公开(公告)号：US20080058733A1

公开(公告)日：2008-03-06

申请号：US11931895

申请日：2007-10-31

申请人： Sebastian Vogt ,  Matthias Schnabelrauch ,  Klaus Kuhn

发明人： Sebastian Vogt ,  Matthias Schnabelrauch ,  Klaus Kuhn

IPC分类号： A61F2/00 ,  A61B17/56 ,  A61K31/08 ,  A61K9/14 ,  A61M5/32 ,  A61K35/00 ,  A61B17/58

CPC分类号： A61L31/16 ,  A61K9/0019 ,  A61K9/0024 ,  A61K31/00 ,  A61K31/7036 ,  A61K47/10 ,  A61K47/32 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L2300/406 ,  A61L2300/45 ,  A61L2300/602 ,  A61L2300/606 ,  C08L33/04

摘要： The present invention relates to an antibiotic(s)-polymer combination, which under physiological conditions guarantees the continuous release of antibiotics over a period of several days and can be used in human and veterinary medicine. The invented antibiotic(s)-polymer combination is wherein in a homogeneous polymer mixture, consisting of one or more hydrophobic polymers from the groups of poly(methacrylic acid esters), the poly(acrylic acid esters) and the poly(methacrylic acid ester-co-acrylic acid esters) and one or more hydrophilic polymers from the group of polyethers, one or more slightly water-soluble antibiotics from the groups of aminoglycoside antibiotics, the lincosamide antibiotics, the tetracycline antibiotics and quinolone antibiotics, possibly an easily water-soluble antibiotic from the groups of aminoglycoside antibiotics, the lincosamide antibiotics and the tetracycline antibiotics, and possibly one or more organic adjuvants are suspended, and that this suspension forms a composite.

摘要翻译： 本发明涉及抗生素 - 聚合物组合，其在生理条件下保证抗生素在数天内持续释放并可用于人和兽医学。 本发明的抗生素聚合物组合是在由聚（甲基丙烯酸酯），聚（丙烯酸酯）和聚（甲基丙烯酸酯 - 酯）组成的一组或多种疏水聚合物组成的均匀聚合物混合物中， 共聚丙烯酸酯）和一种或多种来自聚醚组的亲水性聚合物，一种或多种来自氨基糖苷类抗生素的轻微水溶性抗生素，氯胺素抗生素，四环素抗生素和喹诺酮类抗生素，可能是易溶于水的 来自氨基糖苷类抗生素组的抗生素，林可素类抗生素和四环素抗生素，以及可能的一种或多种有机助剂悬浮，并且该悬浮液形成复合物。

公开(公告)号：US20060006040A1

公开(公告)日：2006-01-12

申请号：US11172312

申请日：2005-06-29

申请人： Andreas Orlamunder ,  Thorsten Muller ,  Michael Kuhner ,  Winfried Bokisch ,  Sebastian Vogt ,  Waldemar Mensch

发明人： Andreas Orlamunder ,  Thorsten Muller ,  Michael Kuhner ,  Winfried Bokisch ,  Sebastian Vogt ,  Waldemar Mensch

IPC分类号： F16D13/70

CPC分类号： F16D13/385

摘要： A friction clutch is configured with a pressure plate arrangement having: a housing rotatably fixed to an abutment arrangement for joint rotation about an axis of rotation; a plate arrangement having at least one intermediate plate and a pressure plate, at least one of the intermediate and pressure plates being mounted in the housing and operative to axially move relative thereto and to rotate about the axis of rotation; an energy storage device coupled to the housing and operative to generate a elastic restoring force exerted on the plate arrangement, the energy storage device being coupled to the pressure plate; a releasing spring arrangement located between the housing and plate arrangement and coupled thereto, the releasing spring arrangement being tensioned to generate an elastic restoring force exerted at least on the pressure plate in a second direction opposite to the first direction in response to the elastic restoring force; and a clutch disk arrangement clamped between the abutment arrangement and the at least one intermediate plate, or between the at least one intermediate and pressure plates, or between the at least one and an additional intermediate plates.

摘要翻译： 摩擦离合器构造有压板装置，该压力板装置具有：可旋转地固定到邻接装置的壳体，用于围绕旋转轴线的关节旋转; 具有至少一个中间板和压力板的板装置，所述中间板和压板中的至少一个安装在所述壳体中并且可操作地相对于其轴向移动并围绕所述旋转轴线旋转; 能量存储装置，其耦合到所述壳体并且可操作以产生施加在所述板装置上的弹性恢复力，所述能量存储装置联接到所述压力板; 释放弹簧装置，位于壳体和板装置之间并联接到其上，释放弹簧装置被张紧以响应于弹性恢复力产生至少在与第一方向相反的第二方向上施加在压板上的弹性恢复力 ; 以及夹在所述邻接装置和所述至少一个中间板之间，或所述至少一个中间和压力板之间，或在所述至少一个和附加中间板之间的离合器盘装置。

公开(公告)号：US06767635B1

公开(公告)日：2004-07-27

申请号：US10088437

申请日：2002-05-24

申请人： Michael Bahr ,  Dimitri Berkov ,  Norbert Buske ,  Joachim Clement ,  Peter Görnert ,  Klaus Höffken ,  Kay-Oliver Kliche ,  Thomas Kober ,  Matthias Schnabelrauch ,  Sebastian Vogt ,  Kerstin Wagner ,  Christian Gansau

发明人： Michael Bahr ,  Dimitri Berkov ,  Norbert Buske ,  Joachim Clement ,  Peter Görnert ,  Klaus Höffken ,  Kay-Oliver Kliche ,  Thomas Kober ,  Matthias Schnabelrauch ,  Sebastian Vogt ,  Kerstin Wagner ,  Christian Gansau

IPC分类号： B32B516

CPC分类号： B82Y5/00 ,  A61K47/6923 ,  Y10T428/2982 ,  Y10T428/2989 ,  Y10T428/2991 ,  Y10T428/2998

摘要： The invention relates to magnetic nanoparticles, their production, and their use. The object of the invention is to provide nanoparticles capable of specifically forming bonds to intracellular biomacromolecules even in the intracellular region of cells, so that separation is possible by exposure to an exterior magnetic field. This is accomplished by means of magnetic nanoparticles having biochemical activity, consisting of a magnetic core particle and an envelope layer fixed to the core particle, and including a compound of general formula M-S-L-Z (I), the linkage sites between S and L and L and Z having covalently bound functional groups, wherein M represents said magnetic core particle; S represents a biocompatible substrate fixed to M; L represents a linker group; and Z represents a group comprised of nucleic acids, peptides or proteins or derivatives thereof, which group has at least one structure capable of specifically binding to a binding domain of an intracellular biomacromolecule.

摘要翻译： 本发明涉及磁性纳米颗粒及其制备及其用途。本发明的目的是提供即使在细胞的细胞内区域也能特异性地形成与细胞内生物大分子的结合的纳米粒子，从而可以通过暴露于外部磁性 这是通过具有生物化学活性的磁性纳米颗粒来实现的，该磁性纳米颗粒由固定在核心颗粒上的磁芯颗粒和包膜层组成，并且包括通式MSLZ（I）的化合物，S和L之间的连接位点和 L和Z具有共价结合的官能团，其中M表示所述磁芯颗粒; S表示固定于M的生物相容性底物; L表示连接基团; Z表示由核酸，肽或蛋白质或其衍生物组成的组，该基团具有至少一种能够特异性结合细胞内生物大分子的结合结构域的结构。

公开(公告)号：US06578687B2

公开(公告)日：2003-06-17

申请号：US09950201

申请日：2001-09-10

申请人： Andreas Dau ,  Andreas Orlamünder ,  Albert Kammermeier ,  Hartmut Bach ,  Cora Carlson ,  Matthias Dörfler ,  Günther Esly ,  Reinhard Feldhaus ,  Ingrid Hoffelner ,  Christoph Kleuker ,  Paul Kraus ,  Bernd Peinemann ,  Michael Peterseim ,  Gerhard Röll ,  Ralf Till ,  Sebastian Vogt

发明人： Andreas Dau ,  Andreas Orlamünder ,  Albert Kammermeier ,  Hartmut Bach ,  Cora Carlson ,  Matthias Dörfler ,  Günther Esly ,  Reinhard Feldhaus ,  Ingrid Hoffelner ,  Christoph Kleuker ,  Paul Kraus ,  Bernd Peinemann ,  Michael Peterseim ,  Gerhard Röll ,  Ralf Till ,  Sebastian Vogt

IPC分类号： F16D1344

CPC分类号： F16D13/71 ,  F16D2013/706

摘要： A pressure plate assembly for a friction clutch includes a housing arrangement and a pressure plate arrangement, which is held by at least one leaf spring arrangement with freedom of axial movement relative to the housing arrangement. The at least one leaf spring arrangement is fixed by a first attachment area to a first fastening area of the pressure plate arrangement and by a second attachment area to a second fastening area of the housing arrangement. The end area of the first fastening area and/or the second fastening area curves away from the minimum of one leaf spring arrangement, this end area being located in the area along which the at least one leaf spring arrangement extends.

公开(公告)号：US06409002B1

公开(公告)日：2002-06-25

申请号：US09602804

申请日：2000-06-23

申请人： Andreas Orlamünder ,  Achim Link ,  Wolfgang Reiber ,  Sebastian Vogt

发明人： Andreas Orlamünder ,  Achim Link ,  Wolfgang Reiber ,  Sebastian Vogt

IPC分类号： F16D1356

CPC分类号： F16D13/52 ,  F16D13/385 ,  F16D13/71 ,  F16D2013/581 ,  Y10T29/49844 ,  Y10T29/49849

摘要： A pressure plate subassembly for a friction clutch includes a housing connectable to an abutment arrangement for joint rotation about an axis of rotation, a pressure plate arranged in the housing so that the pressure plate is rotatable together with the housing about the axis of rotation (A) and so that the pressure plate is displaceable relative to the housing in the direction of the axis of rotation, and a force accumulator for generating a pressure force, the force accumulator being supported on the housing and on the pressure plate. The force accumulator is arranged outside the housing.

摘要翻译： 用于摩擦离合器的压板组件包括可连接到用于围绕旋转轴线的关节旋转的邻接装置的壳体，布置在壳体中的压板，使得压板可与壳体围绕旋转轴线（A ），并且使得压板相对于壳体沿着旋转轴线的方向可移动，以及用于产生压力的力蓄能器，该蓄能器支撑在壳体和压力板上。 力蓄能器布置在外壳的外部。

公开(公告)号：US09827030B2

公开(公告)日：2017-11-28

申请号：US13696214

申请日：2011-04-15

申请人： Sebastian Vogt ,  Hubert Buechner

发明人： Sebastian Vogt ,  Hubert Buechner

IPC分类号： A61B17/88 ,  A61C5/64 ,  B05C17/005

CPC分类号： A61B17/8805 ,  A61C5/64 ,  B05C17/00506 ,  B05C17/00513 ,  B05C17/00553 ,  B05C17/00576

摘要： Cartridge system for mixing and applying a mix of a medical cement. Cartridges are arranged parallel to each other and an outlet opening. The cartridges each comprise at least one opening that connect(s) the cartridges to the outlet opening, and the cartridges are bordered laterally through cartridge walls. Each cartridge comprises a feed plunger for expelling starting components of the mix from the cartridges through the openings. The feed plungers are fixedly connected to each other through at least one fin. The cartridge walls of the cartridges are connected through the fin(s). The walls comprise slits that are arranged parallel to the cartridge axis, whereby the width of the slits is well-suited for taking up the fin or fins, and the at least one fin moves through regions of the slits when the feed plungers perform a motion in the cartridges.

公开(公告)号：US09078959B2

公开(公告)日：2015-07-14

申请号：US13330936

申请日：2011-12-20

申请人： Sebastian Vogt ,  Klaus-Dieter Kühn

发明人： Sebastian Vogt ,  Klaus-Dieter Kühn

IPC分类号： B05C11/00 ,  A61L31/16 ,  A61L27/30 ,  A61L27/32 ,  A61L27/54 ,  A61L31/08

CPC分类号： A61L31/16 ,  A61L27/306 ,  A61L27/32 ,  A61L27/54 ,  A61L31/086 ,  A61L31/088 ,  A61L2300/60 ,  A61L2430/24

摘要： A device for coating at least regions of a medical implant includes an elastically deformable transfer means having a liquid that contains at least one pharmaceutically active substance. The liquid can be transferred to the medical implant when the transfer means is contacted with a surface of the medical implant.

摘要翻译： 用于涂覆医疗植入物的至少区域的装置包括具有含有至少一种药物活性物质的液体的可弹性变形的转移装置。 当转移装置与医用植入物的表面接触时，可将液体转移到医疗植入物。

公开(公告)号：US08770451B2

公开(公告)日：2014-07-08

申请号：US13822897

申请日：2011-08-10

申请人： Sebastian Vogt ,  Hubert Buechner

发明人： Sebastian Vogt ,  Hubert Buechner

IPC分类号： B65D3/00

CPC分类号： B65D83/0005 ,  A61B17/8822 ,  A61B2017/00544 ,  A61B2017/8838 ,  B01F13/0023 ,  B01F15/0237 ,  B01F15/0261 ,  B01F2215/0027 ,  B01F2215/0029 ,  B05B1/1636 ,  B05C17/00516 ,  B05C17/00553 ,  B05C17/00556 ,  B05C17/00573

摘要： A cartridge system has two cartridges and a discharge opening, wherein the cartridges are delimited by cartridge walls and by a cartridge head, wherein at least one cartridge opening for expelling the cartridge contents from both cartridges is provided in each case in the cartridge head. A device regulates streams of fluid from the cartridges and is arranged rotatably or slideably on the cartridge head, wherein on at least two openings at least one wing is in each case arranged which at least in some areas protrudes past the opening, such that a flow through the openings applies to the device a force which force leads to a sliding or turning of the device against the cartridge head, such that a housing having a discharge opening is arranged on the cartridge head, in which the housing is arranged so as to rotate or slide.

摘要翻译： 盒式系统具有两个盒和排出口，其中盒由盒壁和盒头限定，其中至少一个用于从两个盒排出盒内容物的盒开口设置在盒头中。 装置调节来自盒的流体流并且可旋转地或可滑动地布置在盒头上，其中在至少两个开口上，至少在一个区域中布置至少一个翼，至少在一些区域突出穿过开口，使得流 通过这些开口向装置施加一种力，该力使得该装置相对于盒头滑动或转动，使得具有排出口的壳体设置在盒头上，其中壳体被布置成旋转 或幻灯片。

公开(公告)号：US08757866B2

公开(公告)日：2014-06-24

申请号：US12824310

申请日：2010-06-28

申请人： Sebastian Vogt ,  Hubert Buechner

发明人： Sebastian Vogt ,  Hubert Buechner

IPC分类号： B01F13/06 ,  B01F15/02 ,  A61B17/58 ,  A61B17/60 ,  A61F2/00 ,  B67D7/76

CPC分类号： B01F11/0082 ,  A61B17/8825 ,  A61B17/8827 ,  A61B2017/8838 ,  A61F2002/4631 ,  A61F2002/4685 ,  B01F13/002 ,  B01F13/06 ,  B01F15/00071 ,  B01F15/0201 ,  B01F15/0205 ,  B01F15/0237 ,  B01F15/0258 ,  B01F15/0279

摘要： A device (10) for mixing and dispensing bone cement includes a mixing cylinder (20), in which a mixing plunger (21) is arranged, the mixing plunger (21) being axially movable by an actuation rod (50) guided out in a sealed manner at a first cylinder end (30). A sealing plunger (42) is arranged in a region of the first cylinder end (30), is axially movable on the actuation rod (50) and seals the mixing cylinder (20) in a gas-tight manner. A sterilization plunger (41) is arranged in the region of the first cylinder end (30) between the mixing plunger (21) and the sealing plunger (42), is axially movable on the actuation rod (50) separately from the sealing plunger (42), and seals the mixing cylinder (20) in a gas-permeable manner. The sterilization plunger (41) and the sealing plunger (42) form a two-part plunger system (40).

摘要翻译： 用于混合和分配骨水泥的装置（10）包括：混合缸（20），其中布置有混合柱塞（21），所述混合柱塞（21）可通过致动杆（50）轴向移动，所述致动杆 在第一气缸端（30）处密封。 密封柱塞（42）布置在第一气缸端部（30）的区域中，可在致动杆（50）上轴向移动并以气密方式密封混合气缸（20）。 灭菌柱塞（41）布置在混合柱塞（21）和密封柱塞（42）之间的第一气缸端部（30）的区域中，可在致动杆（50）上与密封柱塞分开地轴向移动 42），并且以气体可渗透的方式密封混合缸（20）。 灭菌柱塞（41）和密封柱塞（42）形成两部分柱塞系统（40）。

公开(公告)号：US08642064B2

公开(公告)日：2014-02-04

申请号：US10580549

申请日：2004-11-25

申请人： Matthias Schnabelrauch ,  Sebastian Vogt ,  Ute (Erbe) Reif

发明人： Matthias Schnabelrauch ,  Sebastian Vogt ,  Dieter Reif

IPC分类号： A61F2/00 ,  A61F13/00 ,  C09K3/00

CPC分类号： A61L24/0084 ,  A61L24/0036 ,  A61L24/0042 ,  A61L27/46 ,  A61L27/56 ,  A61L27/58 ,  A61L2430/02

摘要： A method of producing a self-hardening, bioabsorbable composite material, the material produced and its areas of application are described. The method is based on the principal method steps (I) immobilisation of a polymerisation initiator in a microporous pore system of a first partial amount of a bioabsorbable calcium phosphate used in producing the self-hardening, bioabsorbable composite material, (II) immobilisation of a polymerisation activator in the microporous pore system of a second partial amount of the bioabsorbable calcium phosphate used in producing the self-hardening, bioabsorbable composite material and (III) homogeneous mixing of the components according to (I) and (II) with a liquid or paste-form, multi-functional monomer capable of forming a biocompatible, bioabsorbable polymer network or a corresponding monomer mixture and, optionally, with further constituents which modify the properties of the monomer or monomer mixture. The described self-hardening, bioabsorbable composite materials can be used as bone adhesives for the fixing of bone fractures, as shaped pieces of standardised dimensions and as implants that are individual to a patient in the context of regenerative bone healing in humans and animals.

摘要翻译： 描述了生产自硬化生物可吸收复合材料的方法，所生产的材料及其应用领域。 该方法基于主要方法步骤（I）将聚合引发剂固定在用于生产自硬化生物可吸收复合材料的第一部分量的生物可吸收磷酸钙的微孔孔系统中，（II）固定化 用于生产自硬化生物可吸收复合材料的第二部分量的生物可吸收磷酸钙的微孔孔体系中的聚合活化剂和（III）根据（I）和（II）的组分与液体或 糊状的多功能单体，其能够形成生物相容的生物可吸收的聚合物网络或相应的单体混合物，并且任选地具有改变单体或单体混合物的性质的其它组分。 所描述的自硬化生物可吸收复合材料可用作固定骨折的骨粘合剂，​​作为标准尺寸的成形件，以及在人和动物的再生骨愈合背景下对患者个体的植入物。