公开(公告)号：US20170181643A1

公开(公告)日：2017-06-29

申请号：US15459581

申请日：2017-03-15

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Niema Pahlevan ,  Morteza Gharib

IPC: A61B5/021 ,  A61B5/00 ,  A61B8/00 ,  A61B8/04

CPC classification number: A61B5/021 ,  A61B5/02007 ,  A61B5/0507 ,  A61B5/742 ,  A61B8/04 ,  A61B8/06 ,  A61B8/4427 ,  A61B8/485 ,  A61B8/5223

Abstract: Hardware and software methodology are described for a non-invasive approach to blood pressure measurement in pulmonary artery and systemic arteries by using wall displacement and blood velocity that are measured using ultrasound, microwave techniques and/or other radiofrequency (RF) techniques.

公开(公告)号：US09668859B2

公开(公告)日：2017-06-06

申请号：US13862302

申请日：2013-04-12

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY ,  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Arash Kheradvar ,  Gregory S. Kelley ,  Morteza Gharib

IPC: A61F2/24 ,  A61B8/12 ,  A61B8/08 ,  A61B90/00

CPC classification number: A61F2/2439 ,  A61B8/0841 ,  A61B8/0891 ,  A61B8/12 ,  A61B90/37 ,  A61B2090/3782 ,  A61F2/2427

Abstract: Embodiments described herein address the need for improved catheter devices for delivery, repositioning and/or percutaneous retrieval of the percutaneously implanted heart valves. One embodiment employs a plurality of spring-loaded arms releasably engaged with a stent frame for controlling expansion for valve deployment. Another embodiment employs a plurality of filaments passing through a distal end of a pusher sleeve and apertures in a self-expandable stent frame to control its state of deployment. With additional features, lateral positioning of the stent frame may also be controlled. Yet another embodiment includes plurality of outwardly biased arms held to complimentary stent frame features by overlying sheath segments. Still another embodiment integrates a visualization system in the subject delivery system. Variations on hardware and methods associated with the use of these embodiments are contemplated in addition to those shown and described.

公开(公告)号：US20170020414A1

公开(公告)日：2017-01-26

申请号：US15279246

申请日：2016-09-28

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Niema Pahlevan ,  Peyman Tavallali ,  Derek Rinderknecht ,  Morteza Gharib

IPC: A61B5/11 ,  A61B5/029 ,  A61B8/08 ,  A61B8/06 ,  A61B5/021 ,  A61B5/00 ,  A61B5/02 ,  A61B5/026

CPC classification number: A61B5/1128 ,  A61B5/0004 ,  A61B5/0013 ,  A61B5/02028 ,  A61B5/021 ,  A61B5/02405 ,  A61B5/0261 ,  A61B5/029 ,  A61B5/1102 ,  A61B5/7235 ,  A61B5/7278 ,  A61B5/7282 ,  A61B8/065 ,  A61B8/5223 ,  A61B2562/0228

Abstract: Hardware and software methodology are described for non-invasively monitoring cardiac health. Hemodynamic waveforms variously acquired for a subject are analyzed to calculate or approximate intrinsic frequencies in two domains in two domains across the Dicrotic Notch. Together with associated notch timing, heart rate and blood pressure values left ventricle ejection fraction and/or stroke volume can be determination.

Abstract translation: 硬件和软件方法被描述为非侵入性地监测心脏健康。 分析针对受试者各种获得的血流动力学波形，以计算或近似跨越Dicrotic Notch的两个域中的两个域中的固有频率。 与相关的切口定时一起，可以确定心率和血压值左心室射血分数和/或冲程体积。

公开(公告)号：US09480406B2

公开(公告)日：2016-11-01

申请号：US14517702

申请日：2014-10-17

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Niema Pahlevan ,  Peyman Tavallali ,  Derek Rinderknecht ,  Morteza Gharib

IPC: A61B5/05 ,  A61B5/024 ,  A61B8/02 ,  A61B8/08 ,  A61B5/029 ,  A61B5/00 ,  A61B8/06 ,  A61B5/02

CPC classification number: A61B5/1128 ,  A61B5/0004 ,  A61B5/0013 ,  A61B5/02028 ,  A61B5/021 ,  A61B5/02405 ,  A61B5/0261 ,  A61B5/029 ,  A61B5/1102 ,  A61B5/7235 ,  A61B5/7278 ,  A61B5/7282 ,  A61B8/065 ,  A61B8/5223 ,  A61B2562/0228

Abstract: Hardware and software methodology are described for non-invasively monitoring cardiac health. Hemodynamic waveforms variously acquired for a subject are analyzed to calculate or approximate intrinsic frequencies in two domains in two domains across the Dicrotic Notch. Together with associated notch timing, heart rate and blood pressure values left ventricle ejection fraction and/or stroke volume can be determination.

Abstract translation: 硬件和软件方法被描述为非侵入性地监测心脏健康。 分析针对受试者各种获得的血流动力学波形，以计算或近似跨越Dicrotic Notch的两个域中的两个域中的固有频率。 与相关的切口定时一起，可以确定心率和血压值左心室射血分数和/或冲程体积。

公开(公告)号：US09462953B2

公开(公告)日：2016-10-11

申请号：US14684662

申请日：2015-04-13

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Niema Pahlevan ,  Peyman Tavallali ,  Thomas Yizhao Hou ,  Morteza Gharib

IPC: A61B5/05 ,  A61B5/024 ,  A61B5/00 ,  A61B8/02 ,  A61B8/08 ,  A61B8/00 ,  A61B5/02 ,  A61B8/06

CPC classification number: A61B5/02416 ,  A61B5/0004 ,  A61B5/0013 ,  A61B5/0077 ,  A61B5/02028 ,  A61B5/02405 ,  A61B5/02438 ,  A61B5/0507 ,  A61B5/7235 ,  A61B5/7278 ,  A61B5/7282 ,  A61B5/746 ,  A61B8/02 ,  A61B8/06 ,  A61B8/5223 ,  A61B8/565

Abstract: Hardware and software methodology are described for cardiac health measurement. Hemodynamic waveforms variously acquired for a subject are analyzed to calculate or approximate intrinsic frequencies in two domains in two domains across the Dicrotic Notch. The intrinsic frequencies provide metrics/measures that correlate to the cardiac health of the subject. The systems may be used for monitoring a condition and/or is diagnosis. Exemplary uses include identifying (diagnosing) the presence of arrhythmia, heat failure, atrial fibrillation, aneurysms, vessel stenosis or aortic valve dysfunction and the necessity for valve replacement and/or monitoring congestive heart failure progression, together with identifying the acute need for hospitalization in connection with daily testing for any such condition.

公开(公告)号：US20150312555A1

公开(公告)日：2015-10-29

申请号：US14739565

申请日：2015-06-15

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Morteza Gharib ,  Jian Lu ,  Emilio Graff ,  Francisco Pereira

IPC: H04N13/02 ,  G06T7/00

CPC classification number: H04N13/254 ,  G01B11/2509 ,  G02B5/005 ,  G02B2207/129 ,  G03B15/12 ,  G03B35/02 ,  G06T7/50 ,  H04N13/204 ,  H04N13/207

Abstract: A device and method for three-dimensional (3-D) imaging using a defocusing technique is disclosed. The device comprises a lens, a central aperture located along an optical axis for projecting an entire image of a target object, at least one defocusing aperture located off of the optical axis, a sensor operable for capturing electromagnetic radiation transmitted from an object through the lens and the central aperture and the at least one defocusing aperture, and a processor communicatively connected with the sensor for processing the sensor information and producing a 3-D image of the object. Different optical filters can be used for the central aperture and the defocusing apertures respectively, whereby a background image produced by the central aperture can be easily distinguished from defocused images produced by the defocusing apertures.

Abstract translation: 公开了一种使用散焦技术进行三维（3-D）成像的装置和方法。 该装置包括透镜，沿着光轴定位的中心孔，用于投影目标物体的整个图像，位于光轴外的至少一个散焦孔;可操作用于捕获从物体透过透镜的电磁辐射的传感器 以及与所述传感器通信地连接的处理所述传感器信息并产生所述对象的3D图像的处理器。 可以分别使用不同的光学滤光器用于中心孔和散焦孔，由此可以容易地区分由中心孔产生的背景图像与由散焦孔产生的散焦图像。

公开(公告)号：US20150155108A1

公开(公告)日：2015-06-04

申请号：US14612951

申请日：2015-02-03

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Adrianus Indrat Aria ,  Bradley Lyon ,  Morteza Gharib

IPC: H01G11/86 ,  H01G11/36

CPC classification number: H01G11/86 ,  B82Y10/00 ,  B82Y30/00 ,  H01G11/36 ,  Y02E60/13

Abstract: A method of increasing the area of carbon nanotubes used in fabricating capacitors is described. The method involves reacting carbon nanotubes with electrically conductive ions, molecules or nanoparticles that increase the surface area of the nanotubes. The capacitance and the energy stored in the capacitor can be increased by such treatment. Devices constructed from such treated materials and their properties are described.

Abstract translation: 描述了增加用于制造电容器的碳纳米管面积的方法。 该方法包括使碳纳米管与增加纳米管表面积的导电离子，分子或纳米颗粒反应。 可以通过这种处理来增加电容器中存储的电容和能量。 描述了由这种处理材料构成的器件及其性质。

公开(公告)号：US20140248216A1

公开(公告)日：2014-09-04

申请号：US14085235

申请日：2013-11-20

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Morteza Gharib ,  Adrianus Indrat Aria ,  Masoud Beizai

IPC: A61K47/02 ,  A61K49/00 ,  A61K9/51 ,  A61K31/337

CPC classification number: A61K47/02 ,  A61K9/5192 ,  A61K31/337 ,  A61K31/352 ,  A61K47/6929 ,  A61K49/0004 ,  A61K49/0095 ,  A61L29/103 ,  A61L29/16 ,  A61L2300/422 ,  B82Y5/00 ,  B82Y40/00

Abstract: The invention generally relates to carbon nanotube based drug delivery methods, devices, and compositions. More particularly, the invention relates to controlled drug delivery using anchored carbon nanotube arrays.

Abstract translation: 本发明一般涉及基于碳纳米管的药物递送方法，装置和组合物。 更具体地，本发明涉及使用锚定碳纳米管阵列的受控药物递送。

公开(公告)号：US20140234097A1

公开(公告)日：2014-08-21

申请号：US14183447

申请日：2014-02-18

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Daegyoum Kim ,  Morteza Gharib

IPC: F03D1/04

CPC classification number: F03D1/04 ,  F03D1/0691 ,  Y02E10/721 ,  Y10T29/49826 ,  Y10T29/49888

Abstract: Horizontal axis wind turbine (HAWT) systems are described that include a turbine with deflector in front of the turbine in order to change flow encountered by the turbine's blades. Such an arrangement improves turbine efficiency and may be embodied in a range of size scales for numerous wind (or water) power generation applications.

Abstract translation: 描述了水平轴风力涡轮机（HAWT）系统，其包括在涡轮机前面具有偏转器的涡轮机，以便改变涡轮叶片所遇到的流动。 这种布置提高了涡轮效率，并且可以在许多风（或水）发电应用的尺寸范围内实施。

公开(公告)号：US20140162048A1

公开(公告)日：2014-06-12

申请号：US13948051

申请日：2013-07-22

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Amir Gat ,  Aria Vahdani ,  Morteza Gharib

IPC: B32B5/02 ,  F16K15/14 ,  A43B1/00 ,  A41D27/00 ,  A43B17/00

CPC classification number: B32B5/02 ,  A41B11/005 ,  A41D27/00 ,  A41D31/02 ,  A41D31/102 ,  A43B1/00 ,  A43B7/125 ,  A43B19/00 ,  A43B23/022 ,  F16K15/14 ,  Y10T137/7879 ,  Y10T428/249921 ,  Y10T428/249962 ,  Y10T428/2835

Abstract: Multi-layer fabrics and products incorporating the same are described in which the fabrics are configured to provide asymmetric resistance to liquid flow from one side of the fabric to the other. In garments or other products worn by a user, the effect can be utilized to prevent penetration of liquids (e.g., rain droplets) and contact of liquids from the exterior with the user's skin while allowing for extraction of droplets (e.g., sweat) in contact with an inner layer of the fabric out of contact with the skin and accelerating their evaporation. Medical and industrial applications of the fabric are contemplated as well.

Abstract translation: 描述了包含其的多层织物和产品，其中织物被配置为对从织物的一侧到另一侧的液体流提供不对称的阻力。 在用户佩戴的服装或其他产品中，可以利用该效果来防止液体（例如，雨滴）的渗透和来自外部的液体与使用者的皮肤的接触，同时允许提取接触中的液滴（例如汗液） 织物的内层与皮肤接触并加速它们的蒸发。 也可以考虑织物的医疗和工业应用。