利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

433 条记录 (耗时 0.06 秒)

    Method and apparatus for extruding polymers employing microwave energy
    72.
    发明授权
    Method and apparatus for extruding polymers employing microwave energy 失效
    使用微波能量挤出聚合物的方法和装置

    公开(公告)号：US07163655B2

    公开(公告)日：2007-01-16

    申请号：US10347005

    申请日：2003-01-17

    申请人： Jan Weber ,  Scott Schewe

    发明人： Jan Weber ,  Scott Schewe

    IPC分类号： H05B6/78 ,  H05B6/64 ,  B29C43/30 ,  B29C43/26 ,  B29C47/06 ,  B29C47/24 ,  A61M25/10 ,  A61M25/16 ,  B29C61/06

    CPC分类号： A61M25/1029 ,  A61M25/1027 ,  A61M25/1034 ,  A61M25/1036 ,  B29B13/024 ,  B29C33/06 ,  B29C35/0805 ,  B29C45/14655 ,  B29C47/0023 ,  B29C47/0026 ,  B29C47/0033 ,  B29C47/0071 ,  B29C47/86 ,  B29C47/862 ,  B29C47/8835 ,  B29C47/884 ,  B29C47/8895 ,  B29C47/903 ,  B29C47/907 ,  B29C49/0042 ,  B29C49/64 ,  B29C49/66 ,  B29C49/78 ,  B29C49/783 ,  B29C2035/0855 ,  B29C2049/0089 ,  B29C2793/009 ,  B29K2105/258 ,  B29L2022/022 ,  B29L2031/7542 ,  H05B6/80

    摘要： An apparatus and method for molding balloon catheters is disclosed. The balloon may be molded by providing a polymeric tube within a mold having an interior cavity in the shape of the desired balloon. Microwave energy, which may be generated by a gyrotron, may then be directed toward the mold, to heat the polymeric material without heating the mold. Once heated, pressurized fluid may be injected into the tube to blow the polymeric material against the interior cavity whereupon the material can cool to form the balloon or can be further heatset by additional microwave energy and be cooled to form the balloon. In accordance with one embodiment, microwave energy can also be used without a mold to form a medical device. A polymer extrusion apparatus is disclosed utilizing a microwave energy for heating polymer feedstock material within the extruder tip and die unit just prior to formation of the extrudate product. A cooling bath mechanism, which in one embodiment can also include a cooling tube member having a cooling medium forced therethrough, is also disclosed. An apparatus for preparing polymer disk members, to use as the polymer feedstock material for the microwave extrusion apparatus, is also disclosed. Apparatus for interconnecting and rotating the polymer disk members, the die tip, or the die, or any combination thereof, for creating angularity characteristics in the polymer extrudate, is also disclosed.

    摘要翻译： 公开了一种用于模制球囊导管的装置和方法。 可以通过在具有所需球囊形状的内部空腔的模具内提供聚合物管来模制球囊。 可以由陀螺仪产生的微波能量然后可以被引向模具，以加热聚合材料而不加热模具。 一旦加热，加压流体可以被注入到管中以将聚合物材料吹向内部空腔，由此该材料可以冷却以形成球囊，或者可以通过额外的微波能量进一步热固并被冷却以形成气囊。 根据一个实施例，微波能量也可以在没有模具的情况下用于形成医疗装置。 公开了一种聚合物挤出设备，其利用微波能量来在挤出物产物形成之前在挤出机顶端和模具单元内加热聚合物原料。 还公开了一种冷却浴机构，其在一个实施例中还可以包括具有强制通过其中的冷却介质的冷却管构件。 还公开了一种用于制备用于微波挤出装置的聚合物原料的聚合物盘构件的装置。 还公开了用于互连和旋转聚合物盘构件，模头或模具或其任何组合的装置，用于在聚合物挤出物中产生角度特性。

    Internal medical devices for delivery of therapeutic agent in conjunction with a source of electrical power
    73.
    发明申请
    Internal medical devices for delivery of therapeutic agent in conjunction with a source of electrical power 有权
    用于与电力源一起递送治疗剂的内部医疗装置

    公开(公告)号：US20080262412A1

    公开(公告)日：2008-10-23

    申请号：US12077603

    申请日：2008-03-20

    申请人： Liliana Atanasoska ,  Thomas J. Holman ,  Jan Weber ,  Robert Warner ,  Scott Schewe

    发明人： Liliana Atanasoska ,  Thomas J. Holman ,  Jan Weber ,  Robert Warner ,  Scott Schewe

    IPC分类号： A61N1/30 ,  A61M25/10

    CPC分类号： A61N1/325 ,  A61N1/05 ,  A61N1/306 ,  A61N1/327

    摘要： The invention generally relates to internal (e.g., implantable, insertable, etc.) drug delivery devices which contain the following: (a) one or more sources of one or more therapeutic agents; (b) one or more first electrodes, (c) one or more second electrodes and (d) one or more power sources for applying voltages across the first and second electrodes. The power sources may be adapted, for example, to promote electrically assisted therapeutic agent delivery within a subject, including electroporation and/or iontophoresis. In one aspect of the invention, the first and second electrodes are adapted to have tissue of a subject positioned between them upon deployment of the medical device within the subject, such that an electric field may be generated, which is directed into the tissue. Furthermore, the therapeutic agent sources are adapted to introduce the therapeutic agents into the electric field. In another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of ion-conductive polymers and one or more types of charged therapeutic agents. In yet another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of electrically conductive polymers and one or more types of charged therapeutic agents.

    摘要翻译： 本发明一般涉及含有以下物质的内部（例如，可植入，可插入等）药物递送装置：（a）一种或多种一种或多种治疗剂来源; （b）一个或多个第一电极，（c）一个或多个第二电极和（d）用于在第一和第二电极上施加电压的一个或多个电源。 电源可以适应于例如促进受试者内的电辅助治疗剂递送，包括电穿孔和/或离子电渗疗法。 在本发明的一个方面中，第一和第二电极适于在医疗装置在受试者内展开时使被检体的组织位于它们之间，使得可以产生被引导到组织中的电场。 此外，治疗剂源适于将治疗剂引入电场。 另一方面，治疗剂来源是含有一种或多种类型的离子导电聚合物和一种或多种类型的带电治疗剂的聚合物区域。 在另一方面，治疗剂来源是含有一种或多种类型的导电聚合物和一种或多种类型的带电治疗剂的聚合物区域。

    Apparatus for Extruding Polymers Employing Microwave Energy
    74.
    发明申请
    Apparatus for Extruding Polymers Employing Microwave Energy 失效
    用于挤出使用微波能量的聚合物的装置

    公开(公告)号：US20070102848A1

    公开(公告)日：2007-05-10

    申请号：US11563315

    申请日：2006-11-27

    申请人： Jan Weber ,  Scott Schewe

    发明人： Jan Weber ,  Scott Schewe

    IPC分类号： H05B6/64 ,  B29C35/10

    CPC分类号： A61M25/1029 ,  A61M25/1027 ,  A61M25/1034 ,  A61M25/1036 ,  B29B13/024 ,  B29C33/06 ,  B29C35/0805 ,  B29C45/14655 ,  B29C47/0023 ,  B29C47/0026 ,  B29C47/0033 ,  B29C47/0071 ,  B29C47/86 ,  B29C47/862 ,  B29C47/8835 ,  B29C47/884 ,  B29C47/8895 ,  B29C47/903 ,  B29C47/907 ,  B29C49/0042 ,  B29C49/64 ,  B29C49/66 ,  B29C49/78 ,  B29C49/783 ,  B29C2035/0855 ,  B29C2049/0089 ,  B29C2793/009 ,  B29K2105/258 ,  B29L2022/022 ,  B29L2031/7542 ,  H05B6/80

    摘要： An apparatus and method for molding balloon catheters is disclosed. The balloon may be molded by providing a polymeric tube within a mold having an interior cavity in the shape of the desired balloon. Microwave energy, which may be generated by a gyrotron, may then be directed toward the mold, to heat the polymeric material without heating the mold. Once heated, pressurized fluid may be injected into the tube to blow the polymeric material against the interior cavity whereupon the material can cool to form the balloon or can be further heatset by additional microwave energy and be cooled to form the balloon. In accordance with one embodiment, microwave energy can also be used without a mold to form a medical device. A polymer extrusion apparatus is disclosed utilizing a microwave energy for heating polymer feedstock material within the extruder tip and die unit just prior to formation of the extrudate product. A cooling bath mechanism, which in one embodiment can also include a cooling tube member having a cooling medium forced therethrough, is also disclosed. An apparatus for preparing polymer disk members, to use as the polymer feedstock material for the microwave extrusion apparatus, is also disclosed. Apparatus for interconnecting and rotating the polymer disk members, the die tip, or the die, or any combination thereof, for creating angularity characteristics in the polymer extrudate, is also disclosed.

    摘要翻译： 公开了一种用于模制球囊导管的装置和方法。 可以通过在具有所需球囊形状的内部空腔的模具内提供聚合物管来模制球囊。 可以由陀螺仪产生的微波能量然后可以被引向模具，以加热聚合材料而不加热模具。 一旦加热，加压流体可以被注入到管中以将聚合物材料吹向内部空腔，由此该材料可以冷却以形成球囊，或者可以通过额外的微波能量进一步热固并被冷却以形成气囊。 根据一个实施例，微波能量也可以在没有模具的情况下用于形成医疗装置。 公开了一种聚合物挤出设备，其利用微波能量来在挤出物产物形成之前在挤出机顶端和模具单元内加热聚合物原料。 还公开了一种冷却浴机构，其在一个实施例中还可以包括具有强制通过其中的冷却介质的冷却管构件。 还公开了一种用于制备用于微波挤出装置的聚合物原料的聚合物盘构件的装置。 还公开了用于互连和旋转聚合物盘构件，模头或模具或其任何组合的装置，用于在聚合物挤出物中产生角度特性。

    Medical devices having superhydrophobic surfaces, superhydrophilic surfaces, or both
    75.
    发明申请
    Medical devices having superhydrophobic surfaces, superhydrophilic surfaces, or both 审中-公开
    具有超疏水表面，超亲水性表面或两者的医疗装置

    公开(公告)号：US20070005024A1

    公开(公告)日：2007-01-04

    申请号：US11150082

    申请日：2005-06-10

    申请人： Jan Weber ,  Scott Schewe ,  Brian Berg

    发明人： Jan Weber ,  Scott Schewe ,  Brian Berg

    IPC分类号： A61M25/00

    CPC分类号： A61L29/14 ,  A61M2205/0222 ,  A61M2205/0238

    摘要： According to an aspect of the invention, medical devices are provided, which have the following (a) one or more superhydrophobic surface regions, (b) one or more superhydrophilic surface regions having a durometer of at least 40 A, or (c) a combination of one or more superhydrophobic surface regions and one or more superhydrophilic surface regions having a durometer of at least 40 A. Such surfaces are created, for example, to provide reduced resistance to the movement of adjacent materials, including adjacent fluids and solids. Examples of medical device surface regions benefiting from the present invention include, for example, outside and/or inside (luminal) surfaces of the following: vascular catheters, urinary catheters, hydrolyser catheters, guide wires, pullback sheaths, left ventricular assist devices, endoscopes, airway tubes and injection needles, among many other devices.

    摘要翻译： 根据本发明的一个方面，提供了医疗装置，其具有以下（a）一个或多个超疏水表面区域，（b）一个或多个具有至少40A的硬度的超亲水性表面区域，或（c） 一个或多个超疏水表面区域和一个或多个具有至少40的硬度的超亲水表面区域的组合。例如，这样的表面被产生以提供对相邻材料（包括相邻流体和固体）的运动的降低的阻力。 受益于本发明的医疗器械表面区域的实例包括例如以下的外部和/或内部（腔）表面：血管导管，导尿管，水解导管，引导线，回拉鞘，左心室辅助装置，内窥镜 ，气道管和注射针等。

    Internal medical devices for delivery of therapeutic agent in conjunction with a source of electrical power
    77.
    发明授权
    Internal medical devices for delivery of therapeutic agent in conjunction with a source of electrical power 有权
    用于与电力源一起递送治疗剂的内部医疗装置

    公开(公告)号：US08538515B2

    公开(公告)日：2013-09-17

    申请号：US12939363

    申请日：2010-11-04

    申请人： Liliana Atanasoska ,  Thomas J. Holman ,  Jan Weber ,  Robert Warner ,  Scott Schewe

    发明人： Liliana Atanasoska ,  Thomas J. Holman ,  Jan Weber ,  Robert Warner ,  Scott Schewe

    IPC分类号： A61N1/30

    CPC分类号： A61N1/325 ,  A61N1/05 ,  A61N1/306 ,  A61N1/327

    摘要： The invention generally relates to internal (e.g., implantable, insertable, etc.) drug delivery devices which contain the following: (a) one or more sources of one or more therapeutic agents; (b) one or more first electrodes, (c) one or more second electrodes and (d) one or more power sources for applying voltages across the first and second electrodes. The power sources may be adapted, for example, to promote electrically assisted therapeutic agent delivery within a subject, including electroporation and/or iontophoresis. In one aspect of the invention, the first and second electrodes are adapted to have tissue of a subject positioned between them upon deployment of the medical device within the subject, such that an electric field may be generated, which is directed into the tissue. Furthermore, the therapeutic agent sources are adapted to introduce the therapeutic agents into the electric field. In another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of ion-conductive polymers and one or more types of charged therapeutic agents. In yet another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of electrically conductive polymers and one or more types of charged therapeutic agents.

    摘要翻译： 本发明一般涉及含有以下物质的内部（例如，可植入，可插入等）药物递送装置：（a）一种或多种一种或多种治疗剂来源; （b）一个或多个第一电极，（c）一个或多个第二电极和（d）用于在第一和第二电极上施加电压的一个或多个电源。 电源可以适应于例如促进受试者内的电辅助治疗剂递送，包括电穿孔和/或离子电渗疗法。 在本发明的一个方面中，第一和第二电极适于在医疗装置在受试者内展开时使被检体的组织位于它们之间，使得可以产生被引导到组织中的电场。 此外，治疗剂源适于将治疗剂引入电场。 另一方面，治疗剂来源是含有一种或多种类型的离子导电聚合物和一种或多种类型的带电治疗剂的聚合物区域。 在另一方面，治疗剂来源是含有一种或多种类型的导电聚合物和一种或多种类型的带电治疗剂的聚合物区域。

    Apparatus for extruding polymers employing microwave energy
    80.
    发明授权
    Apparatus for extruding polymers employing microwave energy 失效
    用于使用微波能量挤出聚合物的装置

    公开(公告)号：US07458798B2

    公开(公告)日：2008-12-02

    申请号：US11563315

    申请日：2006-11-27

    申请人： Jan Weber ,  Scott Schewe

    发明人： Jan Weber ,  Scott Schewe

    IPC分类号： B29C47/86

    CPC分类号： A61M25/1029 ,  A61M25/1027 ,  A61M25/1034 ,  A61M25/1036 ,  B29B13/024 ,  B29C33/06 ,  B29C35/0805 ,  B29C45/14655 ,  B29C47/0023 ,  B29C47/0026 ,  B29C47/0033 ,  B29C47/0071 ,  B29C47/86 ,  B29C47/862 ,  B29C47/8835 ,  B29C47/884 ,  B29C47/8895 ,  B29C47/903 ,  B29C47/907 ,  B29C49/0042 ,  B29C49/64 ,  B29C49/66 ,  B29C49/78 ,  B29C49/783 ,  B29C2035/0855 ,  B29C2049/0089 ,  B29C2793/009 ,  B29K2105/258 ,  B29L2022/022 ,  B29L2031/7542 ,  H05B6/80

    摘要： An apparatus and method for molding balloon catheters is disclosed. The balloon may be molded by providing a polymeric tube within a mold having an interior cavity in the shape of the desired balloon. Microwave energy, which may be generated by a gyrotron, may then be directed toward the mold, to heat the polymeric material without heating the mold. Once heated, pressurized fluid may be injected into the tube to blow the polymeric material against the interior cavity whereupon the material can cool to form the balloon or can be further heatset by additional microwave energy and be cooled to form the balloon. In accordance with one embodiment, microwave energy can also be used without a mold to form a medical device. A polymer extrusion apparatus is disclosed utilizing a microwave energy for heating polymer feedstock material within the extruder tip and die unit just prior to formation of the extrudate product. A cooling bath mechanism, which in one embodiment can also include a cooling tube member having a cooling medium forced therethrough, is also disclosed. An apparatus for preparing polymer disk members, to use as the polymer feedstock material for the microwave extrusion apparatus, is also disclosed. Apparatus for interconnecting and rotating the polymer disk members, the die tip, or the die, or any combination thereof, for creating angularity characteristics in the polymer extrudate, is also disclosed.

    摘要翻译： 公开了一种用于模制球囊导管的装置和方法。 可以通过在具有所需球囊形状的内部空腔的模具内提供聚合物管来模制球囊。 可以由陀螺仪产生的微波能量然后可以被引向模具，以加热聚合材料而不加热模具。 一旦加热，加压流体可以被注入到管中以将聚合物材料吹向内部空腔，由此该材料可以冷却以形成球囊，或者可以通过额外的微波能量进一步热固并被冷却以形成气囊。 根据一个实施例，微波能量也可以在没有模具的情况下用于形成医疗装置。 公开了一种聚合物挤出设备，其利用微波能量来在挤出物产物形成之前在挤出机顶端和模具单元内加热聚合物原料。 还公开了一种冷却浴机构，其在一个实施例中还可以包括具有强制通过其中的冷却介质的冷却管构件。 还公开了一种用于制备用于微波挤出装置的聚合物原料的聚合物盘构件的装置。 还公开了用于互连和旋转聚合物盘构件，模头或模具或其任何组合的装置，用于在聚合物挤出物中产生角度特性。