI0 image; acquiring an IMRI1 image of the target site during performance of the procedure; registering the image iMRI0 to the iMRIj image to obtain a non-rigid body transform (NRT); and applying RT0 and NRT to MRI0 to provide a high resolution (hiQ-iMRIj) image.

    Abstract translation: 一种提供执行医疗程序的患者身体的目标部位的术中磁共振图像的方法，所述方法包括：获取患者的第一区域的高分辨率术前磁共振图像（MRI）MRI0 所述MRI0图像包括具有体素的多个切片MRI0 n; 使用具有视场（FOV）的iMRI扫描仪获取包括所述目标部位的所述患者的第二区域的术前iMRI0图像，所述iMRI0图像包括具有体素的多个切片iMRI0 m; 将MRI0图像注册到iMRI0图像以提供将MRI0转换为iMRI0图像的刚体变换（RT0）; 在执行程序期间获取目标站点的IMRI1图像; 将图像iMRI0注册到iMRIj图像以获得非刚体变换（NRT）; 并将RT0和NRT应用于MRI0以提供高分辨率（hiQ-iMRIj）图像。

    COMPOSITIONS AND METHODS FOR EXPRESSING RECOMBINANT POLYPEPTIDES
    75.
    发明申请
    COMPOSITIONS AND METHODS FOR EXPRESSING RECOMBINANT POLYPEPTIDES 审中-公开
    用于表达重组多聚体的组合物和方法

    公开(公告)号：US20160251410A1

    公开(公告)日：2016-09-01

    申请号：US14914003

    申请日：2014-09-03

    Applicant: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. ,  TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICE LTD.

    Inventor： Boaz TIROSH ,  Maya DADIANI

    IPC: C07K16/00

    CPC classification number: C07K16/00 ,  C07K2317/14 ,  C12N15/1135 ,  C12N15/67 ,  C12N2310/14

    Abstract: Methods of expressing a recombinant polypeptide of interest are provided. Accordingly there is provided a method comprising providing a cell having been contacted with an agent which downregulates an expression of a tuberous sclerosis (TSC) protein or directly inhibits an activity of same; and contacting the cell with a polynucleotide encoding the recombinant polypeptide of interest. Also provided is a method comprising contacting a cell with an agent which downregulates expression of a tuberous sclerosis (TSC) protein or directly inhibits an activity of same; and a polynucleotide encoding the recombinant polypeptide of interest. Also provided are isolated cells, cell cultures and articles of manufacture for recombinant expression of a recombinant polypeptide of interest.

    Abstract translation: 提供表达目标重组多肽的方法。 因此，提供了一种方法，其包括提供与下调结节性硬化症（TSC）蛋白的表达或直接抑制其活性的药剂接触的细胞; 并使细胞与编码感兴趣的重组多肽的多核苷酸接触。 还提供了一种方法，其包括使细胞与下调结节性硬化症（TSC）蛋白质的表达的试剂接触或直接抑制其活性; 和编码目的重组多肽的多核苷酸。 还提供了用于重组表达感兴趣的重组多肽的分离的细胞，细胞培养物和制品。

    MAGNETIC RESONANCE MAPS FOR ANALYZING TISSUE
    76.
    发明申请
    MAGNETIC RESONANCE MAPS FOR ANALYZING TISSUE 审中-公开
    用于分析组织的磁共振谱

    公开(公告)号：US20160109539A1

    公开(公告)日：2016-04-21

    申请号：US14787040

    申请日：2014-04-24

    Applicant: TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD. ,  RAMOT AT TEL-AVIV UNIVERSITY LTD.

    Inventor： Yael MARDOR ,  Leor ZACH ,  David GUEZ ,  David LAST ,  Dianne DANIELS

    IPC: G01R33/28 ,  G01R33/56 ,  G01R33/48 ,  A61B5/055 ,  A61B5/00

    Abstract: Apparatus for operating MRI is disclosed. The apparatus comprises: a control for operating an MRI scanner to carry out an MRI scan; an input for receiving first and second MRI scans respectively at the beginning and end of a predetermined time interval post contrast administration; a subtraction map former for forming a subtraction map from the first and the second MRI scans by analyzing the scans to distinguish between a population in which contrast clearance from the tissue is slower than contrast accumulation, and a population in which clearance is faster than accumulation; and an output to provide an indication of distribution of the populations. The control is configured to carry out the first scan at least five minutes and no more than twenty minutes post contrast administration and to carry out the second scan such that the predetermined time period is at least twenty minutes.

    Abstract translation: 公开了用于操作MRI的装置。 该装置包括：用于操作MRI扫描仪以执行MRI扫描的控制; 用于在对比度施加后的预定时间间隔的开始和结束时分别接收第一和第二MRI扫描的输入; 用于通过分析扫描来区分来自组织的对比度清除比对比度累积慢的群体和其中间隙比累积快的群体的从第一和第二MRI扫描形成减法映射的减法映射表; 以及提供人口分布指示的输出。 控制被配置为在造影剂给药后至少五分钟且不超过二十分钟进行第一次扫描，并执行第二扫描，使得预定时间段至少为20分钟。

Patent Agency Ranking