公开(公告)号：US20060035315A1

公开(公告)日：2006-02-16

申请号：US10203486

申请日：2001-02-23

申请人： Henry Yue ,  Y Tang ,  Preeti Lal ,  Jennifer Policky ,  Danniel Nguyen ,  Janice Au-Young ,  Monique Yao ,  Farrah Khan ,  Narinder Walia ,  Ameena Gandhi ,  Catherine Tribouley ,  Chandra Arvizu ,  Michael Thornton ,  Barrie Greene ,  Roberto Hernandez ,  Mark Borowsky ,  Madhu Sanjanwala

发明人： Henry Yue ,  Y Tang ,  Preeti Lal ,  Jennifer Policky ,  Danniel Nguyen ,  Janice Au-Young ,  Monique Yao ,  Farrah Khan ,  Narinder Walia ,  Ameena Gandhi ,  Catherine Tribouley ,  Chandra Arvizu ,  Michael Thornton ,  Barrie Greene ,  Roberto Hernandez ,  Mark Borowsky ,  Madhu Sanjanwala

IPC分类号： C07K14/705 ,  C07H21/04 ,  C12P21/06 ,  C12N15/74

CPC分类号： C07K14/705 ,  A61K38/00

摘要： The invention provides human transporters and ion channels (TRICH) and polynucleotides which identify and encode TRICH. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of TRICH.

公开(公告)号：US20050084936A1

公开(公告)日：2005-04-21

申请号：US10965898

申请日：2004-10-18

申请人： Preeti Lal ,  Olga Bandman ,  Jennifer Hillman ,  Janice Au-Young ,  Y. Tang ,  Henry Yue ,  Purvi Shah ,  Karl Guegler ,  Neil Corley

发明人： Preeti Lal ,  Olga Bandman ,  Jennifer Hillman ,  Janice Au-Young ,  Y. Tang ,  Henry Yue ,  Purvi Shah ,  Karl Guegler ,  Neil Corley

IPC分类号： C12N15/09 ,  A61K38/00 ,  A61K45/00 ,  A61P35/00 ,  C07K14/47 ,  C07K16/18 ,  C12M1/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12P21/02 ,  C12Q1/68 ,  G01N37/00 ,  C07H21/04 ,  C07K14/705

CPC分类号： C07K14/4702 ,  A61K38/00

摘要： The invention provides human regulatory proteins collectively designated HRGP, and polynucleotides which identify and encode these molecules. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention further provides methods for diagnosing, treating, and preventing disorders associated with expression of human regulatory proteins.

摘要翻译： 本发明提供了统称为HRGP的人调节蛋白，以及鉴定和编码这些分子的多核苷酸。 本发明还提供表达载体，宿主细胞，激动剂，抗体和拮抗剂。 本发明还提供了用于诊断，治疗和预防与人类调节蛋白表达相关的紊乱的方法。

公开(公告)号：US20050048623A1

公开(公告)日：2005-03-03

申请号：US10959539

申请日：2004-10-06

申请人： Jennifer Hillman ,  Preeti Lal ,  Y. Tang ,  Henry Yue ,  Janice Au-Young ,  Olga Bandman ,  Yalda Azimzai ,  Junming Yang ,  Dyung Lu ,  Mariah Baughn ,  Chandra Arvizu ,  Purvi Shah

发明人： Jennifer Hillman ,  Preeti Lal ,  Y. Tang ,  Henry Yue ,  Janice Au-Young ,  Olga Bandman ,  Yalda Azimzai ,  Junming Yang ,  Dyung Lu ,  Mariah Baughn ,  Chandra Arvizu ,  Purvi Shah

IPC分类号： A61K38/00 ,  C07K14/47 ,  C07H21/04 ,  C12N9/64 ,  C12P21/04

CPC分类号： C07K14/47 ,  A01K2217/05 ,  A61K38/00

摘要： The invention provides human cell cycle and proliferation proteins (CCYPR) and polynucleotides which identify and encode CCYPR. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of CCYPR.

摘要翻译： 本发明提供鉴定和编码CCYPR的人类细胞周期和增殖蛋白（CCYPR）和多核苷酸。 本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。 本发明还提供了用于诊断，治疗或预防与CCYPR表达相关的疾病的方法。

公开(公告)号：US20050033018A1

公开(公告)日：2005-02-10

申请号：US10477714

申请日：2002-05-16

申请人： Preeti Lal ,  Bridget Warren ,  Yuming Xu ,  Brendan Duggan ,  Cynthia Honchell ,  Deborah Kallick ,  Mariah Baughn ,  Y. Tang ,  Henry Yue ,  Olga Bandman ,  Karen Jones ,  Shanya Becha ,  Uyen Tran ,  Janice Au-Young ,  Jennifer Griffin ,  Yeganeh Zebarjadian ,  Ernestie Lee ,  Vicki Elliott ,  Kavitha Thangavelu ,  Jayalaxmi Ramkumar ,  Yan Lu ,  April Hafalia ,  Narinder Chawla ,  Craig Ison ,  Michael Thornton ,  Anita Swarnakar ,  Junming Yang ,  Thomas Richardson ,  Brooke Emerling ,  Monique Yao ,  Benjamin Cocks ,  Bharati Sanjanwala ,  Patricia Mason ,  Ameena Gandhi ,  Joana Li ,  Rajagopal Gururajan ,  Kimberly Gietzen ,  Ian Forsythe

发明人： Preeti Lal ,  Bridget Warren ,  Yuming Xu ,  Brendan Duggan ,  Cynthia Honchell ,  Deborah Kallick ,  Mariah Baughn ,  Y. Tang ,  Henry Yue ,  Olga Bandman ,  Karen Jones ,  Shanya Becha ,  Uyen Tran ,  Janice Au-Young ,  Jennifer Griffin ,  Yeganeh Zebarjadian ,  Ernestie Lee ,  Vicki Elliott ,  Kavitha Thangavelu ,  Jayalaxmi Ramkumar ,  Yan Lu ,  April Hafalia ,  Narinder Chawla ,  Craig Ison ,  Michael Thornton ,  Anita Swarnakar ,  Junming Yang ,  Thomas Richardson ,  Brooke Emerling ,  Monique Yao ,  Benjamin Cocks ,  Bharati Sanjanwala ,  Patricia Mason ,  Ameena Gandhi ,  Joana Li ,  Rajagopal Gururajan ,  Kimberly Gietzen ,  Ian Forsythe

IPC分类号： G01N33/50 ,  A61K45/00 ,  A61K49/00 ,  A61P1/00 ,  A61P3/00 ,  A61P25/00 ,  A61P29/00 ,  A61P31/12 ,  A61P35/00 ,  A61P37/06 ,  C07K14/47 ,  C07K14/705 ,  C07K16/28 ,  C07K16/46 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/02 ,  C12N15/09 ,  C12P21/02 ,  C12P21/08 ,  C12Q1/02 ,  C12Q1/68 ,  G01N33/15 ,  G01N33/53 ,  G01N33/566 ,  C07H21/04

CPC分类号： C07K14/705 ,  C07K14/47

摘要： The invention provides human receptors and membrane-associated proteins (REMAP) and polynucleotides which identify and encode REMAP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of REMAP.

摘要翻译： 本发明提供鉴定和编码REMAP的人受体和膜相关蛋白（REMAP）和多核苷酸。 本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。 本发明还提供用于诊断，治疗或预防与REMAP的异常表达相关的紊乱的方法。

公开(公告)号：US06492505B1

公开(公告)日：2002-12-10

申请号：US09495050

申请日：2000-01-31

申请人： Roopa Reddy ,  Karl J. Guegler ,  Janice Au-Young

发明人： Roopa Reddy ,  Karl J. Guegler ,  Janice Au-Young

IPC分类号： C07H2102

CPC分类号： C12Q1/6876 ,  C12Q1/6834 ,  C12Q2600/158 ,  Y02A50/52

摘要： The present invention relates to a composition comprising a plurality of polynucleotide sequences. The composition can be used as probes or array elements.

摘要翻译： 本发明涉及包含多个多核苷酸序列的组合物。 该组合物可用作探针或阵列元件。

公开(公告)号：US06265547B1

公开(公告)日：2001-07-24

申请号：US09370102

申请日：1999-08-06

申请人： Henry Yue ,  Janice Au-Young ,  Chandra Patterson

发明人： Henry Yue ,  Janice Au-Young ,  Chandra Patterson

IPC分类号： C07K100

CPC分类号： C07K14/47 ,  A61K38/00 ,  A61K48/00 ,  Y02A50/423

摘要： The invention provides a human cell junction PDZ protein (CJPDZ) and polynucleotides which identify and encode CJPDZ. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of CJPDZ.

摘要翻译： 本发明提供了人类细胞连接PDZ蛋白（CJPDZ）和识别和编码CJPDZ的多核苷酸。 本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。 本发明还提供了用于诊断，治疗或预防与CJPDZ表达相关的疾病的方法。

公开(公告)号：US06235880B1

公开(公告)日：2001-05-22

申请号：US09208716

申请日：1998-12-09

申请人： Janice Au-Young ,  Olga Bandman ,  Roger Coleman

发明人： Janice Au-Young ,  Olga Bandman ,  Roger Coleman

IPC分类号： C07K14705

CPC分类号： C07K14/705 ,  A61K38/00

摘要： The present invention provides a human sulfonylurea receptor (SURH) and the polynucleotides which identify and encode SURH. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding SURH and methods for producing the protein. The invention also provides pharmaceutical compositions containing SURH, agonists to SURH, or antagonists to SURH, and in the use of such compositions for the prevention or treatment of diseases associated with the expression of SURH. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding SURH for the treatment of diseases associated with the expression of SURH. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, to hybridize to the genomic sequence or transcripts of polynucleotides encoding SURH, or anti-SURH antibodies which specifically bind to SURH.

公开(公告)号：US6077693A

公开(公告)日：2000-06-20

申请号：US79981

申请日：1998-05-14

申请人： Y. Tom Tang ,  Brian McKelligon ,  Janice Au-Young ,  Neil C. Corley ,  Karl J. Guegler ,  Chandra Patterson

发明人： Y. Tom Tang ,  Brian McKelligon ,  Janice Au-Young ,  Neil C. Corley ,  Karl J. Guegler ,  Chandra Patterson

IPC分类号： A61K38/00 ,  C07K14/47 ,  C12N15/12 ,  C12N15/19 ,  C07K14/52 ,  C12N5/10 ,  C12N15/63

CPC分类号： C07K14/4747 ,  C07K14/4702 ,  A61K38/00

摘要： The invention provides a human promonocyte associated protein (PRMNC) and polynucleotides which identify and encode PRMNC. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating or preventing disorders associated with expression of PRMNC.

摘要翻译： 本发明提供了人类促细胞相关蛋白（PRMNC）和识别和编码PRMNC的多核苷酸。 本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。 本发明还提供用于诊断，治疗或预防与PRMNC表达相关的疾病的方法。

公开(公告)号：US6043222A

公开(公告)日：2000-03-28

申请号：US388993

申请日：1999-09-02

申请人： Janice Au-Young ,  Preeti Lal ,  Olga Bandman

发明人： Janice Au-Young ,  Preeti Lal ,  Olga Bandman

IPC分类号： A01N37/18 ,  A61K38/00 ,  C07H21/04 ,  C07K1/00 ,  C07K14/47 ,  C12N1/21 ,  C12N15/09 ,  C12N15/21 ,  C12Q1/68

CPC分类号： C07K14/47 ,  A61K38/00 ,  Y10S530/827 ,  Y10S530/839

摘要： The invention provides a two new human DnaJ-like proteins (HSPJ1 or HSPJ2) and polynucleotides which identify and encode HSPJ1 or HSPJ2. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of HSPJ1 or HSPJ2.

摘要翻译： 本发明提供两种新的人类DnaJ样蛋白（HSPJ1或HSPJ2）和识别和编码HSPJ1或HSPJ2的多核苷酸。 本发明还提供表达载体，宿主细胞，激动剂，抗体和拮抗剂。 本发明还提供了治疗与HSPJ1或HSPJ2表达相关的疾病的方法。

公开(公告)号：US6030826A

公开(公告)日：2000-02-29

申请号：US208804

申请日：1998-12-09

申请人： Janice Au-Young

发明人： Janice Au-Young

IPC分类号： A61K38/00 ,  C12N1/21 ,  C12N9/90 ,  A61K38/52

CPC分类号： C12N9/90 ,  A61K38/00

摘要： The present invention provides a human parvulin-like protein (HPVLP) and polynucleotides which identify and encode HPVLP. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding HPVLP and a method for producing HPVLP. The invention also provides for agonists, antibodies, or antagonists specifically binding HPVLP, and their use, in the prevention and treatment of diseases associated with expression of HPVLP. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding HPVLP for the treatment of diseases associated with the expression of HPVLP. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding HPVLP.

摘要翻译： 本发明提供了人类parvulin样蛋白（HPVLP）和识别和编码HPVLP的多核苷酸。 本发明还提供了遗传工程改造的表达载体和包含编码HPVLP的核酸序列的宿主细胞和用于产生HPVLP的方法。 本发明还提供特异性结合HPVLP的激动剂，抗体或拮抗剂及其在预防和治疗与HPVLP表达有关的疾病中的用途。 此外，本发明提供了反义分子用于编码HPVLP的多核苷酸用于治疗与HPVLP表达相关的疾病的用途。 本发明还提供利用多核苷酸或其片段或其补体以及特异性结合HPVLP的抗体的诊断测定法。