公开(公告)号：US20200367493A1

公开(公告)日：2020-11-26

申请号：US16323787

申请日：2017-06-06

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Ilana KOLODKIN-GAL ,  Asaph AHARONI

IPC: A01N43/16 ,  A01N43/12

Abstract: The present invention relates to the identification and use of natural plant compounds for inducing, enhancing and maintaining beneficial rhizobacteria biofilm formation on a plant or plant part thereof, and conversely, inhibiting formation of biofilms and pellicle by plant pathogens. Methods of use for stimulating matrix production from the beneficial rhizobacteria and enhanced adhesion of the rhizobacteria to a plant or plant part thereof are also described. Methods of use for inhibition plant pathogen adhesion to biofilms are also described.

公开(公告)号：US20200338001A1

公开(公告)日：2020-10-29

申请号：US16809816

申请日：2020-03-05

Applicant: YEDA RESEARCH AND DEVELOPMENT CO., LTD. ,  YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM, LTD.

Inventor： Jacob Klein ,  Ronit Goldberg ,  Yechezkel Barenholtz ,  Avi Schroeder

IPC: A61K9/127 ,  A61L27/50

Abstract: The invention provides a method for lubricating one or more surfaces, comprising applying gel-phase liposomes onto said one or more surfaces, wherein the temperature of said surface(s) at the time of lubrication is below the phase transition temperature Tm of said liposomes. The method can be used for lubricating non-biological surfaces, and also for lubricating the surfaces of a biological tissue in a mammalian subject, e.g., for treating joint dysfunction.

公开(公告)号：US20200332391A1

公开(公告)日：2020-10-22

申请号：US16759751

申请日：2018-11-01

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Igor LUBOMIRSKY ,  Valery KAPLAN ,  Nurlan DOSMUKHAMEDOV ,  Erzhan ZHOLDASBAY

IPC: C22B11/06 ,  C22B1/00 ,  C22B11/02

Abstract: A method for recovery of gold from gold-containing materials, such as electronic waste material, minerals and sands is described. The method includes crushing the gold containing material to obtain a particulate material. The particulate material is then preheated in an oxygen-containing gas environment in a preheating zone. The method also includes mixing the oxidized particulate material with a chlorine-containing material and treating the mixture in a reaction zone. The treatment is carried out by heating the mixture to provide thermal decomposition of the chlorine-containing material and produce a chlorine-containing gas mixture, and by applying an electromagnetic field to the chlorine-containing gas mixture to provide ionization of chlorine. A volatile gold-containing chloride product, produced in the reaction zone as a result of a chemical reaction between gold and chlorine ions, is then cooled to convert the volatile gold-containing chloride product into solid phase gold-containing materials.

公开(公告)号：US20200300829A1

公开(公告)日：2020-09-24

申请号：US16894916

申请日：2020-06-08

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Noam SOBEL ,  Shani AGRON ,  Kobi SNITZ ,  Ethan LIVNE ,  Ofer PERL ,  Kineret WEISSLER ,  Aharon RAVIA ,  Danielle Ricca HONIGSTEIN ,  Maya FINKEL

IPC: G01N33/00

Abstract: A method of assessing odors, comprises providing an electronic nose that extracts measurements from odors, from which measurements at least n chemical descriptors are extracted where n is greater than unity, and typically around 18. The electronic nose is applied to an odor, and odor information is extracted. The information is plotted to a first location on an n-dimensional sample space, each dimension being related to a respective one of the n chemical descriptors or otherwise optimized for the particular enose and the measurements it makes; and an assessment of the odor is provided based on the plotted location. The assessment may be a description based on odor describing terms, or may be a chemical description in terms of chemicals that can synthesize the odor, and the odor may then be synthesized based on the chemical description.

公开(公告)号：US10776653B2

公开(公告)日：2020-09-15

申请号：US15751188

申请日：2016-08-11

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Avishay Gal-Yam ,  Barak Zackay ,  Eran Ofek

IPC: G06K9/46 ,  G06T7/254 ,  G06K9/00 ,  G06K9/20 ,  G06K9/40

Abstract: A System and a method for processing at least two M-dimensional data-measurements (DMs) of a physical-property for detecting one or more new-objects and/or a transition of one or more known-objects, in complex constant-background DMs, using at least one processor and at least one memory element, the method comprising: generating a filtered-new-DM by match-filtering a new-DM, respective to impulse response of a reference-DM; generating a filtered-reference-DM by match-filtering the reference-DM, respective to impulse response of the new-DM; generating an M-dimensional object-indicator (OI) by subtracting the filtered-reference-DM from the filtered-new-DM, or vice versa; and generating an M-dimensional data score (DS) from the M-dimensional OI, where each of the scores is a probe for existence of an object at a specific M-dimensional location.

公开(公告)号：US10767156B2

公开(公告)日：2020-09-08

申请号：US15030876

申请日：2014-10-14

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Rotem Sorek ,  Hila Sberro ,  Tamara Goldfarb

IPC: C12N1/21 ,  C12N9/10 ,  C12N9/02 ,  C12N9/16 ,  C12N9/48 ,  C12N9/52 ,  C07K14/245 ,  C07K14/32 ,  C07K14/195 ,  C12N1/20 ,  A23C9/123 ,  C12N9/12 ,  C12N9/14 ,  C12N15/52

Abstract: Isolated polynucleotides encoding a BREX system are provided. Accordingly there is provided an isolated polynucleotide encoding a BREX system comprising a nucleic acid sequence encoding the BREX system comprising brxC/pglY, pglZ and at least one of pglX, pglXI, brxP, brxHI, brxHII, brxL, brxD, brxA, brxB, brxF, and brxE, with the proviso that said BREX system does not comprise pglW, and wherein said BREX system confers phage resistance to a bacteria recombinantly expressing same; Also provided is an isolated polynucleotide encoding a BREX system comprising a nucleic acid sequence encoding the BREX system comprising brxC/pglY, pglZ, pglX, pglW and at least one of brxD and brxHI, and wherein said BREX system confers phage resistance to a bacteria recombinantly expressing same. Also provided are compositions and methods for conferring phage resistance to bacteria or for conferring bacterial susceptibility to phages.

公开(公告)号：US10751368B2

公开(公告)日：2020-08-25

申请号：US15873943

申请日：2018-01-18

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Yair Reisner ,  Esther Bachar-Lustig ,  Shlomit Reich-Zeliger

IPC: A61K35/17 ,  C07K16/28 ,  A61P35/00 ,  A61K35/28 ,  A61K39/395

Abstract: A method of transplantation is disclosed. The method comprising administering to a subject in need of transplantation of cells in suspension, a therapeutically effective amount of tolerance inducing anti-third party cytotoxic T-lymphocytes (CTLs), wherein the tolerance inducing anti-third party CTLs are generated by directing T-lymphocytes of a donor against a third party antigen or antigens, the tolerance inducing anti-third party CTLs being substantially depleted of T-lymphocytes capable of developing into alloreactive CTLs, and wherein the tolerance inducing anti-third party CTLs do not comprise cells having a central memory T-lymphocyte (Tcm) phenotype, wherein the cells in suspension comprise non-hematopoietic cells or hematopoietic cells which are not stem cells. Methods of treating and kits are also provided.

公开(公告)号：US10730976B2

公开(公告)日：2020-08-04

申请号：US16064498

申请日：2016-12-22

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Jacob Klein ,  Weifeng Lin ,  Ronit Goldberg

IPC: C07F9/10 ,  C08F130/02 ,  A61K9/127 ,  A61K9/08 ,  A61P19/02 ,  A61K9/00 ,  A61K47/69

Abstract: A polymeric compound is disclosed herein, having the general formula I: wherein m, n, X, Y, Z and L are as defined herein. Further disclosed herein are lipid bilayers comprising at least one bilayer-forming lipid and the aforementioned polymeric compound, and liposomes comprising such a bilayer, as well as methods, uses and compositions utilizing such bilayers and/or liposomes for reducing a friction coefficient of a surface and/or for inhibiting biofilm formation.

公开(公告)号：US10688330B2

公开(公告)日：2020-06-23

申请号：US15535050

申请日：2015-12-10

Applicant: Yeda Research and Development Co. Ltd. ,  University of Washington

Inventor： Dan S. Tawfik ,  Haim Leader ,  Yaacov Ashani ,  Izhack Cherny ,  Moshe Goldsmith ,  Per Jr. Greisen ,  Sagar D. Khare ,  Gustav Oberdorfer ,  David Baker ,  Sarel Fleishman ,  Adi Goldenzweig ,  Nidhi Aggarwal

IPC: C12N9/16 ,  A61P25/00 ,  A62D3/02 ,  A62D101/02 ,  A62D101/26

Abstract: A genetically modified polypeptide is disclosed which comprises an amino acid sequence of phosphotriesterase (PTE) having at least twice the catalytic efficiency for a V-type nerve agent as a polypeptide which consists of the sequence as set forth in SEQ ID NO: 1, when assayed under identical conditions.

公开(公告)号：US20200131232A1

公开(公告)日：2020-04-30

申请号：US16726290

申请日：2019-12-24

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Ada YONATH ,  Zohar EYAL ,  Donna MATZOV ,  Haim ROZENBERG ,  Ella ZIMMERMAN ,  Anat BASHAN

IPC: C07K14/31 ,  C07H17/08 ,  C07D263/20 ,  C07D211/54 ,  G16C20/50 ,  G16B15/00 ,  G16B30/00

Abstract: A composition-of-matter comprising a crystallized form of a large ribosomal (50S) subunit of a pathogenic bacterium, and the atomic coordinates of the three-dimensional structure thereof are provided herein, as well as methods for crystallizing the same, and using the atomic coordinates of the same to design de novo ligands with high specificity thereto.